LLPS-Caf-0573
PPP1R12B
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein phosphatase 1 regulatory subunit 12B |
| Gene Name: | PPP1R12B |
| Ensembl Gene: | ENSCAFG00000010497.4 |
| Ensembl Protein: | ENSCAFP00000015441.3 |
| Organism: | Canis familiaris |
| Taxa ID: | 9615 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, P-body, Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCAFT00000016685.4 | ENSCAFP00000015441.3 |
| Ensembl | ENSCAFT00000047397.1 | ENSCAFP00000036594.1 |
| UniProt | E2RHS3, E2RHS3_CANLF | |
| GeneBank | AAEX03004979, AAEX03004978, AAEX03004977, AAEX03004980 | |
| RefSeq | XM_547351.6 | XP_547351.2 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAELEHLGGK RAESARMRRA EQLRRWRGSL TEQEPAERRG AGRQPQPRRG SPRVRFEDGA 60 61 VFLAACSSGD TDEVKKLLAR GADINTVNVD GLTALHQACI DENLDMVKFL VENKANVNQQ 120 121 DNEGWTPLHA AASCGYLNIA EYFINHGASV GIVNSEGEVP SDLAEEPAMK DLLLEQVKKQ 180 181 GVDLEQSRKE EEQQMLQDAR QWLNSGKIED VRQPRSGATA LHVAAAKGYS EVLRLLIQAG 240 241 YELNVQDYDG WTPLHAAAHW GVKEACSILA EALCDMDVRN KLGQTPFDVA DEGLVEHLEM 300 301 LQKKQNVLRS EKETRNKLIE SDLNSKLQSG LFKNKEKMLY EEEIPKSQEM EEESKESSSS 360 361 SSEEEEEGED EASESEAEKE ADKKPEAIVN HSNSESKNII TEQIPTPAQN TFSASSARRF 420 421 SSSLFNKPEE PKDESPSSWR LGLRKTGSHN MLSEVANPRE ALRDRGSSIY RSSSSPRISA 480 481 LLDNKDKERE NKSYFSSLAP RRLSSTSDVE EKENRESAVN LVRSGSYTRQ LWRDEAKGNE 540 541 TPQSVAPSTY VSTYLKRTPY KSQADSTVEK TADNVSSSTP LCVITNRPPP NTANGVTTAT 600 601 LLSTPGTDSS VEARDRRRSY LTPVRDEEAE SLRKARSRQA RQTRRSTQGV TLTDLQEAER 660 661 TFSRSRAERQ AQEQPGQKPT GTEGLEGSSE KHEPPAVPAK EAGEGRQPWS GSLDEEPVYR 720 721 RLRYTAQPDK STTPVSPSAS RPSLYTSSHL LRTSRSSVPD SESTETTPNT AVAKEMDKNE 780 781 SEEADVDDQS SNRLSIRERR RPKERRRGTG INFWTKDEDE TDVSEEVKEA LHERLSRLES 840 841 GGSNPTSSDS YGDRASARAR REAREARLAT LTSRVEEDSN RDYKKLYESA LTENQKLKTK 900 901 LQEAQLELAD IKSKLEKMAQ QKQEKTSDRS SMLEMEKRER RALERKMSEM EEEMKVLTEL 960 961 KSDNQRLKDE NGALIRVISK LSK 983 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGAGC TGGAGCACCT GGGCGGGAAG CGGGCCGAGT CGGCGCGAAT GCGGCGGGCT 60 61 GAGCAGCTGC GGCGCTGGCG GGGCTCGCTG ACGGAGCAGG AGCCCGCGGA GCGGCGAGGC 120 121 GCGGGGCGGC AGCCGCAGCC GCGTCGCGGG AGCCCCAGGG TCCGCTTCGA GGACGGAGCC 180 181 GTCTTCCTGG CCGCCTGCTC CAGCGGGGAC ACCGACGAGG TGAAGAAGCT GCTGGCCAGG 240 241 GGCGCCGACA TCAACACGGT CAACGTGGAC GGCTTGACAG CCCTCCACCA GGCCTGTATT 300 301 GATGAAAATT TGGACATGGT GAAGTTTCTG GTGGAGAACA AAGCCAATGT AAACCAACAA 360 361 GACAACGAGG GCTGGACACC CCTTCATGCA GCAGCTTCCT GTGGCTATCT GAACATAGCA 420 421 GAGTATTTCA TTAACCATGG AGCCAGTGTG GGTATTGTGA ATAGTGAAGG TGAAGTCCCT 480 481 TCTGACCTTG CAGAAGAGCC CGCCATGAAG GATCTTCTTC TGGAGCAAGT GAAGAAGCAA 540 541 GGAGTTGATC TAGAGCAGTC AAGAAAAGAA GAGGAACAAC AGATGTTACA GGATGCCCGC 600 601 CAGTGGCTCA ACAGTGGGAA AATAGAGGAT GTAAGGCAGC CTCGCTCAGG GGCCACAGCC 660 661 CTCCATGTGG CTGCTGCCAA GGGCTATTCT GAGGTCCTCA GACTTTTAAT CCAGGCTGGC 720 721 TATGAACTCA ATGTTCAGGA TTACGATGGC TGGACTCCCC TCCATGCTGC TGCACACTGG 780 781 GGAGTGAAGG AGGCTTGCTC CATCCTGGCA GAAGCACTCT GTGACATGGA TGTCAGGAAC 840 841 AAGCTGGGCC AGACACCGTT TGATGTGGCT GATGAAGGGC TTGTGGAGCA CTTGGAGATG 900 901 CTCCAGAAGA AGCAGAATGT GCTTCGAAGT GAAAAAGAGA CACGGAATAA GCTCATTGAG 960 961 TCAGACCTGA ACAGCAAGTT ACAGAGTGGA CTCTTTAAGA ACAAAGAGAA GATGCTCTAT 1020 1021 GAAGAAGAGA TACCCAAGTC CCAAGAAATG GAGGAAGAAA GTAAAGAGTC CAGCAGCTCC 1080 1081 AGCTCCGAGG AGGAGGAGGA GGGTGAAGAT GAAGCTTCTG AGTCAGAAGC TGAGAAGGAG 1140 1141 GCAGATAAAA AGCCAGAAGC CATTGTCAAC CATTCCAACT CTGAAAGCAA GAATATTATC 1200 1201 ACGGAACAGA TACCAACACC AGCTCAGAAT ACCTTCTCTG CCTCTTCAGC TAGGAGATTC 1260 1261 TCCTCCAGCC TTTTTAACAA GCCGGAAGAA CCCAAAGATG AATCTCCTTC TTCGTGGAGA 1320 1321 CTGGGACTCA GAAAAACTGG CAGCCACAAC ATGTTGAGTG AGGTGGCCAA TCCCAGGGAA 1380 1381 GCTCTAAGGG ACCGAGGCTC TTCCATCTAC CGGTCATCAT CAAGTCCTCG GATTTCTGCT 1440 1441 CTCCTGGACA ACAAAGATAA GGAGAGAGAA AACAAAAGCT ATTTTAGTTC ACTAGCACCC 1500 1501 CGGAGGCTCA GCAGCACAAG TGACGTTGAA GAAAAGGAGA ACAGAGAATC AGCTGTGAAT 1560 1561 CTAGTGAGGA GTGGTTCATA TACACGGCAG CTGTGGAGGG ATGAAGCGAA GGGAAATGAA 1620 1621 ACTCCACAGT CAGTTGCTCC TTCTACCTAT GTATCAACCT ACTTGAAAAG GACTCCTTAC 1680 1681 AAATCCCAGG CTGACTCAAC AGTAGAGAAA ACAGCAGACA ATGTCTCTTC TAGCACCCCA 1740 1741 CTCTGTGTGA TCACTAATCG CCCTCCACCT AACACTGCCA ATGGGGTTAC AACTGCCACT 1800 1801 CTGCTCTCCA CTCCTGGAAC AGACTCCTCT GTGGAAGCCA GGGACAGGAG GAGGTCGTAT 1860 1861 CTGACTCCTG TACGGGATGA GGAAGCAGAG TCTTTACGGA AAGCACGCTC CAGACAAGCT 1920 1921 CGGCAGACTC GAAGGTCTAC TCAAGGTGTG ACGCTAACGG ACCTTCAAGA AGCAGAAAGG 1980 1981 ACTTTCAGCC GGTCGAGAGC AGAACGGCAA GCTCAGGAGC AGCCTGGCCA GAAGCCCACA 2040 2041 GGCACCGAAG GGCTTGAGGG CAGCTCGGAG AAGCATGAGC CCCCAGCAGT CCCAGCAAAG 2100 2101 GAAGCTGGTG AAGGCCGTCA ACCCTGGAGC GGGAGTCTGG ACGAAGAGCC TGTCTATCGT 2160 2161 CGCCTGAGGT ATACAGCTCA GCCAGACAAA TCCACAACAC CGGTGTCTCC TTCTGCCTCA 2220 2221 AGACCCTCTC TCTACACCAG TTCCCATCTG CTACGGACAA GCAGATCTTC AGTCCCTGAC 2280 2281 TCTGAGAGCA CAGAGACCAC CCCAAACACT GCAGTTGCAA AGGAAATGGA CAAAAATGAG 2340 2341 AGTGAAGAAG CAGATGTGGA TGATCAGTCC TCTAATAGAC TGTCCATCCG TGAGAGGAGG 2400 2401 CGGCCCAAGG AGCGACGACG AGGCACAGGC ATCAATTTCT GGACAAAAGA TGAAGATGAA 2460 2461 ACTGATGTCT CTGAAGAAGT AAAAGAAGCA CTGCATGAAA GACTTTCTAG GTTGGAATCA 2520 2521 GGAGGTAGTA ACCCTACAAG CAGCGATTCC TATGGGGACC GGGCCTCAGC AAGAGCCCGC 2580 2581 CGGGAGGCCC GGGAGGCCCG CCTCGCCACC CTGACCAGCC GCGTGGAGGA AGACAGCAAC 2640 2641 CGGGATTATA AAAAACTCTA CGAGAGTGCC CTGACTGAAA ACCAAAAACT GAAAACAAAA 2700 2701 CTTCAAGAGG CCCAGCTAGA GCTAGCAGAT ATAAAGTCCA AGCTTGAGAA GATGGCCCAG 2760 2761 CAGAAACAAG AGAAGACCTC TGACCGATCA TCAATGCTGG AGATGGAGAA ACGGGAGAGG 2820 2821 CGAGCCTTGG AGCGGAAAAT GTCAGAAATG GAAGAGGAGA TGAAGGTGTT AACAGAGCTG 2880 2881 AAGTCCGACA ACCAGAGGCT GAAAGATGAA AACGGCGCCC TCATCCGAGT CATCAGCAAA 2940 2941 CTATCCAAG 2949 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-3618 | Ursus maritimus | 98.79 | 7e-95 | 304 |
| LLPS-Dio-3133 | Dipodomys ordii | 96.69 | 1e-105 | 333 |
| LLPS-Fec-2798 | Felis catus | 95.89 | 0.0 | 795 |
| LLPS-Ora-2708 | Ornithorhynchus anatinus | 94.42 | 1e-165 | 510 |
| LLPS-Mup-0131 | Mustela putorius furo | 94.1 | 0.0 | 1583 |
| LLPS-Nol-0544 | Nomascus leucogenys | 93.19 | 0.0 | 767 |
| LLPS-Aim-2753 | Ailuropoda melanoleuca | 92.0 | 0.0 | 926 |
| LLPS-Chs-2156 | Chlorocebus sabaeus | 90.03 | 0.0 | 1483 |
| LLPS-Orc-2894 | Oryctolagus cuniculus | 89.53 | 0.0 | 1457 |
| LLPS-Otg-2514 | Otolemur garnettii | 89.52 | 0.0 | 1486 |
| LLPS-Poa-2331 | Pongo abelii | 88.81 | 0.0 | 1460 |
| LLPS-Bot-3615 | Bos taurus | 88.79 | 0.0 | 613 |
| LLPS-Ict-0385 | Ictidomys tridecemlineatus | 88.77 | 0.0 | 1456 |
| LLPS-Ten-0362 | Tetraodon nigroviridis | 87.76 | 1e-06 | 57.0 |
| LLPS-Loa-3270 | Loxodonta africana | 86.66 | 0.0 | 1327 |
| LLPS-Mum-0987 | Mus musculus | 85.95 | 0.0 | 1412 |
| LLPS-Fud-0046 | Fukomys damarensis | 85.95 | 0.0 | 1419 |
| LLPS-Xet-3059 | Xenopus tropicalis | 85.71 | 2e-06 | 56.2 |
| LLPS-Ran-1412 | Rattus norvegicus | 85.54 | 0.0 | 1411 |
| LLPS-Orl-1959 | Oryzias latipes | 84.62 | 1e-07 | 60.1 |
| LLPS-Hos-2197 | Homo sapiens | 84.2 | 0.0 | 1409 |
| LLPS-Pat-2025 | Pan troglodytes | 84.0 | 0.0 | 1414 |
| LLPS-Pap-1374 | Pan paniscus | 83.91 | 0.0 | 1416 |
| LLPS-Gog-1825 | Gorilla gorilla | 83.81 | 0.0 | 1413 |
| LLPS-Mam-0860 | Macaca mulatta | 83.52 | 0.0 | 1399 |
| LLPS-Caj-0777 | Callithrix jacchus | 82.81 | 0.0 | 1382 |
| LLPS-Anc-3384 | Anolis carolinensis | 82.76 | 1e-09 | 66.6 |
| LLPS-Aon-0491 | Aotus nancymaae | 82.71 | 0.0 | 1394 |
| LLPS-Cas-3114 | Carlito syrichta | 81.8 | 0.0 | 1167 |
| LLPS-Maf-3881 | Macaca fascicularis | 81.74 | 0.0 | 1353 |
| LLPS-Man-2201 | Macaca nemestrina | 81.74 | 0.0 | 1353 |
| LLPS-Cea-1206 | Cercocebus atys | 81.64 | 0.0 | 1350 |
| LLPS-Mal-2080 | Mandrillus leucophaeus | 81.64 | 0.0 | 1353 |
| LLPS-Myl-0650 | Myotis lucifugus | 81.62 | 0.0 | 692 |
| LLPS-Paa-0681 | Papio anubis | 81.55 | 0.0 | 1349 |
| LLPS-Cap-0588 | Cavia porcellus | 81.51 | 0.0 | 1355 |
| LLPS-Pof-3106 | Poecilia formosa | 81.48 | 1e-07 | 60.5 |
| LLPS-Rhb-3632 | Rhinopithecus bieti | 81.28 | 0.0 | 1350 |
| LLPS-Ova-0543 | Ovis aries | 81.16 | 4e-108 | 347 |
| LLPS-Sus-1234 | Sus scrofa | 81.08 | 0.0 | 1311 |
| LLPS-Eqc-1097 | Equus caballus | 80.35 | 0.0 | 1293 |
| LLPS-Mea-2865 | Mesocricetus auratus | 80.33 | 3e-10 | 68.9 |
| LLPS-Lac-2898 | Latimeria chalumnae | 80.33 | 3e-10 | 68.6 |
| LLPS-Tar-2999 | Takifugu rubripes | 78.95 | 1e-07 | 60.5 |
| LLPS-Leo-0015 | Lepisosteus oculatus | 76.67 | 3e-08 | 62.4 |
| LLPS-Asm-4084 | Astyanax mexicanus | 76.19 | 2e-09 | 65.9 |
| LLPS-Mod-3023 | Monodelphis domestica | 76.11 | 0.0 | 1215 |
| LLPS-Sah-0618 | Sarcophilus harrisii | 75.85 | 0.0 | 1128 |
| LLPS-Anp-2177 | Anas platyrhynchos | 73.5 | 0.0 | 1040 |
| LLPS-Tag-1314 | Taeniopygia guttata | 71.73 | 0.0 | 1018 |
| LLPS-Fia-2195 | Ficedula albicollis | 67.09 | 0.0 | 662 |
| LLPS-Scf-1365 | Scleropages formosus | 66.41 | 4e-51 | 184 |
| LLPS-Gaga-1435 | Gallus gallus | 66.1 | 0.0 | 1083 |
| LLPS-Pes-2450 | Pelodiscus sinensis | 64.76 | 5e-133 | 434 |
| LLPS-Orn-3965 | Oreochromis niloticus | 64.48 | 4e-131 | 428 |
| LLPS-Meg-0465 | Meleagris gallopavo | 64.46 | 3e-132 | 431 |
| LLPS-Gaa-3042 | Gasterosteus aculeatus | 64.06 | 4e-07 | 58.5 |
| LLPS-Dar-1811 | Danio rerio | 62.97 | 1e-128 | 424 |
| LLPS-Xim-4102 | Xiphophorus maculatus | 62.69 | 3e-131 | 431 |
| LLPS-Scm-3465 | Scophthalmus maximus | 62.39 | 5e-133 | 434 |
| LLPS-Icp-2985 | Ictalurus punctatus | 60.61 | 1e-16 | 89.4 |
| LLPS-Cis-0795 | Ciona savignyi | 56.39 | 3e-95 | 308 |
| LLPS-Cii-1022 | Ciona intestinalis | 54.79 | 1e-98 | 340 |
| LLPS-Drm-1908 | Drosophila melanogaster | 40.39 | 9e-52 | 199 |
| LLPS-Cae-0877 | Caenorhabditis elegans | 37.18 | 8e-42 | 165 |