LLPS-Cae-a055
rpn-6.1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Probable 26S proteasome regulatory subunit rpn-6.1 |
| Gene Name: | rpn-6.1, F57B9.10 |
| Ensembl Gene: | WBGene00004462 |
| Ensembl Protein: | F57B9.10b |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | F57B9.10b | F57B9.10b |
| Ensembl | F57B9.10a | F57B9.10a |
| UniProt | Q20938, PS11A_CAEEL, Q5DX45 | |
| GeneBank | FO081266 | CCD70319.1, CCD70320.1 |
| RefSeq | NM_001027450.2, NM_001027451.2 | NP_001022621.1, NP_001022622.1 |
| Entrez | 175972 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRETSSREDT NNIGKAPEMS GGTIMDTMTS LPHQNDQNVI RHLTNLVKSP ASGDDDIKKK 60 61 EDSIMELGNI LAQNKQTEEL RNMIEQTRPF LVSLGKAKAA KLVRDLVDLC LKIDDQDGDI 120 121 KVGLVKECIQ WATEQNRTFL RQTLTARLVR LYNDLQRYTQ ALPLAADLIR ELKKVDDKDV 180 181 LVEVELEESK AYYNLSNIGR ARASLTGART TANAIYVNPR MQAALDLQSG ILHAADEKDF 240 241 KTAFSYFYEA FEGYDSVDEK VSALTALKYM LLCKVMLDLP DEVNSLLSAK LALKYNGSDL 300 301 DAMKAIAAAA QKRSLKDFQV AFGSFPQELQ MDPVVRKHFH SLSERMLEKD LCRIIEPYSF 360 361 VQIEHVAQQI GIDRSKVEKK LSQMILDQKL SGSLDQGEGM LIVFEIAVPD EAYQTALDTI 420 421 HAMGEVVDAL YSNASKIN 438 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGGAG GAACCATTAT GGATACAATG ACTTCACTTC CACATCAAAA CGACCAAAAC 60 61 GTCATTCGTC ACCTCACCAA TCTCGTAAAA TCACCAGCAT CTGGGGACGA TGATATCAAG 120 121 AAGAAAGAAG ATTCGATCAT GGAATTGGGA AATATTTTGG CTCAAAATAA GCAAACTGAA 180 181 GAGCTCCGAA ATATGATTGA ACAAACGAGG CCATTTTTGG TGTCATTGGG AAAGGCAAAG 240 241 GCTGCAAAAC TTGTCAGAGA TCTTGTTGAT CTATGTCTTA AAATTGATGA TCAAGATGGA 300 301 GATATTAAGG TTGGACTCGT TAAAGAATGT ATTCAATGGG CCACCGAGCA AAATCGCACT 360 361 TTCCTCCGTC AAACACTCAC TGCTCGTCTT GTTCGCCTCT ATAATGATCT TCAAAGATAC 420 421 ACTCAGGCTC TTCCACTTGC TGCCGATTTG ATTCGTGAAC TGAAAAAAGT CGACGATAAG 480 481 GACGTTCTCG TGGAAGTCGA ACTTGAGGAA AGCAAAGCGT ACTATAATCT TTCCAATATT 540 541 GGTCGTGCTC GTGCTTCTCT CACTGGTGCT CGTACAACTG CCAACGCAAT CTATGTGAAT 600 601 CCTCGCATGC AAGCAGCTCT CGATCTTCAA TCGGGAATTC TTCACGCTGC CGACGAGAAG 660 661 GACTTCAAGA CAGCTTTCTC ATACTTTTAC GAAGCATTTG AGGGATACGA TTCGGTTGAT 720 721 GAAAAAGTGT CCGCCCTCAC CGCTCTTAAG TATATGCTTC TGTGCAAGGT GATGCTTGAC 780 781 CTTCCAGATG AGGTGAACAG TCTTCTGTCC GCAAAACTTG CTCTTAAATA CAATGGTTCT 840 841 GATTTGGATG CGATGAAGGC GATCGCCGCA GCTGCACAAA AGAGATCTCT TAAGGATTTC 900 901 CAAGTTGCAT TCGGTTCTTT CCCACAGGAA CTTCAAATGG ATCCAGTTGT CCGAAAACAT 960 961 TTCCATTCTT TGAGTGAACG AATGCTTGAA AAAGATCTGT GCCGTATTAT TGAGCCATAC 1020 1021 TCATTCGTTC AAATTGAACA TGTTGCTCAA CAGATTGGAA TTGATAGATC AAAGGTCGAA 1080 1081 AAGAAGTTGT CCCAAATGAT TCTCGATCAA AAACTTTCGG GATCTCTTGA TCAAGGCGAG 1140 1141 GGAATGCTTA TTGTATTTGA AATTGCTGTT CCCGATGAGG CGTACCAAAC TGCTCTGGAT 1200 1201 ACAATTCATG CAATGGGAGA GGTTGTCGAT GCACTCTATA GTAATGCTTC GAAAATTAAC 1260 1261 TGA 1263 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Cellular Component | Proteasome accessory complex | |
Cellular Component | Proteasome regulatory particle, lid subcomplex | |
Molecular Function | Structural molecule activity | |
Biological Process | Determination of adult lifespan | |
Biological Process | Proteasome assembly | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a287 | Homo sapiens | 2e-139 | 415 | undefined |
| LLPS-Mum-a287 | Mus musculus | 5e-140 | 417 | undefined |