LLPS-Cae-2151
tiar-2

▼ OVERVIEW

Status: Reviewed
Protein Name: TIA-1/TIAL RNA binding protein homolog
Gene Name: tiar-2, CELE_Y46G5A.13, Y46G5A.13
Ensembl Gene: WBGene00012904
Ensembl Protein: Y46G5A.13
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Scaffold


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Minimum set of experiments:
In vitro
ExperimentDescriptionPMIDs
Assembly
"...TIAR-2 undergoes liquid-liquid phase separation in vitro and forms granules with liquid-like properties in vivo."
31378567
In cells
ExperimentDescriptionPMIDs
Assembly
"...TIAR-2 undergoes liquid-liquid phase separation in vitro and forms granules with liquid-like properties in vivo."
31378567

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...Similarly, heat shock in C. elegans caused PAB-1 and TIAR-2 to form stress granules."
N/A28076789

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblY46G5A.13Y46G5A.13
UniProtQ9U2F5, Q9U2F5_CAEEL
GeneBankBX284602CAB60356.1
RefSeqNM_064317.1NP_496718.1
Entrez174909

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATSFYTGGG  EDGDGFNPRV  HARIAEREGF  QLASGSEDPR  TLFVANLDPA  ITDEFLATLF  60
61    NQIGAVMKAK  IIFEGLNDPY  AFVEFSDHNQ  ATLALQSHNG  RELLEKEMHV  TWAFEPREPG  120
121   ENRSKPETSR  HFHVFVGDLC  SEIDSTKLRE  AFVKFGEVSE  AKIIRDNNTN  KGKGYGFVSY  180
181   PRREDAERAI  DEMNGAWLGR  RTIRTNWATR  KPDEDGERGG  DRGDRRGGGG  GGRDRYHNQS  240
241   EKTYDEIFNQ  AAADNTSVYV  GNIANLGEDE  IRRAFDRFGP  INEVRTFKIQ  GYAFVKFETK  300
301   ESAARAIVQM  NNADIGGQIV  RCSWGKSGDS  GKPSERGSGG  GGGSGNYGYG  YGNSGGGGGS  360
361   GGPGNSQFSN  FNQRPPPSGN  GGSGGGSGGQ  NNQYWQYYSQ  YYNNPHLMQQ  WNNYWQKDGP  420
421   PPPPAAAASS  TGGN  434
Nucleotide CDS Sequence (FASTA)
1     ATGGCCACTT  CGTTCTACAC  GGGAGGTGGC  GAAGACGGAG  ACGGCTTCAA  TCCCCGTGTG  60
61    CACGCGAGAA  TCGCCGAACG  AGAGGGTTTT  CAGCTGGCTT  CTGGCTCCGA  GGACCCGAGA  120
121   ACTTTATTCG  TTGCAAATCT  GGATCCGGCG  ATAACCGACG  AGTTTCTCGC  GACGCTTTTC  180
181   AATCAAATTG  GCGCCGTTAT  GAAGGCAAAA  ATTATTTTTG  AAGGACTCAA  CGATCCGTAC  240
241   GCTTTCGTGG  AGTTTTCCGA  TCATAATCAG  GCTACGCTGG  CTTTACAGAG  CCACAACGGG  300
301   CGGGAGCTGC  TGGAAAAAGA  AATGCACGTA  ACGTGGGCAT  TCGAGCCCCG  CGAGCCGGGC  360
361   GAAAACCGCT  CAAAACCCGA  AACTTCTCGA  CATTTTCACG  TTTTCGTCGG  CGATTTGTGC  420
421   TCCGAAATTG  ATTCGACAAA  GCTCCGTGAA  GCTTTTGTTA  AGTTCGGAGA  AGTTTCTGAG  480
481   GCGAAAATTA  TTCGCGATAA  CAATACGAAC  AAGGGAAAAG  GCTACGGATT  CGTATCATAC  540
541   CCCCGTCGAG  AAGATGCCGA  AAGAGCTATA  GATGAGATGA  ATGGAGCATG  GCTTGGCCGA  600
601   CGGACTATTC  GAACAAACTG  GGCCACCCGG  AAGCCTGATG  AAGATGGTGA  ACGTGGTGGT  660
661   GATCGTGGTG  ATAGAAGAGG  TGGAGGTGGC  GGTGGAAGAG  ATCGTTATCA  TAATCAATCG  720
721   GAAAAGACTT  ATGATGAGAT  TTTTAATCAA  GCTGCTGCTG  ATAATACATC  GGTTTATGTC  780
781   GGAAATATTG  CCAATCTTGG  GGAAGACGAA  ATTCGCCGAG  CTTTTGACCG  TTTCGGACCA  840
841   ATCAACGAAG  TACGAACATT  CAAAATTCAG  GGATACGCAT  TTGTGAAATT  TGAGACTAAA  900
901   GAATCAGCGG  CACGGGCGAT  TGTACAGATG  AATAATGCAG  ATATTGGAGG  ACAAATTGTT  960
961   CGATGCAGTT  GGGGAAAAAG  TGGAGATTCT  GGAAAGCCAT  CCGAGCGAGG  ATCCGGCGGT  1020
1021  GGTGGCGGCA  GTGGCAACTA  CGGTTACGGT  TACGGTAACA  GCGGTGGCGG  CGGCGGCAGC  1080
1081  GGAGGACCCG  GAAATTCGCA  ATTTTCGAAT  TTTAATCAAC  GACCCCCACC  ATCTGGAAAT  1140
1141  GGTGGTTCTG  GAGGCGGAAG  TGGAGGCCAA  AATAATCAAT  ATTGGCAGTA  CTATTCGCAA  1200
1201  TACTACAATA  ATCCACATTT  GATGCAACAA  TGGAATAATT  ATTGGCAAAA  GGATGGACCA  1260
1261  CCACCACCAC  CAGCTGCAGC  AGCTTCATCT  ACTGGAGGAA  ATTGA  1305

▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
Compute pI/MwAAindex
Function
ENPD

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Drm-0330Drosophila melanogaster46.413e-56 202
LLPS-Nol-0085Nomascus leucogenys44.625e-63 213
LLPS-Ora-0476Ornithorhynchus anatinus44.221e-62 213
LLPS-Asm-0350Astyanax mexicanus44.188e-72 238
LLPS-Urm-1173Ursus maritimus44.143e-73 241
LLPS-Pat-0434Pan troglodytes44.143e-73 241
LLPS-Gaga-1415Gallus gallus44.142e-73 241
LLPS-Chs-0001Chlorocebus sabaeus44.143e-73 241
LLPS-Caj-0338Callithrix jacchus44.143e-73 241
LLPS-Ova-1218Ovis aries44.143e-73 241
LLPS-Mup-1887Mustela putorius furo44.143e-73 241
LLPS-Pof-1063Poecilia formosa44.036e-76 248
LLPS-Xim-0207Xiphophorus maculatus43.692e-75 247
LLPS-Dar-0236Danio rerio43.494e-76 249
LLPS-Fia-1636Ficedula albicollis43.34e-70 233
LLPS-Myl-0852Myotis lucifugus43.39e-70 232
LLPS-Bot-2321Bos taurus43.251e-69 233
LLPS-Scf-3313Scleropages formosus43.152e-72 239
LLPS-Scm-0701Scophthalmus maximus42.812e-75 247
LLPS-Ran-0013Rattus norvegicus42.811e-73 242
LLPS-Icp-0663Ictalurus punctatus42.719e-74 243
LLPS-Gaa-2665Gasterosteus aculeatus42.79e-69 228
LLPS-Man-0277Macaca nemestrina42.622e-72 239
LLPS-Loa-0445Loxodonta africana42.625e-72 238
LLPS-Hos-0303Homo sapiens42.623e-72 239
LLPS-Fec-0262Felis catus42.624e-72 238
LLPS-Orc-1017Oryctolagus cuniculus42.623e-72 239
LLPS-Caf-0859Canis familiaris42.626e-72 238
LLPS-Poa-0183Pongo abelii42.628e-71 235
LLPS-Eqc-1057Equus caballus42.625e-72 239
LLPS-Aon-0935Aotus nancymaae42.622e-72 239
LLPS-Cea-0431Cercocebus atys42.622e-72 239
LLPS-Sus-0370Sus scrofa42.624e-72 238
LLPS-Maf-0268Macaca fascicularis42.622e-72 239
LLPS-Tut-0360Tursiops truncatus42.622e-71 237
LLPS-Mal-2146Mandrillus leucophaeus42.622e-72 239
LLPS-Mam-1809Macaca mulatta42.575e-72 238
LLPS-Rhb-0957Rhinopithecus bieti42.552e-55 192
LLPS-Orl-0027Oryzias latipes42.477e-75 246
LLPS-Leo-0760Lepisosteus oculatus42.478e-73 240
LLPS-Tar-0015Takifugu rubripes42.475e-76 248
LLPS-Aim-0600Ailuropoda melanoleuca42.473e-70 234
LLPS-Mea-0224Mesocricetus auratus42.282e-71 237
LLPS-Mum-1698Mus musculus42.289e-72 238
LLPS-Fud-0748Fukomys damarensis42.282e-71 237
LLPS-Pes-1349Pelodiscus sinensis42.125e-72 238
LLPS-Ict-0494Ictidomys tridecemlineatus42.126e-69 230
LLPS-Orn-0416Oreochromis niloticus41.957e-73 241
LLPS-Cap-2190Cavia porcellus41.785e-68 228
LLPS-Pap-1096Pan paniscus41.692e-70 234
LLPS-Otg-1087Otolemur garnettii41.692e-70 234
LLPS-Paa-1430Papio anubis41.692e-70 234
LLPS-Mod-1651Monodelphis domestica41.611e-71 237
LLPS-Cas-0159Carlito syrichta41.612e-69 231
LLPS-Lac-2390Latimeria chalumnae41.377e-70 233
LLPS-Ten-2282Tetraodon nigroviridis41.367e-75 246
LLPS-Sah-1876Sarcophilus harrisii41.13e-68 228
LLPS-Anp-0963Anas platyrhynchos41.083e-69 231
LLPS-Tag-1121Taeniopygia guttata41.081e-62 212
LLPS-Anc-1956Anolis carolinensis41.043e-68 229
LLPS-Xet-0771Xenopus tropicalis41.046e-69 231
LLPS-Meg-0318Meleagris gallopavo40.961e-70 234
LLPS-Ere-0070Erinaceus europaeus40.923e-67 225
LLPS-Dio-0181Dipodomys ordii40.842e-67 226
LLPS-Gog-0498Gorilla gorilla39.162e-56 197
LLPS-Put-0516Puccinia triticina38.461e-55 197
LLPS-Pug-0143Puccinia graminis38.134e-55 196
LLPS-Nec-1122Neurospora crassa38.11e-58 205
LLPS-Asn-0266Aspergillus nidulans37.762e-60 210
LLPS-Ved-0557Verticillium dahliae37.412e-51 186
LLPS-Abg-0353Absidia glauca37.411e-49 178
LLPS-Tum-0874Tuber melanosporum37.417e-59 206
LLPS-Mel-0516Melampsora laricipopulina37.131e-54 194
LLPS-Nef-0476Neosartorya fischeri37.074e-59 206
LLPS-Cog-0774Colletotrichum gloeosporioides37.072e-56 199
LLPS-Cogr-0174Colletotrichum graminicola37.072e-56 199
LLPS-Dos-0345Dothistroma septosporum37.072e-59 208
LLPS-Beb-1010Beauveria bassiana37.057e-57 200
LLPS-Orbr-1494Oryza brachyantha37.043e-0859.3
LLPS-Lep-0184Leersia perrieri37.049e-0858.2
LLPS-Ast-0217Aspergillus terreus36.951e-59 208
LLPS-Fus-0498Fusarium solani36.723e-57 201
LLPS-Fuo-0644Fusarium oxysporum36.724e-57 201
LLPS-Fuv-0318Fusarium verticillioides36.728e-58 201
LLPS-Trv-0105Trichoderma virens36.455e-57 201
LLPS-Coo-0139Colletotrichum orbiculare36.392e-55 197
LLPS-Mao-1001Magnaporthe oryzae36.211e-56 200
LLPS-Pyt-0650Pyrenophora teres36.211e-57 203
LLPS-Trr-0586Trichoderma reesei36.137e-57 201
LLPS-Asc-0051Aspergillus clavatus36.091e-58 205
LLPS-Zyt-0750Zymoseptoria tritici36.094e-59 204
LLPS-Aso-0257Aspergillus oryzae35.931e-56 200
LLPS-Asf-0643Aspergillus flavus35.931e-56 200
LLPS-Gag-0271Gaeumannomyces graminis35.884e-57 201
LLPS-Map-0047Magnaporthe poae35.885e-57 201
LLPS-Phn-1074Phaeosphaeria nodorum35.056e-58 204
LLPS-Cii-0303Ciona intestinalis34.981e-46 171
LLPS-Crn-0178Cryptococcus neoformans34.912e-53 190
LLPS-Miv-0837Microbotryum violaceum34.883e-55 196
LLPS-Scs-0736Sclerotinia sclerotiorum34.831e-57 203
LLPS-Pytr-0819Pyrenophora triticirepentis34.554e-51 185
LLPS-Blg-0267Blumeria graminis34.391e-57 203
LLPS-Mua-0117Musa acuminata34.353e-47 173
LLPS-Tra-1221Triticum aestivum34.348e-47 172
LLPS-Sot-0475Solanum tuberosum34.244e-44 164
LLPS-Prp-1051Prunus persica34.231e-46 172
LLPS-Brd-0052Brachypodium distachyon34.221e-47 175
LLPS-Zem-1325Zea mays34.113e-45 168
LLPS-Nia-2597Nicotiana attenuata34.14e-42 159
LLPS-Pot-1643Populus trichocarpa34.012e-46 171
LLPS-Tru-0281Triticum urartu34.011e-47 174
LLPS-Sol-1413Solanum lycopersicum33.99e-44 164
LLPS-Arl-0734Arabidopsis lyrata33.91e-42 160
LLPS-Hov-0837Hordeum vulgare33.891e-46 173
LLPS-Via-1507Vigna angularis33.795e-45 167
LLPS-Brn-1332Brassica napus33.784e-41 156
LLPS-Art-0627Arabidopsis thaliana33.672e-41 157
LLPS-Ors-0863Oryza sativa33.673e-44 166
LLPS-Orr-0239Oryza rufipogon33.673e-44 166
LLPS-Orm-0030Oryza meridionalis33.673e-44 165
LLPS-Org-0737Oryza glaberrima33.673e-44 166
LLPS-Orb-0909Oryza barthii33.674e-44 165
LLPS-Ori-1240Oryza indica33.673e-44 166
LLPS-Orni-1000Oryza nivara33.673e-44 166
LLPS-Orgl-0699Oryza glumaepatula33.673e-44 166
LLPS-Gor-0394Gossypium raimondii33.563e-41 157
LLPS-Mae-0016Manihot esculenta33.566e-42 159
LLPS-Phv-0582Phaseolus vulgaris33.568e-45 167
LLPS-Thc-1165Theobroma cacao33.562e-41 157
LLPS-Dac-0474Daucus carota33.453e-42 160
LLPS-Sob-1812Sorghum bicolor33.223e-47 174
LLPS-Sei-0144Setaria italica33.228e-46 171
LLPS-Met-0566Medicago truncatula33.221e-44 166
LLPS-Viv-2472Vitis vinifera33.112e-41 157
LLPS-Asfu-1202Aspergillus fumigatus33.114e-49 180
LLPS-Sem-0919Selaginella moellendorffii32.897e-45 167
LLPS-Php-0383Physcomitrella patens32.837e-44 165
LLPS-Cus-2045Cucumis sativus32.548e-41 155
LLPS-Brr-1661Brassica rapa32.422e-41 157
LLPS-Bro-1248Brassica oleracea32.421e-41 157
LLPS-Glm-1163Glycine max32.318e-42 158
LLPS-Coc-0607Corchorus capsularis32.212e-41 157
LLPS-Orp-0653Oryza punctata32.083e-42 159
LLPS-Amt-0827Amborella trichopoda31.789e-44 164
LLPS-Hea-0059Helianthus annuus31.741e-41 157