LLPS-Cae-2127
rsa-1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulator of spindle assembly protein 1; Serine/threonine-protein phosphatase 2A 72kDa regulatory subunit rsa-1; Serine/threonine-protein phosphatase 2A regulatory subunit B'' rsa-1 |
| Gene Name: | rsa-1, C25A1.9 |
| Ensembl Gene: | WBGene00007710 |
| Ensembl Protein: | C25A1.9b |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Centrosome/Spindle pole body | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 17218259 |
| Centrosome/Spindle pole body | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 17218259 |
▼ FUNCTION
| Regulatory subunit of phosphatase let-92 which recruits let-92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | C25A1.9b | C25A1.9b |
| Ensembl | C25A1.9a | C25A1.9a |
| UniProt | O02217, P2R31_CAEEL, A5Z2U4 | |
| GeneBank | BX284601 | CAN99683.1, CAB02769.1 |
| RefSeq | NM_001128952.2, NM_060282.5 | NP_001122424.1, NP_492683.1 |
| Entrez | 172886 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPTDEPSKRK SILPTIPTSL MLKKSNEALS DFERTFNDRV MDIFAENRRI DVEEFKKNAE 60 61 CFLNIIRSNK IDLNWGEGGE SRYVTITRLM KILKTSPQSI KDLLPHNTVS NFVKITNYNL 120 121 TIDITLLEEL VRTVIHAEES YIKLLPFSEN STEISSYSLQ DFVATHFIPI MIEEPENPVY 180 181 YTAYAVGTIF FLLGARRRDC VYLKDLLAST LLLQLEECIH AENHCLSPPK IDVFTVAQFR 240 241 TTLSEFRFLD SQRKGLLAPA DLKFFRDGIF NEVFTKRIFE ISITYEDGRI DFKAFVDFVT 300 301 ALKFRHTTAS AKYHFEILDL KDDGLLDEEE IRSISSFQLQ NLPDYVPEDN SVNPEVATAE 360 361 LRDMMRLNQN GITLEEFLAN RMNSTFAGFL SNSDDYMKYE RREQ 404 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCAACCG ACGAACCTTC GAAGCGAAAA TCCATTTTAC CAACGATTCC AACATCCCTG 60 61 ATGTTGAAGA AAAGTAACGA AGCATTGAGT GACTTCGAAC GAACATTTAA TGATCGAGTT 120 121 ATGGATATAT TTGCCGAAAA TCGAAGAATA GATGTAGAGG AGTTTAAAAA AAATGCCGAA 180 181 TGCTTTTTAA ACATCATTCG ATCGAACAAA ATCGATTTAA ATTGGGGTGA AGGGGGAGAA 240 241 AGTAGATATG TGACGATAAC TCGATTAATG AAAATACTCA AAACTTCACC ACAATCAATC 300 301 AAAGATCTAC TTCCACATAA CACAGTGTCG AATTTCGTTA AAATAACCAA TTATAATTTA 360 361 ACAATTGATA TCACTCTTTT AGAGGAGCTT GTACGAACAG TCATTCACGC TGAGGAGTCC 420 421 TACATCAAAC TTCTTCCATT TTCAGAAAAT AGCACAGAGA TTTCCAGTTA TAGTCTCCAA 480 481 GACTTTGTGG CCACACATTT TATTCCAATT ATGATTGAAG AACCGGAAAA TCCTGTCTAT 540 541 TATACAGCTT ACGCAGTTGG AACAATATTT TTCCTATTGG GTGCTCGACG GCGAGACTGT 600 601 GTATATTTGA AGGATTTACT TGCTTCAACA CTTCTACTAC AACTCGAAGA GTGTATTCAT 660 661 GCAGAGAATC ATTGCTTATC ACCTCCGAAA ATTGATGTAT TCACCGTCGC TCAATTTCGA 720 721 ACCACTTTAT CAGAATTCCG ATTCCTTGAC TCCCAACGAA AGGGATTGTT GGCGCCAGCG 780 781 GACTTGAAAT TTTTCAGAGA CGGAATCTTC AATGAGGTTT TCACCAAGCG AATCTTCGAA 840 841 ATTTCAATAA CCTATGAAGA TGGACGTATT GATTTCAAAG CGTTCGTTGA TTTTGTCACC 900 901 GCTCTAAAGT TCCGTCATAC CACTGCCTCC GCCAAATACC ATTTCGAAAT TCTGGATCTA 960 961 AAGGATGATG GACTGTTGGA TGAGGAAGAA ATTCGATCAA TACTTCAAAA CCTGCCAGAT 1020 1021 TACGTCCCGG AAGATAATAG TGTGAACCCG GAAGTAGCAA CTGCCGAACT GAGAGATATG 1080 1081 ATGCGTCTGA ATCAGAATGG AATTACATTG GAAGAGTTTC TTGCTAATCG GATGAACTCG 1140 1141 ACGTTTGCTG GATTCCTCTC CAATTCCGAT GATTACATGA AGTACGAACG ACGCGAGCAA 1200 1201 TAG 1203 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Cytoplasm | |
Molecular Function | Protein phosphatase 2A binding | |
Biological Process | Embryo development ending in birth or egg hatching | |
Biological Process | Mitotic spindle assembly | |
Biological Process | Mitotic spindle organization | |
Biological Process | Protein localization to organelle |