LLPS-Cae-2103
npp-6
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Nuclear Pore complex Protein |
| Gene Name: | npp-6, CELE_F56A3.3, F56A3.3 |
| Ensembl Gene: | WBGene00003792 |
| Ensembl Protein: | F56A3.3a.2 |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Here we describe a systematic RNAi screen in C. elegans that identified 224 genes with diverse cellular functions whose inactivations result in a dramatic increase in the number of P bodies." | Caenorhabditis elegans | 22180091 |
| P granule | "...Here we report on a genomewide RNAi screen in C. elegans, which identified 173 genes that affect the stability, localization, and function of P granules." | Caenorhabditis elegans | 19805813 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | F56A3.3a.2 | F56A3.3a.2 |
| Ensembl | F56A3.3a.1 | F56A3.3a.1 |
| Ensembl | F56A3.3b | F56A3.3b |
| Ensembl | F56A3.3a.3 | F56A3.3a.3 |
| UniProt | P91350, P91350_CAEEL | |
| GeneBank | BX284601 | CCD66430.1 |
| RefSeq | NM_170857.3 | NP_740844.1 |
| Entrez | 172156 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQPRPLFLNS NGAPYGGVFG SIHHCFVKFY IAKCQNMKLI MELVYGSEIS FTDGFAIKPA 60 61 RTFVVNTNAP LHSNGFDVQP SAGVATFPHC SNYGDRIFLW RAIGQKLFIE ERSLLYSITD 120 121 GSLCIDFTRT PIIPGTSITI FEEGVLCIVV PTASAIHRFY ARLHSKGHDT FSILARIKED 180 181 DDFRRFRTSH SLSTPGRPIR ASVTHHPSRN TISYCTAEGQ LVIVTLGSYT ESSDKHEEFT 240 241 MGEVGLLGKL LGGTDKRVSD ACVMKNLRPT SGVTRERKIS VQSDIVFAVT RDGWVQAWNV 300 301 ETKKQLPSTI DLNNYFASDG KSLNRDLESA DFEEEKSPME PTETVYSIRA YSFDVDILLI 360 361 VGCDLAVSGK SVGMRVHILK VSNDQIQHLQ MFETSMSVDE RLVDLELIQN YFPSKESESL 420 421 DETQDGELYN PLTAALFSLS ALFKSSSAKK TYSMKRISFA IQWKKGRVFT DFDWHSVRQF 480 481 TSPATTKEEP IGNTDEVEPA IERPYNLSAD SSIETLIDVV FDTDIYPFDI VFRAVQIVSD 540 541 NFRGTLGQVR NNNWPELSKL VDTYLTSVEF NRKFQQKTDR SIRLRLNAPQ ESQKTALKDF 600 601 WWALLRACEE LDFAARGAIS LAPIQFCGDL RIMAVVHRDR MTFLGDNNTE FLEIISSENI 660 661 PKQGNVEEKF RKLPNKHFID LIEEASKFAD RRVFLMNRER ARLTNAKNGV AVVEDDNVEN 720 721 AYDYDSDGRF INIKTALEGP IVKLAAAFVE ASTFDNSKPF EDPHPQIFGG SFTQSVVSAN 780 781 IRVSVESRVH FALTLQTLLN AITEKKSRAG APSFGDVEAL SCELREIIRV YRELNEQLDI 840 841 KIVQNGAKMS IGTWLTSDAE GLSMMKKEGG YGPHGYDEIR ENDFNWFVGV TTEAAIRALL 900 901 SSSEILVLPR RLVLQKQYKV LLTILNSYIS ETRALKPVIT FYRGIAYSGT DHPVKALNSF 960 961 QSCLDAFSEG NNALRKAVYF LLPKRFDVAQ GKDPVEELTA SEYFLTVVRF LQEHNHAEEV 1020 1021 CSVAVKAIEN LPIENESVQL ISNTLFNHLT NRREWFQSLK LILRTTLRSE TRRASIRELL 1080 1081 SLMLACGEWE AIATMKFGEH EQVVEDFLRD AACRQSPSEK KHYFELLFAF YVARKDFRKG 1140 1141 ACAMYEYARH IESTTCMTPE LLRRKRDCLA VVLNLQSVLG MEPDDDRAIY DDATDTNLVF 1200 1201 PEPSDDEDEL ITESDSSGEN GKLPSGNKDS GSGTGNNSSP DNSNGTSSSG TGVDLVALKA 1260 1261 RQMAYALGSD DMDTDDTEDD MKGGSIPLFK RRKLLVLSEK DIRDELVLCS ARVGLLSSDQ 1320 1321 FKGVPPTDLN ELFSLLVDNQ HFDEAFDIAR QFNLDSHRLF FTMTREAIMI DALRDDLNIE 1380 1381 MAATHQAGWV RLNRRHCAAV ATAEEHWSVV RGLVDAAQAE WPGDSRPLRG STEAFLSFKL 1440 1441 NVPVWLHSVF ENNDANDYLR CLVDYESYSI ALQVLSDIVE QETLQASQSN ARTWLPYGII 1500 1501 DELMIRSADY IRKMSLKSPE DQVVAAEVAN LRKSADQKML IYFRKVADFE QAQKMSSRFF 1560 1561 DK 1562 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAGCCAC GCCCCTTATT TTTGAATTCG AATGGAGCTC CATATGGAGG CGTTTTCGGC 60 61 TCAATTCATC ATTGTTTTGT AAAATTTTAC ATCGCAAAGT GTCAAAATAT GAAGCTTATT 120 121 ATGGAGCTGG TTTACGGGTC GGAAATCAGC TTCACGGATG GATTTGCTAT AAAGCCGGCT 180 181 AGAACTTTTG TGGTAAACAC CAATGCGCCG CTTCATTCGA ATGGATTTGA TGTGCAACCG 240 241 TCCGCAGGAG TTGCAACATT TCCGCACTGC TCAAATTACG GCGATCGGAT TTTCCTGTGG 300 301 CGTGCGATTG GCCAGAAACT GTTCATTGAG GAGCGTTCTT TGCTCTACTC AATCACGGAT 360 361 GGATCGTTGT GCATTGACTT CACACGCACA CCTATTATTC CTGGAACATC GATAACAATT 420 421 TTCGAGGAAG GGGTTTTATG TATTGTCGTT CCCACAGCTT CTGCAATTCA TCGTTTCTAC 480 481 GCGAGACTCC ACTCCAAAGG CCATGATACG TTCTCAATTC TTGCAAGAAT TAAAGAAGAT 540 541 GACGATTTCC GCCGATTCAG AACATCTCAC TCCCTTTCAA CACCAGGGCG CCCGATTCGT 600 601 GCAAGTGTTA CACATCATCC TTCAAGAAAT ACGATTTCTT ACTGTACCGC TGAAGGGCAG 660 661 TTGGTCATTG TCACATTGGG ATCATACACG GAATCCAGTG ATAAACACGA AGAATTCACA 720 721 ATGGGAGAAG TTGGTCTTCT GGGAAAACTT CTAGGTGGCA CTGATAAACG AGTCAGTGAT 780 781 GCATGTGTTA TGAAGAATCT TCGCCCGACT TCTGGAGTCA CGAGAGAGCG AAAAATTTCA 840 841 GTCCAATCCG ATATTGTGTT CGCTGTTACC AGAGACGGAT GGGTGCAAGC ATGGAATGTT 900 901 GAGACGAAAA AACAATTGCC AAGCACTATT GACTTGAATA ACTACTTTGC TTCAGACGGA 960 961 AAATCTTTGA ATCGAGATCT AGAATCTGCA GACTTCGAGG AAGAAAAGTC TCCAATGGAA 1020 1021 CCAACTGAAA CTGTATATTC TATCAGAGCT TATTCATTCG ATGTGGATAT TCTTCTGATT 1080 1081 GTTGGATGTG ATTTGGCAGT TTCGGGAAAA AGCGTCGGGA TGAGAGTTCA TATTCTCAAA 1140 1141 GTTTCAAATG ATCAAATTCA ACATCTACAA ATGTTCGAAA CATCGATGTC CGTTGATGAA 1200 1201 CGACTTGTTG ATCTCGAGCT TATTCAAAAC TATTTCCCAT CAAAGGAATC GGAAAGTCTT 1260 1261 GATGAGACAC AAGATGGGGA ATTGTATAAT CCTCTCACAG CTGCACTATT TTCACTTTCT 1320 1321 GCTCTTTTCA AAAGTTCATC TGCAAAGAAA ACCTATTCGA TGAAACGGAT CTCATTTGCT 1380 1381 ATCCAATGGA AAAAGGGACG AGTTTTCACA GATTTCGATT GGCATTCCGT TCGTCAGTTC 1440 1441 ACTTCGCCTG CCACTACCAA AGAAGAACCG ATCGGCAATA CGGATGAAGT GGAACCTGCA 1500 1501 ATTGAGCGCC CATATAACCT CTCGGCAGAT TCAAGCATAG AAACACTGAT TGATGTGGTT 1560 1561 TTTGATACAG ATATCTATCC ATTTGATATT GTTTTCCGTG CTGTCCAGAT TGTTTCCGAC 1620 1621 AATTTCCGCG GTACACTTGG TCAGGTACGG AACAATAATT GGCCTGAACT ATCGAAACTT 1680 1681 GTGGACACAT ACCTCACATC AGTTGAATTC AACCGGAAAT TTCAGCAGAA GACTGATAGA 1740 1741 AGTATTCGTT TGAGATTAAA TGCTCCACAA GAATCGCAGA AAACTGCGCT GAAAGATTTC 1800 1801 TGGTGGGCTC TTCTCCGTGC ATGTGAAGAA CTGGATTTCG CCGCTCGCGG TGCTATTTCA 1860 1861 CTCGCTCCAA TTCAATTTTG CGGAGATTTG AGAATAATGG CAGTTGTTCA TCGCGATCGA 1920 1921 ATGACTTTCC TCGGCGATAA TAATACCGAG TTCCTTGAAA TTATTAGCTC AGAGAACATC 1980 1981 CCGAAACAAG GAAATGTCGA AGAAAAGTTC AGAAAGTTGC CGAACAAACA TTTCATTGAT 2040 2041 TTGATTGAAG AAGCATCAAA GTTTGCTGAT AGACGTGTAT TCTTGATGAA TCGTGAGAGA 2100 2101 GCTAGGCTTA CAAATGCCAA GAACGGAGTC GCCGTGGTCG AGGATGATAA TGTCGAAAAT 2160 2161 GCATATGATT ACGATTCAGA CGGCCGATTC ATCAACATTA AAACTGCGCT TGAAGGTCCA 2220 2221 ATTGTGAAAC TTGCTGCTGC ATTTGTCGAA GCGTCCACAT TTGATAACTC GAAACCGTTT 2280 2281 GAAGACCCAC ATCCTCAAAT TTTTGGAGGA TCTTTCACAC AAAGTGTTGT ATCGGCCAAT 2340 2341 ATTCGAGTTT CTGTAGAGTC ACGTGTTCAT TTTGCACTCA CACTACAAAC ATTGCTCAAC 2400 2401 GCAATCACTG AGAAGAAATC TCGTGCTGGC GCCCCTTCAT TTGGAGATGT TGAGGCCTTG 2460 2461 TCATGTGAAT TAAGAGAGAT CATTCGTGTG TATAGAGAAC TCAATGAACA ACTGGACATC 2520 2521 AAGATTGTGC AAAACGGAGC CAAAATGAGC ATTGGAACAT GGTTGACATC GGACGCCGAG 2580 2581 GGACTTTCAA TGATGAAGAA AGAGGGTGGT TACGGACCAC ATGGCTATGA TGAAATTCGA 2640 2641 ATGGAACCAG CTCGTCAGGA ACAGGTGTAG 2670 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Element | ||||
| circBase | RAID | microRNA.org | ||