LLPS-Cae-1849
sel-10

▼ OVERVIEW

Status: Unreviewed
Protein Name: F-box/WD repeat-containing protein sel-10; Egg laying defective protein 41; Suppressor/enhancer of lin-12 protein 10
Gene Name: sel-10, egl-41, F55B12.3
Ensembl Gene: WBGene00004767
Ensembl Protein: F55B12.3b.1
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MWPRNDVHMD  DGSMTPEDQE  PVTDNDMEYN  DNGEESSYSN  GSSSSYNADK  LSSPLQHKLD  60
61    LSASPSRNND  LNPRVEHLIA  LFKDLSSAEQ  MDAFTRLLQE  SNMTNIRQLR  AIIEPHFQRD  120
121   FLSCLPVELG  MKILHNLTGY  DLLKVAQVSK  NWKLISEIDK  IWKSLGVEEF  KHHPDPTDRV  180
181   TGAWQGTAIA  AGVTIPDHIQ  PCDLNVHRFL  KLQKFGDIFE  RAADKSRYLR  ADKIEKNWNA  240
241   NPIMGSAVLR  GHEDHVITCM  QIHDDVLVTG  SDDNTLKVWC  IDKGEVMYTL  VGHTGGVWTS  300
301   QISQCGRYIV  SGSTDRTVKV  WSTVDGSLLH  TLQGHTSTVR  CMAMAGSILV  TGSRDTTLRV  360
361   WDVESGRHLA  TLHGHHAAVR  CVQFDGTTVV  SGGYDFTVKI  WNAHTGRCIR  TLTGHNNRVY  420
421   SLLFESERSI  VCSGSLDTSI  RVWDFTRPEG  QECVALLQGH  TSLTSGMQLR  GNILVSCNAD  480
481   SHVRVWDIHE  GTCVHMLSGH  RSAITSLQWF  GRNMVATSSD  DGTVKLWDIE  RGALIRDLVT  540
541   LDSGGNGGCI  WRLCSTSTML  ACAVGSRNNT  EETKVILLDF  DAVYP  585
Nucleotide CDS Sequence (FASTA)
1     ATGTGGCCAC  GAAATGATGT  ACACATGGAT  GATGGATCGA  TGACACCGGA  GGACCAGGAG  60
61    CCTGTTACCG  ATAATGATAT  GGAATATAAT  GACAATGGAG  AAGAAAGCTC  GTACAGCAAT  120
121   GGCTCTTCTT  CCAGCTACAA  TGCTGACAAA  TTATCGTCTT  CCAGACCTTT  GCAACACAAA  180
181   CTTGATTTAT  CGGCTTCTCC  CTCTCGAAAC  AACGACCTCA  ATCCGCGTGT  CGAACATTTG  240
241   ATCGCATTAT  TCAAGGATCT  ATCAAGCGCG  GAACAAATGG  ATGCATTCAC  ACGTCTGCTT  300
301   CAGGAATCCA  ACATGACAAA  TATTCGACAG  CTGCGTGCCA  TTATTGAACC  CCATTTCCAG  360
361   CGTGATTTCC  TCTCCTGCCT  CCCTGTCGAG  CTCGGAATGA  AAATCCTTCA  CAATTTAACC  420
421   GGATATGACC  TGCTCAAAGT  GGCACAGGTG  TCGAAAAATT  GGAAATTGAT  ATCTGAAATT  480
481   GACAAAATTT  GGAAGAGTCT  TGGTGTCGAA  GAGTTTAAAC  ATCATCCAGA  TCCCACAGAC  540
541   CGAGTTACTG  GTGCGTGGCA  AGGAACTGCA  ATTGCTGCTG  GAGTCACTAT  TCCTGATCAC  600
601   ATTCAGCCAT  GTGATCTTAA  TGTTCATCGA  TTTCTAAAGT  TGCAGAAGTT  TGGAGATATC  660
661   TTCGAACGCG  CTGCTGACAA  GTCACGTTAT  CTTCGAGCCG  ATAAAATTGA  AAAGAACTGG  720
721   AATGCGAATC  CAATTATGGG  GTCAGCAGTG  CTACGAGGAC  ACGAAGATCA  TGTAATCACT  780
781   TGTATGCAAA  TTCATGATGA  TGTCTTGGTG  ACTGGATCTG  ACGATAACAC  TCTTAAAGTA  840
841   TGGTGTATTG  ACAAAGGAGA  GGTTATGTAC  ACACTAGTCG  GCCACACTGG  AGGAGTTTGG  900
901   ACATCACAGA  TTTCTCAATG  CGGAAGATAT  ATTGTTAGCG  GGTCCACTGA  TAGAACTGTA  960
961   AAAGTTTGGA  GTACTGTAGA  TGGTTCACTT  CTTCATACAC  TTCAAGGACA  TACTTCCACT  1020
1021  GTTCGATGCA  TGGCTATGGC  TGGTTCCATA  CTTGTCACTG  GATCACGAGA  TACCACTCTT  1080
1081  CGTGTATGGG  ACGTAGAATC  CGGACGTCAC  CTGGCAACTT  TACATGGCCA  TCATGCAGCC  1140
1141  GTTCGATGCG  TTCAATTCGA  TGGAACAACT  GTTGTTTCGG  GAGGATATGA  TTTTACCGTT  1200
1201  AAAATTTGGA  ATGCTCATAC  TGGGAGATGT  ATCCGTACTC  TGACCGGTCA  TAACAATAGA  1260
1261  GTTTATTCTC  TTCTCTTTGA  AAGCGAGCGA  TCGATCGTGT  GCTCTGGCTC  TCTGGACACT  1320
1321  TCAATTCGCG  TGTGGGATTT  TACACGACCG  GAAGGCCAAG  AATGTGTGGC  TCTTTTGCAA  1380
1381  GGACACACCT  CACTTACATC  CGGAATGCAA  CTTCGAGGCA  ATATTCTCGT  GTCATGCAAT  1440
1441  GCAGATAGCC  ATGTTAGAGT  ATGGGATATT  CACGAGGGAA  CTTGTGTACA  CATGCTTTCT  1500
1501  GGACATCGAT  CCGCTATCAC  TTCACTTCAA  TGGTTTGGAC  GAAATATGGT  AGCAACGAGT  1560
1561  AGTGACGATG  GAACTGTCAA  ATTGTGGGAT  ATTGAGAGAG  GTGCACTGAT  TCGAGATCTA  1620
1621  GTAACTTTGG  ATTCTGGAGG  CAATGGTGGC  TGTATTTGGA  GACTTTGTTC  TACTTCTACG  1680
1681  ATGCTAGCGT  GTGCAGTCGG  ATCTCGTAAC  AACACCGAGG  AGACCAAAGT  TATCCTTCTC  1740
1741  GACTTTGATG  CTGTATACCC  TTAA  1764

▼ KEYWORD

ID
Family
Alternative splicing
Cell projection
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Reference proteome
Repeat
Sexual differentiation
Ubl conjugation pathway
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cytoplasm
Cellular Component
Nucleolus
Molecular Function
Protein homodimerization activity
Molecular Function
Protein kinase binding
Biological Process
Cell differentiation
Biological Process
Female sex differentiation
Biological Process
Negative regulation of centrosome duplication
Biological Process
Negative regulation of Notch signaling pathway
Biological Process
Notch signaling pathway
Biological Process
Regulation of Notch signaling pathway
Biological Process
Regulation of protein stability
Biological Process
Regulation of vulval development
Biological Process
Ribosomal large subunit assembly

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Otg-0762Otolemur garnettii57.499e-134 402
LLPS-Drm-2193Drosophila melanogaster49.97e-151 474
LLPS-Lac-1427Latimeria chalumnae48.633e-152 462
LLPS-Xim-0871Xiphophorus maculatus48.631e-151 462
LLPS-Asm-3902Astyanax mexicanus48.631e-149 457
LLPS-Icp-2104Ictalurus punctatus48.631e-150 459
LLPS-Pof-3577Poecilia formosa48.539e-154 460
LLPS-Leo-3341Lepisosteus oculatus48.533e-153 459
LLPS-Scm-3281Scophthalmus maximus48.241e-150 460
LLPS-Ten-2222Tetraodon nigroviridis48.142e-152 457
LLPS-Tar-3659Takifugu rubripes48.045e-150 458
LLPS-Orn-3438Oreochromis niloticus47.753e-150 451
LLPS-Cis-1737Ciona savignyi47.714e-147 447
LLPS-Scf-2505Scleropages formosus47.554e-152 456
LLPS-Anp-1209Anas platyrhynchos47.461e-151 454
LLPS-Usm-1372Ustilago maydis45.697e-54 203
LLPS-Gaa-3912Gasterosteus aculeatus45.623e-146 441
LLPS-Spr-0562Sporisorium reilianum44.832e-53 202
LLPS-Cii-2308Ciona intestinalis40.08e-84 272
LLPS-Asfu-0923Aspergillus fumigatus38.386e-31 132
LLPS-Nef-1276Neosartorya fischeri38.385e-31 133
LLPS-Phn-0838Phaeosphaeria nodorum38.272e-30 130
LLPS-Chc-0507Chondrus crispus37.692e-31 134
LLPS-Asf-0969Aspergillus flavus37.32e-29 128
LLPS-Trv-0720Trichoderma virens37.122e-62 226
LLPS-Trr-1556Trichoderma reesei37.124e-62 226
LLPS-Nec-1427Neurospora crassa37.127e-66 237
LLPS-Orl-2891Oryzias latipes37.05e-29 123
LLPS-Zyt-1358Zymoseptoria tritici36.965e-65 234
LLPS-Cog-1425Colletotrichum gloeosporioides36.625e-65 234
LLPS-Lem-1547Leptosphaeria maculans36.468e-64 233
LLPS-Pytr-0843Pyrenophora triticirepentis36.44e-30 130
LLPS-Pyt-0826Pyrenophora teres36.44e-30 130
LLPS-Coo-0092Colletotrichum orbiculare36.363e-64 232
LLPS-Ova-0521Ovis aries36.281e-103 335
LLPS-Blg-1129Blumeria graminis36.25e-59 218
LLPS-Dos-1309Dothistroma septosporum36.114e-63 229
LLPS-Cogr-1221Colletotrichum graminicola36.112e-63 229
LLPS-Fuo-0779Fusarium oxysporum36.111e-63 230
LLPS-Fus-0734Fusarium solani36.111e-63 231
LLPS-Map-0765Magnaporthe poae36.113e-64 232
LLPS-Gag-1025Gaeumannomyces graminis36.111e-64 233
LLPS-Fuv-1192Fusarium verticillioides36.111e-63 230
LLPS-Ast-1180Aspergillus terreus35.959e-61 222
LLPS-Asn-0392Aspergillus nidulans35.953e-61 224
LLPS-Ved-1269Verticillium dahliae35.865e-64 231
LLPS-Beb-1561Beauveria bassiana35.611e-62 228
LLPS-Mao-0742Magnaporthe oryzae35.615e-63 229
LLPS-Miv-1248Microbotryum violaceum35.592e-58 217
LLPS-Xet-0111Xenopus tropicalis35.483e-31 130
LLPS-Dar-3371Danio rerio35.457e-33 134
LLPS-Ran-0787Rattus norvegicus35.363e-46 173
LLPS-Asc-0736Aspergillus clavatus35.192e-59 218
LLPS-Aim-2970Ailuropoda melanoleuca35.06e-46 172
LLPS-Mum-4798Mus musculus35.01e-44 169
LLPS-Tum-1421Tuber melanosporum34.91e-64 234
LLPS-Pug-1052Puccinia graminis34.835e-56 207
LLPS-Aso-1287Aspergillus oryzae34.682e-59 218
LLPS-Ict-0985Ictidomys tridecemlineatus34.641e-44 169
LLPS-Caf-1277Canis familiaris34.645e-44 167
LLPS-Urm-3554Ursus maritimus34.643e-45 170
LLPS-Mup-3232Mustela putorius furo34.641e-44 169
LLPS-Gaga-1848Gallus gallus34.52e-29 126
LLPS-Tag-2439Taeniopygia guttata34.53e-29 125
LLPS-Pes-2558Pelodiscus sinensis34.52e-28 124
LLPS-Fia-0593Ficedula albicollis34.52e-29 125
LLPS-Mod-4291Monodelphis domestica34.52e-29 125
LLPS-Crn-1400Cryptococcus neoformans34.59e-26 116
LLPS-Ora-2646Ornithorhynchus anatinus34.52e-29 125
LLPS-Sah-3535Sarcophilus harrisii34.52e-29 125
LLPS-Scp-1210Schizosaccharomyces pombe34.432e-29 125
LLPS-Meg-2971Meleagris gallopavo34.336e-28 121
LLPS-Eqc-1400Equus caballus34.294e-44 168
LLPS-Cap-0759Cavia porcellus34.167e-43 164
LLPS-Mea-1466Mesocricetus auratus34.084e-28 120
LLPS-Cas-3050Carlito syrichta34.04e-28 122
LLPS-Nol-3079Nomascus leucogenys34.04e-28 122
LLPS-Mam-4117Macaca mulatta34.05e-28 122
LLPS-Orc-2219Oryctolagus cuniculus34.04e-28 122
LLPS-Rhb-3681Rhinopithecus bieti34.05e-28 122
LLPS-Hos-2431Homo sapiens34.04e-28 122
LLPS-Pap-0267Pan paniscus34.03e-28 123
LLPS-Pat-2827Pan troglodytes34.03e-28 123
LLPS-Fec-3196Felis catus34.05e-28 122
LLPS-Man-1680Macaca nemestrina34.04e-28 122
LLPS-Loa-4569Loxodonta africana34.04e-28 122
LLPS-Mal-1570Mandrillus leucophaeus34.05e-28 122
LLPS-Paa-0599Papio anubis34.04e-28 122
LLPS-Myl-0243Myotis lucifugus34.03e-28 122
LLPS-Tut-2380Tursiops truncatus34.06e-28 122
LLPS-Dio-0661Dipodomys ordii34.05e-28 122
LLPS-Bot-2982Bos taurus34.04e-28 122
LLPS-Gog-3759Gorilla gorilla34.04e-28 122
LLPS-Fud-4304Fukomys damarensis34.06e-28 122
LLPS-Caj-0980Callithrix jacchus34.04e-28 122
LLPS-Maf-3233Macaca fascicularis34.05e-28 122
LLPS-Chs-3919Chlorocebus sabaeus34.03e-28 122
LLPS-Sus-3887Sus scrofa34.04e-28 122
LLPS-Aon-3105Aotus nancymaae34.04e-28 122
LLPS-Cea-1666Cercocebus atys34.04e-28 122
LLPS-Yal-1340Yarrowia lipolytica33.997e-26 116
LLPS-Poa-2785Pongo abelii33.574e-43 164
LLPS-Abg-0419Absidia glauca32.915e-79 270
LLPS-Anc-1312Anolis carolinensis32.52e-37 149
LLPS-Hea-1495Helianthus annuus32.242e-39 152
LLPS-Scc-0494Schizosaccharomyces cryophilus32.214e-27 119
LLPS-Sol-0428Solanum lycopersicum32.041e-40 154
LLPS-Asni-1584Aspergillus niger31.942e-65 235
LLPS-Sot-1154Solanum tuberosum31.728e-40 152
LLPS-Mel-1266Melampsora laricipopulina30.956e-23 106
LLPS-Kop-1485Komagataella pastoris30.091e-69 246
LLPS-Asg-0941Ashbya gossypii30.099e-56 206
LLPS-Scj-0289Schizosaccharomyces japonicus28.685e-48 180
LLPS-Sac-0645Saccharomyces cerevisiae28.175e-62 224