LLPS-Cae-1485
rpn-2

▼ OVERVIEW

Status: Unreviewed
Protein Name: 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit rpn-2
Gene Name: rpn-2, C23G10.4
Ensembl Gene: WBGene00004459
Ensembl Protein: C23G10.4b.1
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLTLLNRWRS  QPGGASNAAA  FIRVLESPKS  AVTDKVLVLK  AFNDWDVLVN  TWFEVADALP  60
61    AVEQLLDNNT  FPEHSSAALL  VSKVYFCLEQ  YERALEFALR  GDFNVVPATR  TGLGNDAEYV  120
121   NKIIETAIDT  YKTLSKQGSG  IPQKLRDLID  RIVARNLDKR  EIWFVISLGF  ETTNLAMIDR  180
181   AISAMPADLT  IKNQTTLVET  LNRVVNGAFD  RSFRFQVIDT  VIKTYLKCPS  PDMSKICECY  240
241   VLTDNAEAAA  DTITSLIAKS  LSTRAYQIAF  DLYETASQGF  LDRVLKRFQQ  QDARDEKSME  300
301   KIHSILKGHE  TVKAYLDFFV  RHNHTDSVLM  EEIKENIRTA  SAHNALLISN  GLMQYGTTCD  360
361   DFLRNNLNWV  SKATNWNKFN  AVASLGLIHH  GQESSAMKVL  EPYLPKESVE  GFGFKEGGAM  420
421   LAYGLIHAKH  GDATAMSTLA  QWLKTAENEP  VRHGACLGFG  VAGLGSSSVS  NYEKVREVLQ  480
481   RDEAVSGESA  GIAMGLIMAG  HLNQEVFNEL  KQYTVDTQHD  KTQRGIRTGL  ACAAFGLQGD  540
541   AEPYIKEAIG  AKSNPMLRST  GICMLSMAYA  GTGSPDVVRR  LLEKVATDPN  LDVKRYATIG  600
601   IGFVLSKDPS  TCLSYVAMLT  EHFNGHVRYG  AAMALGIACA  GTGNMEAIAL  IEPMISDKEG  660
661   FVRKGALLSL  ALIMCQQTDY  TCPKVNGFRK  QLLKKIGEKN  EDSLVKFGAI  IAQGLLDIGG  720
721   QNAAVTMQNS  DKQPDMGSMV  GMMCFLHGWF  WHSMHFFIAL  AAKPSCLVMM  NENLKIPVLD  780
781   YICHANSQKF  AYPPRAESKK  DKDVKKIETV  VLSITGKKNA  SKKLIAEEKK  RREAAASASS  840
841   AAAAPSSSST  SGTAPAAEDE  KMEVDQPGKS  KKEKAPEKDT  KPLHRLQNPA  RVIPAQRQLI  900
901   SISDARAYSP  MKPLYKGGII  VADRVDKERE  EKLVSEVVTQ  VNTPASSGNT  ENKPHSTFEI  960
961   NINDF  965
Nucleotide CDS Sequence (FASTA)
1     ATGTTGACAT  TGTTGAACAG  ATGGAGATCT  CAGCCAGGAG  GCGCTTCAAA  CGCAGCCGCA  60
61    TTCATTCGTG  TTCTCGAGTC  ACCGAAATCA  GCAGTGACCG  ACAAAGTGCT  CGTTCTCAAA  120
121   GCATTTAACG  ATTGGGATGT  TCTTGTGAAC  ACATGGTTTG  AGGTCGCTGA  CGCCCTTCCA  180
181   GCTGTAGAGC  AGCTCCTTGA  CAACAACACG  TTCCCAGAGC  ATTCATCCGC  TGCACTGCTC  240
241   GTCTCCAAAG  TTTATTTCTG  CTTGGAGCAG  TATGAACGTG  CTTTGGAGTT  TGCTCTTCGT  300
301   GGTGATTTCA  ACGTCGTTCC  TGCTACAAGA  ACCGGTCTTG  GAAACGACGC  AGAATATGTT  360
361   AACAAGATCA  TCGAGACGGC  CATTGACACG  TACAAGACGC  TGAGCAAGCA  AGGATCTGGA  420
421   ATTCCTCAGA  AACTCCGAGA  TTTGATCGAC  CGAATTGTTG  CTAGAAATCT  GGATAAACGA  480
481   GAGATATGGT  TTGTCATCTC  GTTAGGATTT  GAGACGACCA  ATCTGGCTAT  GATCGACAGG  540
541   GCCATTAGCG  CGATGCCTGC  AGATTTGACC  ATCAAGAATC  AGACTACACT  TGTCGAAACG  600
601   CTCAACCGTG  TTGTCAATGG  CGCGTTCGAT  CGTTCATTCC  GATTCCAAGT  TATCGATACA  660
661   GTCATCAAGA  CGTACTTGAA  GTGCCCATCG  CCGGACATGT  CCAAGATTTG  CGAGTGTTAC  720
721   GTGCTCACGG  ATAACGCCGA  GGCCGCTGCT  GACACGATTA  CGAGTTTGAT  CGCGAAGTCT  780
781   CTCAGCACTC  GTGCATATCA  GATCGCATTT  GATTTATATG  AAACAGCGAG  TCAAGGATTC  840
841   CTCGATCGAG  TTTTGAAACG  TTTCCAACAG  CAGGATGCTC  GTGATGAGAA  GTCGATGGAA  900
901   AAGATTCATT  CAATTCTCAA  AGGTCATGAA  ACTGTCAAGG  CTTACCTCGA  CTTCTTTGTC  960
961   CGTCATAATC  ACACTGATTC  TGTTCTAATG  GAAGAGATCA  AGGAGAACAT  TCGAACAGCC  1020
1021  TCTGCCCACA  ATGCTCTTCT  CATCTCAAAT  GGTCTTATGC  AATATGGAAC  TACTTGTGAC  1080
1081  GATTTCCTCC  GTAACAACTT  GAACTGGGTT  TCCAAAGCTA  CGAACTGGAA  CAAGTTCAAT  1140
1141  GCGGTCGCTT  CACTTGGACT  CATTCATCAC  GGACAAGAAT  CGTCTGCAAT  GAAGGTACTT  1200
1201  GAGCCATATT  TGCCAAAGGA  ATCTGTCGAA  GGATTTGGAT  TTAAAGAGGG  AGGAGCAATG  1260
1261  CTGGCATATG  GATTGATTCA  CGCCAAACAC  GGAGATGCAA  CTGCCATGAG  CACTCTGGCT  1320
1321  CAGTGGCTCA  AAACCGCCGA  AAACGAGCCA  GTGAGACACG  GAGCTTGTCT  TGGATTTGGA  1380
1381  GTTGCTGGAC  TTGGATCGTC  TTCTGTTTCG  AATTACGAGA  AAGTTCGGGA  AGTTCTCCAA  1440
1441  CGTGATGAAG  CAGTTTCCGG  AGAATCCGCA  GGAATCGCCA  TGGGCCTTAT  CATGGCTGGA  1500
1501  CATCTGAATC  AAGAGGTGTT  CAATGAGCTC  AAGCAATACA  CTGTTGACAC  ACAGCATGAC  1560
1561  AAAACTCAAC  GTGGTATCCG  AACTGGACTT  GCCTGTGCCG  CATTCGGACT  CCAAGGAGAT  1620
1621  GCTGAGCCTT  ACATCAAAGA  AGCAATCGGA  GCTAAGAGCA  ATCCAATGCT  CCGTTCCACT  1680
1681  GGAATCTGTA  TGCTGTCGAT  GGCTTACGCC  GGAACCGGAT  CTCCAGATGT  AGTACGCCGT  1740
1741  CTTCTCGAGA  AAGTAGCCAC  CGATCCAAAT  TTGGATGTCA  AGAGATACGC  TACAATTGGT  1800
1801  ATCGGATTCG  TTCTCTCCAA  GGATCCATCA  ACCTGCTTAT  CCTACGTGGC  CATGCTCACC  1860
1861  GAACATTTCA  ATGGACATGT  CAGATACGGA  GCAGCTATGG  CACTGGGAAT  TGCTTGTGCT  1920
1921  GGAACAGGAA  ACATGGAAGC  TATTGCTCTG  ATTGAGCCAA  TGATTTCTGA  TAAGGAAGGT  1980
1981  TTCGTTCGTA  AAGGAGCACT  TCTTTCACTT  GCTCTCATCA  TGTGCCAGCA  GACAGACTAC  2040
2041  ACTTGTCCCA  AGGTGAACGG  TTTCCGTAAG  CAATTGCTCA  AAAAGATCGG  AGAGAAGAAC  2100
2101  GAGGACTCTC  TTGTCAAATT  TGGAGCAATT  ATTGCTCAAG  GACTTCTCGA  CATCGGAGGG  2160
2161  CAGAACGCTG  CGGTCACAAT  GCAAAATTCT  GACAAGCAGC  CAGATATGGG  ATCAATGGTC  2220
2221  GGAATGATGT  GCTTCCTTCA  CGGATGGTTC  TGGCACTCGA  TGCATTTCTT  CATCGCCCTT  2280
2281  GCTGCTAAGC  CATCATGCCT  TGTGATGATG  AACGAGAATC  TGAAGATTCC  AGTACTTGAC  2340
2341  TACATCTGCC  ATGCCAATAG  TCAGAAGTTT  GCCTATCCAC  CACGAGCCGA  ATCAAAGAAG  2400
2401  GATAAGGATG  TCAAAAAGAT  TGAGACTGTT  GTTCTGTCCA  TCACCGGAAA  GAAGAATGCG  2460
2461  TCAAAGAAGC  TGATCGCTGA  GGAGAAAAAA  AGACGAGAAG  CTGCAGCTTC  CGCTTCTAGT  2520
2521  GCTGCTGCTG  CCCCATCATC  ATCGTCCACT  TCAGGAACAG  CACCAGCTGC  TGAAGATGAG  2580
2581  AAAATGGAGG  TTGATCAACC  AGGAAAATCC  AAGAAAGAAA  AGGCTCCAGA  AAAGGACACG  2640
2641  AAGCCATTGC  ACCGCCTACA  GAATCCAGCT  CGTGTGATTC  CTGCTCAACG  ACAGCTAATC  2700
2701  TCGATCAGTG  ACGCTCGAGC  CTACAGTCCC  ATGAAGCCAC  TTTACAAGGG  TGGAATTATT  2760
2761  GTGGCGGATC  GTGTTGATAA  GGAGAGAGAG  GAGAAGCTTG  TCAGTGAAGT  CGTCACTCAG  2820
2821  GTCAATACTC  CTGCGAGCTC  TGGAAATACC  GAAAACAAAC  CCCATTCGAC  GTTCGAGATC  2880
2881  AATATCAACG  ATTTTTGA  2898

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Proteasome
Reference proteome
Repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell cortex
Cellular Component
Cytoplasm
Cellular Component
Mitotic spindle
Cellular Component
Nuclear membrane
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Proteasome regulatory particle, base subcomplex
Cellular Component
Proteasome storage granule
Molecular Function
Enzyme regulator activity
Molecular Function
Protein kinase C binding
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process
Regulation of protein catabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaa-2781Gasterosteus aculeatus39.345e-82 290
LLPS-Mao-1506Magnaporthe oryzae37.252e-0759.3
LLPS-Scm-1493Scophthalmus maximus36.972e-174 540
LLPS-Orn-2785Oreochromis niloticus36.827e-172 533
LLPS-Abg-1056Absidia glauca36.820.0 579
LLPS-Cog-0276Colletotrichum gloeosporioides36.734e-0758.5
LLPS-Xim-1996Xiphophorus maculatus36.611e-171 533
LLPS-Coo-0718Colletotrichum orbiculare36.369e-149 478
LLPS-Pes-1094Pelodiscus sinensis36.271e-169 523
LLPS-Blg-1584Blumeria graminis36.274e-0861.6
LLPS-Pof-4159Poecilia formosa36.256e-171 531
LLPS-Anp-0405Anas platyrhynchos36.240.0 558
LLPS-Asm-1048Astyanax mexicanus36.244e-172 534
LLPS-Zyt-1315Zymoseptoria tritici36.145e-132 433
LLPS-Scf-3788Scleropages formosus36.13e-172 535
LLPS-Icp-3345Ictalurus punctatus36.062e-171 532
LLPS-Dos-0888Dothistroma septosporum35.942e-131 431
LLPS-Leo-1830Lepisosteus oculatus35.911e-178 551
LLPS-Dar-1471Danio rerio35.895e-168 525
LLPS-Tar-2170Takifugu rubripes35.822e-172 535
LLPS-Lac-4048Latimeria chalumnae35.712e-143 452
LLPS-Xet-0844Xenopus tropicalis35.530.0 582
LLPS-Rhb-3167Rhinopithecus bieti35.463e-167 521
LLPS-Chc-1214Chondrus crispus35.443e-121 402
LLPS-Cogr-1381Colletotrichum graminicola35.293e-149 479
LLPS-Gag-0373Gaeumannomyces graminis35.295e-0758.2
LLPS-Meg-3183Meleagris gallopavo35.230.0 578
LLPS-Fia-3271Ficedula albicollis35.190.0 577
LLPS-Tag-1683Taeniopygia guttata35.190.0 575
LLPS-Scs-0634Sclerotinia sclerotiorum35.142e-151 484
LLPS-Ova-0662Ovis aries35.130.0 582
LLPS-Urm-3327Ursus maritimus35.070.0 579
LLPS-Aon-4716Aotus nancymaae35.020.0 581
LLPS-Aim-4205Ailuropoda melanoleuca35.020.0 581
LLPS-Anc-1608Anolis carolinensis34.970.0 573
LLPS-Caf-4220Canis familiaris34.920.0 579
LLPS-Fud-1442Fukomys damarensis34.920.0 577
LLPS-Gaga-2093Gallus gallus34.880.0 578
LLPS-Loa-4300Loxodonta africana34.810.0 582
LLPS-Sah-2044Sarcophilus harrisii34.810.0 576
LLPS-Sus-4129Sus scrofa34.770.0 583
LLPS-Bot-3498Bos taurus34.770.0 582
LLPS-Pap-0108Pan paniscus34.710.0 582
LLPS-Fus-1417Fusarium solani34.77e-149 474
LLPS-Caj-1832Callithrix jacchus34.70.0 563
LLPS-Pat-4098Pan troglodytes34.670.0 582
LLPS-Hos-0317Homo sapiens34.670.0 582
LLPS-Fec-2722Felis catus34.670.0 582
LLPS-Orc-2221Oryctolagus cuniculus34.670.0 583
LLPS-Poa-4551Pongo abelii34.670.0 582
LLPS-Eqc-1948Equus caballus34.670.0 582
LLPS-Cap-3105Cavia porcellus34.670.0 578
LLPS-Mam-2556Macaca mulatta34.670.0 582
LLPS-Ict-3913Ictidomys tridecemlineatus34.670.0 583
LLPS-Maf-4749Macaca fascicularis34.670.0 582
LLPS-Mum-4104Mus musculus34.670.0 583
LLPS-Cea-4665Cercocebus atys34.670.0 582
LLPS-Gog-4315Gorilla gorilla34.670.0 582
LLPS-Ran-3676Rattus norvegicus34.670.0 583
LLPS-Paa-3750Papio anubis34.670.0 582
LLPS-Mal-3305Mandrillus leucophaeus34.670.0 582
LLPS-Mup-1988Mustela putorius furo34.670.0 582
LLPS-Tum-1094Tuber melanosporum34.672e-156 493
LLPS-Mod-3920Monodelphis domestica34.660.0 568
LLPS-Cis-1415Ciona savignyi34.640.0 580
LLPS-Beb-1593Beauveria bassiana34.635e-147 473
LLPS-Orl-2570Oryzias latipes34.621e-177 549
LLPS-Otg-1835Otolemur garnettii34.570.0 582
LLPS-Myl-3078Myotis lucifugus34.570.0 579
LLPS-Miv-1559Microbotryum violaceum34.511e-166 522
LLPS-Mea-4056Mesocricetus auratus34.430.0 582
LLPS-Nol-3229Nomascus leucogenys34.240.0 565
LLPS-Aso-1326Aspergillus oryzae34.151e-0967.0
LLPS-Asf-1457Aspergillus flavus34.151e-0967.0
LLPS-Ten-2626Tetraodon nigroviridis34.092e-173 538
LLPS-Put-1212Puccinia triticina34.071e-166 523
LLPS-Ved-1257Verticillium dahliae33.951e-147 475
LLPS-Usm-0582Ustilago maydis33.91e-163 517
LLPS-Chr-0903Chlamydomonas reinhardtii33.91e-156 496
LLPS-Spr-1011Sporisorium reilianum33.728e-161 510
LLPS-Dio-1474Dipodomys ordii33.652e-176 545
LLPS-Asc-0957Aspergillus clavatus33.612e-0966.2
LLPS-Scp-1209Schizosaccharomyces pombe33.581e-157 496
LLPS-Scj-0005Schizosaccharomyces japonicus33.511e-164 514
LLPS-Glm-1047Glycine max33.479e-165 516
LLPS-Sem-2354Selaginella moellendorffii33.472e-160 504
LLPS-Mel-0477Melampsora laricipopulina33.449e-168 525
LLPS-Met-0134Medicago truncatula33.42e-164 515
LLPS-Chs-0480Chlorocebus sabaeus33.373e-169 526
LLPS-Ast-1545Aspergillus terreus33.337e-0860.8
LLPS-Nef-0426Neosartorya fischeri33.336e-0964.7
LLPS-Asfu-0391Aspergillus fumigatus33.333e-0965.5
LLPS-Hea-1944Helianthus annuus33.331e-166 521
LLPS-Pot-0454Populus trichocarpa33.232e-162 510
LLPS-Viv-2492Vitis vinifera33.162e-166 521
LLPS-Yal-1293Yarrowia lipolytica33.166e-164 512
LLPS-Pytr-0006Pyrenophora triticirepentis33.138e-141 456
LLPS-Cus-0536Cucumis sativus33.069e-167 521
LLPS-Phv-0843Phaseolus vulgaris33.033e-161 507
LLPS-Via-0960Vigna angularis33.032e-161 508
LLPS-Trv-1563Trichoderma virens33.021e-157 502
LLPS-Osl-1225Ostreococcus lucimarinus32.946e-153 484
LLPS-Trr-1186Trichoderma reesei32.898e-157 499
LLPS-Ors-1664Oryza sativa32.882e-162 509
LLPS-Orr-0737Oryza rufipogon32.882e-162 509
LLPS-Org-2110Oryza glaberrima32.882e-162 509
LLPS-Ori-0736Oryza indica32.882e-162 509
LLPS-Coc-0980Corchorus capsularis32.864e-155 488
LLPS-Asni-1444Aspergillus niger32.841e-141 459
LLPS-Orni-1896Oryza nivara32.841e-155 491
LLPS-Orgl-1865Oryza glumaepatula32.843e-154 491
LLPS-Pyt-0252Pyrenophora teres32.741e-140 455
LLPS-Orm-1666Oryza meridionalis32.712e-161 507
LLPS-Sob-1068Sorghum bicolor32.532e-169 528
LLPS-Fuo-1561Fusarium oxysporum32.538e-155 494
LLPS-Lem-0163Leptosphaeria maculans32.526e-140 456
LLPS-Brr-2419Brassica rapa32.462e-161 508
LLPS-Amt-2295Amborella trichopoda32.451e-162 511
LLPS-Asn-0719Aspergillus nidulans32.414e-141 457
LLPS-Orp-0326Oryza punctata32.43e-165 518
LLPS-Orb-1803Oryza barthii32.42e-165 518
LLPS-Tru-1203Triticum urartu32.396e-156 491
LLPS-Brn-3360Brassica napus32.378e-161 506
LLPS-Sac-1421Saccharomyces cerevisiae32.362e-130 424
LLPS-Scc-1364Schizosaccharomyces cryophilus32.357e-156 492
LLPS-Arl-1031Arabidopsis lyrata32.352e-165 518
LLPS-Orbr-1812Oryza brachyantha32.34e-164 514
LLPS-Nia-1346Nicotiana attenuata32.283e-161 507
LLPS-Lep-1224Leersia perrieri32.254e-163 511
LLPS-Hov-1851Hordeum vulgare32.258e-165 515
LLPS-Brd-1095Brachypodium distachyon32.252e-168 526
LLPS-Gor-1255Gossypium raimondii32.185e-163 512
LLPS-Thc-0853Theobroma cacao32.162e-160 505
LLPS-Man-4179Macaca nemestrina32.152e-106 357
LLPS-Dac-0592Daucus carota32.155e-160 504
LLPS-Sei-0799Setaria italica32.152e-164 516
LLPS-Fuv-1009Fusarium verticillioides32.147e-151 484
LLPS-Bro-2683Brassica oleracea32.124e-160 504
LLPS-Mae-1853Manihot esculenta32.061e-152 484
LLPS-Cas-3402Carlito syrichta32.059e-101 335
LLPS-Vir-1855Vigna radiata31.972e-152 483
LLPS-Sol-2441Solanum lycopersicum31.81e-163 513
LLPS-Sot-1033Solanum tuberosum31.777e-163 511
LLPS-Zem-1392Zea mays31.74e-165 517
LLPS-Ora-0649Ornithorhynchus anatinus31.587e-105 347
LLPS-Prp-1452Prunus persica31.485e-162 510
LLPS-Crn-0055Cryptococcus neoformans31.451e-147 471
LLPS-Art-2801Arabidopsis thaliana31.394e-157 496
LLPS-Tra-0130Triticum aestivum30.892e-159 503
LLPS-Mua-0137Musa acuminata30.832e-144 463
LLPS-Nec-1316Neurospora crassa30.66e-147 474
LLPS-Kop-0546Komagataella pastoris30.591e-150 478
LLPS-Phn-1358Phaeosphaeria nodorum30.54e-148 476
LLPS-Asg-1378Ashbya gossypii30.169e-132 427
LLPS-Gas-0820Galdieria sulphuraria29.569e-133 431
LLPS-Cii-2330Ciona intestinalis29.215e-1167.8
LLPS-Cym-0185Cyanidioschyzon merolae27.272e-96 335
LLPS-Php-2387Physcomitrella patens23.593e-1275.1
LLPS-Map-0705Magnaporthe poae23.222e-1172.8