LLPS-Cae-1424
mpk-1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Mitogen-activated protein kinase mpk-1; MAP kinase sur-1
Gene Name: mpk-1, sur-1, F43C1.2
Ensembl Gene: WBGene00003401
Ensembl Protein: F43C1.2b
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, P-body, Stress granule, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION

Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation (PubMed:8299935, PubMed:8299936). Plays a negative role in proximal germline proliferation in the mitotic zone (PubMed:16319922). Required for progression of developing oocytes through the pachytene stage (PubMed:16319922, PubMed:19826475, PubMed:21901106). In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3 (PubMed:21160027). Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Involved in fluid homeostasis (PubMed:11689700). In addition, involved in the up-regulation of lysozyme ilys-3 expression in the intestine in responses to M.nematophilum-mediated bacterial infection (PubMed:27525822). By phosphorylating transcription factor skn-1 (isoform c) may play a role in increasing life span downstream of lin-45, let-60 and mek-2 (PubMed:20624915). By up-regulating cep-1 and down-regulating gld-1 expression in the late pachytene stage, plays a role in germline apoptosis in response to DNA damage (PubMed:21901106). Regulates egl-1 expression in response to DNA damage, probably upstream of cep-1 (PubMed:21901106).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPTWIPNNLC  AQPTTRNAKP  PSNGHPQATQ  QQSAPGSLAY  RNSSNIPNGA  TNHVRQQKWQ  60
61    YTRSGHRKMA  DGEAVISTVN  NVEEVHGQLF  EVAPRYVNLS  YIGEGAYGMV  ASALDTITRD  120
121   RVAIKKISPF  EHQTFCQRTL  REIKILNRFK  HENIINIQEI  IRSETVDSLK  DIYIVQCLME  180
181   TDLYKLLKTQ  KLSNDHVCYF  LYQILRGLKY  IHSANVLHRD  LKPSNLLLNT  TCDLKICDFG  240
241   LARVTDPQTD  HTGFLTEYVA  TRWYRAPEIM  LNSKGYTKSI  DVWSVGCILA  EMLSNRPLFP  300
301   GKHYLDQLNL  ILAVVGSPSN  ADLQCIINDK  ARSYLISLPH  KPKQPWARLY  PGADPRALDL  360
361   LDKMLTFNPH  NRIDIEQALA  HPYLEQYYDP  GDEPVCEEPF  TLEMEFDDLP  KEKLKELIWE  420
421   EAEAHHRRME  AEAAARNNGG  QNPV  444
Nucleotide CDS Sequence (FASTA)
1     ATGCCAACGT  GGATACCTAA  CAATTTGTGC  GCACAGCCGA  CAACGAGAAA  TGCTAAACCA  60
61    CCATCGAACG  GGCATCCACA  AGCGACACAA  CAACAATCTG  CTCCGGGATC  ATTGGCATAC  120
121   CGTAATTCGA  GCAACATACC  GAATGGAGCA  ACCAACCACG  TCAGACAACA  GAAATGGCAG  180
181   TACACTCGTT  CAGGACATAG  AAAGATGGCC  GACGGAGAAG  CGGTTATCTC  GACGGTCAAC  240
241   AATGTCGAGG  AAGTTCATGG  GCAACTTTTT  GAGGTTGCTC  CCCGTTATGT  GAATCTTTCA  300
301   TATATTGGAG  AAGGTGCTTA  CGGGATGGTC  GCCTCTGCAC  TTGACACAAT  TACTCGTGAT  360
361   CGCGTTGCTA  TCAAAAAGAT  TTCTCCATTC  GAACATCAGA  CATTCTGTCA  ACGGACACTT  420
421   CGGGAAATCA  AAATTCTTAA  TCGATTCAAG  CATGAGAATA  TCATCAATAT  TCAAGAAATC  480
481   ATCCGTTCGG  AGACTGTCGA  TAGTTTGAAG  GATATTTACA  TAGTTCAATG  CCTGATGGAG  540
541   ACTGATTTGT  ACAAATTGCT  GAAAACTCAA  AAGCTCTCAA  ATGATCACGT  TTGCTACTTT  600
601   CTCTATCAAA  TTCTCCGTGG  TCTCAAATAC  ATTCACTCTG  CAAATGTGCT  CCATCGTGAT  660
661   TTGAAACCAT  CGAATTTGTT  GCTCAACACC  ACATGTGATC  TCAAAATTTG  CGATTTTGGA  720
721   TTGGCACGTG  TCACCGACCC  ACAAACCGAT  CATACTGGGT  TCTTGACCGA  GTATGTGGCT  780
781   ACTCGTTGGT  ATAGAGCTCC  AGAGATTATG  CTCAATTCAA  AGGGATACAC  TAAATCGATT  840
841   GATGTCTGGT  CTGTCGGATG  TATTCTCGCA  GAAATGCTCA  GTAATCGGCC  ATTGTTCCCG  900
901   GGAAAACATT  ATTTGGATCA  ACTCAATTTG  ATTTTGGCAG  TTGTTGGATC  CCCGTCAAAT  960
961   GCTGATTTAC  AATGTATTAT  TAATGATAAG  GCTCGATCAT  ATCTCATTTC  ATTGCCACAC  1020
1021  AAACCAAAAC  AACCATGGGC  TCGGCTCTAT  CCAGGAGCTG  ATCCAAGAGC  TCTTGATTTA  1080
1081  TTGGACAAAA  TGCTCACTTT  CAATCCACAT  AATCGTATCG  ACATCGAGCA  AGCATTGGCT  1140
1141  CACCCATACT  TGGAGCAATA  CTACGATCCA  GGAGATGAGC  CAGTTTGTGA  GGAACCATTC  1200
1201  ACTTTGGAAA  TGGAATTCGA  CGATTTACCG  AAGGAGAAGC  TGAAGGAGCT  GATTTGGGAA  1260
1261  GAAGCCGAGG  CTCATCACAG  ACGAATGGAG  GCAGAAGCGG  CTGCAAGGAA  TAATGGAGGG  1320
1321  CAGAATCCTG  TTTAG  1335

▼ KEYWORD

ID
Family
Alternative splicing
ATP-binding
Cell cycle
Complete proteome
Differentiation
Kinase
Magnesium
Meiosis
Metal-binding
Nucleotide-binding
Oogenesis
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
MAP kinase activity
Molecular Function
Metal ion binding
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Cellular response to organic substance
Biological Process
Defense response to Gram-positive bacterium
Biological Process
Determination of adult lifespan
Biological Process
Intracellular signal transduction
Biological Process
MAPK cascade
Biological Process
Meiotic cell cycle
Biological Process
Oocyte maturation
Biological Process
Peptidyl-serine phosphorylation
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process
Protein phosphorylation
Biological Process
Ras protein signal transduction
Biological Process
Regulation of gene expression
Biological Process
Vulval development

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tag-1809Taeniopygia guttata82.470.0 539
LLPS-Meg-0813Meleagris gallopavo82.470.0 539
LLPS-Pes-1937Pelodiscus sinensis82.260.0 540
LLPS-Fia-1888Ficedula albicollis82.20.0 539
LLPS-Anp-0970Anas platyrhynchos82.20.0 534
LLPS-Ova-3395Ovis aries82.140.0 536
LLPS-Fud-3931Fukomys damarensis82.140.0 536
LLPS-Cap-3372Cavia porcellus82.140.0 536
LLPS-Gaga-1203Gallus gallus81.940.0 540
LLPS-Lac-0301Latimeria chalumnae81.90.0 584
LLPS-Ict-2883Ictidomys tridecemlineatus81.880.0 536
LLPS-Aim-1333Ailuropoda melanoleuca81.820.0 535
LLPS-Mup-1512Mustela putorius furo81.820.0 537
LLPS-Tut-1321Tursiops truncatus81.820.0 535
LLPS-Rhb-2604Rhinopithecus bieti81.820.0 575
LLPS-Nol-1330Nomascus leucogenys81.760.0 573
LLPS-Asm-0884Astyanax mexicanus81.730.0 539
LLPS-Bot-1038Bos taurus81.60.0 583
LLPS-Cas-1941Carlito syrichta81.60.0 583
LLPS-Fec-0544Felis catus81.60.0 583
LLPS-Mod-0265Monodelphis domestica81.60.0 585
LLPS-Gog-2566Gorilla gorilla81.490.0 583
LLPS-Paa-1650Papio anubis81.310.0 583
LLPS-Ran-0507Rattus norvegicus81.310.0 582
LLPS-Caj-2449Callithrix jacchus81.310.0 582
LLPS-Sus-2278Sus scrofa81.310.0 583
LLPS-Cea-1430Cercocebus atys81.310.0 583
LLPS-Chs-1011Chlorocebus sabaeus81.310.0 583
LLPS-Maf-1016Macaca fascicularis81.310.0 583
LLPS-Mum-0899Mus musculus81.310.0 582
LLPS-Mea-1338Mesocricetus auratus81.310.0 582
LLPS-Eqc-3406Equus caballus81.310.0 586
LLPS-Caf-0536Canis familiaris81.310.0 583
LLPS-Hos-0658Homo sapiens81.310.0 583
LLPS-Pat-1929Pan troglodytes81.310.0 583
LLPS-Pap-0485Pan paniscus81.290.0 538
LLPS-Otg-3099Otolemur garnettii81.030.0 528
LLPS-Urm-1185Ursus maritimus81.030.0 536
LLPS-Dio-0614Dipodomys ordii81.010.0 581
LLPS-Icp-2840Ictalurus punctatus81.010.0 574
LLPS-Scm-3216Scophthalmus maximus80.830.0 533
LLPS-Gaa-1997Gasterosteus aculeatus80.590.0 576
LLPS-Dar-0047Danio rerio80.590.0 578
LLPS-Orn-1761Oreochromis niloticus80.530.0 575
LLPS-Tar-1978Takifugu rubripes80.290.0 574
LLPS-Orc-0701Oryctolagus cuniculus80.250.0 538
LLPS-Orl-3942Oryzias latipes80.240.0 572
LLPS-Sah-3491Sarcophilus harrisii80.060.0 538
LLPS-Leo-2500Lepisosteus oculatus79.880.0 576
LLPS-Loa-2538Loxodonta africana79.620.0 533
LLPS-Mam-2972Macaca mulatta79.530.0 566
LLPS-Pof-2219Poecilia formosa79.350.0 567
LLPS-Ten-3328Tetraodon nigroviridis79.30.0 570
LLPS-Cis-1357Ciona savignyi79.230.0 570
LLPS-Mal-2003Mandrillus leucophaeus79.080.0 540
LLPS-Xim-1224Xiphophorus maculatus79.060.0 565
LLPS-Anc-2486Anolis carolinensis79.060.0 576
LLPS-Cii-0606Ciona intestinalis78.640.0 565
LLPS-Xet-1685Xenopus tropicalis78.590.0 580
LLPS-Aon-2206Aotus nancymaae78.510.0 575
LLPS-Drm-1082Drosophila melanogaster78.240.0 576
LLPS-Myl-1475Myotis lucifugus78.210.0 525
LLPS-Ere-0635Erinaceus europaeus77.060.0 565
LLPS-Poa-2835Pongo abelii77.060.0 566
LLPS-Man-1330Macaca nemestrina77.060.0 566
LLPS-Scf-0907Scleropages formosus76.520.0 540
LLPS-Ora-3354Ornithorhynchus anatinus62.12e-126 378
LLPS-Put-1317Puccinia triticina59.153e-129 384
LLPS-Blg-0109Blumeria graminis58.388e-129 384
LLPS-Miv-1145Microbotryum violaceum58.161e-134 399
LLPS-Asf-0067Aspergillus flavus57.783e-125 375
LLPS-Aso-1078Aspergillus oryzae57.783e-125 375
LLPS-Asn-0808Aspergillus nidulans57.786e-125 374
LLPS-Asc-0264Aspergillus clavatus57.784e-125 374
LLPS-Fuv-1462Fusarium verticillioides57.784e-127 379
LLPS-Asfu-0446Aspergillus fumigatus57.782e-125 375
LLPS-Ved-1323Verticillium dahliae57.788e-127 379
LLPS-Fuo-1110Fusarium oxysporum57.784e-127 379
LLPS-Fus-0130Fusarium solani57.788e-127 379
LLPS-Nef-0216Neosartorya fischeri57.785e-125 374
LLPS-Scc-0428Schizosaccharomyces cryophilus57.748e-123 369
LLPS-Zyt-0152Zymoseptoria tritici57.491e-126 378
LLPS-Nec-0597Neurospora crassa57.492e-127 380
LLPS-Asni-0219Aspergillus niger57.491e-124 373
LLPS-Coo-0304Colletotrichum orbiculare57.491e-126 378
LLPS-Cogr-0779Colletotrichum graminicola57.491e-126 378
LLPS-Dos-1199Dothistroma septosporum57.491e-126 378
LLPS-Cog-0948Colletotrichum gloeosporioides57.491e-126 378
LLPS-Ast-0588Aspergillus terreus57.496e-125 374
LLPS-Pyt-1370Pyrenophora teres57.191e-126 378
LLPS-Lem-1205Leptosphaeria maculans57.192e-126 378
LLPS-Map-0360Magnaporthe poae57.191e-126 378
LLPS-Mao-0308Magnaporthe oryzae57.191e-126 378
LLPS-Gag-0388Gaeumannomyces graminis57.191e-126 378
LLPS-Phn-1051Phaeosphaeria nodorum57.191e-126 378
LLPS-Pytr-1189Pyrenophora triticirepentis57.191e-126 378
LLPS-Trv-0767Trichoderma virens56.988e-128 381
LLPS-Trr-0236Trichoderma reesei56.694e-127 379
LLPS-Tum-0649Tuber melanosporum56.599e-132 391
LLPS-Yal-0434Yarrowia lipolytica56.471e-134 399
LLPS-Beb-1223Beauveria bassiana56.43e-125 375
LLPS-Pug-0157Puccinia graminis55.622e-131 393
LLPS-Scp-1500Schizosaccharomyces pombe55.152e-124 373
LLPS-Abg-0676Absidia glauca54.891e-132 394
LLPS-Usm-0305Ustilago maydis54.875e-133 394
LLPS-Mel-0383Melampsora laricipopulina54.731e-130 390
LLPS-Cus-1082Cucumis sativus54.444e-121 365
LLPS-Spr-0914Sporisorium reilianum54.341e-132 394
LLPS-Nia-1027Nicotiana attenuata53.718e-127 379
LLPS-Chr-0981Chlamydomonas reinhardtii53.572e-122 369
LLPS-Mua-2228Musa acuminata53.559e-123 369
LLPS-Sem-2436Selaginella moellendorffii53.555e-123 370
LLPS-Scj-0561Schizosaccharomyces japonicus53.431e-126 379
LLPS-Arl-1076Arabidopsis lyrata53.257e-122 367
LLPS-Viv-1922Vitis vinifera53.252e-120 363
LLPS-Brd-0379Brachypodium distachyon53.121e-119 362
LLPS-Lep-0599Leersia perrieri52.964e-120 363
LLPS-Orgl-0685Oryza glumaepatula52.962e-119 362
LLPS-Dac-2197Daucus carota52.963e-121 365
LLPS-Orni-0137Oryza nivara52.961e-119 362
LLPS-Orb-1262Oryza barthii52.966e-120 362
LLPS-Orr-0923Oryza rufipogon52.962e-119 362
LLPS-Mae-1517Manihot esculenta52.964e-120 363
LLPS-Orp-0213Oryza punctata52.962e-119 362
LLPS-Ors-1527Oryza sativa52.962e-119 362
LLPS-Crn-1391Cryptococcus neoformans52.927e-124 373
LLPS-Tra-0021Triticum aestivum52.821e-118 359
LLPS-Hov-1259Hordeum vulgare52.826e-119 359
LLPS-Via-0417Vigna angularis52.661e-118 359
LLPS-Glm-1830Glycine max52.662e-118 359
LLPS-Zem-2142Zea mays52.661e-118 359
LLPS-Prp-0738Prunus persica52.662e-120 363
LLPS-Phv-1813Phaseolus vulgaris52.668e-119 360
LLPS-Amt-1432Amborella trichopoda52.662e-119 360
LLPS-Sob-1453Sorghum bicolor52.664e-119 361
LLPS-Osl-1285Ostreococcus lucimarinus52.413e-119 361
LLPS-Thc-2386Theobroma cacao52.371e-119 361
LLPS-Pot-1619Populus trichocarpa52.377e-120 362
LLPS-Brr-2835Brassica rapa52.372e-119 364
LLPS-Orbr-0988Oryza brachyantha52.071e-117 357
LLPS-Met-0572Medicago truncatula51.785e-119 359
LLPS-Art-2096Arabidopsis thaliana51.334e-120 362
LLPS-Bro-1758Brassica oleracea50.741e-117 355
LLPS-Gas-1171Galdieria sulphuraria47.578e-123 370