LLPS-Cae-1210
kin-3

▼ OVERVIEW

Status: Unreviewed
Protein Name: Casein kinase II subunit alpha
Gene Name: kin-3, B0205.7
Ensembl Gene: WBGene00002191
Ensembl Protein: B0205.7
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblB0205.7B0205.7
UniProtP18334, CSK2A_CAEEL
GeneBankJ05274, FO080112AAA27984.1, CCD61302.1
RefSeqNM_060410.4NP_492811.1
Entrez172978

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPPIPSRARV  YAEVNPSRPR  EYWDYEAHMI  EWGQIDDYQL  VRKLGRGKYS  EVFEGFKMST  60
61    DEKVVVKILK  PVKKKKIKRE  IKILENLRGG  TNIITLLDVV  KDPISRTPAL  IFEHVNNSDF  120
121   KQLYQTLSDY  DIRYYLYELL  KALDFCHSQG  IMHRDVKPHN  VMIDAEKREL  RLIDWGLAEF  180
181   YHPRQDYNVR  VASRYFKGPE  LLVDYQCYDY  SLDMWSLGCM  LASMIFRKEP  FFHGHDNYDQ  240
241   LVRIAKVLGT  DELYEYIARY  HIDLDPRFND  ILGRHSRKRW  ERFIHAENQH  LVTPEALDFL  300
301   DKLLRYDHAE  RLTAQEAMGH  EYFRPVVEAH  ARANGTEQAD  GQGASNSASS  QSSDAKIDGA  360
Nucleotide CDS Sequence (FASTA)
1     ATGCCTCCGA  TTCCTAGCCG  GGCGAGGGTC  TACGCCGAGG  TGAATCCGTC  GAGACCACGC  60
61    GAGTACTGGG  ACTATGAGGC  TCACATGATC  GAATGGGGAC  AAATCGATGA  TTATCAGCTG  120
121   GTACGCAAGT  TGGGACGTGG  AAAATATTCG  GAGGTTTTTG  AAGGATTCAA  GATGAGCACT  180
181   GACGAGAAAG  TTGTTGTCAA  GATTCTCAAG  CCAGTCAAAA  AGAAGAAGAT  CAAGCGTGAG  240
241   ATTAAAATTT  TGGAGAATCT  TCGTGGCGGG  ACAAACATCA  TCACCCTCCT  CGACGTCGTC  300
301   AAGGATCCTA  TTTCGAGAAC  TCCGGCTCTT  ATTTTCGAGC  ATGTTAACAA  TTCGGACTTC  360
361   AAGCAATTGT  ATCAAACCCT  CAGTGACTAT  GATATCCGTT  ACTACCTCTA  CGAGCTCTTG  420
421   AAGGCTCTCG  ACTTCTGCCA  TTCTCAAGGA  ATTATGCACA  GAGATGTTAA  GCCGCACAAT  480
481   GTGATGATTG  ACGCCGAAAA  ACGGGAACTT  CGATTAATAG  ATTGGGGATT  AGCCGAATTC  540
541   TATCATCCAA  GACAGGACTA  TAATGTTCGT  GTTGCTTCTA  GATATTTCAA  GGGACCCGAG  600
601   CTTCTTGTCG  ATTATCAATG  TTACGATTAT  TCGTTGGATA  TGTGGAGTTT  GGGATGCATG  660
661   TTGGCTAGTA  TGATCTTCAG  GAAGGAACCA  TTCTTCCACG  GCCATGATAA  CTACGATCAG  720
721   CTAGTCCGCA  TTGCAAAGGT  ATTGGGAACT  GATGAGCTTT  ACGAGTACAT  TGCGAGATAT  780
781   CACATTGATC  TCGATCCACG  CTTCAACGAT  ATTCTCGGGC  GACACTCAAG  AAAACGCTGG  840
841   GAAAGATTTA  TCCACGCTGA  AAATCAACAT  CTTGTCACCC  CAGAGGCTCT  TGATTTCCTT  900
901   GATAAACTTC  TTCGCTACGA  TCACGCGGAA  CGCCTAACTG  CTCAAGAGGC  CATGGGTCAC  960
961   GAATACTTCC  GCCCAGTTGT  TGAAGCACAT  GCTCGTGCCA  ATGGAACTGA  ACAAGCTGAC  1020
1021  GGACAGGGTG  CATCGAATTC  CGCTTCTTCT  CAATCCTCCG  ATGCCAAAAT  TGACGGCGCT  1080
1081  TAA  1083

▼ KEYWORD

ID
Family
ATP-binding
Behavior
Cell projection
Cilium
Complete proteome
Kinase
Nucleotide-binding
Reference proteome
Serine/threonine-protein kinase
Transferase
Wnt signaling pathway

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cilium
Cellular Component
Dendrite
Cellular Component
Neuronal cell body
Cellular Component
Non-motile cilium
Cellular Component
Nucleus
Cellular Component
Perikaryon
Cellular Component
Protein kinase CK2 complex
Molecular Function
ATP binding
Molecular Function
Protein kinase activity
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Peptidyl-serine phosphorylation
Biological Process
Protein phosphorylation
Biological Process
Response to hermaphrodite contact
Biological Process
Vulval location
Biological Process
Wnt signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tar-2324Takifugu rubripes83.80.0 529
LLPS-Bot-0550Bos taurus83.443e-169 487
LLPS-Eqc-0211Equus caballus83.443e-169 488
LLPS-Sah-3013Sarcophilus harrisii83.330.0 544
LLPS-Fia-1607Ficedula albicollis83.330.0 544
LLPS-Mod-2757Monodelphis domestica83.330.0 544
LLPS-Cas-0878Carlito syrichta83.330.0 541
LLPS-Anc-2172Anolis carolinensis82.730.0 538
LLPS-Mum-0312Mus musculus82.390.0 544
LLPS-Leo-0881Lepisosteus oculatus82.390.0 546
LLPS-Icp-0935Ictalurus punctatus82.340.0 545
LLPS-Ran-2246Rattus norvegicus82.340.0 541
LLPS-Meg-1610Meleagris gallopavo82.340.0 544
LLPS-Gaga-1196Gallus gallus82.340.0 544
LLPS-Tag-0698Taeniopygia guttata82.340.0 544
LLPS-Ict-1954Ictidomys tridecemlineatus82.340.0 542
LLPS-Orl-0626Oryzias latipes82.180.0 540
LLPS-Xim-0938Xiphophorus maculatus82.180.0 536
LLPS-Gaa-3070Gasterosteus aculeatus82.180.0 539
LLPS-Scm-1959Scophthalmus maximus82.180.0 540
LLPS-Pof-1081Poecilia formosa82.180.0 540
LLPS-Gog-1467Gorilla gorilla82.090.0 542
LLPS-Caj-1888Callithrix jacchus82.090.0 542
LLPS-Fud-2250Fukomys damarensis82.090.0 542
LLPS-Chs-3511Chlorocebus sabaeus82.090.0 542
LLPS-Maf-2238Macaca fascicularis82.090.0 542
LLPS-Sus-1974Sus scrofa82.090.0 542
LLPS-Aon-0595Aotus nancymaae82.090.0 542
LLPS-Cea-1964Cercocebus atys82.090.0 542
LLPS-Myl-2051Myotis lucifugus82.090.0 541
LLPS-Ova-0181Ovis aries82.090.0 542
LLPS-Aim-2166Ailuropoda melanoleuca82.090.0 541
LLPS-Mup-0636Mustela putorius furo82.090.0 542
LLPS-Paa-0236Papio anubis82.090.0 542
LLPS-Mal-2844Mandrillus leucophaeus82.090.0 542
LLPS-Tut-0040Tursiops truncatus82.090.0 541
LLPS-Dio-0099Dipodomys ordii82.090.0 542
LLPS-Pes-1131Pelodiscus sinensis82.090.0 545
LLPS-Otg-4128Otolemur garnettii82.090.0 542
LLPS-Orc-1395Oryctolagus cuniculus82.090.0 542
LLPS-Fec-0481Felis catus82.090.0 542
LLPS-Hos-0580Homo sapiens82.090.0 542
LLPS-Pap-0814Pan paniscus82.090.0 542
LLPS-Urm-1813Ursus maritimus82.090.0 542
LLPS-Pat-1997Pan troglodytes82.090.0 542
LLPS-Loa-1424Loxodonta africana82.090.0 542
LLPS-Man-1300Macaca nemestrina82.090.0 542
LLPS-Nol-1517Nomascus leucogenys82.090.0 542
LLPS-Cap-0104Cavia porcellus82.090.0 542
LLPS-Caf-0073Canis familiaris82.090.0 542
LLPS-Poa-0742Pongo abelii82.090.0 542
LLPS-Mam-0346Macaca mulatta82.090.0 542
LLPS-Asm-0776Astyanax mexicanus82.040.0 544
LLPS-Scf-1158Scleropages formosus82.040.0 543
LLPS-Anp-0120Anas platyrhynchos82.040.0 545
LLPS-Ten-0622Tetraodon nigroviridis81.930.0 534
LLPS-Cii-1782Ciona intestinalis81.90.0 531
LLPS-Dar-1687Danio rerio81.790.0 544
LLPS-Orn-0454Oreochromis niloticus81.440.0 542
LLPS-Cis-0058Ciona savignyi80.850.0 525
LLPS-Drm-0787Drosophila melanogaster80.840.0 528
LLPS-Rhb-0500Rhinopithecus bieti79.150.0 518
LLPS-Ora-0707Ornithorhynchus anatinus78.740.0 519
LLPS-Xet-1059Xenopus tropicalis77.980.0 516
LLPS-Lac-0363Latimeria chalumnae77.062e-176 503
LLPS-Orm-0182Oryza meridionalis75.171e-146 424
LLPS-Hov-1582Hordeum vulgare75.082e-159 458
LLPS-Tru-0835Triticum urartu75.081e-159 458
LLPS-Orr-1194Oryza rufipogon75.081e-159 460
LLPS-Osl-1188Ostreococcus lucimarinus74.694e-164 470
LLPS-Ori-0592Oryza indica74.592e-152 442
LLPS-Thc-1510Theobroma cacao74.387e-162 464
LLPS-Lep-1435Leersia perrieri74.353e-131 387
LLPS-Tra-1776Triticum aestivum74.315e-163 469
LLPS-Orni-1373Oryza nivara74.072e-162 468
LLPS-Orb-0800Oryza barthii74.072e-162 468
LLPS-Sob-0016Sorghum bicolor74.072e-162 468
LLPS-Org-0498Oryza glaberrima74.072e-162 468
LLPS-Brr-0223Brassica rapa74.014e-165 475
LLPS-Hea-1272Helianthus annuus73.949e-166 477
LLPS-Sol-0645Solanum lycopersicum73.81e-156 451
LLPS-Brd-1605Brachypodium distachyon73.773e-162 465
LLPS-Orgl-1419Oryza glumaepatula73.772e-162 465
LLPS-Nia-1631Nicotiana attenuata73.779e-162 464
LLPS-Orp-1210Oryza punctata73.777e-162 464
LLPS-Brn-1204Brassica napus73.78e-165 472
LLPS-Bro-0865Brassica oleracea73.78e-164 473
LLPS-Gor-2621Gossypium raimondii73.644e-164 473
LLPS-Mea-0775Mesocricetus auratus73.499e-162 463
LLPS-Cus-0918Cucumis sativus73.462e-160 460
LLPS-Met-2295Medicago truncatula73.334e-164 473
LLPS-Sei-0451Setaria italica73.255e-162 468
LLPS-Mua-1805Musa acuminata73.234e-164 472
LLPS-Coc-0429Corchorus capsularis73.196e-165 472
LLPS-Arl-2608Arabidopsis lyrata73.092e-163 471
LLPS-Art-0131Arabidopsis thaliana73.091e-163 472
LLPS-Zem-1809Zea mays73.012e-159 459
LLPS-Prp-1960Prunus persica72.843e-159 457
LLPS-Via-1906Vigna angularis72.72e-163 468
LLPS-Glm-2418Glycine max72.421e-161 464
LLPS-Php-1568Physcomitrella patens72.128e-161 465
LLPS-Viv-2442Vitis vinifera72.126e-163 470
LLPS-Mae-2679Manihot esculenta71.997e-163 470
LLPS-Crn-1332Cryptococcus neoformans71.963e-156 450
LLPS-Ors-1858Oryza sativa71.917e-159 456
LLPS-Amt-1286Amborella trichopoda71.691e-161 463
LLPS-Phv-2410Phaseolus vulgaris71.641e-160 464
LLPS-Orbr-0522Oryza brachyantha71.62e-159 457
LLPS-Vir-1975Vigna radiata71.482e-131 384
LLPS-Pot-0533Populus trichocarpa71.391e-162 466
LLPS-Pug-0648Puccinia graminis70.722e-153 446
LLPS-Dac-1621Daucus carota70.33e-153 445
LLPS-Miv-1147Microbotryum violaceum70.121e-156 451
LLPS-Coo-0347Colletotrichum orbiculare69.473e-148 429
LLPS-Mel-0072Melampsora laricipopulina69.473e-152 439
LLPS-Blg-1508Blumeria graminis69.36e-155 446
LLPS-Ved-1000Verticillium dahliae69.289e-150 433
LLPS-Usm-1430Ustilago maydis68.673e-153 442
LLPS-Fuv-1227Fusarium verticillioides68.367e-153 441
LLPS-Abg-1758Absidia glauca68.361e-155 448
LLPS-Fus-0695Fusarium solani68.364e-152 439
LLPS-Fuo-0123Fusarium oxysporum68.367e-153 441
LLPS-Cogr-1071Colletotrichum graminicola68.21e-147 428
LLPS-Beb-0341Beauveria bassiana68.174e-151 437
LLPS-Cog-0524Colletotrichum gloeosporioides68.032e-143 417
LLPS-Put-0819Puccinia triticina67.472e-154 445
LLPS-Zyt-1335Zymoseptoria tritici67.271e-150 435
LLPS-Gas-1061Galdieria sulphuraria66.352e-142 415
LLPS-Scj-0450Schizosaccharomyces japonicus65.431e-138 405
LLPS-Kop-1162Komagataella pastoris61.041e-129 382
LLPS-Yal-0821Yarrowia lipolytica60.753e-131 386
LLPS-Asg-1227Ashbya gossypii58.449e-119 354
LLPS-Sac-1620Saccharomyces cerevisiae58.333e-121 361