LLPS-Cae-0936
pmk-2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Mitogen-activated protein kinase pmk-2; Stress-activated protein kinase pmk-2; p38 MAP kinase 2
Gene Name: pmk-2, F42G8.3
Ensembl Gene: WBGene00004056
Ensembl Protein: F42G8.3d
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGMSATMGDS  ASIPGVFFAD  FGPAPPEITP  EGYHEVELNK  TKWVLPQWYN  SLKPLGEGAY  60
61    GVVCTAEYEP  TGDRVAIKKF  FRPFQSTIHA  KRTYRELKLL  RTLQHDNVLE  MIDVFTPDPD  120
121   ASSLNNVYFV  SVLMGSDLQN  IMKIQRLTDE  QIQLLIYQVL  RGLKYIHSAG  IIHRDLKPSN  180
181   IAVNERCEVK  ILDFGLARAQ  DAEMTGYVAT  RWYRAPEIML  NWMHYTQTVD  VWSVGCILAE  240
241   LVSGRPLFPG  DDHIDQLTKI  MSVVGTPKEE  FWSKIQSEEA  RNYIKNRSPI  IRQDFVTLFP  300
301   MASPYALELL  EMMLILDPDR  RISVSSALRH  DYLREYSVPN  DEPVAMDTVI  NSIVTIDPAE  360
361   ERATTLSDWR  ELIWNEIRLF  QNSARRLSFV  SCTDTEEEPM  KI  402
Nucleotide CDS Sequence (FASTA)
1     ATGGGGATGT  CGGCGACCAT  GGGCGATTCA  GCCAGCATTC  CCGGTGTCTT  TTTTGCCGAT  60
61    TTTGGTCCTG  CCCCGCCTGA  GATTACTCCA  GAAGGATATC  ATGAGGTCGA  ACTAAACAAA  120
121   ACGAAATGGG  TCTTACCTCA  ATGGTACAAC  AGTTTGAAGC  CTCTAGGAGA  AGGAGCGTAT  180
181   GGAGTTGTAT  GCACAGCAGA  ATATGAGCCA  ACTGGAGATC  GAGTTGCAAT  TAAAAAGTTC  240
241   TTTCGCCCAT  TTCAAAGTAC  AATTCACGCA  AAACGAACCT  ATCGGGAACT  GAAACTTCTA  300
301   AGAACTCTAC  AACATGATAA  TGTATTGGAA  ATGATTGATG  TATTCACACC  AGATCCAGAT  360
361   GCATCTTCTT  TGAATAATGT  ATATTTCGTA  TCCGTTCTGA  TGGGCTCCGA  TTTACAAAAT  420
421   ATTATGAAAA  TCCAACGACT  GACCGATGAA  CAAATCCAAC  TGCTTATCTA  TCAAGTGTTA  480
481   CGTGGGCTCA  AGTATATCCA  TTCGGCAGGG  ATTATCCATC  GCGATTTAAA  ACCATCGAAT  540
541   ATTGCTGTCA  ATGAGAGATG  CGAAGTCAAG  ATTCTCGATT  TTGGATTGGC  TCGTGCTCAA  600
601   GACGCCGAAA  TGACTGGATA  CGTGGCAACA  AGATGGTACA  GAGCTCCAGA  GATTATGCTC  660
661   AATTGGATGC  ATTATACACA  GACTGTTGAT  GTTTGGTCAG  TTGGATGTAT  TCTTGCGGAA  720
721   CTGGTATCCG  GGAGACCATT  GTTTCCAGGC  GATGATCATA  TTGATCAGCT  AACAAAGATA  780
781   ATGTCAGTTG  TGGGTACCCC  AAAAGAAGAA  TTCTGGTCCA  AAATTCAATC  AGAAGAAGCT  840
841   CGAAATTATA  TTAAAAATCG  TTCTCCAATT  ATCCGTCAGG  ACTTCGTTAC  ATTGTTTCCA  900
901   ATGGCTTCTC  CATATGCTCT  CGAACTTCTC  GAAATGATGC  TAATTTTGGA  TCCGGACAGA  960
961   AGAATTTCTG  TATCAAGTGC  TCTTCGTCAT  GACTATCTTC  GTGAATACTC  TGTGCCAAAT  1020
1021  GATGAACCAG  TTGCAATGGA  TACGGTAATA  AATAGCATAG  TCACAATTGA  TCCAGCTGAA  1080
1081  GAACGAGCAA  CAACGTTATC  CGACTGGCGA  GAGTTAATTT  GGAATGAGAT  TCGATTATTC  1140
1141  CAAAACTCGG  CACGAAGACT  AAGTTTTGTA  AGCTGTACGG  ATACGGAAGA  AGAGCCAATG  1200
1201  AAAATATGA  1209

▼ KEYWORD

ID
Family
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
MAP kinase activity
Biological Process
Cellular response to organic substance
Biological Process
Intracellular signal transduction
Biological Process
Regulation of gene expression
Biological Process
Response to osmotic stress

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Eqc-2725Equus caballus60.515e-140 414
LLPS-Pes-2882Pelodiscus sinensis60.327e-132 389
LLPS-Meg-1427Meleagris gallopavo60.321e-131 389
LLPS-Anp-0077Anas platyrhynchos60.321e-131 388
LLPS-Mea-2443Mesocricetus auratus60.198e-141 413
LLPS-Tag-0322Taeniopygia guttata59.599e-146 426
LLPS-Bot-0493Bos taurus59.32e-141 422
LLPS-Tar-2267Takifugu rubripes58.925e-134 396
LLPS-Myl-3945Myotis lucifugus58.914e-147 429
LLPS-Fia-0088Ficedula albicollis58.911e-145 425
LLPS-Anc-1425Anolis carolinensis58.916e-146 426
LLPS-Orc-0970Oryctolagus cuniculus58.889e-133 392
LLPS-Fud-2509Fukomys damarensis58.714e-129 382
LLPS-Nol-2037Nomascus leucogenys58.714e-129 382
LLPS-Ict-4019Ictidomys tridecemlineatus58.711e-128 380
LLPS-Gog-0069Gorilla gorilla58.632e-129 382
LLPS-Pap-3141Pan paniscus58.632e-129 382
LLPS-Caj-0973Callithrix jacchus58.626e-146 426
LLPS-Mum-1765Mus musculus58.622e-146 427
LLPS-Chs-1321Chlorocebus sabaeus58.626e-146 426
LLPS-Cea-2737Cercocebus atys58.626e-146 426
LLPS-Paa-0982Papio anubis58.626e-146 426
LLPS-Ova-1070Ovis aries58.626e-146 426
LLPS-Hos-3051Homo sapiens58.626e-146 426
LLPS-Pat-1467Pan troglodytes58.626e-146 426
LLPS-Mod-0510Monodelphis domestica58.621e-146 428
LLPS-Loa-2301Loxodonta africana58.626e-146 426
LLPS-Cap-1554Cavia porcellus58.625e-146 426
LLPS-Urm-0033Ursus maritimus58.445e-131 388
LLPS-Otg-3473Otolemur garnettii58.334e-145 424
LLPS-Caf-2138Canis familiaris58.332e-145 425
LLPS-Poa-2707Pongo abelii58.334e-145 424
LLPS-Gaga-3887Gallus gallus58.293e-146 427
LLPS-Orl-1411Oryzias latipes58.263e-142 417
LLPS-Lac-3685Latimeria chalumnae58.249e-143 419
LLPS-Xim-1241Xiphophorus maculatus58.173e-144 422
LLPS-Pof-1810Poecilia formosa58.173e-144 422
LLPS-Sah-2909Sarcophilus harrisii57.786e-128 379
LLPS-Orn-3238Oreochromis niloticus57.666e-118 355
LLPS-Dar-0307Danio rerio57.596e-142 416
LLPS-Maf-3517Macaca fascicularis57.472e-143 419
LLPS-Aon-1766Aotus nancymaae57.474e-143 419
LLPS-Ran-0999Rattus norvegicus57.478e-144 421
LLPS-Mup-2737Mustela putorius furo57.474e-143 419
LLPS-Aim-3860Ailuropoda melanoleuca57.478e-143 418
LLPS-Dio-3118Dipodomys ordii57.472e-143 419
LLPS-Rhb-2874Rhinopithecus bieti57.472e-143 419
LLPS-Fec-0484Felis catus57.474e-143 419
LLPS-Man-0818Macaca nemestrina57.472e-143 419
LLPS-Sus-2245Sus scrofa57.181e-142 417
LLPS-Xet-2512Xenopus tropicalis56.982e-145 425
LLPS-Icp-3182Ictalurus punctatus56.823e-142 417
LLPS-Leo-1669Lepisosteus oculatus56.736e-141 413
LLPS-Asm-0213Astyanax mexicanus56.457e-141 413
LLPS-Gaa-2747Gasterosteus aculeatus56.452e-140 412
LLPS-Scf-2995Scleropages formosus56.037e-139 408
LLPS-Scm-3750Scophthalmus maximus55.846e-140 411
LLPS-Mam-1015Macaca mulatta55.843e-133 393
LLPS-Cis-1726Ciona savignyi55.276e-140 411
LLPS-Drm-0463Drosophila melanogaster54.653e-141 414
LLPS-Ten-0771Tetraodon nigroviridis54.292e-132 391
LLPS-Mal-1076Mandrillus leucophaeus53.451e-123 369
LLPS-Tut-1878Tursiops truncatus51.01e-130 387
LLPS-Ora-1676Ornithorhynchus anatinus50.02e-124 372
LLPS-Asn-0075Aspergillus nidulans49.843e-95 296
LLPS-Asni-0869Aspergillus niger49.839e-105 322
LLPS-Osl-1285Ostreococcus lucimarinus48.673e-97 303
LLPS-Kop-0715Komagataella pastoris48.065e-97 301
LLPS-Miv-1010Microbotryum violaceum47.94e-107 327
LLPS-Sac-1000Saccharomyces cerevisiae47.52e-101 315
LLPS-Abg-0455Absidia glauca47.482e-105 323
LLPS-Sob-0439Sorghum bicolor47.451e-96 300
LLPS-Zem-0250Zea mays47.456e-97 301
LLPS-Usm-1558Ustilago maydis47.311e-105 323
LLPS-Spr-1538Sporisorium reilianum47.311e-105 323
LLPS-Asg-1221Ashbya gossypii47.176e-100 311
LLPS-Mel-0383Melampsora laricipopulina47.024e-95 297
LLPS-Crn-0017Cryptococcus neoformans47.012e-108 331
LLPS-Scp-1500Schizosaccharomyces pombe46.861e-100 311
LLPS-Put-0805Puccinia triticina46.713e-95 297
LLPS-Mae-1517Manihot esculenta46.653e-95 298
LLPS-Scc-0790Schizosaccharomyces cryophilus46.571e-105 323
LLPS-Tum-0649Tuber melanosporum46.546e-97 300
LLPS-Scj-0163Schizosaccharomyces japonicus46.412e-107 327
LLPS-Met-0572Medicago truncatula46.311e-96 300
LLPS-Ved-0936Verticillium dahliae46.22e-108 330
LLPS-Cogr-1273Colletotrichum graminicola46.22e-108 330
LLPS-Yal-0680Yarrowia lipolytica46.111e-102 316
LLPS-Nia-1027Nicotiana attenuata45.926e-96 298
LLPS-Fuv-1012Fusarium verticillioides45.914e-107 327
LLPS-Nec-1525Neurospora crassa45.916e-107 326
LLPS-Blg-0480Blumeria graminis45.913e-108 330
LLPS-Cog-1471Colletotrichum gloeosporioides45.913e-108 330
LLPS-Fus-0731Fusarium solani45.915e-107 327
LLPS-Fuo-1597Fusarium oxysporum45.914e-107 327
LLPS-Mua-0942Musa acuminata45.831e-95 298
LLPS-Map-1078Magnaporthe poae45.774e-107 327
LLPS-Mao-0960Magnaporthe oryzae45.775e-108 329
LLPS-Amt-0072Amborella trichopoda45.728e-96 298
LLPS-Asc-0536Aspergillus clavatus45.612e-106 325
LLPS-Zyt-1406Zymoseptoria tritici45.614e-105 322
LLPS-Trr-0388Trichoderma reesei45.616e-106 324
LLPS-Nef-1090Neosartorya fischeri45.613e-106 325
LLPS-Beb-0354Beauveria bassiana45.611e-106 326
LLPS-Asfu-1286Aspergillus fumigatus45.613e-106 325
LLPS-Phv-1035Phaseolus vulgaris45.563e-96 299
LLPS-Viv-1922Vitis vinifera45.438e-96 298
LLPS-Dos-0325Dothistroma septosporum45.326e-104 319
LLPS-Trv-0445Trichoderma virens45.322e-106 325
LLPS-Gag-0668Gaeumannomyces graminis45.192e-106 325
LLPS-Sol-1686Solanum lycopersicum45.193e-96 299
LLPS-Sot-1043Solanum tuberosum45.194e-96 299
LLPS-Coc-1373Corchorus capsularis45.134e-95 296
LLPS-Pyt-1192Pyrenophora teres45.034e-105 322
LLPS-Pytr-1252Pyrenophora triticirepentis45.034e-105 322
LLPS-Sem-0204Selaginella moellendorffii44.412e-96 300
LLPS-Php-1637Physcomitrella patens44.239e-99 306
LLPS-Pug-1356Puccinia graminis44.22e-107 329
LLPS-Coo-0395Colletotrichum orbiculare43.533e-103 318