LLPS-Cae-0861
mat-1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 3; Metaphase-to-anaphase transition defect protein 1 |
| Gene Name: | mat-1, apc-3, cdc-27, pod-5, Y110A7A.17 |
| Ensembl Gene: | WBGene00003132 |
| Ensembl Protein: | Y110A7A.17b |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:12620985, PubMed:11134076). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Y110A7A.17b | Y110A7A.17b |
| Ensembl | Y110A7A.17a | Y110A7A.17a |
| UniProt | Q9N593, CDC27_CAEEL, Q6AW18, Q8T4K4 | |
| GeneBank | FO080728, AY081955 | AAL92523.1, CCD66209.1, CCD66210.1 |
| RefSeq | NM_001026543.4, NM_001026544.2 | NP_001021714.1, NP_001021715.1 |
| Entrez | 172145 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKESAASVAV RPQLREVFER FPADAHRTIE DEIHEMMKCY AFDDAIFLAE LHYETDKSNN 60 61 SESLLLYADC LYRANKKEEC YGLLSSVKLS GARLFYLLAR VSYDLNKIDD CRGALFEHDD 120 121 GVIRKDILEE PRVASHANLL HAQMLCDESY MDLALESCQK SLDENILLWS AIITYLRFGG 180 181 HDLAHTFEKH HRKSNGLYLD SPASSLKSET PSPNVPGPSS SSAASTAEPS RLESSVRRST 240 241 RGTIASANRE TRNTTSNITP RQSTPGSTPS RINPTAPRKS SRISEMTTRR TESSVTGSRS 300 301 SLFTEPERPH TRATHSSRNR ANAALNSDTE NSNASNTRTR SGIASVTRGS SSSQRTNPVR 360 361 TSIRIADAAA AANKTAKTLS QRRRNEKQPL VSRNSNLARS LSGSTNSVAS TASERPSEDE 420 421 VSQINPPLPS VASSLNNDEP MDIVDGVYDP EYKKLFDVYQ HIALIEESIS TYNWRSADAL 480 481 FAKLDRDIIL NTSMVRLQLG RACFEQSEYR ECRNILDDLH KRRKWKVDGT ELLSTSMWHL 540 541 QDTHALSALS QILTTESRER PQSWCAAGNC FSLQRQHTQA IECMERAIQL DKRFAYAYTL 600 601 LGHELIVQDE LDKAAGSFRS ALLLSPRDYR AWYGLGLVHL KKEQNLTALT NIQKAVNINP 660 661 TNRAMLCTLS QIEQQRGQID TALVLIDRAL TLNPLDVACR FNRSRLLFEA NRNEECLVEL 720 721 DKLKASSPDE AFIFHLLARV HRRMGNTHLA LLNYSWAAEL DPRGEQNITD SNVINREEYE 780 781 DDEYGSPV 788 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAAGAAT CAGCTGCGTC TGTAGCTGTG CGGCCTCAAT TGAGAGAGGT GTTCGAGCGT 60 61 TTTCCAGCGG ACGCACACCG AACAATTGAA GATGAGATTC ATGAAATGAT GAAGTGTTAC 120 121 GCTTTTGATG ATGCTATTTT TCTAGCCGAG CTTCATTACG AAACCGATAA AAGCAACAAC 180 181 TCCGAATCTC TTCTTCTATA CGCTGATTGT CTGTATAGAG CCAATAAGAA AGAGGAATGT 240 241 TATGGTCTCC TTAGTTCAGT TAAATTGAGC GGAGCTAGAC TCTTCTATCT ACTTGCAAGG 300 301 GTATCCTACG ATTTAAATAA AATCGATGAC TGTAGAGGAG CTCTTTTCGA ACATGACGAT 360 361 GGAGTGATAC GGAAAGATAT CCTGGAAGAG CCACGGGTTG CATCACATGC TAATTTGCTT 420 421 CATGCTCAAA TGCTTTGCGA TGAAAGTTAC ATGGATCTGG CTTTAGAATC TTGTCAAAAG 480 481 TCTCTGGATG AGAATATTTT GTTGTGGTCA GCTATCATAA CTTATTTACG GTTTGGAGGT 540 541 CATGATCTCG CCCATACTTT TGAAAAACAT CACCGAAAAT CAAATGGTCT ATACCTGGAT 600 601 AGTCCAGCTT CGAGTTTGAA ATCCGAAACA CCATCACCAA ATGTTCCTGG GCCGTCGTCT 660 661 TCTTCAGCTG CCAGCACTGC TGAACCTTCC AGACTGGAAA GTTCGGTCAG ACGATCTACA 720 721 CGCGGTACGA TTGCTTCGGC GAATCGCGAG ACAAGAAATA CCACATCAAA CATCACTCCA 780 781 AGACAATCCA CTCCTGGATC CACACACGAG GGCTACACAT AG 822 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Biological Process | Asymmetric cell division | |
Biological Process | Cortical granule exocytosis | |
Biological Process | Meiotic cell cycle | |
Biological Process | Polarity specification of anterior/posterior axis | |
Biological Process | Protein ubiquitination |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sah-3683 | Sarcophilus harrisii | 42.66 | 2e-79 | 278 |
| LLPS-Icp-3363 | Ictalurus punctatus | 41.25 | 1e-80 | 282 |
| LLPS-Dar-2881 | Danio rerio | 40.94 | 1e-79 | 279 |
| LLPS-Asm-1130 | Astyanax mexicanus | 40.94 | 7e-83 | 280 |
| LLPS-Otg-4067 | Otolemur garnettii | 40.82 | 9e-81 | 282 |
| LLPS-Fec-1292 | Felis catus | 40.82 | 9e-81 | 282 |
| LLPS-Orl-2917 | Oryzias latipes | 40.8 | 1e-64 | 226 |
| LLPS-Orc-0666 | Oryctolagus cuniculus | 40.51 | 2e-80 | 281 |
| LLPS-Mod-1393 | Monodelphis domestica | 40.51 | 4e-80 | 281 |
| LLPS-Pap-1618 | Pan paniscus | 40.51 | 2e-80 | 281 |
| LLPS-Urm-1816 | Ursus maritimus | 40.51 | 2e-80 | 281 |
| LLPS-Pat-4546 | Pan troglodytes | 40.51 | 3e-80 | 281 |
| LLPS-Hos-1636 | Homo sapiens | 40.51 | 2e-80 | 281 |
| LLPS-Loa-2866 | Loxodonta africana | 40.51 | 2e-80 | 281 |
| LLPS-Man-0819 | Macaca nemestrina | 40.51 | 3e-80 | 281 |
| LLPS-Cas-1508 | Carlito syrichta | 40.51 | 7e-81 | 282 |
| LLPS-Ict-1878 | Ictidomys tridecemlineatus | 40.51 | 3e-80 | 281 |
| LLPS-Nol-1687 | Nomascus leucogenys | 40.51 | 2e-80 | 281 |
| LLPS-Eqc-3823 | Equus caballus | 40.51 | 3e-80 | 281 |
| LLPS-Caf-0472 | Canis familiaris | 40.51 | 2e-80 | 281 |
| LLPS-Mam-4095 | Macaca mulatta | 40.51 | 2e-80 | 281 |
| LLPS-Gog-1396 | Gorilla gorilla | 40.51 | 2e-81 | 281 |
| LLPS-Caj-3442 | Callithrix jacchus | 40.51 | 3e-80 | 281 |
| LLPS-Fud-0771 | Fukomys damarensis | 40.51 | 2e-80 | 281 |
| LLPS-Chs-1760 | Chlorocebus sabaeus | 40.51 | 2e-80 | 281 |
| LLPS-Mea-4417 | Mesocricetus auratus | 40.51 | 2e-79 | 275 |
| LLPS-Maf-4481 | Macaca fascicularis | 40.51 | 2e-80 | 281 |
| LLPS-Aon-1649 | Aotus nancymaae | 40.51 | 2e-80 | 281 |
| LLPS-Cea-3114 | Cercocebus atys | 40.51 | 2e-80 | 281 |
| LLPS-Sus-0608 | Sus scrofa | 40.51 | 2e-80 | 281 |
| LLPS-Myl-2711 | Myotis lucifugus | 40.51 | 1e-80 | 281 |
| LLPS-Ova-2814 | Ovis aries | 40.51 | 2e-80 | 281 |
| LLPS-Aim-2194 | Ailuropoda melanoleuca | 40.51 | 2e-80 | 281 |
| LLPS-Mup-3711 | Mustela putorius furo | 40.51 | 2e-80 | 281 |
| LLPS-Paa-4522 | Papio anubis | 40.51 | 2e-80 | 281 |
| LLPS-Mal-2088 | Mandrillus leucophaeus | 40.51 | 3e-80 | 281 |
| LLPS-Bot-4246 | Bos taurus | 40.51 | 2e-80 | 281 |
| LLPS-Dio-1577 | Dipodomys ordii | 40.51 | 2e-80 | 281 |
| LLPS-Drm-1942 | Drosophila melanogaster | 40.29 | 4e-67 | 244 |
| LLPS-Pes-3770 | Pelodiscus sinensis | 40.19 | 8e-80 | 280 |
| LLPS-Fia-3273 | Ficedula albicollis | 40.19 | 9e-80 | 280 |
| LLPS-Meg-2347 | Meleagris gallopavo | 40.19 | 5e-80 | 280 |
| LLPS-Anp-2481 | Anas platyrhynchos | 40.19 | 7e-80 | 280 |
| LLPS-Gaga-0714 | Gallus gallus | 40.19 | 5e-80 | 280 |
| LLPS-Tag-0080 | Taeniopygia guttata | 40.19 | 6e-80 | 280 |
| LLPS-Cap-1924 | Cavia porcellus | 40.19 | 3e-80 | 281 |
| LLPS-Mum-4945 | Mus musculus | 40.19 | 2e-79 | 279 |
| LLPS-Ran-4682 | Rattus norvegicus | 40.19 | 2e-79 | 279 |
| LLPS-Ten-2407 | Tetraodon nigroviridis | 40.0 | 2e-81 | 271 |
| LLPS-Leo-2178 | Lepisosteus oculatus | 40.0 | 2e-78 | 275 |
| LLPS-Tar-3755 | Takifugu rubripes | 40.0 | 2e-77 | 273 |
| LLPS-Anc-2275 | Anolis carolinensis | 39.87 | 9e-79 | 277 |
| LLPS-Gaa-0632 | Gasterosteus aculeatus | 39.87 | 5e-78 | 274 |
| LLPS-Rhb-3830 | Rhinopithecus bieti | 39.56 | 2e-74 | 264 |
| LLPS-Orn-3081 | Oreochromis niloticus | 39.56 | 8e-76 | 268 |
| LLPS-Xet-3258 | Xenopus tropicalis | 39.56 | 9e-79 | 276 |
| LLPS-Scf-3718 | Scleropages formosus | 39.38 | 3e-77 | 273 |
| LLPS-Pof-2650 | Poecilia formosa | 39.24 | 1e-76 | 270 |
| LLPS-Lac-3578 | Latimeria chalumnae | 38.92 | 1e-74 | 265 |
| LLPS-Xim-1154 | Xiphophorus maculatus | 38.92 | 6e-75 | 265 |
| LLPS-Chr-1576 | Chlamydomonas reinhardtii | 38.17 | 1e-32 | 140 |
| LLPS-Scp-1220 | Schizosaccharomyces pombe | 38.08 | 3e-55 | 206 |
| LLPS-Cis-1846 | Ciona savignyi | 37.15 | 2e-58 | 218 |
| LLPS-Asn-1310 | Aspergillus nidulans | 36.9 | 9e-26 | 117 |
| LLPS-Crn-0600 | Cryptococcus neoformans | 36.69 | 5e-55 | 207 |
| LLPS-Scj-1336 | Schizosaccharomyces japonicus | 36.65 | 1e-51 | 196 |
| LLPS-Nef-0233 | Neosartorya fischeri | 36.43 | 5e-52 | 197 |
| LLPS-Asfu-0895 | Aspergillus fumigatus | 36.43 | 2e-51 | 196 |
| LLPS-Coo-0799 | Colletotrichum orbiculare | 36.3 | 2e-50 | 193 |
| LLPS-Asf-0679 | Aspergillus flavus | 36.07 | 1e-51 | 196 |
| LLPS-Aso-1459 | Aspergillus oryzae | 36.07 | 6e-51 | 195 |
| LLPS-Trv-0193 | Trichoderma virens | 35.79 | 2e-45 | 178 |
| LLPS-Gas-1054 | Galdieria sulphuraria | 35.66 | 9e-44 | 172 |
| LLPS-Map-0970 | Magnaporthe poae | 35.61 | 3e-46 | 181 |
| LLPS-Gag-0259 | Gaeumannomyces graminis | 35.61 | 2e-45 | 179 |
| LLPS-Tum-0822 | Tuber melanosporum | 35.59 | 1e-47 | 185 |
| LLPS-Yal-1546 | Yarrowia lipolytica | 35.35 | 8e-53 | 198 |
| LLPS-Fuo-0432 | Fusarium oxysporum | 35.27 | 2e-51 | 186 |
| LLPS-Fuv-0815 | Fusarium verticillioides | 35.27 | 2e-51 | 186 |
| LLPS-Cog-0794 | Colletotrichum gloeosporioides | 35.23 | 5e-48 | 186 |
| LLPS-Ved-0938 | Verticillium dahliae | 35.18 | 6e-43 | 161 |
| LLPS-Trr-1549 | Trichoderma reesei | 34.81 | 4e-45 | 177 |
| LLPS-Scc-1449 | Schizosaccharomyces cryophilus | 34.54 | 2e-51 | 195 |
| LLPS-Fus-0535 | Fusarium solani | 34.52 | 1e-48 | 188 |
| LLPS-Mua-0986 | Musa acuminata | 34.42 | 3e-47 | 183 |
| LLPS-Asni-0543 | Aspergillus niger | 34.38 | 2e-52 | 199 |
| LLPS-Asc-1435 | Aspergillus clavatus | 34.38 | 4e-52 | 198 |
| LLPS-Pytr-1084 | Pyrenophora triticirepentis | 34.02 | 5e-47 | 182 |
| LLPS-Pyt-1383 | Pyrenophora teres | 34.02 | 4e-47 | 183 |
| LLPS-Beb-0758 | Beauveria bassiana | 33.81 | 1e-45 | 179 |
| LLPS-Cogr-1504 | Colletotrichum graminicola | 33.72 | 5e-50 | 192 |
| LLPS-Ast-0176 | Aspergillus terreus | 33.44 | 4e-50 | 192 |
| LLPS-Kop-0223 | Komagataella pastoris | 33.33 | 3e-50 | 191 |
| LLPS-Blg-1522 | Blumeria graminis | 33.23 | 2e-52 | 200 |
| LLPS-Lem-0147 | Leptosphaeria maculans | 33.14 | 8e-49 | 189 |
| LLPS-Mao-1251 | Magnaporthe oryzae | 33.13 | 2e-46 | 182 |
| LLPS-Miv-0387 | Microbotryum violaceum | 32.96 | 1e-37 | 155 |
| LLPS-Amt-1948 | Amborella trichopoda | 32.89 | 7e-47 | 182 |
| LLPS-Via-1491 | Vigna angularis | 32.71 | 1e-45 | 178 |
| LLPS-Glm-0448 | Glycine max | 32.68 | 5e-44 | 174 |
| LLPS-Sob-2079 | Sorghum bicolor | 32.6 | 4e-46 | 180 |
| LLPS-Zem-1541 | Zea mays | 32.6 | 3e-46 | 180 |
| LLPS-Sac-1537 | Saccharomyces cerevisiae | 32.46 | 5e-43 | 171 |
| LLPS-Coc-1038 | Corchorus capsularis | 32.44 | 4e-45 | 177 |
| LLPS-Bro-0941 | Brassica oleracea | 32.36 | 1e-42 | 169 |
| LLPS-Dos-1374 | Dothistroma septosporum | 32.36 | 7e-40 | 162 |
| LLPS-Brn-0516 | Brassica napus | 32.36 | 1e-42 | 169 |
| LLPS-Pot-0419 | Populus trichocarpa | 32.3 | 4e-45 | 177 |
| LLPS-Sei-0244 | Setaria italica | 32.23 | 3e-45 | 178 |
| LLPS-Zyt-0935 | Zymoseptoria tritici | 32.18 | 1e-46 | 182 |
| LLPS-Phv-2313 | Phaseolus vulgaris | 31.99 | 6e-39 | 159 |
| LLPS-Art-2499 | Arabidopsis thaliana | 31.99 | 4e-42 | 168 |
| LLPS-Osl-0097 | Ostreococcus lucimarinus | 31.99 | 6e-49 | 181 |
| LLPS-Arl-2167 | Arabidopsis lyrata | 31.99 | 8e-43 | 170 |
| LLPS-Cym-0479 | Cyanidioschyzon merolae | 31.94 | 4e-35 | 145 |
| LLPS-Orbr-0769 | Oryza brachyantha | 31.87 | 2e-44 | 175 |
| LLPS-Mae-0401 | Manihot esculenta | 31.76 | 1e-44 | 176 |
| LLPS-Brr-2726 | Brassica rapa | 31.65 | 3e-42 | 168 |
| LLPS-Dac-0101 | Daucus carota | 31.53 | 7e-43 | 171 |
| LLPS-Brd-0377 | Brachypodium distachyon | 31.5 | 9e-44 | 173 |
| LLPS-Hov-2156 | Hordeum vulgare | 31.5 | 8e-44 | 173 |
| LLPS-Prp-2389 | Prunus persica | 31.42 | 2e-44 | 175 |
| LLPS-Met-0306 | Medicago truncatula | 31.42 | 2e-45 | 177 |
| LLPS-Nec-1395 | Neurospora crassa | 31.42 | 3e-44 | 175 |
| LLPS-Ors-1871 | Oryza sativa | 31.14 | 6e-44 | 167 |
| LLPS-Orm-0721 | Oryza meridionalis | 31.14 | 1e-43 | 172 |
| LLPS-Ori-0697 | Oryza indica | 31.14 | 1e-43 | 172 |
| LLPS-Tra-2929 | Triticum aestivum | 31.14 | 7e-44 | 173 |
| LLPS-Lep-1663 | Leersia perrieri | 31.14 | 2e-40 | 163 |
| LLPS-Thc-2006 | Theobroma cacao | 31.13 | 7e-44 | 174 |
| LLPS-Pug-0942 | Puccinia graminis | 31.09 | 2e-30 | 133 |
| LLPS-Sol-2232 | Solanum lycopersicum | 31.08 | 8e-45 | 174 |
| LLPS-Nia-2535 | Nicotiana attenuata | 30.87 | 7e-42 | 167 |
| LLPS-Sem-1334 | Selaginella moellendorffii | 30.77 | 5e-48 | 184 |
| LLPS-Cii-2071 | Ciona intestinalis | 30.77 | 4e-57 | 214 |
| LLPS-Orgl-1414 | Oryza glumaepatula | 30.77 | 2e-39 | 160 |
| LLPS-Chc-0685 | Chondrus crispus | 30.7 | 4e-32 | 137 |
| LLPS-Orp-2158 | Oryza punctata | 30.57 | 5e-42 | 166 |
| LLPS-Viv-2514 | Vitis vinifera | 30.39 | 1e-44 | 176 |
| LLPS-Vir-1540 | Vigna radiata | 30.35 | 7e-40 | 162 |
| LLPS-Php-2067 | Physcomitrella patens | 30.12 | 8e-40 | 161 |
| LLPS-Hea-1915 | Helianthus annuus | 30.1 | 2e-43 | 172 |
| LLPS-Cus-2201 | Cucumis sativus | 29.83 | 2e-41 | 166 |
| LLPS-Orr-0522 | Oryza rufipogon | 29.67 | 1e-32 | 139 |
| LLPS-Orni-0571 | Oryza nivara | 29.67 | 6e-33 | 140 |
| LLPS-Orb-1481 | Oryza barthii | 29.67 | 7e-33 | 139 |
| LLPS-Asg-1380 | Ashbya gossypii | 29.64 | 1e-37 | 154 |
| LLPS-Sot-2089 | Solanum tuberosum | 29.0 | 5e-40 | 162 |
| LLPS-Gor-1365 | Gossypium raimondii | 28.68 | 8e-44 | 173 |
| LLPS-Mel-1493 | Melampsora laricipopulina | 27.37 | 2e-27 | 119 |
| LLPS-Tru-0457 | Triticum urartu | 24.91 | 4e-24 | 112 |