LLPS-Cae-0377
nath-10

▼ OVERVIEW

Status: Unreviewed
Protein Name: RNA cytidine acetyltransferase; 18S rRNA cytosine acetyltransferase
Gene Name: nath-10, F55A12.8
Ensembl Gene: WBGene00018866
Ensembl Protein: F55A12.8
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatin, Nucleolus, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblF55A12.8F55A12.8
UniProtO01757, NAT10_CAEEL
GeneBankFO080647CCD65443.1
RefSeqNM_059173.4NP_491574.1
Entrez172182

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRTKLDGRIR  TQIENGVASG  HRSMFAVVGD  KARDQVPILY  HILSKSTVSA  RPNVLWCYKK  60
61    ELSFSTHRAK  KAKKMKKATT  TISGSLPDAD  PFDVFISSTQ  IRYCYYNETE  KILGNTFGVL  120
121   VLQDFEAMTP  NLLARTIETI  EGGGMVILLM  QSVRSLRQLY  TISMDVHNRY  RTEAHNEITA  180
181   RFNERFILSL  ASCSSVLVLD  DQLRVLPISS  HIENVEAIPA  SQKKIQSESD  AELASLKEAM  240
241   KETKPIGPLL  SRARTACQAK  ALLRFLDVIT  EKQSNVTCSL  TAGRGRGKSA  AVGLSLAGAI  300
301   AFGYTNIFVT  SPSPENLKTL  FEFVVKGFDA  LDYQEHTDYE  LIQSANPEFK  NCLVRINVFR  360
361   EHKQTIQYIS  PTDVQKLGQC  ELIVIDEAAA  IPLPLVKELI  SGPYISFLSS  TINGYEGTGR  420
421   SLSLKLLQQL  RQQSAGGEAK  EGKSASNKGK  TLHEMHMEES  IRYKPGDKIE  KWLNRLLCLD  480
481   ATNCQLKLEC  GTPPPAACEL  YIVNRDTLFS  FHDASEAFLQ  QVMAIFVSAH  YKNSPNDLQM  540
541   LSDAPAHNLF  VLMAPIDKSR  KTIPEVLAVV  QVCLEGRLDS  DNIQNGLESG  KRAAGDLLPW  600
601   TVSQQFMDKQ  FGTLCGGRIV  RVAVHPDYQS  MGYGGRAVQL  IEQYYLGLAT  SLDEEEKAPA  660
661   PPSKTVIKQV  KDGHTVELLE  ERIEPRADLP  PLLQRLDERK  PERLDYLGVS  FGLTVPLLKF  720
721   WKRNEFVPVY  IRQNSNDITG  EHTCIILKGL  EHGGSDSDEE  PSATWLPVYW  REFRRRIVNL  780
781   LSFDFSSFPA  QMALSLLQLK  NKHVEKQMKR  LVIERSELAI  HLSNTDLRRM  SQYGRNMVDS  840
841   HIITDILPIV  AKLNFEQRLP  QELKLAVTQS  AILLARGLQH  KHFEDISKEL  DLPMNQIFAL  900
901   LTKAIRRIGD  WFDEVCETAV  RENLDKEAEA  SAANKPTSSL  PKAVPLANLE  DELESAAKEI  960
961   RARHDRDRKA  LLAELGNELQ  KYEIIQDEKE  LAEAYESVNM  KYANKLVSVK  SKRTAIQAAI  1020
1021  PDAKDPANKN  AKKKKRFSSG  GRR  1043
Nucleotide CDS Sequence (FASTA)
1     ATGAGGACCA  AACTTGATGG  TCGCATTCGC  ACTCAAATTG  AAAATGGAGT  GGCCAGTGGA  60
61    CATCGATCGA  TGTTCGCGGT  AGTTGGTGAT  AAAGCAAGGG  ATCAAGTTCC  TATTCTTTAT  120
121   CACATTCTAT  CAAAGTCCAC  AGTTTCTGCT  CGACCAAATG  TTCTCTGGTG  CTACAAAAAA  180
181   GAGCTTTCAT  TTTCAACACA  TCGTGCGAAG  AAGGCAAAGA  AAATGAAGAA  GGCCACAACA  240
241   ACAATTTCCG  GAAGTCTGCC  AGATGCTGAT  CCGTTTGATG  TTTTCATTTC  TTCAACGCAG  300
301   ATTCGATACT  GTTATTATAA  TGAAACTGAG  AAGATTTTAG  GAAATACATT  TGGAGTTCTC  360
361   GTCCTGCAGG  ACTTTGAAGC  AATGACGCCA  AATCTTCTTG  CGAGAACCAT  CGAAACGATT  420
421   GAAGGAGGTG  GAATGGTCAT  TCTTCTGATG  CAATCCGTTC  GTTCTCTTCG  TCAACTTTAC  480
481   ACAATCTCCA  TGGATGTTCA  CAATAGATAT  CGTACGGAGG  CTCACAATGA  GATTACAGCT  540
541   CGCTTCAATG  AAAGATTCAT  TCTGTCATTG  GCTTCATGTT  CGTCAGTTCT  GGTTCTTGAT  600
601   GATCAACTGA  GAGTTTTGCC  GATTTCCAGT  CACATTGAGA  ATGTCGAAGC  GATTCCAGCA  660
661   TCTCAAAAGA  AAATCCAAAG  CGAATCAGAT  GCAGAACTTG  CCAGTTTGAA  AGAAGCAATG  720
721   AAAGAGACAA  AACCAATCGG  ACCATTGCTT  TCTCGTGCTC  GTACTGCTTG  TCAAGCCAAG  780
781   GCTCTTCTCC  GTTTTCTCGA  CGTCATCACA  GAAAAGCAAT  CGAATGTCAC  TTGCTCTTTG  840
841   ACCGCTGGTC  GTGGACGTGG  AAAGTCTGCA  GCCGTTGGAC  TCTCCTTGGC  TGGAGCTATT  900
901   GCTTTTGGAT  ACACAAATAT  TTTTGTGACG  TCTCCATCAC  CGGAAAACTT  GAAGACATTG  960
961   TTCGAGTTTG  TTGTCAAAGG  ATTCGATGCA  CTGGATTATC  AAGAACACAC  TGATTATGAG  1020
1021  CTTATTCAAT  CAGCAAATCC  GGAATTCAAA  AACTGTTTGG  TTCGAATCAA  TGTGTTCCGT  1080
1081  GAGCACAAAC  AGACTATTCA  GTACATTAGC  CCCACAGATG  TGCAGAAACT  TGGTCAATGT  1140
1141  GAACTGATCG  TAATTGATGA  AGCCGCTGCA  ATTCCCCTGC  CTCTGGTCAA  GGAGCTGATT  1200
1201  TCTGGCCCAT  ACATCTCGTT  TTTATCTTCT  ACAATCAATG  GATACGAAGG  AACCGGTCGT  1260
1261  TCATTATCTC  TGAAACTTTT  GCAACAACTC  CGCCAACAGT  CTGCTGGAGG  AGAAGCAAAG  1320
1321  GAAGGTAAAA  GTGCGTCGAA  CAAAGGAAAA  ACTCTTCACG  AAATGCACAT  GGAGGAAAGT  1380
1381  ATCAGATACA  AGCCAGGAGA  TAAGATCGAA  AAATGGCTCA  ATCGACTTCT  CTGCCTTGAC  1440
1441  GCCACCAACT  GCCAGCTGAA  ACTTGAGTGT  GGAACACCTC  CGCCAGCCGC  CTGCGAGCTG  1500
1501  TACATTGTAA  ATCGAGACAC  GCTTTTCTCA  TTCCATGACG  CATCTGAAGC  CTTCCTGCAA  1560
1561  CAAGTCATGG  CAATCTTTGT  TTCTGCGCAT  TACAAGAACA  GTCCAAACGA  CTTGCAAATG  1620
1621  CTTTCCGATG  CTCCAGCTCA  CAATCTGTTT  GTTCTGATGG  CTCCAATTGA  CAAGTCACGA  1680
1681  AAAACGATTC  CTGAAGTCTT  GGCTGTGGTC  CAAGTTTGTC  TAGAAGGTCG  CCTCGATTCT  1740
1741  GATAATATTC  AAAATGGACT  TGAAAGTGGA  AAACGAGCAG  CTGGAGATCT  CCTTCCGTGG  1800
1801  ACAGTTTCCC  AACAATTCAT  GGATAAGCAG  TTCGGAACAC  TTTGTGGTGG  AAGAATTGTT  1860
1861  CGTGTCGCTG  TACATCCAGA  TTATCAGTCA  ATGGGATATG  GTGGTCGTGC  TGTTCAATTG  1920
1921  ATTGAGCAGT  ACTATCTTGG  ATTGGCAACC  TCTTTGGACG  AAGAAGAAAA  AGCACCAGCT  1980
1981  CCGCCATCTA  AAACAGTGAT  TAAGCAAGTG  AAGGATGGCC  ATACCGTTGA  ACTTCTTGAA  2040
2041  GAGCGTATTG  AACCCAGAGC  TGATCTTCCA  CCACTGCTTC  AACGTCTCGA  TGAAAGAAAG  2100
2101  CCTGAAAGAT  TAGACTATTT  GGGCGTATCA  TTCGGACTCA  CTGTTCCACT  TTTAAAATTC  2160
2161  TGGAAGCGAA  ACGAGTTTGT  GCCAGTTTAC  ATTCGTCAGA  ATTCGAACGA  CATTACCGGA  2220
2221  GAGCATACTT  GTATTATACT  GAAAGGACTC  GAACACGGAG  GATCTGATAG  TGATGAAGAA  2280
2281  CCATCTGCCA  CTTGGCTGCC  TGTGTATTGG  CGTGAATTTC  GTCGCCGTAT  CGTCAATCTA  2340
2341  CTTTCATTTG  ACTTTTCCTC  GTTCCCGGCT  CAAATGGCAC  TTTCTCTTCT  CCAACTCAAG  2400
2401  AATAAGCATG  TCGAAAAACA  GATGAAACGG  CTTGTAATTG  AACGTTCCGA  GTTGGCAATT  2460
2461  CATCTTTCAA  ACACTGATCT  TCGACGAATG  AGCCAATATG  GACGAAATAT  GGTTGATTCT  2520
2521  CATATTATCA  CTGATATTCT  CCCAATCGTT  GCAAAATTGA  ACTTCGAACA  GAGATTGCCA  2580
2581  CAAGAGTTGA  AATTAGCTGT  AACTCAATCT  GCAATTCTTC  TTGCTCGTGG  TCTGCAACAC  2640
2641  AAACATTTCG  AAGATATTTC  CAAAGAGTTG  GATCTTCCAA  TGAATCAGAT  ATTCGCTTTA  2700
2701  CTGACAAAAG  CGATTCGGCG  AATCGGAGAT  TGGTTCGATG  AAGTTTGTGA  GACAGCAGTT  2760
2761  AGAGAAAATC  TCGATAAAGA  AGCTGAAGCA  TCTGCGGCGA  ACAAGCCAAC  ATCAAGTCTC  2820
2821  CCGAAAGCTG  TGCCACTTGC  CAATTTGGAA  GATGAGCTCG  AGTCGGCTGC  CAAAGAGATT  2880
2881  CGTGCTCGTC  ACGATAGGGA  CAGAAAAGCA  CTGCTCGCTG  AGCTTGGAAA  CGAATTGCAA  2940
2941  AAGTATGAGA  TTATACAGGA  CGAGAAAGAG  TTGGCTGAAG  CTTATGAATC  TGTTAATATG  3000
3001  AAATATGCAA  ACAAATTGGT  CAGCGTTAAG  AGCAAACGAA  CTGCTATCCA  AGCCGCAATT  3060
3061  CCTGATGCAA  AAGATCCGGC  GAATAAAAAT  GCCAAAAAGA  AGAAGCGCTT  CTCGTCTGGT  3120
3121  GGACGCCGTT  GA  3132

▼ KEYWORD

ID
Family
Acyltransferase
ATP-binding
Complete proteome
Nucleotide-binding
Nucleus
Reference proteome
rRNA processing
Transferase
tRNA processing

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Molecular Function
ATP binding
Molecular Function
RRNA cytidine N-acetyltransferase activity
Biological Process
RRNA acetylation involved in maturation of SSU-rRNA
Biological Process
TRNA acetylation

▼ ANNOTATION

Disorder
IUPred2A
PTM
EPSD
Interaction
IIDMIST
Physicochemical
Compute pI/MwAAindex
Function
PIRSF

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-1016Pongo abelii61.540.0 839
LLPS-Icp-1635Ictalurus punctatus56.822e-92 302
LLPS-Meg-0037Meleagris gallopavo55.470.0 961
LLPS-Sah-1309Sarcophilus harrisii55.430.0 984
LLPS-Paa-0891Papio anubis55.140.01002
LLPS-Cea-0526Cercocebus atys55.040.0 999
LLPS-Aon-0588Aotus nancymaae55.040.01003
LLPS-Maf-1227Macaca fascicularis55.030.01003
LLPS-Orc-2463Oryctolagus cuniculus54.990.01001
LLPS-Caj-1260Callithrix jacchus54.950.01000
LLPS-Rhb-0666Rhinopithecus bieti54.950.01002
LLPS-Hos-2192Homo sapiens54.850.0 998
LLPS-Mam-1423Macaca mulatta54.850.0 999
LLPS-Phv-0095Phaseolus vulgaris54.830.0 681
LLPS-Tag-1325Taeniopygia guttata54.80.01011
LLPS-Chs-0307Chlorocebus sabaeus54.750.0 994
LLPS-Nol-0756Nomascus leucogenys54.750.0 998
LLPS-Man-1603Macaca nemestrina54.650.0 995
LLPS-Caf-0130Canis familiaris54.550.01009
LLPS-Anc-0532Anolis carolinensis54.550.01023
LLPS-Fia-1365Ficedula albicollis54.510.01002
LLPS-Mup-0115Mustela putorius furo54.450.01009
LLPS-Aim-0704Ailuropoda melanoleuca54.450.01006
LLPS-Urm-1143Ursus maritimus54.450.01005
LLPS-Gaga-0262Gallus gallus54.410.01006
LLPS-Ran-1493Rattus norvegicus54.360.01001
LLPS-Cap-0928Cavia porcellus54.30.01020
LLPS-Mum-0480Mus musculus54.260.0 984
LLPS-Ova-0013Ovis aries54.250.01000
LLPS-Fec-1891Felis catus54.250.01003
LLPS-Mod-0205Monodelphis domestica54.250.01037
LLPS-Bot-0124Bos taurus54.210.0 997
LLPS-Sus-1941Sus scrofa54.160.0 999
LLPS-Asm-0865Astyanax mexicanus54.150.01045
LLPS-Fud-0611Fukomys damarensis54.150.0 997
LLPS-Otg-3446Otolemur garnettii54.140.01004
LLPS-Anp-2356Anas platyrhynchos54.020.0 963
LLPS-Ict-0631Ictidomys tridecemlineatus54.00.0 999
LLPS-Ora-1033Ornithorhynchus anatinus53.980.0 981
LLPS-Tar-1187Takifugu rubripes53.910.0 986
LLPS-Cas-0669Carlito syrichta53.90.01005
LLPS-Ten-1564Tetraodon nigroviridis53.860.0 977
LLPS-Lac-0183Latimeria chalumnae53.810.01029
LLPS-Gaa-0406Gasterosteus aculeatus53.710.0 981
LLPS-Dio-0801Dipodomys ordii53.670.0 981
LLPS-Loa-0476Loxodonta africana53.670.01016
LLPS-Cii-0166Ciona intestinalis53.660.01021
LLPS-Leo-1075Lepisosteus oculatus53.590.0 994
LLPS-Xet-0055Xenopus tropicalis53.580.01048
LLPS-Scf-2513Scleropages formosus53.470.0 990
LLPS-Xim-1737Xiphophorus maculatus53.420.01008
LLPS-Pes-0755Pelodiscus sinensis53.420.0 989
LLPS-Mea-0381Mesocricetus auratus53.370.0 740
LLPS-Gog-0235Gorilla gorilla53.370.0 961
LLPS-Dar-0768Danio rerio53.370.0 978
LLPS-Pat-0296Pan troglodytes53.370.0 963
LLPS-Pap-1518Pan paniscus53.370.0 963
LLPS-Scm-1279Scophthalmus maximus53.320.0 996
LLPS-Myl-1366Myotis lucifugus53.220.0 978
LLPS-Orn-0356Oreochromis niloticus53.220.01009
LLPS-Pof-1060Poecilia formosa53.030.01030
LLPS-Orl-0173Oryzias latipes52.930.01019
LLPS-Mal-2027Mandrillus leucophaeus52.250.0 922
LLPS-Sot-1354Solanum tuberosum51.90.0 721
LLPS-Eqc-0392Equus caballus51.70.0 970
LLPS-Osl-0180Ostreococcus lucimarinus51.590.0 905
LLPS-Scj-0246Schizosaccharomyces japonicus50.240.0 924
LLPS-Scs-0517Sclerotinia sclerotiorum49.890.0 879
LLPS-Map-0820Magnaporthe poae49.630.0 853
LLPS-Scp-0278Schizosaccharomyces pombe49.560.0 906
LLPS-Kop-0123Komagataella pastoris49.510.0 895
LLPS-Asc-0424Aspergillus clavatus49.260.0 897
LLPS-Abg-0526Absidia glauca49.230.0 973
LLPS-Scc-0250Schizosaccharomyces cryophilus49.170.0 896
LLPS-Aso-0048Aspergillus oryzae49.160.0 898
LLPS-Asf-1038Aspergillus flavus49.160.0 898
LLPS-Blg-0253Blumeria graminis49.110.0 862
LLPS-Cog-0470Colletotrichum gloeosporioides49.10.0 872
LLPS-Asni-0501Aspergillus niger48.990.0 915
LLPS-Zyt-0962Zymoseptoria tritici48.80.0 862
LLPS-Chc-0670Chondrus crispus48.80.0 841
LLPS-Sem-0403Selaginella moellendorffii48.730.0 890
LLPS-Amt-1157Amborella trichopoda48.730.0 881
LLPS-Nec-0509Neurospora crassa48.710.0 890
LLPS-Art-0194Arabidopsis thaliana48.660.0 830
LLPS-Asfu-0428Aspergillus fumigatus48.610.0 906
LLPS-Php-0876Physcomitrella patens48.490.0 912
LLPS-Gas-0367Galdieria sulphuraria48.480.0 847
LLPS-Trv-0163Trichoderma virens48.470.0 858
LLPS-Asn-0564Aspergillus nidulans48.420.0 893
LLPS-Fus-0347Fusarium solani48.420.0 892
LLPS-Nef-0385Neosartorya fischeri48.320.0 904
LLPS-Asg-0527Ashbya gossypii48.160.0 887
LLPS-Gor-1814Gossypium raimondii48.113e-1682.4
LLPS-Brn-1315Brassica napus48.080.0 827
LLPS-Brr-0692Brassica rapa48.080.0 827
LLPS-Dos-0313Dothistroma septosporum48.050.0 874
LLPS-Drm-0627Drosophila melanogaster48.030.0 873
LLPS-Ved-0254Verticillium dahliae47.90.0 893
LLPS-Bro-1000Brassica oleracea47.860.0 803
LLPS-Sac-0419Saccharomyces cerevisiae47.820.0 914
LLPS-Crn-0372Cryptococcus neoformans47.780.0 868
LLPS-Coo-0815Colletotrichum orbiculare47.760.0 864
LLPS-Mao-0101Magnaporthe oryzae47.740.0 855
LLPS-Yal-0029Yarrowia lipolytica47.640.0 901
LLPS-Ast-0485Aspergillus terreus47.60.0 853
LLPS-Phn-0546Phaeosphaeria nodorum47.510.0 872
LLPS-Trr-0239Trichoderma reesei47.480.0 862
LLPS-Chr-0128Chlamydomonas reinhardtii47.420.0 824
LLPS-Usm-0759Ustilago maydis47.410.0 839
LLPS-Beb-0418Beauveria bassiana47.340.0 885
LLPS-Spr-0028Sporisorium reilianum47.120.0 814
LLPS-Zem-0301Zea mays47.050.0 768
LLPS-Pug-1113Puccinia graminis46.960.0 892
LLPS-Pot-0127Populus trichocarpa46.930.0 831
LLPS-Pytr-0451Pyrenophora triticirepentis46.930.0 818
LLPS-Arl-1323Arabidopsis lyrata46.920.0 800
LLPS-Dac-0987Daucus carota46.730.0 872
LLPS-Pyt-0468Pyrenophora teres46.710.0 872
LLPS-Mel-0286Melampsora laricipopulina46.560.0 926
LLPS-Orbr-0311Oryza brachyantha46.560.0 823
LLPS-Lem-0835Leptosphaeria maculans46.290.0 871
LLPS-Fuo-0974Fusarium oxysporum46.250.0 867
LLPS-Gag-0183Gaeumannomyces graminis46.240.0 847
LLPS-Glm-0201Glycine max46.240.0 854
LLPS-Thc-0102Theobroma cacao45.940.0 825
LLPS-Cogr-0198Colletotrichum graminicola45.940.0 864
LLPS-Orni-0809Oryza nivara45.930.0 811
LLPS-Sei-0874Setaria italica45.930.0 816
LLPS-Orr-0682Oryza rufipogon45.930.0 811
LLPS-Via-0826Vigna angularis45.850.0 858
LLPS-Orgl-0357Oryza glumaepatula45.850.0 812
LLPS-Viv-0067Vitis vinifera45.810.0 835
LLPS-Lep-0849Leersia perrieri45.780.0 826
LLPS-Orb-0291Oryza barthii45.750.0 811
LLPS-Org-0385Oryza glaberrima45.750.0 811
LLPS-Prp-0389Prunus persica45.690.0 812
LLPS-Cus-0522Cucumis sativus45.680.0 826
LLPS-Miv-0537Microbotryum violaceum45.670.0 838
LLPS-Coc-0412Corchorus capsularis45.590.0 782
LLPS-Sol-0095Solanum lycopersicum45.560.0 852
LLPS-Mae-0179Manihot esculenta45.540.0 850
LLPS-Fuv-0921Fusarium verticillioides45.490.0 834
LLPS-Met-0783Medicago truncatula45.450.0 834
LLPS-Sob-0627Sorghum bicolor45.340.0 804
LLPS-Hea-0727Helianthus annuus45.330.0 818
LLPS-Tum-0759Tuber melanosporum45.180.0 798
LLPS-Ori-0172Oryza indica45.080.0 799
LLPS-Nia-1023Nicotiana attenuata45.050.0 846
LLPS-Mua-0278Musa acuminata44.780.0 818
LLPS-Brd-0426Brachypodium distachyon44.620.0 803
LLPS-Orm-0079Oryza meridionalis44.570.0 796
LLPS-Put-0861Puccinia triticina44.140.0 807
LLPS-Hov-0387Hordeum vulgare44.120.0 798
LLPS-Tra-0181Triticum aestivum44.020.0 801
LLPS-Orp-0954Oryza punctata42.70.0 706
LLPS-Vir-0323Vigna radiata42.470.0 757
LLPS-Tru-0264Triticum urartu40.060.0 675
LLPS-Cym-0583Cyanidioschyzon merolae38.560.0 623
LLPS-Ors-0311Oryza sativa36.091e-96 322