LLPS-Cae-0312
cyp-31a3

▼ OVERVIEW

Status: Reviewed
Protein Name: CYtochrome P450 family
Gene Name: cyp-31a3, cyp-31A3, CELE_Y17G9B.3, Y17G9B.3
Ensembl Gene: WBGene00021200
Ensembl Protein: Y17G9B.3
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P granule
"...Here we report on a genomewide RNAi screen in C. elegans, which identified 173 genes that affect the stability, localization, and function of P granules."
Caenorhabditis elegans19805813

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblY17G9B.3Y17G9B.3
UniProtQ9N574, Q9N574_CAEEL
GeneBankBX284604CCD68717.1
RefSeqNM_068236.2NP_500637.2
Entrez189467

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGVIIPAVLL  ASATIIAWLL  YKHLRMRQAL  KHLNQPRSYP  IVGHGLVTKP  DPEGFMNQVI  60
61    GMGYLYPDPR  MCLLWIGPFP  CLMLYSADLV  EPIFSSTKHL  NKGFAYVLLE  PWLGISILTS  120
121   QKEQWRPKRK  LLTPTFHYDI  LKDFLPIFNE  QSKILVQKMC  SLGAEEEVDV  LSVITLCTLD  180
181   IICETSMGKA  IGAQLAENNE  YVWAVHTINK  LISKRTNNPL  MWNSFIYNLT  EDGRTHEKCL  240
241   RILHDFTKKV  IVERKEALQE  NDYKMEGRLA  FLDLLLEMVK  SGQMDETDVQ  AEVDTFMFEG  300
301   HDTTSTGLMW  AIHLLGNHPE  VQRKVQAELD  EVMGDDEDVT  IEHLSRMKYL  ECALKEALRL  360
361   FPSVPIITRE  LSDDQVIGGV  NIPKGVTFLL  NLYLVHRDPS  QWKDPDVFDP  DRFLPENSIA  420
421   RKSFAFIPFS  AGSRNCIGQR  FALMEEKVIM  AHLLRNFNVK  AVELMHEVRP  KMEIIVRPVT  480
481   PIHMKLTRRR  PIVSP  495
Nucleotide CDS Sequence (FASTA)
1     ATGGGGGTTA  TCATCCCCGC  TGTACTTCTC  GCTTCGGCGA  CGATAATCGC  TTGGCTTCTC  60
61    TACAAACACT  TGAGAATGCG  TCAAGCTTTG  AAGCATCTCA  ATCAACCACG  TTCATATCCA  120
121   ATCGTCGGTC  ACGGACTGGT  CACCAAGCCA  GATCCAGAGG  GATTCATGAA  CCAAGTAATT  180
181   GGAATGGGAT  ATTTATATCC  AGATCCACGT  ATGTGTCTTT  TGTGGATTGG  TCCGTTCCCT  240
241   TGCCTGATGC  TCTACTCCGC  CGATCTCGTG  GAACCAATTT  TCTCGTCGAC  GAAACATCTG  300
301   AACAAAGGTT  TCGCATACGT  TTTGCTTGAG  CCATGGCTTG  GAATCAGTAT  TTTGACAAGC  360
361   CAGAAGGAAC  AATGGCGTCC  AAAGCGAAAA  CTCTTGACAC  CCACCTTCCA  TTATGATATT  420
421   CTGAAGGATT  TTTTGCCGAT  TTTCAACGAG  CAATCAAAGA  TTTTGGTTCA  GAAAATGTGT  480
481   TCCCTCGGAG  CAGAGGAAGA  AGTTGATGTT  CTCTCCGTTA  TAACCTTGTG  CACTCTTGAT  540
541   ATCATTTGTG  AAACTTCCAT  GGGCAAAGCT  ATCGGTGCTC  AACTCGCGGA  GAATAACGAG  600
601   TATGTATGGG  CGGTGCACAC  AATCAACAAG  CTGATCTCAA  AGCGAACAAA  TAATCCGTTA  660
661   ATGTGGAATT  CGTTTATTTA  CAATTTAACA  GAAGACGGAC  GAACGCATGA  AAAATGTCTT  720
721   CGTATTCTAC  ATGATTTCAC  GAAGAAAGTA  ATTGTCGAGA  GAAAAGAAGC  GCTACAGGAG  780
781   AATGATTATA  AGATGGAAGG  TCGTCTCGCA  TTTTTAGATC  TTCTTCTCGA  AATGGTGAAA  840
841   AGTGGACAAA  TGGACGAAAC  AGATGTTCAG  GCAGAAGTTG  ACACATTCAT  GTTTGAAGGC  900
901   CACGATACAA  CATCTACAGG  ACTAATGTGG  GCAATACATC  TTCTGGGAAA  TCATCCTGAA  960
961   GTTCAGAGAA  AAGTTCAAGC  GGAATTGGAT  GAAGTGATGG  GCGATGATGA  GGACGTGACT  1020
1021  ATTGAACATC  TCTCCAGAAT  GAAATATCTC  GAATGTGCAC  TAAAAGAAGC  TCTCCGATTG  1080
1081  TTCCCATCTG  TTCCAATTAT  TACAAGAGAA  TTGAGTGATG  ATCAAGTGAT  TGGAGGTGTT  1140
1141  AATATTCCAA  AAGGAGTCAC  TTTTCTGCTC  AACCTGTACC  TTGTTCATCG  TGATCCTTCG  1200
1201  CAATGGAAGG  ATCCTGATGT  ATTCGATCCG  GATCGTTTCC  TTCCTGAAAA  TTCAATTGCT  1260
1261  CGCAAGTCTT  TCGCCTTCAT  TCCATTCTCA  GCTGGAAGTC  GTAACTGCAT  TGGCCAACGT  1320
1321  TTTGCACTCA  TGGAGGAGAA  GGTCATCATG  GCTCATTTGT  TGAGAAATTT  CAATGTAAAA  1380
1381  GCTGTCGAGT  TGATGCATGA  GGTTCGTCCG  AAAATGGAGA  TTATCGTTCG  CCCAGTCACT  1440
1441  CCAATTCACA  TGAAGCTTAC  CAGACGCCGT  CCAATCGTCT  CTCCATAA  1488

▼ ANNOTATION

Disorder
IUPred2A
PTM
EPSD
Drug
CTD
Physicochemical
Compute pI/MwAAindex
Function
PIRSF
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fia-1155Ficedula albicollis48.033e-136 409
LLPS-Otg-3159Otolemur garnettii47.071e-143 430
LLPS-Orl-0554Oryzias latipes46.153e-158 467
LLPS-Xim-0856Xiphophorus maculatus46.091e-157 466
LLPS-Cas-2410Carlito syrichta45.613e-138 414
LLPS-Mum-3532Mus musculus45.43e-145 434
LLPS-Orc-1981Oryctolagus cuniculus45.41e-145 435
LLPS-Leo-2941Lepisosteus oculatus45.224e-147 439
LLPS-Lac-4006Latimeria chalumnae45.065e-143 428
LLPS-Ict-4186Ictidomys tridecemlineatus44.965e-143 428
LLPS-Pof-1567Poecilia formosa44.917e-151 449
LLPS-Fec-3192Felis catus44.622e-148 442
LLPS-Bot-3346Bos taurus44.557e-144 431
LLPS-Gog-4027Gorilla gorilla44.28e-145 433
LLPS-Rhb-2739Rhinopithecus bieti44.22e-145 435
LLPS-Ova-4148Ovis aries44.167e-146 436
LLPS-Sus-3761Sus scrofa44.143e-142 426
LLPS-Paa-3409Papio anubis44.07e-144 431
LLPS-Pap-0211Pan paniscus44.03e-144 431
LLPS-Chs-1137Chlorocebus sabaeus43.82e-143 429
LLPS-Pat-0648Pan troglodytes43.82e-143 429
LLPS-Aim-4218Ailuropoda melanoleuca43.742e-145 434
LLPS-Eqc-3069Equus caballus43.336e-142 426
LLPS-Aon-2568Aotus nancymaae42.961e-110 343
LLPS-Caj-3500Callithrix jacchus42.894e-139 418
LLPS-Nol-1540Nomascus leucogenys42.432e-88 286
LLPS-Poa-0703Pongo abelii42.061e-119 386
LLPS-Dio-0496Dipodomys ordii40.973e-117 360
LLPS-Cii-2368Ciona intestinalis40.381e-128 390
LLPS-Mod-3410Monodelphis domestica38.465e-89 290
LLPS-Urm-3956Ursus maritimus36.754e-83 273
LLPS-Ora-2979Ornithorhynchus anatinus36.442e-90 292
LLPS-Sol-1792Solanum lycopersicum33.641e-28 124
LLPS-Cus-1661Cucumis sativus32.653e-27 116
LLPS-Mup-1763Mustela putorius furo31.721e-1991.7
LLPS-Tru-0695Triticum urartu31.651e-22 105
LLPS-Orbr-0032Oryza brachyantha31.655e-24 108
LLPS-Art-0687Arabidopsis thaliana31.488e-27 117
LLPS-Mae-1116Manihot esculenta31.398e-29 122
LLPS-Maf-3206Macaca fascicularis31.252e-1682.0
LLPS-Glm-1591Glycine max31.254e-26 115
LLPS-Dac-1559Daucus carota31.257e-25 111
LLPS-Orm-1212Oryza meridionalis31.251e-29 125
LLPS-Arl-0602Arabidopsis lyrata31.026e-27 117
LLPS-Bro-2741Brassica oleracea30.941e-27 119
LLPS-Brd-1952Brachypodium distachyon30.847e-28 120
LLPS-Thc-1841Theobroma cacao30.732e-24 110
LLPS-Loa-2004Loxodonta africana30.72e-1582.8
LLPS-Brn-2519Brassica napus30.495e-27 117
LLPS-Brr-0734Brassica rapa30.491e-26 116
LLPS-Sei-2433Setaria italica30.48e-27 117
LLPS-Orp-1444Oryza punctata30.41e-24 110
LLPS-Sob-2154Sorghum bicolor30.45e-26 114
LLPS-Viv-2207Vitis vinifera30.042e-25 112
LLPS-Prp-1256Prunus persica29.966e-27 117
LLPS-Nia-0970Nicotiana attenuata29.966e-26 114
LLPS-Mua-1976Musa acuminata29.822e-26 115
LLPS-Hea-1597Helianthus annuus29.696e-25 111
LLPS-Ast-0916Aspergillus terreus29.634e-1066.6
LLPS-Icp-3179Ictalurus punctatus29.553e-2097.4
LLPS-Sot-0220Solanum tuberosum29.529e-26 114
LLPS-Caf-3328Canis familiaris29.492e-1788.6
LLPS-Gor-1170Gossypium raimondii29.414e-25 112
LLPS-Xet-1088Xenopus tropicalis29.364e-1684.7
LLPS-Orb-1288Oryza barthii28.942e-2095.9
LLPS-Orgl-0229Oryza glumaepatula28.267e-2096.3
LLPS-Orni-1879Oryza nivara28.268e-2096.3
LLPS-Coc-1235Corchorus capsularis28.021e-1068.2
LLPS-Pes-2432Pelodiscus sinensis27.932e-1479.3
LLPS-Asm-2905Astyanax mexicanus27.893e-1994.4
LLPS-Orr-2433Oryza rufipogon27.837e-1993.6
LLPS-Ran-0266Rattus norvegicus27.725e-1581.3
LLPS-Myl-0688Myotis lucifugus27.692e-1788.6
LLPS-Cea-2502Cercocebus atys27.623e-1685.1
LLPS-Mam-1499Macaca mulatta27.624e-1684.7
LLPS-Man-1146Macaca nemestrina27.624e-1684.7
LLPS-Fud-3971Fukomys damarensis27.436e-1580.1
LLPS-Orn-0099Oreochromis niloticus27.131e-1686.3
LLPS-Sah-0152Sarcophilus harrisii27.019e-1889.7
LLPS-Tar-1661Takifugu rubripes26.961e-1377.0
LLPS-Tut-0190Tursiops truncatus26.926e-1890.5
LLPS-Cap-2490Cavia porcellus26.821e-1583.2
LLPS-Anc-1484Anolis carolinensis26.638e-2095.9
LLPS-Ten-2172Tetraodon nigroviridis26.586e-1375.1
LLPS-Mal-2479Mandrillus leucophaeus26.043e-1685.5
LLPS-Phv-2212Phaseolus vulgaris25.779e-27 117
LLPS-Zem-0741Zea mays25.566e-27 117
LLPS-Vir-2178Vigna radiata25.482e-27 119
LLPS-Via-2112Vigna angularis25.343e-28 120
LLPS-Abg-1243Absidia glauca25.122e-1067.4
LLPS-Hos-0014Homo sapiens25.09e-1684.0
LLPS-Amt-2290Amborella trichopoda24.861e-22 105
LLPS-Tag-2475Taeniopygia guttata24.568e-1787.0
LLPS-Scm-1097Scophthalmus maximus24.566e-1684.3
LLPS-Pot-0473Populus trichocarpa24.521e-28 122
LLPS-Sem-0494Selaginella moellendorffii24.32e-21 101
LLPS-Hov-0639Hordeum vulgare24.245e-27 117
LLPS-Tra-2250Triticum aestivum24.184e-26 115
LLPS-Gaa-1302Gasterosteus aculeatus24.176e-22 102
LLPS-Met-0613Medicago truncatula24.115e-24 108
LLPS-Lep-0724Leersia perrieri24.042e-25 112
LLPS-Scf-1736Scleropages formosus23.922e-1994.7
LLPS-Php-2238Physcomitrella patens23.822e-21 101
LLPS-Ori-0888Oryza indica23.62e-24 110
LLPS-Ors-0041Oryza sativa23.61e-24 110
LLPS-Dar-2521Danio rerio23.57e-1787.0
LLPS-Org-1922Oryza glaberrima23.374e-24 109
LLPS-Gaga-1461Gallus gallus22.922e-1685.9
LLPS-Meg-1905Meleagris gallopavo22.926e-1684.3
LLPS-Anp-2328Anas platyrhynchos22.383e-1582.4