LLPS-Cae-0299
vha-19
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Vacuolar H ATPase |
| Gene Name: | vha-19, CELE_Y55H10A.1, Y55H10A.1 |
| Ensembl Gene: | WBGene00021952 |
| Ensembl Protein: | Y55H10A.1 |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Here we describe a systematic RNAi screen in C. elegans that identified 224 genes with diverse cellular functions whose inactivations result in a dramatic increase in the number of P bodies." | Caenorhabditis elegans | 22180091 |
| P granule | "...Here we report on a genomewide RNAi screen in C. elegans, which identified 173 genes that affect the stability, localization, and function of P granules." | Caenorhabditis elegans | 19805813 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Y55H10A.1 | Y55H10A.1 |
| UniProt | Q9TYW1, Q9TYW1_CAEEL | |
| GeneBank | BX284604 | CCD62204.1 |
| RefSeq | NM_067931.4 | NP_500332.1 |
| Entrez | 177103 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRVLFAVFSL IMACQAYDAV LFSNSREIGG TPAAKLVESA TAEEPVVFIV NPDFTLGQFS 60 61 VKANAYTSEP SADYLAKSVK NSNFHESQYF SHQIEATQAQ WLSSADQYSA GSPIYIIYGE 120 121 EWTSMEQLAE QLISKIDNSV GIITSTDAVA HEKSSRVKRV ATDEFNSDSE NSAAAEANGG 180 181 FPFPLVIPPY NQTFYSVKPT NGHSCLFYLE GLTVVVEQKK EKVLYYANAY IPGSNFTWAY 240 241 SETDVTCPNG TIGDFIFKIH LTLENDITGM QGTSKKAFTM KKGDKIDFDL TFTGDLFGYW 300 301 ALNKASASNL AISGYDPYKS ASVDGSKVVN GSATQYTKLN SVAGWSLACG QSQAVFFPTN 360 361 EQSVRIGVAL MNTQIQLFNY QNPEKWVESA HFTLQTEDCT GTFSSGSWMG IVSALVLIAG 420 421 LMFGYVMLQS VQTMDRFDDP KQRQIVINVR E 451 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGGTAC TTTTTGCCGT TTTCTCGCTC ATCATGGCGT GCCAAGCCTA CGACGCCGTC 60 61 CTCTTCTCCA ATTCCAGAGA AATTGGAGGA ACTCCAGCCG CTAAACTCGT CGAATCGGCC 120 121 ACCGCTGAGG AGCCCGTCGT CTTCATTGTT AACCCAGATT TCACTCTTGG TCAATTCTCG 180 181 GTAAAAGCCA ACGCCTACAC ATCTGAACCA TCGGCCGATT ACTTGGCAAA ATCTGTCAAA 240 241 AACAGCAATT TCCACGAATC TCAATACTTT TCACATCAAA TTGAGGCCAC CCAAGCTCAA 300 301 TGGCTCAGCA GCGCCGATCA ATACTCGGCC GGTTCCCCAA TCTACATTAT CTACGGAGAA 360 361 GAATGGACCT CAATGGAGCA GCTCGCCGAG CAATTAATCT CAAAAATCGA TAACTCTGTC 420 421 GGAATTATCA CCTCCACCGA CGCTGTTGCT CACGAGAAAT CAAGCCGTGT CAAGCGTGTC 480 481 GCCACCGATG AATTTAATTC CGATTCGGAA AATTCCGCCG CCGCTGAAGC GAATGGTGGA 540 541 TTCCCATTCC CACTGGTTAT TCCACCATAC AATCAAACAT TTTATTCTGT CAAACCAACC 600 601 AACGGACACT CATGTCTTTT CTATTTGGAG GGTCTTACTG TTGTCGTCGA GCAGAAAAAG 660 661 GAGAAAGTGC TCTACTATGC CAATGCTTAT ATTCCAGGCT CAAACTTCAC GTGGGCCTAC 720 721 TCGGAAACCG ATGTAACCTG CCCGAATGGA ACAATTGGAG ATTTCATTTT TAAGATTCAT 780 781 CTCACCCTCG AAAACGATAT TACTGGAATG CAGGGTACCA GCAAGAAGGC TTTCACAATG 840 841 AAAAAAGGAG ATAAAATCGA TTTTGACCTC ACTTTTACTG GAGATTTGTT TGGTTATTGG 900 901 GCACTTAACA AGGCTTCGGC CAGTAATCTT GCTATCAGTG GATATGATCC ATATAAGAGT 960 961 GCCTCCGTTG ACGGCAGCAA AGTGGTAAAT GGCTCAGCAA CCCAATACAC AAAGCTTAAC 1020 1021 TCAGTCGCCG GATGGTCGTT GGCCTGTGGA CAATCTCAAG CAGTCTTTTT CCCAACAAAT 1080 1081 GAACAATCCG TCCGAATTGG TGTGGCTCTT ATGAACACTC AAATTCAACT TTTCAACTAT 1140 1141 CAAAACCCCG AAAAATGGGT CGAATCTGCC CATTTCACAC TACAAACCGA AGATTGTACT 1200 1201 GGAACATTCT CCTCGGGATC CTGGATGGGA ATCGTATCGG CACTTGTTCT GATTGCTGGC 1260 1261 CTAATGTTCG GATATGTTAT GCTTCAGTCC GTTCAGACAA TGGATAGATT TGATGATCCA 1320 1321 AAGCAGAGGC AAATTGTCAT CAATGTTAGA GAATAA 1356 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| PTM | ||||
| PTMcode | ||||
| Interaction | ||||
| MIST | ||||
| Physicochemical | ||||
| AAindex | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Xet-0808 | Xenopus tropicalis | 48.0 | 3e-08 | 60.1 |
| LLPS-Dar-1802 | Danio rerio | 46.3 | 3e-08 | 60.1 |
| LLPS-Loa-0172 | Loxodonta africana | 40.54 | 2e-07 | 57.4 |
| LLPS-Lac-0450 | Latimeria chalumnae | 38.1 | 1e-08 | 61.2 |
| LLPS-Gaga-1217 | Gallus gallus | 37.5 | 3e-08 | 59.7 |
| LLPS-Fia-0883 | Ficedula albicollis | 37.5 | 2e-08 | 60.1 |
| LLPS-Meg-1462 | Meleagris gallopavo | 37.21 | 4e-08 | 59.3 |
| LLPS-Tag-2243 | Taeniopygia guttata | 36.36 | 2e-07 | 57.4 |
| LLPS-Anp-1545 | Anas platyrhynchos | 36.36 | 2e-07 | 57.4 |
| LLPS-Scm-2977 | Scophthalmus maximus | 34.07 | 8e-09 | 61.6 |
| LLPS-Orl-0483 | Oryzias latipes | 33.33 | 2e-08 | 60.8 |
| LLPS-Tar-3769 | Takifugu rubripes | 32.59 | 3e-08 | 60.1 |
| LLPS-Ten-0952 | Tetraodon nigroviridis | 32.59 | 9e-09 | 61.6 |
| LLPS-Orn-4057 | Oreochromis niloticus | 32.59 | 1e-08 | 60.8 |
| LLPS-Xim-2104 | Xiphophorus maculatus | 30.83 | 1e-07 | 58.2 |
| LLPS-Icp-3851 | Ictalurus punctatus | 30.23 | 8e-08 | 58.5 |
| LLPS-Pof-0300 | Poecilia formosa | 30.11 | 6e-08 | 58.9 |