LLPS-Cae-0259
ceh-6

▼ OVERVIEW

Status: Reviewed
Protein Name: Homeobox protein ceh-6
Gene Name: ceh-6, K02B12.1
Ensembl Gene: WBGene00000431
Ensembl Protein: K02B12.1
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Here we describe a systematic RNAi screen in C. elegans that identified 224 genes with diverse cellular functions whose inactivations result in a dramatic increase in the number of P bodies."
Caenorhabditis elegans22180091

▼ FUNCTION

Vital for embryonic development and essential for the proper function of the excretory cell (PubMed:11171402). Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development (PubMed:22493276).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblK02B12.1K02B12.1
UniProtP20268, HM06_CAEEL, Q9GSZ8
GeneBankAF286377, BX284601AAG10298.1, CAB00031.2
RefSeqNM_059903.5NP_492304.1
Entrez172640

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLIPSSSSIP  SSLSASASDS  EPSSLNGSGI  SDQNILPNYH  LHHHLINENE  MEAANYAQVI  60
61    KPTCEAFQDW  PHTPMLYQQP  QLHFMLPQHD  WAYPHLAQSL  PPPHHLTPST  AAVAAATIAS  120
121   QSSIINQTSV  VTSTPSCQIK  QEVERPEIIQ  RLMPPWPPAY  QFSCDDSGSV  SGAGGPHQPL  180
181   SDISDDSEQT  CPDDLEGFAK  QFKQRRIKLG  YTQADVGVAL  GTLYGNIFSQ  TTICRFEALQ  240
241   LSFKNMCKLK  PLLFKWLEEA  DSTTGSPNST  FEKMTGQAGR  KRKKRTSIEV  NVKSRLEFHF  300
301   QSNQKPNAQE  ITQVAMELQL  EKEVVRVWFC  NRRQKEKRIA  PNQYDAPHPM  ALNNGYPMTA  360
361   DLFPYQAVVN  HYTQQSPRQQ  380
Nucleotide CDS Sequence (FASTA)
1     ATGCTCATAC  CTTCGTCGTC  ATCCATACCG  TCTTCTTTAT  CTGCTTCAGC  ATCCGATTCT  60
61    GAGCCATCAT  CACTGAACGG  AAGTGGTATA  AGTGATCAGA  ATATTCTACC  TAATTATCAT  120
121   CTTCATCATC  ATCTAATTAA  CGAGAACGAG  ATGGAGGCAG  CCAATTATGC  ACAGGTTATC  180
181   AAACCAACAT  GCGAGGCATT  CCAAGATTGG  CCGCATACTC  CAATGCTGTA  TCAACAACCT  240
241   CAACTTCATT  TCATGCTTCC  ACAACACGAT  TGGGCATATC  CACATCTTGC  TCAATCTCTA  300
301   CCTCCTCCAC  ATCATCTAAC  ACCGTCCACT  GCAGCAGTTG  CTGCTGCAAC  AATTGCCTCA  360
361   CAAAGTTCAA  TAATCAATCA  AACGTCTGTG  GTTACAAGTA  CACCTTCGTG  CCAAATCAAA  420
421   CAGGAAGTTG  AACGACCTGA  AATTATTCAG  AGGTTAATGC  CTCCATGGCC  ACCAGCTTAT  480
481   CAATTTTCTT  GTGATGATAG  TGGATCAGTG  AGTGGAGCTG  GTGGACCACA  TCAGCCATTA  540
541   TCTGATATTT  CCGATGATAG  TGAACAGACG  TGTCCAGATG  ATTTGGAAGG  ATTTGCAAAA  600
601   CAATTTAAGC  AGAGAAGAAT  CAAATTAGGA  TACACACAAG  CAGATGTAGG  TGTGGCTCTC  660
661   GGAACACTCT  ACGGAAATAT  ATTTTCCCAG  ACAACAATTT  GTCGTTTTGA  AGCGCTTCAA  720
721   CTCTCTTTCA  AGAATATGTG  CAAACTAAAG  CCACTTCTAT  TCAAATGGCT  CGAGGAAGCT  780
781   GATTCAACGA  CTGGCTCGCC  CAATTCTACA  TTTGAAAAAA  TGACAGGGCA  AGCTGGAAGA  840
841   AAGAGAAAGA  AGAGAACAAG  CATTGAGGTC  AATGTAAAAT  CTCGTCTTGA  ATTCCATTTC  900
901   CAGTCGAATC  AGAAGCCAAA  TGCACAAGAG  ATTACACAAG  TTGCCATGGA  GTTGCAGCTT  960
961   GAGAAAGAGG  TTGTCCGTGT  CTGGTTCTGC  AATCGTCGTC  AAAAAGAGAA  GCGAATAGCT  1020
1021  CCAAATCAAT  ACGATGCTCC  ACATCCAATG  GCTTTAAACA  ATGGATATCC  AATGACTGCT  1080
1081  GACCTTTTCC  CATATCAAGC  CGTCGTCAAT  CATTATACTC  AACAGAGCCC  GAGACAACAA  1140
1141  TAG  1143

▼ KEYWORD

ID
Family
Complete proteome
Developmental protein
Differentiation
DNA-binding
Homeobox
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
DNA-binding transcription factor activity
Molecular Function
Sequence-specific DNA binding
Biological Process
Cell differentiation
Biological Process
Excretion
Biological Process
Multicellular organism development
Biological Process
Regulation of transcription, DNA-templated
Biological Process
Transdifferentiation
Biological Process
Water homeostasis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-2463Ursus maritimus79.875e-75 238
LLPS-Sah-0816Sarcophilus harrisii77.561e-75 241
LLPS-Aim-4175Ailuropoda melanoleuca77.563e-76 241
LLPS-Ova-0158Ovis aries76.921e-75 239
LLPS-Mup-4181Mustela putorius furo76.921e-73 240
LLPS-Pes-3774Pelodiscus sinensis76.925e-74 241
LLPS-Mod-4202Monodelphis domestica76.925e-74 240
LLPS-Anc-1931Anolis carolinensis76.928e-75 242
LLPS-Gaga-1823Gallus gallus76.928e-75 239
LLPS-Asm-3973Astyanax mexicanus76.888e-75 245
LLPS-Scf-3327Scleropages formosus76.732e-75 243
LLPS-Meg-2188Meleagris gallopavo76.323e-72 229
LLPS-Aon-0495Aotus nancymaae76.251e-74 244
LLPS-Paa-1047Papio anubis75.628e-75 244
LLPS-Ict-4248Ictidomys tridecemlineatus75.621e-75 242
LLPS-Xim-0189Xiphophorus maculatus75.152e-75 241
LLPS-Caj-4700Callithrix jacchus74.852e-74 241
LLPS-Gog-1010Gorilla gorilla74.852e-74 242
LLPS-Cea-3733Cercocebus atys74.852e-74 242
LLPS-Sus-1349Sus scrofa74.852e-74 241
LLPS-Chs-1933Chlorocebus sabaeus74.853e-74 241
LLPS-Mea-2852Mesocricetus auratus74.852e-74 242
LLPS-Mum-3085Mus musculus74.852e-74 241
LLPS-Maf-3814Macaca fascicularis74.852e-74 242
LLPS-Myl-4029Myotis lucifugus74.852e-74 242
LLPS-Mal-3123Mandrillus leucophaeus74.852e-74 242
LLPS-Ran-4276Rattus norvegicus74.852e-74 241
LLPS-Bot-2191Bos taurus74.851e-74 242
LLPS-Dio-0658Dipodomys ordii74.852e-74 241
LLPS-Rhb-3349Rhinopithecus bieti74.852e-74 242
LLPS-Orc-3066Oryctolagus cuniculus74.852e-74 242
LLPS-Man-4255Macaca nemestrina74.851e-74 242
LLPS-Fec-2668Felis catus74.852e-74 241
LLPS-Pap-2678Pan paniscus74.852e-74 242
LLPS-Pat-2441Pan troglodytes74.852e-74 242
LLPS-Hos-3916Homo sapiens74.852e-74 242
LLPS-Cas-0395Carlito syrichta74.851e-74 242
LLPS-Mam-3915Macaca mulatta74.852e-74 242
LLPS-Eqc-4384Equus caballus74.852e-74 241
LLPS-Caf-3514Canis familiaris74.853e-74 241
LLPS-Fud-2945Fukomys damarensis74.73e-76 242
LLPS-Loa-2040Loxodonta africana74.252e-76 242
LLPS-Cap-0445Cavia porcellus73.532e-76 245
LLPS-Poa-3012Pongo abelii73.535e-76 242
LLPS-Icp-1781Ictalurus punctatus73.411e-75 244
LLPS-Pof-2422Poecilia formosa71.029e-75 243
LLPS-Anp-3232Anas platyrhynchos70.866e-75 238
LLPS-Ora-3467Ornithorhynchus anatinus70.621e-74 239
LLPS-Scm-2665Scophthalmus maximus69.682e-76 248
LLPS-Dar-1912Danio rerio69.684e-77 249
LLPS-Gaa-3512Gasterosteus aculeatus69.156e-76 246
LLPS-Tar-3021Takifugu rubripes69.151e-75 245
LLPS-Ten-2978Tetraodon nigroviridis69.152e-75 244
LLPS-Xet-3566Xenopus tropicalis68.823e-76 244
LLPS-Orl-2035Oryzias latipes68.622e-75 245
LLPS-Orn-0283Oreochromis niloticus68.093e-74 242
LLPS-Otg-4090Otolemur garnettii67.384e-74 243
LLPS-Lac-2327Latimeria chalumnae66.55e-77 249
LLPS-Tag-1155Taeniopygia guttata66.011e-60 207
LLPS-Drm-1068Drosophila melanogaster63.928e-58 207
LLPS-Leo-0695Lepisosteus oculatus63.648e-57 203
LLPS-Fia-3249Ficedula albicollis63.294e-57 197
LLPS-Nol-3119Nomascus leucogenys61.842e-55 199
LLPS-Tut-1081Tursiops truncatus59.595e-51 179