LLPS-Cae-0242
cdk-1

▼ OVERVIEW

Status: Reviewed
Protein Name: Cyclin-dependent kinase 1
Gene Name: cdk-1, ncc-1, T05G5.3
Ensembl Gene: WBGene00000405
Ensembl Protein: T05G5.3.1
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A17419992
Pericentriolar matrix
"...This cross-cell activity did not occur when embryos were treated with a cyclin-dependent kinase inhibitor, suggesting that Cdk1 phosphorylation of SPD-2 helps initiate mitotic PCM assembly."
Caenorhabditis elegans29751016
P granule
"...Here we report on a genomewide RNAi screen in C. elegans, which identified 173 genes that affect the stability, localization, and function of P granules."
Caenorhabditis elegans19805813
Nucleolus, P-body, Stress granule, OthersPredicted from orthologsN/A(View)

▼ FUNCTION

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDPIREGEVA  HEGDSVYTLN  DFTKLEKIGE  GTYGVVYKGK  NRRTNAMVAM  KKIRLESEDE  60
61    GVPSTAVREI  SLLKELQHPN  VVGLEAVIMQ  ENRLFLIFEF  LSFDLKRYMD  QLGKDEYLPL  120
121   ETLKSYTFQI  LQAMCFCHQR  RVIHRDLKPQ  NLLVDNNGAI  KLADFGLARA  IGIPIRVYTH  180
181   EVVTLWYRAP  EILMGAQRYS  MGVDMWSIGC  IFAEMATKKP  LFQGDSEIDE  LFRIFRVLGT  240
241   PTELEWNGVE  SLPDYKATFP  KWRENFLRDK  FYDKKTGKHL  LDDTAFSLLE  GLLIYDPSLR  300
301   LNAKKALVHP  YFDNMDTSKL  PAGNYRGELE  LF  332
Nucleotide CDS Sequence (FASTA)
1     ATGGATCCTA  TTCGCGAAGG  AGAAGTGGCC  CACGAGGGAG  ATTCGGTTTA  CACACTCAAC  60
61    GATTTCACGA  AGCTCGAAAA  AATCGGCGAA  GGAACATACG  GAGTCGTCTA  CAAAGGCAAA  120
121   AACAGAAGAA  CCAATGCCAT  GGTTGCTATG  AAGAAAATCA  GATTGGAAAG  TGAAGATGAG  180
181   GGTGTTCCAT  CAACGGCTGT  GCGAGAGATC  AGCTTGCTCA  AAGAGCTCCA  GCATCCGAAT  240
241   GTTGTTGGAT  TGGAAGCGGT  CATTATGCAG  GAGAACCGGC  TTTTCCTGAT  CTTCGAATTC  300
301   CTGTCTTTCG  ACTTGAAACG  ATACATGGAT  CAGTTGGGAA  AAGATGAATA  CCTTCCGCTC  360
361   GAAACTCTTA  AAAGTTACAC  ATTCCAAATT  CTTCAAGCTA  TGTGTTTTTG  TCATCAGCGT  420
421   CGTGTTATTC  ATCGCGATCT  TAAGCCACAG  AACTTGCTGG  TCGACAACAA  TGGAGCAATC  480
481   AAGCTTGCCG  ATTTCGGACT  TGCCAGAGCT  ATTGGTATCC  CGATTCGCGT  TTACACGCAT  540
541   GAAGTTGTCA  CTCTCTGGTA  TAGAGCTCCA  GAAATTCTGA  TGGGTGCTCA  GAGATACTCG  600
601   ATGGGCGTAG  ACATGTGGTC  GATTGGATGC  ATTTTTGCTG  AAATGGCCAC  GAAGAAGCCA  660
661   CTGTTTCAAG  GAGATTCAGA  AATTGATGAG  CTGTTCCGCA  TCTTCAGAGT  TCTCGGCACA  720
721   CCGACTGAGT  TGGAATGGAA  TGGTGTTGAA  TCACTTCCGG  ACTACAAGGC  GACGTTCCCA  780
781   AAATGGCGTG  AGAATTTCCT  CCGTGACAAG  TTCTACGACA  AGAAGACTGG  AAAGCACCTT  840
841   TTGGACGATA  CTGCATTCTC  TCTTCTTGAA  GGTTTGCTGA  TCTACGATCC  ATCACTTCGT  900
901   CTCAACGCGA  AAAAAGCTCT  CGTTCATCCT  TATTTTGACA  ACATGGATAC  GTCAAAGCTG  960
961   CCAGCTGGAA  ATTACCGAGG  AGAACTCGAA  CTCTTTTGA  999

▼ KEYWORD

ID
Family
ATP-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Mitosis
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule organizing center
Cellular Component
Mitotic spindle
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
Cyclin-dependent protein serine/threonine kinase activity
Molecular Function
Protein kinase binding
Molecular Function
RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process
Anterior/posterior axis specification, embryo
Biological Process
Cell division
Biological Process
Meiotic cell cycle
Biological Process
Mitotic cell cycle
Biological Process
Mitotic cell cycle phase transition
Biological Process
Oocyte maturation
Biological Process
Positive regulation of meiotic cell cycle
Biological Process
Positive regulation of meiotic nuclear division
Biological Process
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process
Positive regulation of protein serine/threonine kinase activity
Biological Process
Protein phosphorylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scm-0766Scophthalmus maximus70.615e-126 372
LLPS-Aim-0842Ailuropoda melanoleuca69.881e-129 378
LLPS-Eqc-0411Equus caballus69.61e-127 378
LLPS-Chs-0216Chlorocebus sabaeus68.81e-121 360
LLPS-Nol-3638Nomascus leucogenys67.732e-121 357
LLPS-Lac-0284Latimeria chalumnae66.671e-146 423
LLPS-Leo-0993Lepisosteus oculatus66.562e-149 430
LLPS-Scf-0321Scleropages formosus65.583e-147 424
LLPS-Gaga-0495Gallus gallus65.367e-145 418
LLPS-Dar-0376Danio rerio65.269e-148 426
LLPS-Meg-0644Meleagris gallopavo65.032e-144 417
LLPS-Anp-0879Anas platyrhynchos64.853e-138 402
LLPS-Tag-2116Taeniopygia guttata64.594e-144 416
LLPS-Fia-2390Ficedula albicollis64.594e-144 416
LLPS-Poa-1624Pongo abelii64.557e-142 410
LLPS-Hos-0453Homo sapiens64.554e-142 411
LLPS-Pap-0707Pan paniscus64.554e-142 411
LLPS-Pat-2576Pan troglodytes64.554e-142 411
LLPS-Man-1604Macaca nemestrina64.555e-142 411
LLPS-Rhb-2519Rhinopithecus bieti64.555e-142 411
LLPS-Maf-3122Macaca fascicularis64.555e-142 411
LLPS-Gog-0682Gorilla gorilla64.554e-142 411
LLPS-Anc-2597Anolis carolinensis64.473e-143 414
LLPS-Pes-0323Pelodiscus sinensis64.292e-145 420
LLPS-Mam-0058Macaca mulatta64.219e-142 410
LLPS-Ict-1784Ictidomys tridecemlineatus64.217e-142 410
LLPS-Drm-0505Drosophila melanogaster64.211e-141 410
LLPS-Bot-0207Bos taurus64.212e-142 412
LLPS-Ran-2054Rattus norvegicus64.219e-142 410
LLPS-Paa-0464Papio anubis64.219e-142 410
LLPS-Mal-0285Mandrillus leucophaeus64.215e-141 408
LLPS-Ova-0109Ovis aries64.212e-142 412
LLPS-Mum-1043Mus musculus64.217e-141 408
LLPS-Mea-0012Mesocricetus auratus64.219e-142 410
LLPS-Sah-0732Sarcophilus harrisii64.217e-142 410
LLPS-Cea-1211Cercocebus atys64.212e-141 409
LLPS-Asm-1146Astyanax mexicanus64.082e-145 420
LLPS-Orn-2650Oreochromis niloticus64.053e-143 414
LLPS-Cis-0096Ciona savignyi64.032e-146 422
LLPS-Caf-2162Canis familiaris63.883e-141 409
LLPS-Urm-0940Ursus maritimus63.883e-141 409
LLPS-Fec-2414Felis catus63.882e-141 409
LLPS-Loa-1302Loxodonta africana63.883e-141 409
LLPS-Otg-0211Otolemur garnettii63.883e-141 409
LLPS-Orc-1235Oryctolagus cuniculus63.882e-141 409
LLPS-Mup-1459Mustela putorius furo63.883e-141 409
LLPS-Sus-0304Sus scrofa63.883e-141 409
LLPS-Aon-0661Aotus nancymaae63.884e-141 409
LLPS-Fud-1893Fukomys damarensis63.882e-141 410
LLPS-Xim-1564Xiphophorus maculatus63.846e-143 414
LLPS-Orl-2492Oryzias latipes63.751e-144 418
LLPS-Icp-0488Ictalurus punctatus63.751e-144 418
LLPS-Ere-0583Erinaceus europaeus63.641e-133 389
LLPS-Gaa-0118Gasterosteus aculeatus63.619e-141 408
LLPS-Dio-0069Dipodomys ordii63.552e-140 407
LLPS-Pof-1787Poecilia formosa63.372e-138 402
LLPS-Tar-0832Takifugu rubripes63.281e-140 407
LLPS-Caj-2958Callithrix jacchus63.181e-129 379
LLPS-Tut-1473Tursiops truncatus63.047e-139 403
LLPS-Cas-1601Carlito syrichta63.09e-132 385
LLPS-Ora-0208Ornithorhynchus anatinus62.992e-142 412
LLPS-Mod-0420Monodelphis domestica62.955e-139 403
LLPS-Myl-1203Myotis lucifugus62.881e-137 399
LLPS-Ten-1895Tetraodon nigroviridis62.091e-140 408
LLPS-Mua-1497Musa acuminata59.264e-121 358
LLPS-Org-0504Oryza glaberrima58.782e-122 362
LLPS-Hov-1882Hordeum vulgare58.781e-122 363
LLPS-Orb-1944Oryza barthii58.783e-121 361
LLPS-Ori-1837Oryza indica58.782e-122 362
LLPS-Orm-1746Oryza meridionalis58.677e-76 248
LLPS-Brn-3426Brassica napus58.313e-123 363
LLPS-Xet-1264Xenopus tropicalis58.253e-125 368
LLPS-Orp-0469Oryza punctata58.193e-123 363
LLPS-Tra-1111Triticum aestivum58.191e-123 364
LLPS-Yal-0965Yarrowia lipolytica58.195e-122 361
LLPS-Orni-0155Oryza nivara58.193e-122 363
LLPS-Sob-1321Sorghum bicolor58.142e-122 361
LLPS-Amt-0328Amborella trichopoda58.111e-121 359
LLPS-Viv-1581Vitis vinifera58.051e-120 356
LLPS-Put-0617Puccinia triticina57.955e-120 354
LLPS-Zem-0612Zea mays57.861e-121 358
LLPS-Brd-1580Brachypodium distachyon57.865e-123 362
LLPS-Orbr-1308Oryza brachyantha57.815e-124 365
LLPS-Phv-0361Phaseolus vulgaris57.812e-121 358
LLPS-Nia-0305Nicotiana attenuata57.811e-121 358
LLPS-Via-0688Vigna angularis57.812e-121 358
LLPS-Lep-0298Leersia perrieri57.815e-124 367
LLPS-Glm-1422Glycine max57.817e-122 359
LLPS-Bro-1778Brassica oleracea57.729e-124 364
LLPS-Mae-1428Manihot esculenta57.721e-120 356
LLPS-Chc-0450Chondrus crispus57.632e-120 356
LLPS-Orr-1831Oryza rufipogon57.624e-122 364
LLPS-Orgl-2340Oryza glumaepatula57.626e-122 360
LLPS-Art-0331Arabidopsis thaliana57.481e-123 364
LLPS-Gor-0809Gossypium raimondii57.487e-122 360
LLPS-Cus-1035Cucumis sativus57.384e-120 355
LLPS-Brr-2134Brassica rapa57.283e-124 365
LLPS-Ors-0422Oryza sativa57.141e-122 365
LLPS-Sot-0720Solanum tuberosum57.143e-119 353
LLPS-Sei-0824Setaria italica57.141e-121 358
LLPS-Php-1424Physcomitrella patens57.143e-119 353
LLPS-Dac-0017Daucus carota57.142e-118 351
LLPS-Thc-0590Theobroma cacao57.15e-121 358
LLPS-Prp-0601Prunus persica57.053e-121 358
LLPS-Gas-0038Galdieria sulphuraria56.836e-124 365
LLPS-Sol-0268Solanum lycopersicum56.814e-118 350
LLPS-Kop-0335Komagataella pastoris56.771e-120 357
LLPS-Arl-1464Arabidopsis lyrata56.723e-123 363
LLPS-Mel-0498Melampsora laricipopulina56.711e-127 374
LLPS-Cym-0620Cyanidioschyzon merolae56.611e-119 355
LLPS-Met-2222Medicago truncatula56.489e-120 354
LLPS-Zyt-0548Zymoseptoria tritici56.152e-126 372
LLPS-Hea-1239Helianthus annuus56.154e-119 352
LLPS-Usm-0052Ustilago maydis56.071e-124 366
LLPS-Crn-0512Cryptococcus neoformans55.633e-123 363
LLPS-Miv-0332Microbotryum violaceum55.523e-122 360
LLPS-Fuv-1095Fusarium verticillioides55.521e-121 360
LLPS-Spr-1157Sporisorium reilianum55.459e-124 364
LLPS-Nec-0542Neurospora crassa55.294e-121 359
LLPS-Beb-0183Beauveria bassiana55.025e-123 363
LLPS-Trr-0092Trichoderma reesei54.752e-118 352
LLPS-Trv-0927Trichoderma virens54.432e-118 352
LLPS-Fus-0197Fusarium solani53.379e-121 358
LLPS-Dos-0968Dothistroma septosporum53.033e-120 357
LLPS-Cap-1973Cavia porcellus52.566e-120 357