DrLLPS - Data resource of LLPS

LLPS-Cae-0180
cyb-3

▼ OVERVIEW


Status:	Reviewed
Protein Name:	G2/mitotic-specific cyclin-B3
Gene Name:	cyb-3, cyb-2, T06E6.2
Ensembl Gene:	WBGene00000868
Ensembl Protein:	T06E6.2b
Organism:	Caenorhabditis elegans
Taxa ID:	6239
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
P granule	"...Here we report on a genomewide RNAi screen in C. elegans, which identified 173 genes that affect the stability, localization, and function of P granules."	Caenorhabditis elegans	19805813

▼ FUNCTION

Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II (PubMed:20599902).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	T06E6.2b	T06E6.2b
Ensembl	T06E6.2a.2	T06E6.2a.2
Ensembl	T06E6.2a.1	T06E6.2a.1
UniProt		Q10654, CCNB3_CAEEL, Q95ZP8, Q9U378
GeneBank	Z81117, U21282	CAC42336.2, AAA84395.1, CAB03311.2
RefSeq	NM_001028941.3, NM_074424.6	NP_001024112.2, NP_506825.4
Entrez	180040

▼ SEQUENCE

Protein Sequence (FASTA)
1 MMLRSQAKNV DLTSQADSRH QQKRKQAEQL DALKNPSEPA AKKQHSKGLT ELRAHISGFK 60 61 IDSAKRDPLG KSRTSRRDVE NLPPQKSRYV DPCPHYDYDL EEAGNPDSIS DYAQGIFDYY 120 121 RHREVHFRVR KYLHKHPEVD VKTRAILIDW MVEIQETFEL NHETLYNAVK LTDMYLCKTK 180 181 NVDKNTIQKL ACVAIFIAAK YDERSPPLVD DLIYLSGDRF SRDELLAMER ELFATVGYDL 240 241 GSPLSYRYLR RFGRVCRVDM KTLTMGRFIL ETSLMVYEYA MVSQSRLAAA AFVLAMRMLD 300 301 KNNEYEWNPV LEKYSGFTGE EVMPLVEHMN HILHFSKDKW AQLTSVRQKY SHEVFFHVAS 360 361 IPMLPDTLKV VDSHTYAPVP MLSYP 385
Nucleotide CDS Sequence (FASTA)
1 ATGATGCTGC GAAGCCAGGC CAAGAATGTC GACCTGACTT CACAAGCAGA TTCTCGGCAT 60 61 CAACAAAAAC GAAAGCAGGC TGAGCAATTG GATGCTCTAA AGAATCCATC GGAACCGGCA 120 121 GCCAAGAAGC AACACAGCAA GGGTCTCACC GAGCTCCGCG CACACATCTC TGGATTTAAA 180 181 ATCGACTCGG CAAAGCGAGA TCCACTGGGA AAGTCGAGAA CGAGTAGACG AGACGTCGAG 240 241 AACCTTCCAC CGCAAAAGTC CAGATATGTT GATCCGTGTC CTCATTACGA TTACGACCTC 300 301 GAGGAGGCCG GAAACCCGGA CAGTATCTCG GACTATGCTC AAGGGATTTT TGACTACTAC 360 361 AGACACCGAG AAGTTCACTT TCGAGTGAGA AAGTACCTTC ACAAACATCC GGAGGTTGAC 420 421 GTCAAGACTC GTGCTATCCT CATTGACTGG ATGGTTGAGA TTCAGGAGAC ATTTGAGCTC 480 481 AACCACGAGA CCCTTTACAA CGCCGTTAAG CTCACGGATA TGTACTTGTG CAAGACGAAG 540 541 AATGTTGACA AAAACACCAT TCAGAAGCTT GCATGTGTCG CCATCTTCAT TGCCGCCAAG 600 601 TACGATGAGC GATCTCCACC ACTCGTCGAT GATCTCATCT ACCTTTCCGG AGATCGCTTC 660 661 TCCCGCGATG AGCTTCTTGC CATGGAGCGT GAACTCTTCG CCACCGTCGG ATATGATCTC 720 721 GGCTCACCAC TGAGCTATCG GTATCTTCGC CGCTTCGGTC GTGTCTGTCG TGTCGATATG 780 781 AAGACACTCA CCATGGGACG CTTCATTCTG GAGACATCAC TGATGGTCTA CGAATACGCT 840 841 ATGGTCTCAC AATCCCGTCT TGCCGCCGCC GCTTTCGTCT TGGCCATGCG TATGCTCGAC 900 901 AAGAATAATG AGTACGAGTG GAATCCAGTG CTCGAGAAGT ATTCTGGATT CACTGGAGAG 960 961 GAGGTGATGC CACTGGTGGA GCACATGAAC CACATTCTTC ATTTTTCGAA GGACAAGTGG 1020 1021 GCTCAACTCA CATCCGTTCG CCAGAAGTAT TCTCATGAAG TATTCTTCCA TGTCGCCTCG 1080 1081 ATCCCAATGC TCCCGGATAC CCTCAAGGTT GTGGATTCCC ACACATATGC TCCAGTCCCA 1140 1141 ATGCTCTCAT ACCCATAA 1158

▼ KEYWORD

ID	Family
KW-0025	Alternative splicing
KW-0131	Cell cycle
KW-0132	Cell division
KW-0181	Complete proteome
KW-0195	Cyclin
KW-0469	Meiosis
KW-0498	Mitosis
KW-0539	Nucleus
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005813	Cellular Component	Centrosome
GO:0000307	Cellular Component	Cyclin-dependent protein kinase holoenzyme complex
GO:0005737	Cellular Component	Cytoplasm
GO:0005634	Cellular Component	Nucleus
GO:0016538	Molecular Function	Cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	Molecular Function	Protein kinase binding
GO:0051301	Biological Process	Cell division
GO:0007098	Biological Process	Centrosome cycle
GO:0051383	Biological Process	Kinetochore organization
GO:0051321	Biological Process	Meiotic cell cycle
GO:0045144	Biological Process	Meiotic sister chromatid segregation
GO:0000278	Biological Process	Mitotic cell cycle
GO:0000070	Biological Process	Mitotic sister chromatid segregation
GO:0001556	Biological Process	Oocyte maturation
GO:0045787	Biological Process	Positive regulation of cell cycle
GO:0008284	Biological Process	Positive regulation of cell population proliferation
GO:0045842	Biological Process	Positive regulation of mitotic metaphase/anaphase transition
GO:0001934	Biological Process	Positive regulation of protein phosphorylation
GO:0035046	Biological Process	Pronuclear migration
GO:0006468	Biological Process	Protein phosphorylation
GO:0000079	Biological Process	Regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0010389	Biological Process	Regulation of G2/M transition of mitotic cell cycle
GO:0051445	Biological Process	Regulation of meiotic cell cycle
GO:0007088	Biological Process	Regulation of mitotic nuclear division

▼ KEGG

cel:CELE_T06E6.2

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	CDD	Gene3D

Interaction
HINT	Mentha	PINA	IID	iRefIndex
MIST

Drug
CTD

Physicochemical
AAindex

Element
circBase	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Fia-0531	Ficedula albicollis	44.29	6e-70	232
LLPS-Otg-2518	Otolemur garnettii	44.27	5e-61	218
LLPS-Sus-2651	Sus scrofa	43.77	7e-64	227
LLPS-Poa-2723	Pongo abelii	43.59	4e-55	202
LLPS-Ova-2768	Ovis aries	43.59	8e-65	229
LLPS-Cap-2088	Cavia porcellus	43.53	1e-52	194
LLPS-Sah-0111	Sarcophilus harrisii	43.3	1e-68	229
LLPS-Mod-3348	Monodelphis domestica	43.22	2e-70	233
LLPS-Eqc-2777	Equus caballus	43.22	3e-62	222
LLPS-Gaga-2819	Gallus gallus	42.91	1e-68	228
LLPS-Bot-1852	Bos taurus	42.91	6e-63	224
LLPS-Nol-4416	Nomascus leucogenys	42.71	9e-57	206
LLPS-Meg-2492	Meleagris gallopavo	42.54	1e-68	227
LLPS-Rhb-2383	Rhinopithecus bieti	42.52	5e-44	158
LLPS-Ora-1465	Ornithorhynchus anatinus	42.32	2e-62	209
LLPS-Urm-1242	Ursus maritimus	42.28	7e-58	209
LLPS-Fec-0455	Felis catus	42.27	3e-48	171
LLPS-Caj-4117	Callithrix jacchus	42.27	3e-42	155
LLPS-Cea-3949	Cercocebus atys	42.24	5e-57	207
LLPS-Mal-1935	Mandrillus leucophaeus	42.24	5e-57	207
LLPS-Mup-2381	Mustela putorius furo	42.22	2e-61	219
LLPS-Drm-0872	Drosophila melanogaster	42.21	2e-70	238
LLPS-Man-2784	Macaca nemestrina	41.88	1e-55	203
LLPS-Mam-3544	Macaca mulatta	41.88	1e-55	203
LLPS-Maf-4829	Macaca fascicularis	41.88	1e-55	203
LLPS-Paa-4489	Papio anubis	41.88	5e-56	204
LLPS-Aim-2031	Ailuropoda melanoleuca	41.85	3e-62	222
LLPS-Tut-1695	Tursiops truncatus	41.64	2e-57	208
LLPS-Ran-4643	Rattus norvegicus	41.57	8e-55	201
LLPS-Caf-2188	Canis familiaris	41.37	2e-60	217
LLPS-Fud-3607	Fukomys damarensis	41.33	9e-47	177
LLPS-Pat-3433	Pan troglodytes	41.29	3e-56	205
LLPS-Pap-3615	Pan paniscus	41.29	3e-56	205
LLPS-Hos-3221	Homo sapiens	41.29	6e-56	204
LLPS-Xet-1765	Xenopus tropicalis	41.16	3e-69	230
LLPS-Chs-3806	Chlorocebus sabaeus	41.16	1e-53	197
LLPS-Gog-1393	Gorilla gorilla	40.97	2e-55	202
LLPS-Leo-3692	Lepisosteus oculatus	40.91	3e-66	222
LLPS-Pof-3569	Poecilia formosa	40.88	8e-65	219
LLPS-Mea-1836	Mesocricetus auratus	40.22	1e-47	180
LLPS-Orl-2586	Oryzias latipes	39.78	1e-65	221
LLPS-Xim-1626	Xiphophorus maculatus	39.78	2e-63	215
LLPS-Cas-4038	Carlito syrichta	39.56	5e-63	223
LLPS-Mum-3985	Mus musculus	39.53	2e-54	199
LLPS-Dar-0120	Danio rerio	39.48	2e-67	225
LLPS-Cii-1548	Ciona intestinalis	39.26	2e-62	212
LLPS-Tar-0267	Takifugu rubripes	38.79	2e-65	221
LLPS-Orn-0660	Oreochromis niloticus	38.52	2e-62	213
LLPS-Scm-2355	Scophthalmus maximus	38.52	3e-62	212
LLPS-Lac-1972	Latimeria chalumnae	38.41	5e-63	214
LLPS-Cis-0523	Ciona savignyi	37.8	2e-60	208
LLPS-Asm-3615	Astyanax mexicanus	37.78	2e-64	218
LLPS-Ten-1221	Tetraodon nigroviridis	37.5	2e-64	217
LLPS-Icp-4121	Ictalurus punctatus	37.46	4e-65	220
LLPS-Scf-0075	Scleropages formosus	36.87	3e-64	217
LLPS-Trr-0338	Trichoderma reesei	36.21	2e-39	151
LLPS-Trv-0552	Trichoderma virens	36.21	1e-38	149
LLPS-Myl-3140	Myotis lucifugus	36.02	4e-44	162
LLPS-Anc-0245	Anolis carolinensis	35.39	5e-60	206
LLPS-Fuo-0817	Fusarium oxysporum	35.04	1e-37	146
LLPS-Fus-0727	Fusarium solani	34.68	2e-37	146
LLPS-Chr-0822	Chlamydomonas reinhardtii	34.52	2e-42	159
LLPS-Bro-2598	Brassica oleracea	34.23	7e-41	154
LLPS-Brn-2571	Brassica napus	34.23	7e-41	154
LLPS-Fuv-1036	Fusarium verticillioides	34.1	6e-38	147
LLPS-Zyt-1384	Zymoseptoria tritici	34.04	5e-38	147
LLPS-Sot-0266	Solanum tuberosum	33.83	3e-35	137
LLPS-Beb-1524	Beauveria bassiana	33.78	9e-36	140
LLPS-Phn-1108	Phaeosphaeria nodorum	33.76	1e-36	143
LLPS-Nia-0165	Nicotiana attenuata	33.7	3e-37	145
LLPS-Orbr-0565	Oryza brachyantha	33.59	1e-34	135
LLPS-Orp-2175	Oryza punctata	33.59	2e-34	137
LLPS-Lep-1123	Leersia perrieri	33.59	2e-34	136
LLPS-Viv-1715	Vitis vinifera	33.58	3e-35	139
LLPS-Dos-0220	Dothistroma septosporum	33.47	4e-37	145
LLPS-Brr-0996	Brassica rapa	33.33	2e-39	150
LLPS-Art-3083	Arabidopsis thaliana	33.21	1e-38	147
LLPS-Brd-1468	Brachypodium distachyon	33.2	2e-34	136
LLPS-Hea-1171	Helianthus annuus	33.09	1e-38	148
LLPS-Vir-1549	Vigna radiata	32.83	8e-37	143
LLPS-Mao-0202	Magnaporthe oryzae	32.64	4e-34	136
LLPS-Thc-1957	Theobroma cacao	32.58	4e-36	142
LLPS-Nec-0999	Neurospora crassa	32.54	3e-35	140
LLPS-Cog-0401	Colletotrichum gloeosporioides	32.48	1e-34	138
LLPS-Pytr-0074	Pyrenophora triticirepentis	32.48	6e-35	139
LLPS-Tra-2022	Triticum aestivum	32.48	4e-37	144
LLPS-Osl-0675	Ostreococcus lucimarinus	32.46	2e-37	143
LLPS-Phv-1727	Phaseolus vulgaris	32.45	3e-36	142
LLPS-Coo-0701	Colletotrichum orbiculare	32.42	4e-38	148
LLPS-Sol-2332	Solanum lycopersicum	32.37	1e-37	143
LLPS-Arl-0509	Arabidopsis lyrata	32.37	8e-38	144
LLPS-Orm-1896	Oryza meridionalis	32.3	2e-35	139
LLPS-Asc-0532	Aspergillus clavatus	32.26	1e-33	135
LLPS-Gor-1651	Gossypium raimondii	32.21	1e-35	140
LLPS-Cus-0539	Cucumis sativus	32.21	1e-34	137
LLPS-Blg-0875	Blumeria graminis	32.17	9e-34	135
LLPS-Tag-0034	Taeniopygia guttata	31.94	4e-37	143
LLPS-Sem-0797	Selaginella moellendorffii	31.87	4e-36	140
LLPS-Nef-0310	Neosartorya fischeri	31.85	8e-34	135
LLPS-Asfu-1378	Aspergillus fumigatus	31.85	3e-33	134
LLPS-Mua-0955	Musa acuminata	31.85	4e-34	135
LLPS-Pot-2524	Populus trichocarpa	31.82	5e-35	139
LLPS-Asn-0565	Aspergillus nidulans	31.8	8e-35	138
LLPS-Map-0319	Magnaporthe poae	31.73	2e-36	143
LLPS-Asni-0733	Aspergillus niger	31.73	1e-33	135
LLPS-Sac-1568	Saccharomyces cerevisiae	31.62	1e-34	137
LLPS-Zem-2352	Zea mays	31.46	3e-35	139
LLPS-Coc-1745	Corchorus capsularis	31.46	8e-34	139
LLPS-Ors-0296	Oryza sativa	31.45	1e-35	140
LLPS-Org-0293	Oryza glaberrima	31.45	1e-35	140
LLPS-Orr-0573	Oryza rufipogon	31.45	6e-36	140
LLPS-Orni-0501	Oryza nivara	31.45	8e-36	140
LLPS-Orb-0000	Oryza barthii	31.45	1e-35	140
LLPS-Ori-0663	Oryza indica	31.45	8e-36	140
LLPS-Orgl-0342	Oryza glumaepatula	31.45	1e-35	140
LLPS-Glm-0955	Glycine max	31.44	6e-35	138
LLPS-Pes-1426	Pelodiscus sinensis	31.23	3e-42	158
LLPS-Cogr-1255	Colletotrichum graminicola	31.13	2e-34	137
LLPS-Gag-0555	Gaeumannomyces graminis	31.1	3e-36	142
LLPS-Sei-0103	Setaria italica	31.09	5e-35	138
LLPS-Sob-0032	Sorghum bicolor	30.97	4e-34	135
LLPS-Mae-0305	Manihot esculenta	30.88	1e-34	136
LLPS-Via-2105	Vigna angularis	30.88	2e-34	137
LLPS-Dac-2255	Daucus carota	30.86	1e-33	134
LLPS-Pyt-0507	Pyrenophora teres	30.86	2e-35	140
LLPS-Loa-1010	Loxodonta africana	30.71	4e-33	132
LLPS-Met-0597	Medicago truncatula	30.22	8e-34	135
LLPS-Lem-0369	Leptosphaeria maculans	30.11	3e-34	137
LLPS-Php-0262	Physcomitrella patens	30.09	1e-36	144
LLPS-Orc-0895	Oryctolagus cuniculus	30.04	3e-42	158
LLPS-Ict-2364	Ictidomys tridecemlineatus	29.92	1e-33	134
LLPS-Aon-2423	Aotus nancymaae	29.92	3e-34	136
LLPS-Gaa-0574	Gasterosteus aculeatus	29.85	5e-38	146
LLPS-Anp-0588	Anas platyrhynchos	29.48	6e-41	154
LLPS-Gas-1184	Galdieria sulphuraria	28.62	2e-34	136

LLPS-Cae-0180cyb-3

Protein Sequence

Nucleotide Sequence

LLPS-Cae-0180
cyb-3