LLPS-Cae-0015
rpn-11

▼ OVERVIEW

Status: Reviewed
Protein Name: 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11
Gene Name: rpn-11, K07D4.3
Ensembl Gene: WBGene00004467
Ensembl Protein: K07D4.3
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P granule
"...Here we report on a genomewide RNAi screen in C. elegans, which identified 173 genes that affect the stability, localization, and function of P granules."
Caenorhabditis elegans19805813
Nucleolus, Postsynaptic density, OthersPredicted from orthologsN/A(View)

▼ FUNCTION

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblK07D4.3K07D4.3
UniProtO76577, PSDE_CAEEL
GeneBankFO081599CCD72745.1
RefSeqNM_062311.5NP_494712.1
Entrez173744

▼ SEQUENCE

Protein Sequence (FASTA)
1     MERFLRLGGL  GGNLGTFGAN  PQDSNQVDTS  ETVYISSLAL  LKMLKHGRAG  VPMEVMGLML  60
61    GEFVDDYTVN  VIDVFAMPQS  GTGVSVEAVD  PVFQAKMLDM  LKQTGRPEMV  VGWYHSHPGF  120
121   GCWLSGVDIN  TQQSFEALSD  RAVAVVVDPI  QSVKGKVVID  AFRTINPQSM  ALNQEPRQTT  180
181   SNLGHLQKPS  IQALIHGLNR  HYYSIPIAYR  THDLEQKMLL  NLNKLSWMDA  VSVENYSKCG  240
241   EQNKEHLKAM  LKLAKNYKKA  LEDEKNMTDQ  ELAIKNVGKM  DPKRHIADEV  SKMLNDNIVQ  300
301   SLAGMMATTS  LQ  312
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCGAT  TCCTGCGACT  CGGAGGTCTT  GGTGGAAACC  TTGGAACGTT  CGGAGCCAAT  60
61    CCACAGGACT  CGAATCAAGT  CGACACCTCG  GAAACCGTCT  ACATTTCTTC  GCTGGCGTTG  120
121   CTGAAGATGC  TCAAACACGG  AAGAGCCGGA  GTTCCCATGG  AAGTGATGGG  GCTGATGCTT  180
181   GGAGAATTCG  TCGACGACTA  CACCGTCAAT  GTGATCGACG  TTTTCGCTAT  GCCACAGTCT  240
241   GGAACCGGAG  TCTCAGTCGA  AGCGGTCGAT  CCAGTATTCC  AGGCGAAGAT  GCTCGACATG  300
301   CTCAAACAGA  CCGGAAGACC  CGAGATGGTC  GTCGGATGGT  ACCATTCCCA  TCCAGGATTC  360
361   GGATGTTGGC  TCTCCGGCGT  CGACATCAAC  ACTCAGCAGT  CGTTTGAAGC  GCTTTCCGAC  420
421   AGAGCTGTCG  CCGTTGTCGT  CGACCCGATT  CAATCTGTGA  AGGGAAAGGT  TGTGATCGAC  480
481   GCGTTCCGTA  CGATCAACCC  ACAATCGATG  GCTTTAAATC  AAGAACCACG  TCAAACTACC  540
541   AGTAATTTGG  GTCATTTGCA  GAAGCCGAGC  ATTCAGGCCC  TAATCCACGG  ACTCAATCGT  600
601   CACTACTACT  CCATCCCAAT  CGCCTACAGA  ACCCACGACC  TTGAACAGAA  GATGCTCTTG  660
661   AATCTTAACA  AGCTCTCATG  GATGGACGCA  GTCAGCGTCG  AAAACTACTC  AAAATGCGGT  720
721   GAACAGAACA  AGGAGCACCT  CAAGGCGATG  CTCAAGCTCG  CCAAGAACTA  CAAGAAGGCG  780
781   TTGGAGGACG  AGAAGAACAT  GACGGATCAG  GAGCTCGCGA  TCAAGAACGT  CGGAAAGATG  840
841   GATCCGAAGC  GGCATATTGC  TGATGAAGTG  AGCAAGATGC  TCAACGACAA  TATTGTGCAA  900
901   AGTTTGGCCG  GTATGATGGC  GACGACTTCA  TTGCAATAA  939

▼ KEYWORD

ID
Family
Complete proteome
Hydrolase
Metal-binding
Metalloprotease
Protease
Proteasome
Reference proteome
Ubl conjugation pathway
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Proteasome regulatory particle
Cellular Component
Proteasome regulatory particle, lid subcomplex
Molecular Function
Metal ion binding
Molecular Function
Metallopeptidase activity
Molecular Function
Proteasome binding
Molecular Function
Thiol-dependent ubiquitin-specific protease activity
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process
Protein deubiquitination

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orl-3283Oryzias latipes81.327e-152 436
LLPS-Tar-1894Takifugu rubripes81.323e-151 434
LLPS-Orc-3396Oryctolagus cuniculus80.458e-157 447
LLPS-Mam-0344Macaca mulatta78.853e-161 460
LLPS-Cas-3035Carlito syrichta78.653e-162 462
LLPS-Dar-2504Danio rerio77.511e-163 466
LLPS-Orn-3150Oreochromis niloticus77.246e-164 466
LLPS-Pof-1872Poecilia formosa77.246e-164 466
LLPS-Scm-0867Scophthalmus maximus77.246e-164 466
LLPS-Xet-1051Xenopus tropicalis77.246e-164 466
LLPS-Asm-0273Astyanax mexicanus77.247e-164 466
LLPS-Leo-3516Lepisosteus oculatus77.246e-164 466
LLPS-Xim-3861Xiphophorus maculatus77.246e-164 466
LLPS-Drm-0848Drosophila melanogaster77.244e-165 469
LLPS-Scf-3600Scleropages formosus77.246e-164 466
LLPS-Icp-0359Ictalurus punctatus77.059e-165 468
LLPS-Gaa-0987Gasterosteus aculeatus77.052e-164 468
LLPS-Pes-0336Pelodiscus sinensis76.92e-163 465
LLPS-Fia-1414Ficedula albicollis76.93e-163 464
LLPS-Rhb-1833Rhinopithecus bieti76.94e-162 461
LLPS-Urm-0791Ursus maritimus76.98e-164 466
LLPS-Pap-3706Pan paniscus76.98e-164 466
LLPS-Pat-1138Pan troglodytes76.98e-164 466
LLPS-Meg-2683Meleagris gallopavo76.93e-163 464
LLPS-Hos-4503Homo sapiens76.98e-164 466
LLPS-Fec-2393Felis catus76.98e-164 466
LLPS-Mod-2105Monodelphis domestica76.92e-163 465
LLPS-Man-4269Macaca nemestrina76.98e-164 466
LLPS-Loa-0321Loxodonta africana76.98e-164 466
LLPS-Gaga-2563Gallus gallus76.93e-163 464
LLPS-Ict-3863Ictidomys tridecemlineatus76.98e-164 466
LLPS-Anc-0959Anolis carolinensis76.93e-163 464
LLPS-Tag-0830Taeniopygia guttata76.93e-163 464
LLPS-Ten-3180Tetraodon nigroviridis76.94e-161 459
LLPS-Poa-1198Pongo abelii76.98e-164 466
LLPS-Cap-4447Cavia porcellus76.98e-164 466
LLPS-Gog-4081Gorilla gorilla76.98e-164 466
LLPS-Fud-1261Fukomys damarensis76.98e-164 466
LLPS-Caj-2548Callithrix jacchus76.98e-164 466
LLPS-Mum-4529Mus musculus76.98e-164 466
LLPS-Cii-0731Ciona intestinalis76.92e-164 468
LLPS-Maf-2179Macaca fascicularis76.98e-164 466
LLPS-Ora-0307Ornithorhynchus anatinus76.92e-163 465
LLPS-Chs-1416Chlorocebus sabaeus76.98e-164 466
LLPS-Sah-0124Sarcophilus harrisii76.92e-163 465
LLPS-Sus-1980Sus scrofa76.98e-164 466
LLPS-Ran-3466Rattus norvegicus76.98e-164 466
LLPS-Mup-3223Mustela putorius furo76.98e-164 466
LLPS-Aim-3707Ailuropoda melanoleuca76.98e-164 466
LLPS-Dio-1021Dipodomys ordii76.98e-164 466
LLPS-Bot-3048Bos taurus76.98e-164 466
LLPS-Otg-2386Otolemur garnettii76.717e-165 469
LLPS-Anp-0851Anas platyrhynchos76.715e-164 466
LLPS-Nol-1329Nomascus leucogenys76.711e-163 466
LLPS-Eqc-1881Equus caballus76.712e-164 468
LLPS-Cea-0004Cercocebus atys76.711e-163 466
LLPS-Aon-2111Aotus nancymaae76.713e-164 467
LLPS-Mal-1923Mandrillus leucophaeus76.711e-163 466
LLPS-Paa-0837Papio anubis76.711e-163 466
LLPS-Myl-2244Myotis lucifugus76.712e-164 467
LLPS-Ova-1187Ovis aries76.711e-164 468
LLPS-Tut-0613Tursiops truncatus76.718e-165 468
LLPS-Mea-1948Mesocricetus auratus76.555e-163 464
LLPS-Caf-3969Canis familiaris76.312e-158 452
LLPS-Php-2497Physcomitrella patens73.781e-155 445
LLPS-Sem-1319Selaginella moellendorffii73.082e-153 440
LLPS-Met-0790Medicago truncatula72.221e-153 440
LLPS-Abg-0961Absidia glauca71.973e-153 439
LLPS-Mae-0123Manihot esculenta71.881e-152 437
LLPS-Phv-0035Phaseolus vulgaris71.881e-152 437
LLPS-Nia-2010Nicotiana attenuata71.881e-152 438
LLPS-Viv-0463Vitis vinifera71.887e-153 438
LLPS-Pot-0790Populus trichocarpa71.882e-152 437
LLPS-Tru-1006Triticum urartu71.884e-153 438
LLPS-Coc-0516Corchorus capsularis71.882e-152 437
LLPS-Hea-2746Helianthus annuus71.884e-153 439
LLPS-Thc-0536Theobroma cacao71.884e-152 437
LLPS-Sol-0686Solanum lycopersicum71.888e-153 438
LLPS-Glm-0834Glycine max71.881e-152 437
LLPS-Hov-0954Hordeum vulgare71.882e-152 439
LLPS-Tra-1922Triticum aestivum71.886e-153 438
LLPS-Vir-1561Vigna radiata71.882e-152 437
LLPS-Art-1070Arabidopsis thaliana71.725e-153 438
LLPS-Brr-1754Brassica rapa71.725e-153 438
LLPS-Bro-1495Brassica oleracea71.725e-153 438
LLPS-Brn-2387Brassica napus71.722e-152 437
LLPS-Arl-1750Arabidopsis lyrata71.721e-152 437
LLPS-Gor-0556Gossypium raimondii71.631e-150 432
LLPS-Orbr-2097Oryza brachyantha71.532e-152 437
LLPS-Sob-1467Sorghum bicolor71.531e-151 435
LLPS-Amt-0090Amborella trichopoda71.534e-152 436
LLPS-Ors-2333Oryza sativa71.539e-152 435
LLPS-Orp-0594Oryza punctata71.537e-152 436
LLPS-Zem-2120Zea mays71.531e-151 435
LLPS-Org-0073Oryza glaberrima71.537e-152 436
LLPS-Orr-0173Oryza rufipogon71.537e-152 436
LLPS-Prp-1396Prunus persica71.532e-151 434
LLPS-Orni-2062Oryza nivara71.539e-152 435
LLPS-Orb-1223Oryza barthii71.537e-152 436
LLPS-Ori-1830Oryza indica71.539e-152 435
LLPS-Sei-1299Setaria italica71.538e-152 435
LLPS-Cus-1282Cucumis sativus71.532e-152 437
LLPS-Brd-0930Brachypodium distachyon71.533e-152 436
LLPS-Orgl-1219Oryza glumaepatula71.539e-152 435
LLPS-Lep-1668Leersia perrieri71.532e-150 435
LLPS-Sot-0204Solanum tuberosum71.533e-152 437
LLPS-Dac-0506Daucus carota71.187e-153 438
LLPS-Scs-0974Sclerotinia sclerotiorum71.124e-146 422
LLPS-Ved-1226Verticillium dahliae71.066e-144 416
LLPS-Cogr-1200Colletotrichum graminicola71.066e-144 416
LLPS-Coo-0980Colletotrichum orbiculare71.061e-143 416
LLPS-Mua-2381Musa acuminata70.832e-150 432
LLPS-Lac-0379Latimeria chalumnae70.755e-147 423
LLPS-Asni-0853Aspergillus niger70.554e-145 419
LLPS-Dos-0623Dothistroma septosporum70.54e-148 427
LLPS-Zyt-0359Zymoseptoria tritici70.55e-147 425
LLPS-Lem-0265Leptosphaeria maculans70.58e-147 424
LLPS-Usm-1396Ustilago maydis70.462e-148 427
LLPS-Map-0165Magnaporthe poae70.42e-146 422
LLPS-Gag-1474Gaeumannomyces graminis70.45e-146 422
LLPS-Nec-0577Neurospora crassa70.46e-145 419
LLPS-Mao-0051Magnaporthe oryzae70.332e-144 418
LLPS-Chc-0149Chondrus crispus70.281e-147 425
LLPS-Osl-1103Ostreococcus lucimarinus70.241e-149 430
LLPS-Phn-0076Phaeosphaeria nodorum70.143e-145 420
LLPS-Chr-0682Chlamydomonas reinhardtii70.143e-151 434
LLPS-Spr-0267Sporisorium reilianum70.111e-147 425
LLPS-Beb-0737Beauveria bassiana70.042e-144 417
LLPS-Pyt-0230Pyrenophora teres70.04e-145 419
LLPS-Miv-0762Microbotryum violaceum69.964e-148 426
LLPS-Nef-0495Neosartorya fischeri69.824e-144 417
LLPS-Asfu-1035Aspergillus fumigatus69.823e-144 417
LLPS-Asf-1425Aspergillus flavus69.821e-144 418
LLPS-Aso-0279Aspergillus oryzae69.824e-143 417
LLPS-Trr-1381Trichoderma reesei69.688e-145 419
LLPS-Trv-1488Trichoderma virens69.686e-145 419
LLPS-Fuo-1260Fusarium oxysporum69.682e-143 415
LLPS-Fuv-0154Fusarium verticillioides69.682e-143 415
LLPS-Gas-1058Galdieria sulphuraria69.495e-154 441
LLPS-Ast-0811Aspergillus terreus69.452e-143 415
LLPS-Asn-0246Aspergillus nidulans69.452e-140 407
LLPS-Orm-1481Oryza meridionalis69.361e-148 427
LLPS-Fus-1242Fusarium solani69.316e-143 414
LLPS-Pytr-0160Pyrenophora triticirepentis69.264e-133 387
LLPS-Tum-0940Tuber melanosporum68.661e-144 418
LLPS-Asc-0294Aspergillus clavatus68.424e-126 369
LLPS-Cog-0599Colletotrichum gloeosporioides68.131e-131 384
LLPS-Pug-0364Puccinia graminis67.844e-143 413
LLPS-Yal-0987Yarrowia lipolytica67.847e-138 400
LLPS-Mel-0466Melampsora laricipopulina67.493e-142 411
LLPS-Blg-0070Blumeria graminis67.034e-136 396
LLPS-Scc-1082Schizosaccharomyces cryophilus66.94e-133 388
LLPS-Scj-0398Schizosaccharomyces japonicus66.93e-140 406
LLPS-Crn-0348Cryptococcus neoformans65.842e-140 406
LLPS-Scp-0708Schizosaccharomyces pombe65.741e-139 404
LLPS-Put-0073Puccinia triticina65.727e-130 382
LLPS-Kop-0189Komagataella pastoris65.051e-135 394
LLPS-Sac-1152Saccharomyces cerevisiae64.481e-128 376
LLPS-Asg-0756Ashbya gossypii64.213e-128 375
LLPS-Cym-0546Cyanidioschyzon merolae63.311e-126 372
LLPS-Cis-1771Ciona savignyi39.63e-34 133