LLPS-Bot-a907
TMED10
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transmembrane emp24 domain-containing protein 10; 21 kDa transmembrane-trafficking protein; Transmembrane protein Tmp21; p24 family protein delta-1; p24delta1 |
| Gene Name: | TMED10, TMP21 |
| Ensembl Gene: | ENSBTAG00000005694.6 |
| Ensembl Protein: | ENSBTAP00000007481.6 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000007481.6 | ENSBTAP00000007481.6 |
| UniProt | Q5E971, TMEDA_BOVIN, A4FV04 | |
| GeneBank | BC123529, BT021049 | AAI23530.1, AAX09066.1 |
| RefSeq | NM_001040549.2 | NP_001035639.1 |
| Entrez | 529761 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSGSSGPQAQ RGPCPFALLL LLLLGPSSVL AISFHLPVNS RKCLREEIHK DLLVTGAYEI 60 61 TDQSGGAGGL RTHLKITDSA GHILYSKEDA TKGKFAFTTE DYDMFEVCFE SKGTGRIPDQ 120 121 LVILDMKHGV EAKNYEEIAK VEKLKPLEVE LRRLEDLSES IVNDFAYMKK REEEMRDTNE 180 181 STNTRVLYFS IFSMFCLIGL ATWQVFYLRR FFKAKKLIE 219 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTTGGCT CCTCAGGCCC ACAGGCTCAG CGTGGCCCTT GCCCGTTCGC GTTGCTGCTG 60 61 CTACTCCTGC TGGGCCCCAG CTCGGTCCTC GCCATCTCCT TCCACCTTCC CGTTAACTCC 120 121 CGCAAGTGCC TCCGCGAGGA GATCCACAAG GACCTGCTGG TGACGGGCGC GTACGAGATC 180 181 ACCGACCAGT CTGGGGGCGC CGGCGGCCTG CGCACCCATC TCAAGATTAC AGATTCTGCT 240 241 GGCCATATTC TGTACTCCAA GGAGGATGCG ACCAAGGGGA AGTTTGCCTT TACCACTGAA 300 301 GATTATGACA TGTTTGAAGT GTGTTTTGAG AGCAAGGGTA AGAGTAGAAT TCCTTTTGAT 360 361 CAGCTCGTGA TCCTAGACAT GAATTATGGA GTGGAAGCGA ATAATTATTT AGAAATTGCA 420 421 AAAGTTGAGA AGCTCAAACC TTTGGAGGTG GAGCTACGAC GCCTAGAAGA CCTTTCAGAG 480 481 TCTATTGTTA ATGATTTTGC CTACATGAAG AAGCGAGAAG AGGAGATGCG CGATACCAAT 540 541 GAGTCCACGA ACACTCGGGT CCTGTACTTC AGCATCTTTT CAATGTTCTG CCTCATTGGT 600 601 CTGGCCACCT GGCAGGTCTT CTACCTGCGT CGCTTCTTCA AAGCCAAGAA GTTGATTGAG 660 661 TAA 663 |
▼ KEYWORD
ID | Family |
Cell membrane | |
Complete proteome | |
Cytoplasmic vesicle | |
Endoplasmic reticulum | |
ER-Golgi transport | |
Glycoprotein | |
Golgi apparatus | |
Membrane | |
Methylation | |
Protein transport | |
Reference proteome | |
Signal | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | COPI-coated vesicle | |
Cellular Component | COPII-coated ER to Golgi transport vesicle | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Endoplasmic reticulum-Golgi intermediate compartment | |
Cellular Component | Endoplasmic reticulum-Golgi intermediate compartment membrane | |
Cellular Component | Gamma-secretase complex | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Melanosome | |
Cellular Component | Plasma membrane | |
Cellular Component | Secretory granule membrane | |
Cellular Component | Trans-Golgi network transport vesicle | |
Cellular Component | Transport vesicle membrane | |
Cellular Component | Zymogen granule membrane | |
Molecular Function | Syntaxin binding | |
Biological Process | COPI-coated vesicle budding | |
Biological Process | Endoplasmic reticulum to Golgi vesicle-mediated transport | |
Biological Process | Golgi organization | |
Biological Process | Intracellular protein transport | |
Biological Process | Regulated exocytosis | |
Biological Process | Regulation of amyloid-beta formation | |
Biological Process | Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-a906 | Mus musculus | 3e-145 | 413 | undefined |
| LLPS-Hos-a920 | Homo sapiens | 1e-146 | 417 | undefined |