• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Bot-a849
NDRG2

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Protein NDRG2; N-myc downstream-regulated gene 2 protein
Gene Name: NDRG2
Ensembl Gene: ENSBTAG00000000843.6
Ensembl Protein: ENSBTAP00000001121.6
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAELREVQIT  EEKPLLPGQT  PEVAKTHSVE  TPYGSVTFTV  YGTPKPKRPA  ILTYHDVGLN  60
61    YKSCFQPLFQ  FADMQEIIQN  FVRVHVDAPG  MEEGAPVFPL  GYQYPSLDQL  ADMIPCILQY  120
121   LNFSTIIGIG  VGAGAYVLSR  YALTHPDTVE  GLVLINIDPN  AKGWMDWAAH  KLTGLTSSIS  180
181   EMILGHLFSQ  EELSGNSELI  QKYRNIIAHA  PNLDNIELYW  NSYNNRRDLN  FVRGGDTTLK  240
241   CPVMLVVGDQ  APHEDAVVEC  NSKLDPTQTS  FLKMADSGGQ  PQLTQPGKLT  EAFKYFLQGM  300
301   GYMASSCMTR  LSRSRTASLT  SAASIDGNRS  RSRTLSQSSE  SGTLSSGPPG  HTMEVSC  357
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGAGC  TGCGGGAAGT  GCAGATCACG  GAGGAGAAGC  CGCTGTTGCC  AGGGCAGACA  60
61    CCCGAGGTGG  CCAAGACTCA  CTCTGTGGAG  ACACCTTATG  GTTCTGTCAC  TTTTACTGTC  120
121   TATGGCACCC  CCAAACCCAA  ACGGCCAGCG  ATACTCACCT  ACCATGATGT  GGGACTCAAC  180
181   TATAAATCCT  GCTTCCAGCC  GCTGTTTCAA  TTTGCGGATA  TGCAGGAAAT  CATTCAGAAC  240
241   TTCGTGCGGG  TTCATGTGGA  TGCCCCTGGC  ATGGAAGAGG  GGGCTCCCGT  GTTCCCTTTG  300
301   GGGTATCAGT  ACCCATCTCT  GGACCAGCTT  GCGGACATGA  TCCCTTGCAT  CCTGCAGTAC  360
361   TTAAATTTCT  CCACAATAAT  TGGAATTGGT  GTTGGAGCTG  GGGCCTACGT  CCTGTCGCGA  420
421   TACGCTCTTA  CCCACCCTGA  TACCGTCGAG  GGTCTTGTCC  TCATCAACAT  TGATCCCAAC  480
481   GCCAAAGGCT  GGATGGATTG  GGCAGCGCAC  AAGCTAACAG  GTCTCACCTC  TTCCATTTCG  540
541   GAGATGATCC  TTGGACATCT  TTTCAGCCAG  GAAGAGCTGT  CCGGAAATTC  TGAGTTGATA  600
601   CAAAAGTATA  GAAATATCAT  TGCACATGCC  CCCAACCTGG  ATAACATTGA  ACTGTACTGG  660
661   AACAGCTACA  ACAATCGCCG  AGACCTGAAC  TTTGTGCGTG  GAGGCGATAC  CACCCTCAAG  720
721   TGCCCTGTGA  TGCTGGTGGT  AGGAGACCAA  GCACCCCATG  AAGATGCAGT  GGTGGAATGT  780
781   AACTCAAAAC  TGGACCCCAC  CCAGACTTCT  TTCCTCAAGG  TAAAAGAAAC  AGAAAACACC  840
841   CCAACGGCCT  GCAGTGGGAA  GCCTAGGGAA  GAGAGCCGTC  TCGTACCTCT  CGGCATGGCT  900
901   CATTGGTGTT  CATCCTGCAT  GACTCGCCTG  TCCCGATCTC  GCACGGCCTC  CCTGACCAGC  960
961   GCAGCATCCA  TTGATGGCAA  CCGGTCCCGC  TCTCGCACCC  TGTCCCAGAG  CAGCGAGTCT  1020
1021  GGGACTCTCT  CTTCAGGGCC  CCCAGGGCAC  ACCATGGAGG  TCTCCTGTTG  A  1071

▼ KEYWORD


ID
Family
Acetylation
Cell projection
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Neurogenesis
Phosphoprotein
Reference proteome
Tumor suppressor
Wnt signaling pathway

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Golgi apparatus
Cellular Component
Growth cone
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Biological Process
Cell differentiation
Biological Process
Negative regulation of cytokine production
Biological Process
Negative regulation of ERK1 and ERK2 cascade
Biological Process
Negative regulation of smooth muscle cell proliferation
Biological Process
Nervous system development
Biological Process
Regulation of platelet-derived growth factor production
Biological Process
Regulation of vascular endothelial growth factor production
Biological Process
Signal transduction
Biological Process
Wnt signaling pathway

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hos-a861Homo sapiens0.0717undefined
LLPS-Mum-a847Mus musculus0.0707undefined