LLPS-Bot-a812
GABRB1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1 |
| Gene Name: | GABRB1 |
| Ensembl Gene: | ENSBTAG00000017837.6 |
| Ensembl Protein: | ENSBTAP00000023711.5 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000023711.6 | ENSBTAP00000023711.5 |
| UniProt | P08220, GBRB1_BOVIN | |
| GeneBank | X05718 | CAA29190.1 |
| RefSeq | NM_174544.2 | NP_776969.1 |
| Entrez | 282239 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWTVQNRESL GLLSFPVMIA MVCCAHSANE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP 60 61 VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD 120 121 TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE 180 181 SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK 240 241 RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI 300 301 PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG AGKQDQSANE KNKLEMNKVQ 360 361 VDAHGNILLS TLEIRNETSG SEVLTGVGDP KTTMYSYDSA SIQYRKPMSS REGYGRALDR 420 421 HGAHSKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH 474 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGACAG TACAAAATCG AGAGAGTTTG GGGCTTCTCT CTTTCCCTGT GATGATTGCC 60 61 ATGGTCTGTT GTGCACACAG CGCCAACGAG CCCAGCAACA TGTCATACGT GAAAGAGACA 120 121 GTGGACAGAT TGCTCAAAGG ATATGACATT CGCTTGCGGC CGGACTTTGG AGGGCCCCCC 180 181 GTGGACGTCG GGATGAGGAT CGATGTCGCC AGCATAGACA TGGTCTCCGA AGTGAACATG 240 241 GATTATACTC TCACCATGTA TTTCCAGCAG TCTTGGAAAG ACAAAAGGCT TTCTTATTCT 300 301 GGAATCCCAC TAAACCTCAC ACTAGACAAC AGGGTGGCTG ATCAACTCTG GGTACCAGAC 360 361 ACCTACTTTC TGAATGACAA GAAATCCTTT GTGCATGGGG TTACAGTGAA AAATCGCATG 420 421 ATCCGCCTGC ATCCTGATGG AACAGTTCTC TACGGACTCC GGATCACAAC CACAGCTGCG 480 481 TGCATGATGG ATCTACGAAG ATATCCTCTG GATGAACAAA ACTGCACCCT GGAGATTGAA 540 541 AGTTATGGCT ACACCACTGA TGACATTGAG TTTTACTGGA ATGGAGGAGA GGGCGCAGTA 600 601 ACAGGAGTGA ATAAAATTGA GCTCCCTCAG TTTTCAATTG TTGATTACAA GATGGTGTCC 660 661 AAAAAGGTGG AATTCACAAC AGGGGCATAC CCACGACTGT CACTAAGTTT TCGTCTAAAA 720 721 AGAAACATCG GTTACTTCAT TTTGCAAACC TACATGCCTT CCACACTGAT TACAATTCTG 780 781 TCGTGGGTGT CGTTTTGGAT CAATTATGAC GCATCTGCAG CCAGAGTTGC ACTAGGAATC 840 841 ACCACAGTGC TGACAATGAC CACCATCAGC ACTCACCTCA GGGAGACCCT GCCAAAGATT 900 901 CCTTATGTCA AAGCGATTGA CATTTACCTG ATGGGTTGCT TCGTGTTTGT GTTCCTGGCT 960 961 CTGCTGGAAT ATGCCTTTGT AAATTACATC TTTTTTGGAA AGGGCCCTCA GAAGAAAGGA 1020 1021 GCTGGCAAAC AAGACCAGAG CGCTAATGAG AAGAACAAAC TGGAGATGAA TAAAGTCCAG 1080 1081 GTCGACGCCC ACGGCAACAT TCTCCTCAGT ACCCTGGAGA TCAGGAACGA GACGAGCGGC 1140 1141 TCTGAAGTGC TCACGGGCGT GGGAGACCCC AAGACCACCA TGTACTCCTA CGACAGCGCC 1200 1201 AGCATCCAGT ACCGCAAGCC AATGAGCAGC CGCGAGGGGT ACGGGCGCGC GCTGGACCGG 1260 1261 CACGGCGCGC ACAGCAAGGG GCGCATCCGC AGACGCGCCT CGCAGCTCAA AGTCAAAATC 1320 1321 CCCGACTTGA CTGACGTGAA TTCCATAGAC AAGTGGTCCC GAATGTTCTT CCCCATCACC 1380 1381 TTTTCTCTTT TTAACGTCGT TTATTGGCTT TACTATGTAC ACTAA 1425 |
▼ KEYWORD
ID | Family |
Cell junction | |
Cell membrane | |
Chloride | |
Chloride channel | |
Complete proteome | |
Disulfide bond | |
Glycoprotein | |
Ion channel | |
Ion transport | |
Ligand-gated ion channel | |
Membrane | |
Postsynaptic cell membrane | |
Receptor | |
Reference proteome | |
Signal | |
Synapse | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Chloride channel complex | |
Cellular Component | GABA-A receptor complex | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Neuron projection | |
Cellular Component | Postsynaptic membrane | |
Cellular Component | Synapse | |
Molecular Function | GABA-A receptor activity | |
Molecular Function | GABA-gated chloride ion channel activity | |
Molecular Function | Ligand-gated ion channel activity | |
Biological Process | Cellular response to histamine | |
Biological Process | Chemical synaptic transmission | |
Biological Process | Gamma-aminobutyric acid signaling pathway | |
Biological Process | Ion transmembrane transport | |
Biological Process | Ion transport | |
Biological Process | Nervous system process | |
Biological Process | Regulation of membrane potential | |
Biological Process | Signal transduction |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a822 | Homo sapiens | 0.0 | 968 | undefined |
| LLPS-Mum-a809 | Mus musculus | 0.0 | 967 | undefined |