LLPS-Bot-a671
RGS20
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Regulator of G-protein signaling 20 |
| Gene Name: | RGS20 |
| Ensembl Gene: | ENSBTAG00000003454.6 |
| Ensembl Protein: | ENSBTAP00000004487.5 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000004487.6 | ENSBTAP00000004487.5 |
| Ensembl | ENSBTAT00000052352.2 | ENSBTAP00000049922.1 |
| UniProt | P79348, RGS20_BOVIN | |
| GeneBank | U89254 | AAC48721.1 |
| RefSeq | XM_005215423.3 | XP_005215480.1 |
| Entrez | 614441 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPRLSQDNQQ GHQKHFSRPS RRIQFLPPPW TEAYNVNVHQ TVENEGCATA MHNVKLLGSP 60 61 AAPTLLSLLS GTLSGFARFF ALLLRRPPPE APLRRRDFSA LIPALPAAVL SPGHEERPGR 120 121 LSLLLRAALA LPGRPPGGRL PREVDASAGQ SSSIPPMGSE WMEMRKRPVC AAQEPTACAP 180 181 GQPGVENQGS NACCFCWCCC CSCSCLTVRN QEEQRLRRTS YEARTEDLPT CEESPGPTLE 240 241 EASAWAQSFD KLMLTPAGRN AFREFLRTEF SEENMLFWMA CEELKKEANK ATIEEKARII 300 301 YEDYISILSP KEVSLDSRVR ETINRSMAEP SRNIFDDAQL QIYTLMHRDS YPRFMNSALY 360 361 KDLLRSLSEK AVEA 374 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCCAGGC TTTCCCAAGA CAACCAACAG GGCCACCAGA AACATTTCTC CAGACCATCG 60 61 AGGCGGATAC AATTTCTGCC TCCGCCGTGG ACTGAGGCAT ATAATGTGAA CGTTCACCAA 120 121 ACCGTGGAAA ATGAAGGATG TGCCACAGCC ATGCACAATG TCAAGCTCCT AGGTTCGCCC 180 181 GCTGCCCCGA CGCTGCTCAG CCTCCTCTCC GGCACGCTCT CCGGCTTCGC GCGCTTCTTC 240 241 GCTCTCCTCC TTCGGCGACC CCCTCCCGAG GCTCCCCTGC GGCGCCGGGA CTTCTCCGCC 300 301 CTGATCCCCG CCCTGCCAGC CGCTGTGCTC TCGCCGGGGC ACGAGGAGCG GCCGGGCCGC 360 361 CTCTCGCTCC TGCTCAGGGC AGCTCTGGCA CTGCCTGGCC GACCCCCAGG GGGACGTCTG 420 421 CCTCGGGAAG TGGACGCCAG CGCCGGGCAG AGCTCGTCCA TACCCCCAAT GGGGTCAGAA 480 481 TGGATGGAGA TGCGGAAGCG GCCTGTGTGT GCAGCCCAGG AGCCCACAGC CTGCGCCCCC 540 541 GGCCAGCCCG GAGTAGAGAA CCAGGGATCC AACGCTTGCT GCTTCTGCTG GTGCTGCTGC 600 601 TGCAGCTGTT CCTGTCTCAC TGTGAGAAAC CAGGAGGAAC AAAGACTTAG AAGGACTTCC 660 661 TATGAAGCCA GAACAGAAGA CCTTCCCACC TGTGAAGAAA GCCCGGGTCC CACCCTGGAG 720 721 GAGGCCAGCG CCTGGGCTCA GTCCTTTGAC AAGCTCATGC TCACGCCCGC GGGCAGGAAC 780 781 GCCTTCCGGG AGTTTCTGCG GACCGAGTTC AGCGAGGAGA ACATGCTCTT CTGGATGGCG 840 841 TGCGAGGAAC TGAAGAAAGA AGCGAATAAA GCCACGATTG AAGAGAAAGC GAGGATCATA 900 901 TACGAAGACT ACATTTCTAT TCTCTCTCCT AAGGAGGTCA GCCTGGACTC ACGCGTGCGG 960 961 GAGACCATCA ACAGGAGCAT GGCTGAGCCC TCCCGGAACA TCTTCGACGA TGCCCAGCTG 1020 1021 CAGATCTACA CGCTGATGCA CAGGGACTCA TACCCCCGCT TCATGAACTC CGCTCTCTAC 1080 1081 AAAGACCTGC TCCGCTCCTT ATCTGAGAAA GCAGTGGAAG CCTAG 1125 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Membrane | |
Cellular Component | Nucleus | |
Cellular Component | Trans-Golgi network | |
Biological Process | Negative regulation of signal transduction |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-a670 | Mus musculus | 5e-116 | 351 | undefined |
| LLPS-Hos-a676 | Homo sapiens | 1e-160 | 465 | undefined |