LLPS-Bot-a432
RAP2C
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ras-related protein Rap-2c |
| Gene Name: | RAP2C |
| Ensembl Gene: | ENSBTAG00000004131.6 |
| Ensembl Protein: | ENSBTAP00000067219.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000082519.1 | ENSBTAP00000067219.1 |
| Ensembl | ENSBTAT00000005408.6 | ENSBTAP00000005408.5 |
| Ensembl | ENSBTAT00000068302.1 | ENSBTAP00000061865.1 |
| Ensembl | ENSBTAT00000080153.1 | ENSBTAP00000059791.1 |
| Ensembl | ENSBTAT00000079003.1 | ENSBTAP00000066215.1 |
| UniProt | Q08DI5, RAP2C_BOVIN | |
| GeneBank | BC123730 | AAI23731.1 |
| RefSeq | NM_001075700.1, XM_005227512.3, XM_005227513.3, XM_010821410.2 | NP_001069168.1, XP_005227569.1, XP_005227570.1, XP_010819712.1 |
| Entrez | 515181 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG 60 61 TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI VRVKRYEKVP LILVGNKVDL 120 121 EPEREVMSSE GRALAQEWGC PFMETSAKSK SMVDELFAEI VRQMNYSSLP EKQDQCCTTC 180 181 VVQ 183 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGCGGAGGGG TTGGCAAATC CGCCCTGACT 60 61 GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 120 121 CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 180 181 ACTGAGCAGT TTGCTTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 240 241 GTTTACAGTC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 300 301 GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTGATCCTAG TAGGAAATAA AGTGGATCTG 360 361 GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 420 421 CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 480 481 GTCAGGCAAA TGAACTATTC TTCCCTACCC GAGAAGCAAG ATCAATGTTG TACAACTTGC 540 541 GTTGTCCAGT AA 552 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Bicellular tight junction | |
Cellular Component | Cell-cell contact zone | |
Cellular Component | Cytosol | |
Cellular Component | Plasma membrane | |
Cellular Component | Recycling endosome membrane | |
Molecular Function | GDP binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | Transcription coactivator activity | |
Biological Process | Establishment of endothelial intestinal barrier | |
Biological Process | Negative regulation of cell migration | |
Biological Process | Positive regulation of protein autophosphorylation | |
Biological Process | Rap protein signal transduction | |
Biological Process | Regulation of protein tyrosine kinase activity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a433 | Homo sapiens | 8e-132 | 376 | undefined |
| LLPS-Mum-a431 | Mus musculus | 8e-132 | 376 | undefined |