LLPS-Bot-a401
TMEM214
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transmembrane protein 214 |
| Gene Name: | TMEM214 |
| Ensembl Gene: | ENSBTAG00000017423.5 |
| Ensembl Protein: | ENSBTAP00000023162.4 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000023162.5 | ENSBTAP00000023162.4 |
| UniProt | A4FV45, TM214_BOVIN | |
| GeneBank | BC123724 | AAI23725.1 |
| RefSeq | NM_001083432.1 | NP_001076901.1 |
| Entrez | 514683 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAKTAGGGR WEVVKKGRRP GAGGSGKGGG GDRRALGEAN GVWKYDLTPP IQTTSTLYER 60 61 GFEKIMKRQN KEQVPPPAVE PKKPGNKKQA KKVATLTNQN QKQGRFRSLE EALKALDLAD 120 121 LQKELDKSQS VFSGNPSVWL KDLASYLNYK LQVPPSEPTL SQHPHDYPYS LVSRELRGII 180 181 RGLLAKAAGS LELFFDHCLF TMLQELDKTP GESLHGYRIC IQAILQDKPK IVTTNLGKFL 240 241 ELLRSHQSRP AKCLTIMWAL GQAGFTNLTE GLRVWLGIML PVLGIKSLSP FAIAYLDRLL 300 301 LMHPNLTKGF GMIGPKDLFP LLDFAYMPNN SLTPSLQEQL CQLYPRLKVL AFGAKPESTL 360 361 HTYFPSFLSR ATPGCPLEMK KELLRSLTEC LMVDPLSTSV WRQLYPKHLS QSSLLLEHLL 420 421 RSWERIPKKT QKSLQETIQS FKLTNQDLLR KGGGSNQDVV TCDSACKSLL QQARGFQLPW 480 481 TRLLLLVLVF AIGFLCHDFR SHSSFQASLS GQLLQSSGVL PAGQQACTKI YSYSLQGYSW 540 541 LEKTLPAWGS HLLTVVRPGL QLAWAHTNAT VGFLSAHCAS HLAWFGDSLA NLFQRLQTQL 600 601 PDTLNQLLRS LRELLLFLYH SILLPTWHML LEALAQIQEH CHEACRGEVT WDCMKTQLSE 660 661 AAHWTWLRLQ DTTVAFLDWA LAMISQQ 687 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCGA AGACTGCGGG TGGGGGGCGC TGGGAGGTGG TGAAGAAGGG GCGGCGGCCT 60 61 GGGGCCGGCG GCAGTGGTAA AGGCGGCGGA GGGGACCGCC GGGCGCTCGG GGAGGCGAAC 120 121 GGAGTGTGGA AGTACGACCT GACCCCTCCA ATCCAGACGA CAAGCACCCT GTATGAGCGG 180 181 GGCTTTGAGA AAATCATGAA GCGGCAGAAT AAGGAGCAGG TTCCACCTCC TGCTGTGGAG 240 241 CCTAAGAAAC CGGGGAACAA GAAGCAGGCT AAGAAGGTGG CGACCCTCAC CAACCAGAAC 300 301 CAGAAGCAGG GACGCTTTCG CAGCCTGGAG GAGGCACTGA AAGCTCTGGA CCTGGCAGAT 360 361 CTGCAGAAGG AACTGGACAA GAGCCAGAGT GTGTTCTCTG GAAACCCATC CGTGTGGTTG 420 421 AAGGACCTGG CCAGCTATCT CAACTACAAG CTCCAAGTAC CTCCGAGTGA ACCCACACTT 480 481 AGCCAGCATC CTCACGATTA TCCCTACAGC CTGGTGAGCC GGGAGCTGCG TGGCATCATC 540 541 CGAGGGCTAT TGGCGAAGGC TGCGGGATCC CTGGAGCTCT TTTTCGACCA TTGTCTATTC 600 601 ACCATGCTAC AAGAACTGGA TAAGACTCCA GGGGAGTCAC TGCACGGTTA CCGCATCTGT 660 661 ATCCAGGCCA TTCTGCAAGA CAAGCCCAAG ATTGTCACCA CAAACCTAGG CAAGTTCCTG 720 721 GAACTGCTGA GGTCCCACCA GAGCCGACCA GCCAAGTGTC TGACTATCAT GTGGGCCCTG 780 781 GGTCAAGCAG GTTTTACCAA CCTCACCGAG GGACTGAGAG TGTGGCTGGG GATTATGCTA 840 841 CCTGTGCTGG GCATCAAGTC TCTGTCTCCC TTCGCCATTG CATACCTGGA TCGGCTGCTC 900 901 CTGATGCACC CCAACCTCAC CAAGGGCTTT GGCATGATTG GCCCCAAGGA CCTCTTCCCA 960 961 CTTCTGGACT TTGCCTATAT GCCCAACAAC TCCTTGACTC CCAGCCTGCA GGAGCAGCTA 1020 1021 TGTCAGCTGT ACCCACGACT GAAGGTGTTG GCATTTGGGG CAAAGCCGGA ATCCACGCTG 1080 1081 CATACCTACT TCCCCTCCTT CCTGTCCAGA GCCACCCCTG GCTGCCCTCT GGAGATGAAG 1140 1141 AAAGAGCTCC TGAGAAGCCT GACTGAGTGC CTGATGGTGG ACCCCCTCAG CACCAGCGTC 1200 1201 TGGCGGCAGC TCTACCCCAA GCACCTGTCA CAGTCCAGCC TGCTGCTGGA ACACCTGCTC 1260 1261 AGGTCCTGGG AGCGTATTCC CAAGAAGACA CAGAAGTCAT TGCAAGAAAC CATTCAGTCC 1320 1321 TTCAAGCTTA CCAACCAGGA TCTGCTGAGG AAGGGCGGCG GCAGCAATCA GGATGTCGTC 1380 1381 ACCTGCGACT CGGCCTGCAA GAGTCTGTTG CAGCAGGCTC GGGGCTTCCA GCTGCCCTGG 1440 1441 ACACGGCTAC TTCTGTTGGT GCTGGTCTTT GCCATAGGTT TCCTGTGCCA TGACTTCCGG 1500 1501 TCACACAGCT CTTTCCAGGC CTCCCTTTCT GGCCAGCTGC TTCAGTCATC TGGTGTCTTG 1560 1561 CCTGCTGGCC AACAAGCATG CACCAAGATC TACTCCTATA GCTTGCAGGG CTACAGCTGG 1620 1621 CTGGAGAAGA CATTGCCAGC TTGGGGCTCC CACCTGCTGA CTGTGGTGAG GCCTGGCTTG 1680 1681 CAGCTGGCCT GGGCCCACAC CAATGCCACC GTCGGCTTCC TTTCTGCCCA CTGTGCCTCA 1740 1741 CACCTTGCCT GGTTCGGTGA CAGCCTCGCC AACCTCTTCC AGAGGCTACA GACCCAGCTC 1800 1801 CCTGACACCC TGAACCAGCT GCTCCGTTCT CTGAGGGAGC TGCTCCTGTT TCTTTATCAC 1860 1861 AGCATCCTGC TGCCTACGTG GCACATGCTG CTTGAGGCCC TGGCCCAGAT CCAGGAGCAC 1920 1921 TGCCATGAGG CATGCAGAGG CGAGGTGACT TGGGACTGCA TGAAGACACA GCTCAGTGAA 1980 1981 GCCGCTCACT GGACCTGGCT CAGACTACAG GACACCACAG TGGCTTTCTT GGACTGGGCA 2040 2041 CTTGCCATGA TATCCCAGCA GTAG 2064 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic microtubule | |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Integral component of membrane | |
Biological Process | Apoptotic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a402 | Homo sapiens | 0.0 | 1202 | undefined |
| LLPS-Mum-a401 | Mus musculus | 0.0 | 1117 | undefined |