LLPS-Bot-a159
BLVRB
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Flavin reductase (NADPH) |
| Gene Name: | BLVRB |
| Ensembl Gene: | ENSBTAG00000010508.5 |
| Ensembl Protein: | ENSBTAP00000074394.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000081129.1 | ENSBTAP00000074394.1 |
| Ensembl | ENSBTAT00000013889.5 | ENSBTAP00000013889.4 |
| UniProt | P52556, BLVRB_BOVIN, Q3T0T4 | |
| GeneBank | L35045, BC102269 | AAC37323.1, AAI02270.1 |
| RefSeq | NM_174251.1 | NP_776676.1 |
| Entrez | 281650 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVVKKIALFG ATGNTGLTTL AQAVQAGYEV TVLVRDPSRL PSEGPQPAHV VVGDVRQPAD 60 61 VDKTVAGQDA VIVLLGTRND LSPTTVMSEG AQNIVAAMKA HGVDKVVACT SAFLLWDPSK 120 121 VPPRLQDVTD DHIRMHKVLQ QSGLKYVAVM PPHIGDHPLT GAYTVTLDGR GPSRVISKHD 180 181 LGHFMLHCLT TDKYDGHTTY PSHVYE 206 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTCGTCA AGAAGATTGC CCTTTTCGGC GCCACCGGCA ACACCGGGCT CACCACGCTG 60 61 GCGCAGGCGG TGCAAGCAGG CTATGAGGTG ACGGTGCTGG TGCGGGACCC CTCCAGGCTG 120 121 CCCTCAGAGG GGCCCCAGCC GGCCCACGTG GTGGTGGGTG ACGTCCGGCA GCCGGCCGAT 180 181 GTGGACAAGA CCGTGGCTGG GCAGGACGCT GTCATCGTGC TGCTGGGCAC CCGCAATGAC 240 241 CTCAGTCCTA CCACAGTGAT GTCCGAGGGT GCCCAGAACA TTGTGGCAGC CATGAAGGCC 300 301 CATGGCGTGG ACAAGGTCGT GGCCTGCACC TCGGCCTTCC TACTGTGGGA CCCTTCCAAG 360 361 GTGCCCCCAA GACTGCAGGA TGTGACTGAT GACCATATCC GGATGCACAA GGTACTGCAG 420 421 CAGTCGGGCC TGAAGTACGT GGCCGTGATG CCACCACATA TAGGAGACCA CCCATTGACT 480 481 GGGGCCTACA CAGTGACCCT GGATGGACGA GGGCCCTCGA GAGTCATCTC CAAACATGAC 540 541 CTGGGCCACT TCATGCTGCA CTGCCTCACC ACCGATAAGT ACGACGGGCA CACCACCTAC 600 601 CCCTCCCATG TGTATGAATA G 621 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleoplasm | |
Cellular Component | Plasma membrane | |
Molecular Function | Biliverdin reductase activity | |
Molecular Function | Riboflavin reductase (NADPH) activity | |
Biological Process | Heme catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-a158 | Mus musculus | 4e-103 | 307 | undefined |
| LLPS-Hos-a157 | Homo sapiens | 6e-104 | 309 | undefined |