• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Bot-4434
VPS4B

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Vacuolar protein sorting-associated protein 4B
Gene Name: VPS4B
Ensembl Gene: ENSBTAG00000010492.6
Ensembl Protein: ENSBTAP00000065188.1
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION


Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses). Involved in cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).

▼ SEQUENCE


Protein Sequence (FASTA)
1     MASTPTNLQK  AIDLASKAAQ  EDKAGNYEEA  LQLYQHAVQY  FLHVVKYEAQ  GDKAKQSIRA  60
61    KCTEYLDRAE  KLKEYLKKRE  KKPQKPVKEG  QPAPADEKGN  DSDGEGESDD  PEKKKLQNQL  120
121   QGAIVIERPN  VKWSDVAGLE  GAKEALKEAV  ILPIKFPHLF  TGKRTPWRGI  LLFGPPGTGK  180
181   SYLAKAVATE  ANNSTFFSIS  SSDLVSKWLG  ESEKLVKNLF  QLARENKPSI  IFIDEIDSLC  240
241   GSRSENESEA  ARRIKTEFLV  QMQGVGVDND  GILVLGATNI  PWVLDSAIRR  RFEKRIYIPL  300
301   PEAHARAAMF  KLHLGTTQNS  LTEADFRDLG  KKTEGYSGAD  ISIIVRDALM  QPVRKVQSAT  360
361   HFKKVRGPSR  ADPNNIVDDL  LTPCSPGDPG  AIEMTWMDVP  GDKLLEPVVC  MSDMLRSLSS  420
421   TKPTVNEHDL  LKLKKFTEDF  GQEG  444
Nucleotide CDS Sequence (FASTA)
1     ATGGCGTCCA  CCCCTACCAA  CCTGCAGAAA  GCCATAGATC  TTGCTAGCAA  AGCAGCCCAG  60
61    GAAGATAAAG  CCGGAAACTA  CGAGGAGGCC  CTTCAACTCT  ACCAACATGC  TGTGCAGTAT  120
121   TTTCTCCACG  TGGTTAAATA  TGAAGCACAA  GGTGATAAAG  CCAAGCAGAG  TATCAGGGCG  180
181   AAGTGTACGG  AGTATCTTGA  TAGAGCGGAG  AAGCTGAAGG  AGTACCTGAA  GAAGAGAGAG  240
241   AAGAAGCCCC  AGAAGCCGGT  GAAGGAGGGG  CAGCCGGCCC  CCGCTGACGA  GAAGGGGAAT  300
301   GACAGTGATG  GGGAAGGAGA  ATCTGATGAT  CCCGAAAAAA  AGAAACTGCA  GAATCAACTT  360
361   CAAGGTGCCA  TTGTTATAGA  GCGACCCAAT  GTGAAGTGGA  GCGATGTTGC  TGGTCTGGAA  420
421   GGAGCTAAAG  AAGCTCTGAA  AGAGGCCGTG  ATATTGCCTA  TCAAATTTCC  TCATCTCTTT  480
481   ACAGGCAAGA  GAACGCCTTG  GAGGGGAATC  CTGTTATTTG  GGCCACCTGG  AACAGGAAAG  540
541   TCCTATTTAG  CCAAAGCTGT  AGCCACAGAA  GCAAATAACT  CAACATTTTT  CTCAATATCT  600
601   TCCTCTGACC  TTGTTTCTAA  GTGGCTAGGT  GAAAGTGAAA  AGCTAGTTAA  GAACTTATTC  660
661   CAGCTTGCCA  GAGAGAATAA  ACCTTCGATT  ATCTTCATTG  ATGAAATCGA  TTCTCTGTGT  720
721   GGTTCAAGAA  GTGAAAATGA  AAGTGAAGCT  GCAAGAAGAA  TTAAGACAGA  ATTCCTAGTT  780
781   CAGATGCAAG  GGGTTGGCGT  GGACAATGAT  GGAATTTTGG  TTCTGGGAGC  TACAAATATA  840
841   CCCTGGGTTC  TGGATTCTGC  CATTAGGCGA  AGGTTTGAGA  AACGAATTTA  CATTCCTTTG  900
901   CCTGAGGCGC  ATGCCCGAGC  AGCGATGTTT  AAACTGCACT  TGGGCACCAC  TCAGAACAGT  960
961   CTGACGGAAG  CAGACTTCCG  GGACCTCGGA  AAGAAGACTG  AGGGCTACTC  AGGGGCGGAC  1020
1021  ATAAGCATCA  TTGTACGGGA  CGCACTTATG  CAGCCAGTGA  GGAAAGTGCA  GTCAGCTACC  1080
1081  CATTTTAAAA  AGGTTCGCGG  ACCTTCACGG  GCTGATCCTA  ACAACATAGT  AGATGACCTG  1140
1141  CTCACGCCCT  GCTCTCCAGG  CGACCCTGGT  GCCATTGAGA  TGACATGGAT  GGATGTCCCT  1200
1201  GGGGATAAAC  TTTTGGAGCC  AGTTGTTTGC  ATGTCGGACA  TGTTACGGTC  ACTGTCTAGC  1260
1261  ACAAAGCCCA  CGGTCAATGA  ACACGACCTG  TTAAAACTAA  AGAAGTTTAC  AGAAGATTTT  1320
1321  GGCCAAGAAG  GCTAG  1335

▼ KEYWORD


ID
Family
ATP-binding
Cell cycle
Cell division
Coiled coil
Complete proteome
Endosome
Hydrolase
Membrane
Nucleotide-binding
Phosphoprotein
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cytosol
Cellular Component
Flemming body
Cellular Component
Late endosome membrane
Cellular Component
Nucleus
Cellular Component
Spindle pole
Molecular Function
ATP binding
Molecular Function
ATPase activity
Molecular Function
ATPase activity, coupled
Molecular Function
Protein C-terminus binding
Molecular Function
Protein homodimerization activity
Biological Process
Cholesterol transport
Biological Process
Endosome to lysosome transport via multivesicular body sorting pathway
Biological Process
Late endosomal microautophagy
Biological Process
Midbody abscission
Biological Process
Mitotic metaphase plate congression
Biological Process
Multivesicular body assembly
Biological Process
Negative regulation of cell death
Biological Process
Negative regulation of exosomal secretion
Biological Process
Nucleus organization
Biological Process
Positive regulation of centriole elongation
Biological Process
Positive regulation of exosomal secretion
Biological Process
Positive regulation of G2/M transition of mitotic cell cycle
Biological Process
Positive regulation of viral release from host cell
Biological Process
Potassium ion transport
Biological Process
Protein depolymerization
Biological Process
Protein transport
Biological Process
Regulation of mitotic spindle assembly
Biological Process
Response to lipid
Biological Process
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process
Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
Biological Process
Vacuole organization
Biological Process
Viral budding via host ESCRT complex
Biological Process
Viral release from host cell

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-1169Ovis aries98.650.0 814
LLPS-Fud-2888Fukomys damarensis97.520.0 800
LLPS-Rhb-3669Rhinopithecus bieti96.850.0 801
LLPS-Mal-2989Mandrillus leucophaeus96.620.0 801
LLPS-Dio-0504Dipodomys ordii96.620.0 792
LLPS-Maf-4387Macaca fascicularis96.620.0 796
LLPS-Chs-4788Chlorocebus sabaeus96.620.0 801
LLPS-Cea-0596Cercocebus atys96.620.0 797
LLPS-Poa-3996Pongo abelii96.620.0 801
LLPS-Cap-4162Cavia porcellus96.620.0 795
LLPS-Mam-3409Macaca mulatta96.620.0 801
LLPS-Hos-3929Homo sapiens96.620.0 801
LLPS-Man-2082Macaca nemestrina96.620.0 796
LLPS-Paa-0064Papio anubis96.40.0 795
LLPS-Gog-3079Gorilla gorilla96.40.0 799
LLPS-Loa-3516Loxodonta africana96.170.0 800
LLPS-Caj-4624Callithrix jacchus95.740.0 790
LLPS-Aon-1898Aotus nancymaae95.740.0 789
LLPS-Nol-4462Nomascus leucogenys95.740.0 788
LLPS-Pat-3891Pan troglodytes95.520.0 790
LLPS-Pap-1976Pan paniscus95.520.0 790
LLPS-Ere-0016Erinaceus europaeus94.720.0 714
LLPS-Fia-0651Ficedula albicollis90.160.0 731
LLPS-Gaga-3964Gallus gallus89.950.0 726
LLPS-Pes-0723Pelodiscus sinensis89.930.0 733
LLPS-Meg-3132Meleagris gallopavo89.930.0 726
LLPS-Tag-2911Taeniopygia guttata89.020.0 723
LLPS-Anp-3138Anas platyrhynchos87.840.0 724
LLPS-Dar-0802Danio rerio86.010.0 714
LLPS-Icp-1474Ictalurus punctatus85.810.0 721
LLPS-Orn-1902Oreochromis niloticus82.950.0 708
LLPS-Scm-3733Scophthalmus maximus82.690.0 707
LLPS-Xim-3389Xiphophorus maculatus82.230.0 700
LLPS-Pof-2988Poecilia formosa82.230.0 699
LLPS-Gaa-2483Gasterosteus aculeatus82.130.0 701
LLPS-Anc-0212Anolis carolinensis81.180.0 688
LLPS-Otg-0663Otolemur garnettii80.960.0 686
LLPS-Mea-3071Mesocricetus auratus80.280.0 681
LLPS-Scf-0592Scleropages formosus80.270.0 688
LLPS-Leo-1432Lepisosteus oculatus80.270.0 692
LLPS-Ran-0091Rattus norvegicus80.230.0 687
LLPS-Mum-1587Mus musculus80.230.0 687
LLPS-Cas-0902Carlito syrichta80.230.0 686
LLPS-Orc-0586Oryctolagus cuniculus80.230.0 687
LLPS-Myl-2869Myotis lucifugus80.050.0 682
LLPS-Sus-0550Sus scrofa80.050.0 686
LLPS-Mup-2478Mustela putorius furo80.00.0 688
LLPS-Caf-0571Canis familiaris79.950.0 685
LLPS-Aim-2510Ailuropoda melanoleuca79.910.0 684
LLPS-Mod-1502Monodelphis domestica79.910.0 683
LLPS-Eqc-1220Equus caballus79.90.0 634
LLPS-Sah-1239Sarcophilus harrisii79.820.0 680
LLPS-Ora-0436Ornithorhynchus anatinus79.630.0 682
LLPS-Xet-0204Xenopus tropicalis79.590.0 693
LLPS-Urm-0919Ursus maritimus79.590.0 681
LLPS-Asm-0401Astyanax mexicanus79.550.0 691
LLPS-Ict-3080Ictidomys tridecemlineatus79.550.0 679
LLPS-Fec-0830Felis catus79.550.0 685
LLPS-Tar-0557Takifugu rubripes79.310.0 680
LLPS-Lac-0057Latimeria chalumnae79.270.0 683
LLPS-Ten-2198Tetraodon nigroviridis79.220.0 671
LLPS-Orl-3324Oryzias latipes77.10.0 675
LLPS-Tut-1477Tursiops truncatus76.710.0 678
LLPS-Put-0907Puccinia triticina76.362e-84 266
LLPS-Drm-1454Drosophila melanogaster74.940.0 631
LLPS-Cis-1612Ciona savignyi72.654e-117 349
LLPS-Cii-1044Ciona intestinalis68.490.0 597
LLPS-Cae-0121Caenorhabditis elegans67.280.0 590
LLPS-Crn-0895Cryptococcus neoformans61.424e-166 482
LLPS-Hov-0585Hordeum vulgare61.084e-139 416
LLPS-Asg-0429Ashbya gossypii60.41e-169 491
LLPS-Sac-1212Saccharomyces cerevisiae60.312e-174 503
LLPS-Mel-0130Melampsora laricipopulina59.686e-170 492
LLPS-Kop-0338Komagataella pastoris59.52e-171 495
LLPS-Pug-0580Puccinia graminis59.462e-171 496
LLPS-Blg-0019Blumeria graminis59.043e-170 492
LLPS-Nec-1292Neurospora crassa58.333e-168 488
LLPS-Miv-1422Microbotryum violaceum58.37e-167 484
LLPS-Cym-0316Cyanidioschyzon merolae58.226e-127 385
LLPS-Scp-1222Schizosaccharomyces pombe58.142e-159 465
LLPS-Scc-1154Schizosaccharomyces cryophilus58.141e-157 461
LLPS-Dos-0949Dothistroma septosporum58.099e-166 481
LLPS-Asf-0380Aspergillus flavus57.898e-169 489
LLPS-Asc-0067Aspergillus clavatus57.867e-170 491
LLPS-Ast-0832Aspergillus terreus57.861e-169 491
LLPS-Tum-1042Tuber melanosporum57.826e-168 486
LLPS-Usm-0594Ustilago maydis57.668e-169 490
LLPS-Spr-0962Sporisorium reilianum57.661e-168 490
LLPS-Asni-0022Aspergillus niger57.637e-170 491
LLPS-Lem-0542Leptosphaeria maculans57.563e-161 469
LLPS-Yal-0634Yarrowia lipolytica57.241e-165 480
LLPS-Scj-1478Schizosaccharomyces japonicus57.186e-158 461
LLPS-Asfu-0833Aspergillus fumigatus57.172e-169 490
LLPS-Asn-0968Aspergillus nidulans56.981e-170 494
LLPS-Nef-0231Neosartorya fischeri56.951e-168 488
LLPS-Chr-1513Chlamydomonas reinhardtii56.728e-163 474
LLPS-Zyt-0226Zymoseptoria tritici56.391e-160 468
LLPS-Gag-0359Gaeumannomyces graminis56.32e-150 443
LLPS-Coo-1010Colletotrichum orbiculare55.83e-154 452
LLPS-Mao-0131Magnaporthe oryzae55.782e-160 467
LLPS-Aso-1228Aspergillus oryzae55.753e-165 480
LLPS-Beb-1235Beauveria bassiana55.688e-149 437
LLPS-Sei-2178Setaria italica55.665e-152 446
LLPS-Gas-0335Galdieria sulphuraria55.631e-161 471
LLPS-Cogr-1560Colletotrichum graminicola55.583e-152 446
LLPS-Zem-2303Zea mays55.432e-152 447
LLPS-Pytr-0885Pyrenophora triticirepentis55.436e-156 456
LLPS-Cog-0741Colletotrichum gloeosporioides55.384e-154 451
LLPS-Sob-1314Sorghum bicolor55.33e-154 452
LLPS-Map-0592Magnaporthe poae55.15e-158 462
LLPS-Bro-0918Brassica oleracea55.12e-150 442
LLPS-Brr-2381Brassica rapa55.13e-149 439
LLPS-Pot-0885Populus trichocarpa55.13e-150 441
LLPS-Chc-0879Chondrus crispus55.03e-149 439
LLPS-Trr-0807Trichoderma reesei54.943e-150 441
LLPS-Orr-2069Oryza rufipogon54.95e-144 437
LLPS-Fus-0219Fusarium solani54.886e-149 438
LLPS-Hea-0104Helianthus annuus54.856e-150 441
LLPS-Sol-2004Solanum lycopersicum54.851e-144 427
LLPS-Tra-0488Triticum aestivum54.831e-155 456
LLPS-Ved-0260Verticillium dahliae54.713e-156 457
LLPS-Orgl-1181Oryza glumaepatula54.652e-144 438
LLPS-Orni-0044Oryza nivara54.652e-143 437
LLPS-Orb-0309Oryza barthii54.654e-144 438
LLPS-Ori-0496Oryza indica54.652e-149 439
LLPS-Org-1671Oryza glaberrima54.652e-149 439
LLPS-Orbr-1690Oryza brachyantha54.652e-149 439
LLPS-Mae-1865Manihot esculenta54.652e-149 439
LLPS-Orp-1303Oryza punctata54.652e-149 439
LLPS-Arl-2110Arabidopsis lyrata54.528e-151 443
LLPS-Pyt-0568Pyrenophora teres54.523e-151 444
LLPS-Php-1576Physcomitrella patens54.481e-151 446
LLPS-Mua-2472Musa acuminata54.421e-153 449
LLPS-Dac-0537Daucus carota54.365e-148 436
LLPS-Fuv-1141Fusarium verticillioides54.322e-148 437
LLPS-Fuo-0279Fusarium oxysporum54.322e-148 437
LLPS-Art-2900Arabidopsis thaliana54.34e-150 441
LLPS-Trv-0993Trichoderma virens54.254e-148 436
LLPS-Glm-2644Glycine max54.26e-148 436
LLPS-Phv-2579Phaseolus vulgaris54.23e-146 431
LLPS-Amt-0912Amborella trichopoda54.24e-151 444
LLPS-Nia-2320Nicotiana attenuata54.21e-151 445
LLPS-Thc-2121Theobroma cacao54.056e-151 443
LLPS-Brn-2430Brassica napus53.748e-149 438
LLPS-Brd-1758Brachypodium distachyon53.711e-152 448
LLPS-Coc-0217Corchorus capsularis53.66e-150 441
LLPS-Sem-1833Selaginella moellendorffii53.381e-148 437
LLPS-Sot-1975Solanum tuberosum53.292e-146 432
LLPS-Osl-0483Ostreococcus lucimarinus52.834e-142 421
LLPS-Viv-0676Vitis vinifera52.774e-151 444
LLPS-Lep-2095Leersia perrieri52.611e-144 427
LLPS-Prp-0208Prunus persica52.551e-150 442
LLPS-Orm-0701Oryza meridionalis52.385e-140 416
LLPS-Gor-1335Gossypium raimondii52.325e-150 441
LLPS-Via-0535Vigna angularis52.233e-143 424
LLPS-Ors-0361Oryza sativa52.155e-142 421
LLPS-Cus-1022Cucumis sativus52.113e-146 431
LLPS-Vir-0212Vigna radiata52.012e-142 421
LLPS-Met-0938Medicago truncatula51.326e-144 426
LLPS-Tru-0904Triticum urartu50.755e-78 254
LLPS-Phn-0529Phaeosphaeria nodorum49.212e-131 394