LLPS-Bot-4434
VPS4B
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Vacuolar protein sorting-associated protein 4B |
Gene Name: | VPS4B |
Ensembl Gene: | ENSBTAG00000010492.6 |
Ensembl Protein: | ENSBTAP00000065188.1 |
Organism: | Bos taurus |
Taxa ID: | 9913 |
LLPS Type: | Regulator |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
P-body | Predicted from orthologs | (View) |
▼ FUNCTION
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses). Involved in cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSBTAT00000081581.1 | ENSBTAP00000065188.1 |
Ensembl | ENSBTAT00000068822.1 | ENSBTAP00000071239.1 |
Ensembl | ENSBTAT00000013862.6 | ENSBTAP00000013862.5 |
UniProt | Q0VD48, VPS4B_BOVIN | |
GeneBank | BC119836 | AAI19837.1 |
RefSeq | NM_001076156.1 | NP_001069624.1 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MASTPTNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ GDKAKQSIRA 60 61 KCTEYLDRAE KLKEYLKKRE KKPQKPVKEG QPAPADEKGN DSDGEGESDD PEKKKLQNQL 120 121 QGAIVIERPN VKWSDVAGLE GAKEALKEAV ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK 180 181 SYLAKAVATE ANNSTFFSIS SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC 240 241 GSRSENESEA ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL 300 301 PEAHARAAMF KLHLGTTQNS LTEADFRDLG KKTEGYSGAD ISIIVRDALM QPVRKVQSAT 360 361 HFKKVRGPSR ADPNNIVDDL LTPCSPGDPG AIEMTWMDVP GDKLLEPVVC MSDMLRSLSS 420 421 TKPTVNEHDL LKLKKFTEDF GQEG 444 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGCGTCCA CCCCTACCAA CCTGCAGAAA GCCATAGATC TTGCTAGCAA AGCAGCCCAG 60 61 GAAGATAAAG CCGGAAACTA CGAGGAGGCC CTTCAACTCT ACCAACATGC TGTGCAGTAT 120 121 TTTCTCCACG TGGTTAAATA TGAAGCACAA GGTGATAAAG CCAAGCAGAG TATCAGGGCG 180 181 AAGTGTACGG AGTATCTTGA TAGAGCGGAG AAGCTGAAGG AGTACCTGAA GAAGAGAGAG 240 241 AAGAAGCCCC AGAAGCCGGT GAAGGAGGGG CAGCCGGCCC CCGCTGACGA GAAGGGGAAT 300 301 GACAGTGATG GGGAAGGAGA ATCTGATGAT CCCGAAAAAA AGAAACTGCA GAATCAACTT 360 361 CAAGGTGCCA TTGTTATAGA GCGACCCAAT GTGAAGTGGA GCGATGTTGC TGGTCTGGAA 420 421 GGAGCTAAAG AAGCTCTGAA AGAGGCCGTG ATATTGCCTA TCAAATTTCC TCATCTCTTT 480 481 ACAGGCAAGA GAACGCCTTG GAGGGGAATC CTGTTATTTG GGCCACCTGG AACAGGAAAG 540 541 TCCTATTTAG CCAAAGCTGT AGCCACAGAA GCAAATAACT CAACATTTTT CTCAATATCT 600 601 TCCTCTGACC TTGTTTCTAA GTGGCTAGGT GAAAGTGAAA AGCTAGTTAA GAACTTATTC 660 661 CAGCTTGCCA GAGAGAATAA ACCTTCGATT ATCTTCATTG ATGAAATCGA TTCTCTGTGT 720 721 GGTTCAAGAA GTGAAAATGA AAGTGAAGCT GCAAGAAGAA TTAAGACAGA ATTCCTAGTT 780 781 CAGATGCAAG GGGTTGGCGT GGACAATGAT GGAATTTTGG TTCTGGGAGC TACAAATATA 840 841 CCCTGGGTTC TGGATTCTGC CATTAGGCGA AGGTTTGAGA AACGAATTTA CATTCCTTTG 900 901 CCTGAGGCGC ATGCCCGAGC AGCGATGTTT AAACTGCACT TGGGCACCAC TCAGAACAGT 960 961 CTGACGGAAG CAGACTTCCG GGACCTCGGA AAGAAGACTG AGGGCTACTC AGGGGCGGAC 1020 1021 ATAAGCATCA TTGTACGGGA CGCACTTATG CAGCCAGTGA GGAAAGTGCA GTCAGCTACC 1080 1081 CATTTTAAAA AGGTTCGCGG ACCTTCACGG GCTGATCCTA ACAACATAGT AGATGACCTG 1140 1141 CTCACGCCCT GCTCTCCAGG CGACCCTGGT GCCATTGAGA TGACATGGAT GGATGTCCCT 1200 1201 GGGGATAAAC TTTTGGAGCC AGTTGTTTGC ATGTCGGACA TGTTACGGTC ACTGTCTAGC 1260 1261 ACAAAGCCCA CGGTCAATGA ACACGACCTG TTAAAACTAA AGAAGTTTAC AGAAGATTTT 1320 1321 GGCCAAGAAG GCTAG 1335 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Cytosol | |
Cellular Component | Flemming body | |
Cellular Component | Late endosome membrane | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole | |
Molecular Function | ATP binding | |
Molecular Function | ATPase activity | |
Molecular Function | ATPase activity, coupled | |
Molecular Function | Protein C-terminus binding | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Cholesterol transport | |
Biological Process | Endosome to lysosome transport via multivesicular body sorting pathway | |
Biological Process | Late endosomal microautophagy | |
Biological Process | Midbody abscission | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Multivesicular body assembly | |
Biological Process | Negative regulation of cell death | |
Biological Process | Negative regulation of exosomal secretion | |
Biological Process | Nucleus organization | |
Biological Process | Positive regulation of centriole elongation | |
Biological Process | Positive regulation of exosomal secretion | |
Biological Process | Positive regulation of G2/M transition of mitotic cell cycle | |
Biological Process | Positive regulation of viral release from host cell | |
Biological Process | Potassium ion transport | |
Biological Process | Protein depolymerization | |
Biological Process | Protein transport | |
Biological Process | Regulation of mitotic spindle assembly | |
Biological Process | Response to lipid | |
Biological Process | Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | |
Biological Process | Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway | |
Biological Process | Vacuole organization | |
Biological Process | Viral budding via host ESCRT complex | |
Biological Process | Viral release from host cell |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Ova-1169 | Ovis aries | 98.65 | 0.0 | 814 |
LLPS-Fud-2888 | Fukomys damarensis | 97.52 | 0.0 | 800 |
LLPS-Rhb-3669 | Rhinopithecus bieti | 96.85 | 0.0 | 801 |
LLPS-Mal-2989 | Mandrillus leucophaeus | 96.62 | 0.0 | 801 |
LLPS-Dio-0504 | Dipodomys ordii | 96.62 | 0.0 | 792 |
LLPS-Maf-4387 | Macaca fascicularis | 96.62 | 0.0 | 796 |
LLPS-Chs-4788 | Chlorocebus sabaeus | 96.62 | 0.0 | 801 |
LLPS-Cea-0596 | Cercocebus atys | 96.62 | 0.0 | 797 |
LLPS-Poa-3996 | Pongo abelii | 96.62 | 0.0 | 801 |
LLPS-Cap-4162 | Cavia porcellus | 96.62 | 0.0 | 795 |
LLPS-Mam-3409 | Macaca mulatta | 96.62 | 0.0 | 801 |
LLPS-Hos-3929 | Homo sapiens | 96.62 | 0.0 | 801 |
LLPS-Man-2082 | Macaca nemestrina | 96.62 | 0.0 | 796 |
LLPS-Paa-0064 | Papio anubis | 96.4 | 0.0 | 795 |
LLPS-Gog-3079 | Gorilla gorilla | 96.4 | 0.0 | 799 |
LLPS-Loa-3516 | Loxodonta africana | 96.17 | 0.0 | 800 |
LLPS-Caj-4624 | Callithrix jacchus | 95.74 | 0.0 | 790 |
LLPS-Aon-1898 | Aotus nancymaae | 95.74 | 0.0 | 789 |
LLPS-Nol-4462 | Nomascus leucogenys | 95.74 | 0.0 | 788 |
LLPS-Pat-3891 | Pan troglodytes | 95.52 | 0.0 | 790 |
LLPS-Pap-1976 | Pan paniscus | 95.52 | 0.0 | 790 |
LLPS-Ere-0016 | Erinaceus europaeus | 94.72 | 0.0 | 714 |
LLPS-Fia-0651 | Ficedula albicollis | 90.16 | 0.0 | 731 |
LLPS-Gaga-3964 | Gallus gallus | 89.95 | 0.0 | 726 |
LLPS-Pes-0723 | Pelodiscus sinensis | 89.93 | 0.0 | 733 |
LLPS-Meg-3132 | Meleagris gallopavo | 89.93 | 0.0 | 726 |
LLPS-Tag-2911 | Taeniopygia guttata | 89.02 | 0.0 | 723 |
LLPS-Anp-3138 | Anas platyrhynchos | 87.84 | 0.0 | 724 |
LLPS-Dar-0802 | Danio rerio | 86.01 | 0.0 | 714 |
LLPS-Icp-1474 | Ictalurus punctatus | 85.81 | 0.0 | 721 |
LLPS-Orn-1902 | Oreochromis niloticus | 82.95 | 0.0 | 708 |
LLPS-Scm-3733 | Scophthalmus maximus | 82.69 | 0.0 | 707 |
LLPS-Xim-3389 | Xiphophorus maculatus | 82.23 | 0.0 | 700 |
LLPS-Pof-2988 | Poecilia formosa | 82.23 | 0.0 | 699 |
LLPS-Gaa-2483 | Gasterosteus aculeatus | 82.13 | 0.0 | 701 |
LLPS-Anc-0212 | Anolis carolinensis | 81.18 | 0.0 | 688 |
LLPS-Otg-0663 | Otolemur garnettii | 80.96 | 0.0 | 686 |
LLPS-Mea-3071 | Mesocricetus auratus | 80.28 | 0.0 | 681 |
LLPS-Scf-0592 | Scleropages formosus | 80.27 | 0.0 | 688 |
LLPS-Leo-1432 | Lepisosteus oculatus | 80.27 | 0.0 | 692 |
LLPS-Ran-0091 | Rattus norvegicus | 80.23 | 0.0 | 687 |
LLPS-Mum-1587 | Mus musculus | 80.23 | 0.0 | 687 |
LLPS-Cas-0902 | Carlito syrichta | 80.23 | 0.0 | 686 |
LLPS-Orc-0586 | Oryctolagus cuniculus | 80.23 | 0.0 | 687 |
LLPS-Myl-2869 | Myotis lucifugus | 80.05 | 0.0 | 682 |
LLPS-Sus-0550 | Sus scrofa | 80.05 | 0.0 | 686 |
LLPS-Mup-2478 | Mustela putorius furo | 80.0 | 0.0 | 688 |
LLPS-Caf-0571 | Canis familiaris | 79.95 | 0.0 | 685 |
LLPS-Aim-2510 | Ailuropoda melanoleuca | 79.91 | 0.0 | 684 |
LLPS-Mod-1502 | Monodelphis domestica | 79.91 | 0.0 | 683 |
LLPS-Eqc-1220 | Equus caballus | 79.9 | 0.0 | 634 |
LLPS-Sah-1239 | Sarcophilus harrisii | 79.82 | 0.0 | 680 |
LLPS-Ora-0436 | Ornithorhynchus anatinus | 79.63 | 0.0 | 682 |
LLPS-Xet-0204 | Xenopus tropicalis | 79.59 | 0.0 | 693 |
LLPS-Urm-0919 | Ursus maritimus | 79.59 | 0.0 | 681 |
LLPS-Asm-0401 | Astyanax mexicanus | 79.55 | 0.0 | 691 |
LLPS-Ict-3080 | Ictidomys tridecemlineatus | 79.55 | 0.0 | 679 |
LLPS-Fec-0830 | Felis catus | 79.55 | 0.0 | 685 |
LLPS-Tar-0557 | Takifugu rubripes | 79.31 | 0.0 | 680 |
LLPS-Lac-0057 | Latimeria chalumnae | 79.27 | 0.0 | 683 |
LLPS-Ten-2198 | Tetraodon nigroviridis | 79.22 | 0.0 | 671 |
LLPS-Orl-3324 | Oryzias latipes | 77.1 | 0.0 | 675 |
LLPS-Tut-1477 | Tursiops truncatus | 76.71 | 0.0 | 678 |
LLPS-Put-0907 | Puccinia triticina | 76.36 | 2e-84 | 266 |
LLPS-Drm-1454 | Drosophila melanogaster | 74.94 | 0.0 | 631 |
LLPS-Cis-1612 | Ciona savignyi | 72.65 | 4e-117 | 349 |
LLPS-Cii-1044 | Ciona intestinalis | 68.49 | 0.0 | 597 |
LLPS-Cae-0121 | Caenorhabditis elegans | 67.28 | 0.0 | 590 |
LLPS-Crn-0895 | Cryptococcus neoformans | 61.42 | 4e-166 | 482 |
LLPS-Hov-0585 | Hordeum vulgare | 61.08 | 4e-139 | 416 |
LLPS-Asg-0429 | Ashbya gossypii | 60.4 | 1e-169 | 491 |
LLPS-Sac-1212 | Saccharomyces cerevisiae | 60.31 | 2e-174 | 503 |
LLPS-Mel-0130 | Melampsora laricipopulina | 59.68 | 6e-170 | 492 |
LLPS-Kop-0338 | Komagataella pastoris | 59.5 | 2e-171 | 495 |
LLPS-Pug-0580 | Puccinia graminis | 59.46 | 2e-171 | 496 |
LLPS-Blg-0019 | Blumeria graminis | 59.04 | 3e-170 | 492 |
LLPS-Nec-1292 | Neurospora crassa | 58.33 | 3e-168 | 488 |
LLPS-Miv-1422 | Microbotryum violaceum | 58.3 | 7e-167 | 484 |
LLPS-Cym-0316 | Cyanidioschyzon merolae | 58.22 | 6e-127 | 385 |
LLPS-Scp-1222 | Schizosaccharomyces pombe | 58.14 | 2e-159 | 465 |
LLPS-Scc-1154 | Schizosaccharomyces cryophilus | 58.14 | 1e-157 | 461 |
LLPS-Dos-0949 | Dothistroma septosporum | 58.09 | 9e-166 | 481 |
LLPS-Asf-0380 | Aspergillus flavus | 57.89 | 8e-169 | 489 |
LLPS-Asc-0067 | Aspergillus clavatus | 57.86 | 7e-170 | 491 |
LLPS-Ast-0832 | Aspergillus terreus | 57.86 | 1e-169 | 491 |
LLPS-Tum-1042 | Tuber melanosporum | 57.82 | 6e-168 | 486 |
LLPS-Usm-0594 | Ustilago maydis | 57.66 | 8e-169 | 490 |
LLPS-Spr-0962 | Sporisorium reilianum | 57.66 | 1e-168 | 490 |
LLPS-Asni-0022 | Aspergillus niger | 57.63 | 7e-170 | 491 |
LLPS-Lem-0542 | Leptosphaeria maculans | 57.56 | 3e-161 | 469 |
LLPS-Yal-0634 | Yarrowia lipolytica | 57.24 | 1e-165 | 480 |
LLPS-Scj-1478 | Schizosaccharomyces japonicus | 57.18 | 6e-158 | 461 |
LLPS-Asfu-0833 | Aspergillus fumigatus | 57.17 | 2e-169 | 490 |
LLPS-Asn-0968 | Aspergillus nidulans | 56.98 | 1e-170 | 494 |
LLPS-Nef-0231 | Neosartorya fischeri | 56.95 | 1e-168 | 488 |
LLPS-Chr-1513 | Chlamydomonas reinhardtii | 56.72 | 8e-163 | 474 |
LLPS-Zyt-0226 | Zymoseptoria tritici | 56.39 | 1e-160 | 468 |
LLPS-Gag-0359 | Gaeumannomyces graminis | 56.3 | 2e-150 | 443 |
LLPS-Coo-1010 | Colletotrichum orbiculare | 55.8 | 3e-154 | 452 |
LLPS-Mao-0131 | Magnaporthe oryzae | 55.78 | 2e-160 | 467 |
LLPS-Aso-1228 | Aspergillus oryzae | 55.75 | 3e-165 | 480 |
LLPS-Beb-1235 | Beauveria bassiana | 55.68 | 8e-149 | 437 |
LLPS-Sei-2178 | Setaria italica | 55.66 | 5e-152 | 446 |
LLPS-Gas-0335 | Galdieria sulphuraria | 55.63 | 1e-161 | 471 |
LLPS-Cogr-1560 | Colletotrichum graminicola | 55.58 | 3e-152 | 446 |
LLPS-Zem-2303 | Zea mays | 55.43 | 2e-152 | 447 |
LLPS-Pytr-0885 | Pyrenophora triticirepentis | 55.43 | 6e-156 | 456 |
LLPS-Cog-0741 | Colletotrichum gloeosporioides | 55.38 | 4e-154 | 451 |
LLPS-Sob-1314 | Sorghum bicolor | 55.3 | 3e-154 | 452 |
LLPS-Map-0592 | Magnaporthe poae | 55.1 | 5e-158 | 462 |
LLPS-Bro-0918 | Brassica oleracea | 55.1 | 2e-150 | 442 |
LLPS-Brr-2381 | Brassica rapa | 55.1 | 3e-149 | 439 |
LLPS-Pot-0885 | Populus trichocarpa | 55.1 | 3e-150 | 441 |
LLPS-Chc-0879 | Chondrus crispus | 55.0 | 3e-149 | 439 |
LLPS-Trr-0807 | Trichoderma reesei | 54.94 | 3e-150 | 441 |
LLPS-Orr-2069 | Oryza rufipogon | 54.9 | 5e-144 | 437 |
LLPS-Fus-0219 | Fusarium solani | 54.88 | 6e-149 | 438 |
LLPS-Hea-0104 | Helianthus annuus | 54.85 | 6e-150 | 441 |
LLPS-Sol-2004 | Solanum lycopersicum | 54.85 | 1e-144 | 427 |
LLPS-Tra-0488 | Triticum aestivum | 54.83 | 1e-155 | 456 |
LLPS-Ved-0260 | Verticillium dahliae | 54.71 | 3e-156 | 457 |
LLPS-Orgl-1181 | Oryza glumaepatula | 54.65 | 2e-144 | 438 |
LLPS-Orni-0044 | Oryza nivara | 54.65 | 2e-143 | 437 |
LLPS-Orb-0309 | Oryza barthii | 54.65 | 4e-144 | 438 |
LLPS-Ori-0496 | Oryza indica | 54.65 | 2e-149 | 439 |
LLPS-Org-1671 | Oryza glaberrima | 54.65 | 2e-149 | 439 |
LLPS-Orbr-1690 | Oryza brachyantha | 54.65 | 2e-149 | 439 |
LLPS-Mae-1865 | Manihot esculenta | 54.65 | 2e-149 | 439 |
LLPS-Orp-1303 | Oryza punctata | 54.65 | 2e-149 | 439 |
LLPS-Arl-2110 | Arabidopsis lyrata | 54.52 | 8e-151 | 443 |
LLPS-Pyt-0568 | Pyrenophora teres | 54.52 | 3e-151 | 444 |
LLPS-Php-1576 | Physcomitrella patens | 54.48 | 1e-151 | 446 |
LLPS-Mua-2472 | Musa acuminata | 54.42 | 1e-153 | 449 |
LLPS-Dac-0537 | Daucus carota | 54.36 | 5e-148 | 436 |
LLPS-Fuv-1141 | Fusarium verticillioides | 54.32 | 2e-148 | 437 |
LLPS-Fuo-0279 | Fusarium oxysporum | 54.32 | 2e-148 | 437 |
LLPS-Art-2900 | Arabidopsis thaliana | 54.3 | 4e-150 | 441 |
LLPS-Trv-0993 | Trichoderma virens | 54.25 | 4e-148 | 436 |
LLPS-Glm-2644 | Glycine max | 54.2 | 6e-148 | 436 |
LLPS-Phv-2579 | Phaseolus vulgaris | 54.2 | 3e-146 | 431 |
LLPS-Amt-0912 | Amborella trichopoda | 54.2 | 4e-151 | 444 |
LLPS-Nia-2320 | Nicotiana attenuata | 54.2 | 1e-151 | 445 |
LLPS-Thc-2121 | Theobroma cacao | 54.05 | 6e-151 | 443 |
LLPS-Brn-2430 | Brassica napus | 53.74 | 8e-149 | 438 |
LLPS-Brd-1758 | Brachypodium distachyon | 53.71 | 1e-152 | 448 |
LLPS-Coc-0217 | Corchorus capsularis | 53.6 | 6e-150 | 441 |
LLPS-Sem-1833 | Selaginella moellendorffii | 53.38 | 1e-148 | 437 |
LLPS-Sot-1975 | Solanum tuberosum | 53.29 | 2e-146 | 432 |
LLPS-Osl-0483 | Ostreococcus lucimarinus | 52.83 | 4e-142 | 421 |
LLPS-Viv-0676 | Vitis vinifera | 52.77 | 4e-151 | 444 |
LLPS-Lep-2095 | Leersia perrieri | 52.61 | 1e-144 | 427 |
LLPS-Prp-0208 | Prunus persica | 52.55 | 1e-150 | 442 |
LLPS-Orm-0701 | Oryza meridionalis | 52.38 | 5e-140 | 416 |
LLPS-Gor-1335 | Gossypium raimondii | 52.32 | 5e-150 | 441 |
LLPS-Via-0535 | Vigna angularis | 52.23 | 3e-143 | 424 |
LLPS-Ors-0361 | Oryza sativa | 52.15 | 5e-142 | 421 |
LLPS-Cus-1022 | Cucumis sativus | 52.11 | 3e-146 | 431 |
LLPS-Vir-0212 | Vigna radiata | 52.01 | 2e-142 | 421 |
LLPS-Met-0938 | Medicago truncatula | 51.32 | 6e-144 | 426 |
LLPS-Tru-0904 | Triticum urartu | 50.75 | 5e-78 | 254 |
LLPS-Phn-0529 | Phaeosphaeria nodorum | 49.21 | 2e-131 | 394 |