• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-4145
PTK2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein tyrosine kinase 2
Gene Name: PTK2
Ensembl Gene: ENSBTAG00000009578.6
Ensembl Protein: ENSBTAP00000056419.2
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLLGVAGRGA  LEPQALSMEK  SGCSPFPVCW  AKEYDRYLAS  SKRMAAAYLD  PNLNHTPSSS  60
61    TKTHLGTGVE  RSPGAMERVL  KVFHYFESNS  EPTTWASIIR  HGDATDVRGI  IQKIVDSHKV  120
121   KHVACYGFRL  SHLRSEEVHW  LHLDMGVSNV  REKYELAHPP  EEWKYELRIR  YLPKGFLNQF  180
181   TEDKPTLNFF  YQQVKSDYML  EIADQVDQDI  ALKLGCLEIR  RSYWEMRGNA  LEKKSNYEVL  240
241   EKDVGLKRFF  PRSLLDSVKA  KTLRKLIQQT  FRQFANLNRE  ESILKFFEIL  SPVYRFDKEC  300
301   FKCALGSSWI  ISVELAIGPE  EGISYLTDKG  CNPTHLADFN  QVQTIQYSNS  EDKDRKGTLQ  360
361   LKIAGAPEPL  TVTAPSLTIA  ENMADLIDGY  CRLVHGATQS  FIIRPQKEGE  RALPSIPKLA  420
421   NSEKQGVRTH  AVSVSDEISG  DETDDYAEII  DEEDTYTMPS  KSYGIDEARD  YEIQRERIEL  480
481   GRCIGEGQFG  DVHQGTYTSP  ENPALAVAIK  TCKNCTSDSV  REKFLQEALT  MRQFDHPHIV  540
541   KLIGVITENP  VWIIMELCTL  GELRSFLQVR  KYSLDLASLI  LYAYQLSTAL  AYLESKRFVH  600
601   RDIAARNVLV  SSNDCVKLGD  FGLSRYMEDS  TYYKASKGKL  PIKWMAPESI  NFRRFTSASD  660
661   VWMFGVCMWE  ILMHGVKPFQ  GVKNNDVIGR  IENGERLPMP  PNCPPTLYSL  MTKCWAYDPS  720
721   RRPRFTELKA  QLSTILEEEK  VQQEERMRME  SRRQVTASWD  SGGSDEAPPK  PSRPGYPSPR  780
781   SSEGFYPSPQ  HTVQTNHYQV  SGYPGPHGVT  AMAGSIYPGQ  ASLLDQTDSW  NHRPQEISMW  840
841   QPSVEDSAAL  DLRGLGQALP  THLMEERLIR  QQQEMEEDQR  WLEKEERFLK  PDVRLSRGSI  900
901   DREDGGPQGL  TGNQHIYQPV  GKPDPAAPPK  KPPRPGAPGH  LGSLASLGSP  GDSYNEGVKL  960
961   QPQEISPPPT  ANLDRSNDRV  YENVTGLVRA  VIEMSSKIQP  APPEEYVPMV  KEVGLALRTL  1020
1021  LATVDETIPV  LPASTHREIE  MAQKLLNSDL  GELINKMKLA  QQYVMTSLQQ  EYKKQMLTAA  1080
1081  HALAVDAKNL  LDVIDQARLK  ALGQPRPH  1108
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGCTG  CTTACCTTGA  CCCAAACTTG  AATCACACGC  CGAGTTCAAG  TACCAAGACT  60
61    CACCTGGGGA  CTGGTGTGGA  GCGTTCTCCT  GGGGCCATGG  AGCGAGTATT  AAAGGTCTTT  120
121   CATTATTTTG  AAAGCAACAG  TGAGCCAACC  ACTTGGGCCA  GTATTATCAG  GCATGGAGAT  180
181   GCAACCGACG  TCAGGGGCAT  CATTCAGAAG  ATAGTGGACA  GTCACAAAGT  AAAGCACGTG  240
241   GCCTGCTATG  GATTTCGCCT  GAGTCACCTG  CGGTCAGAGG  AGGTTCACTG  GCTCCATTTG  300
301   GATATGGGTG  TCTCCAATGT  GAGGGAGAAG  TATGAACTTG  CCCACCCACC  AGAGGAGTGG  360
361   AAATATGAAT  TGAGAATTCG  TTATTTGCCA  AAAGGATTTC  TAAACCAGTT  TACTGAAGAC  420
421   AAGCCAACTT  TGAATTTCTT  CTATCAACAG  AAAATTTCAC  GAGCACACAG  CATCAGGTCG  480
481   TGA  483

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Eqc-3431Equus caballus96.390.02098
LLPS-Ova-2836Ovis aries95.730.02048
LLPS-Caf-2955Canis familiaris95.630.02013
LLPS-Mam-3943Macaca mulatta95.40.02084
LLPS-Sus-3890Sus scrofa95.260.02084
LLPS-Ran-2302Rattus norvegicus94.870.02002
LLPS-Myl-3781Myotis lucifugus94.80.02001
LLPS-Cas-0980Carlito syrichta94.770.02063
LLPS-Paa-4588Papio anubis94.680.02060
LLPS-Mal-2441Mandrillus leucophaeus94.680.02060
LLPS-Mup-4265Mustela putorius furo94.680.02047
LLPS-Maf-4572Macaca fascicularis94.680.02060
LLPS-Caj-3570Callithrix jacchus94.680.02058
LLPS-Mum-4875Mus musculus94.660.01974
LLPS-Fud-2093Fukomys damarensis94.640.02007
LLPS-Otg-2457Otolemur garnettii94.630.01997
LLPS-Poa-0435Pongo abelii94.590.02054
LLPS-Loa-2023Loxodonta africana94.590.02018
LLPS-Urm-3836Ursus maritimus94.590.02045
LLPS-Gog-1812Gorilla gorilla94.590.02058
LLPS-Sah-0629Sarcophilus harrisii94.550.01967
LLPS-Hos-2776Homo sapiens94.50.02057
LLPS-Cap-2204Cavia porcellus94.190.01987
LLPS-Chs-3831Chlorocebus sabaeus94.040.01886
LLPS-Pes-2175Pelodiscus sinensis92.760.01941
LLPS-Aon-3902Aotus nancymaae92.610.02010
LLPS-Ict-3046Ictidomys tridecemlineatus92.440.02062
LLPS-Orc-0615Oryctolagus cuniculus91.930.01954
LLPS-Nol-1929Nomascus leucogenys91.610.02011
LLPS-Gaga-3313Gallus gallus91.450.01947
LLPS-Aim-2509Ailuropoda melanoleuca91.040.01642
LLPS-Fia-1378Ficedula albicollis91.020.02007
LLPS-Dio-0644Dipodomys ordii90.980.01944
LLPS-Pat-3783Pan troglodytes90.720.01899
LLPS-Pap-4354Pan paniscus90.720.01899
LLPS-Mea-4453Mesocricetus auratus90.550.01122
LLPS-Mod-2990Monodelphis domestica90.490.01994
LLPS-Rhb-1107Rhinopithecus bieti90.360.01944
LLPS-Meg-1659Meleagris gallopavo89.990.01153
LLPS-Cea-2842Cercocebus atys88.760.01857
LLPS-Man-4384Macaca nemestrina87.420.01904
LLPS-Xet-1345Xenopus tropicalis87.10.01730
LLPS-Scf-0722Scleropages formosus83.580.01812
LLPS-Icp-4044Ictalurus punctatus81.310.01736
LLPS-Asm-3526Astyanax mexicanus80.790.01748
LLPS-Dar-3863Danio rerio79.570.01690
LLPS-Leo-1370Lepisosteus oculatus79.20.01639
LLPS-Gaa-0879Gasterosteus aculeatus76.840.01574
LLPS-Orn-3149Oreochromis niloticus76.80.01572
LLPS-Scm-3096Scophthalmus maximus76.450.01598
LLPS-Ten-0417Tetraodon nigroviridis74.570.01540
LLPS-Orl-3597Oryzias latipes74.510.01578
LLPS-Pof-3518Poecilia formosa74.060.01603
LLPS-Lac-2613Latimeria chalumnae73.750.0 864
LLPS-Xim-4069Xiphophorus maculatus73.710.01581
LLPS-Tar-2437Takifugu rubripes73.660.01551
LLPS-Ora-1482Ornithorhynchus anatinus49.813e-162 506
LLPS-Fec-4385Felis catus48.830.0 645
LLPS-Anc-2144Anolis carolinensis42.429e-68 249
LLPS-Cii-1598Ciona intestinalis42.193e-60 226
LLPS-Tag-3123Taeniopygia guttata41.791e-67 248
LLPS-Anp-1176Anas platyrhynchos40.782e-60 230
LLPS-Drm-1666Drosophila melanogaster39.711e-60 231