LLPS-Bot-3749
HOPX
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Homeodomain-only protein; Odd homeobox protein 1 |
| Gene Name: | HOPX, HOD, HOP, OB1 |
| Ensembl Gene: | ENSBTAG00000002333.6 |
| Ensembl Protein: | ENSBTAP00000003013.3 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000003013.4 | ENSBTAP00000003013.3 |
| UniProt | Q8MJD5, HOP_BOVIN, Q3SZZ6 | |
| GeneBank | AF492683, BC102635 | AAI02636.1, AAM46835.1 |
| RefSeq | NM_174097.2, XM_005207940.2, XM_005207941.3, XM_005207942.2, XM_005207943.2 | NP_776522.1, XP_005207997.1, XP_005207998.1, XP_005207999.1, XP_005208000.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSTETASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLSEEETQKW FKQRLAQWRR 60 61 SEGLPSECRS VTD 73 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGACCG AGACCGCGAG CGGCCCCACT GAGGACCAGG TGGAGATCCT GGAGTACAAC 60 61 TTCAACAAGG TCAACAAGCA CCCGGACCCC ACCACGCTGT GCCTGATCGC GGCAGAGGCA 120 121 GGCCTTTCAG AGGAGGAGAC CCAGAAATGG TTCAAGCAGC GCCTGGCCCA GTGGCGGCGA 180 181 TCTGAAGGCC TACCCTCTGA GTGCAGATCC GTCACAGACT GA 222 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Biological Process | Heart development | |
Biological Process | Histone deacetylation | |
Biological Process | Lung alveolus development | |
Biological Process | Negative regulation of transcription by RNA polymerase II | |
Biological Process | Positive regulation of skeletal muscle tissue regeneration | |
Biological Process | Positive regulation of striated muscle cell differentiation | |
Biological Process | Regulation of heart contraction | |
Biological Process | Regulation of protein binding | |
Biological Process | Trophectodermal cell differentiation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Eqc-0679 | Equus caballus | 98.63 | 1e-47 | 152 |
| LLPS-Fec-0367 | Felis catus | 98.63 | 3e-47 | 151 |
| LLPS-Aim-0780 | Ailuropoda melanoleuca | 98.63 | 1e-47 | 152 |
| LLPS-Ova-3081 | Ovis aries | 98.46 | 8e-41 | 134 |
| LLPS-Tut-0893 | Tursiops truncatus | 97.92 | 2e-27 | 100 |
| LLPS-Ict-3157 | Ictidomys tridecemlineatus | 97.26 | 5e-47 | 150 |
| LLPS-Orc-0553 | Oryctolagus cuniculus | 97.26 | 1e-46 | 149 |
| LLPS-Fud-3609 | Fukomys damarensis | 97.26 | 1e-46 | 149 |
| LLPS-Urm-0680 | Ursus maritimus | 96.15 | 1e-10 | 57.0 |
| LLPS-Caf-1426 | Canis familiaris | 95.89 | 3e-46 | 148 |
| LLPS-Mea-2959 | Mesocricetus auratus | 95.89 | 1e-46 | 149 |
| LLPS-Poa-2561 | Pongo abelii | 94.52 | 3e-45 | 146 |
| LLPS-Cap-2484 | Cavia porcellus | 94.52 | 5e-45 | 145 |
| LLPS-Sus-2299 | Sus scrofa | 94.52 | 4e-44 | 147 |
| LLPS-Pat-1591 | Pan troglodytes | 93.75 | 3e-24 | 93.6 |
| LLPS-Pap-1441 | Pan paniscus | 93.75 | 2e-24 | 93.6 |
| LLPS-Hos-2348 | Homo sapiens | 93.75 | 3e-24 | 93.2 |
| LLPS-Paa-2423 | Papio anubis | 93.75 | 2e-24 | 93.6 |
| LLPS-Gog-4117 | Gorilla gorilla | 93.75 | 2e-24 | 93.6 |
| LLPS-Ran-0624 | Rattus norvegicus | 93.15 | 8e-46 | 147 |
| LLPS-Mum-2773 | Mus musculus | 93.15 | 8e-46 | 147 |
| LLPS-Chs-1056 | Chlorocebus sabaeus | 93.15 | 7e-45 | 145 |
| LLPS-Cea-3432 | Cercocebus atys | 93.15 | 7e-45 | 145 |
| LLPS-Mam-0350 | Macaca mulatta | 91.67 | 7e-24 | 92.4 |
| LLPS-Man-0307 | Macaca nemestrina | 91.67 | 5e-24 | 92.8 |
| LLPS-Rhb-3213 | Rhinopithecus bieti | 91.67 | 7e-24 | 92.4 |
| LLPS-Mal-0872 | Mandrillus leucophaeus | 91.67 | 7e-24 | 92.4 |
| LLPS-Maf-2123 | Macaca fascicularis | 91.67 | 7e-24 | 92.4 |
| LLPS-Caj-0676 | Callithrix jacchus | 89.04 | 2e-42 | 139 |
| LLPS-Dio-3920 | Dipodomys ordii | 88.57 | 1e-38 | 129 |
| LLPS-Myl-2375 | Myotis lucifugus | 88.24 | 7e-24 | 90.9 |
| LLPS-Aon-2449 | Aotus nancymaae | 86.3 | 3e-40 | 133 |
| LLPS-Nol-2173 | Nomascus leucogenys | 84.93 | 2e-38 | 129 |
| LLPS-Loa-0696 | Loxodonta africana | 84.93 | 6e-39 | 129 |
| LLPS-Ora-3228 | Ornithorhynchus anatinus | 83.56 | 5e-39 | 130 |
| LLPS-Anc-2769 | Anolis carolinensis | 80.82 | 2e-37 | 126 |
| LLPS-Gaga-1209 | Gallus gallus | 79.45 | 1e-36 | 124 |
| LLPS-Meg-1909 | Meleagris gallopavo | 79.45 | 1e-36 | 124 |
| LLPS-Anp-2388 | Anas platyrhynchos | 78.08 | 2e-34 | 118 |
| LLPS-Mod-2024 | Monodelphis domestica | 75.34 | 3e-32 | 115 |
| LLPS-Pes-2455 | Pelodiscus sinensis | 75.34 | 4e-36 | 122 |
| LLPS-Fia-0722 | Ficedula albicollis | 75.34 | 3e-33 | 115 |
| LLPS-Orn-3356 | Oreochromis niloticus | 73.44 | 9e-27 | 99.0 |
| LLPS-Asm-2674 | Astyanax mexicanus | 71.43 | 4e-24 | 94.0 |
| LLPS-Dar-1214 | Danio rerio | 68.75 | 4e-25 | 94.4 |
| LLPS-Leo-0389 | Lepisosteus oculatus | 64.06 | 2e-21 | 85.5 |
| LLPS-Xet-1179 | Xenopus tropicalis | 63.24 | 3e-26 | 97.4 |
| LLPS-Lac-0529 | Latimeria chalumnae | 62.5 | 3e-21 | 84.7 |
| LLPS-Scf-4107 | Scleropages formosus | 61.29 | 3e-20 | 82.0 |
| LLPS-Gaa-1330 | Gasterosteus aculeatus | 60.32 | 2e-18 | 79.3 |
| LLPS-Ten-3418 | Tetraodon nigroviridis | 59.38 | 1e-21 | 85.5 |
| LLPS-Tar-2852 | Takifugu rubripes | 59.38 | 1e-21 | 85.5 |
| LLPS-Icp-0169 | Ictalurus punctatus | 59.38 | 1e-20 | 83.2 |
| LLPS-Scm-3076 | Scophthalmus maximus | 56.0 | 2e-18 | 77.4 |
| LLPS-Orl-0613 | Oryzias latipes | 54.84 | 3e-16 | 71.6 |
| LLPS-Xim-3471 | Xiphophorus maculatus | 53.12 | 2e-16 | 72.0 |