• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-3566
CEP19

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Centrosomal protein of 19 kDa
Gene Name: CEP19
Ensembl Gene: ENSBTAG00000013192.5
Ensembl Protein: ENSBTAP00000017558.4
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMCTAKKCGI  RFQPPAIILI  YENEIKGKSR  QRIMPVRNFS  KYSDCSRAAE  QLKNNPRHKG  60
61    YLEQVSLKQL  EKLFSFLRGN  LWGQSLAETM  EQIQRETTID  PEEDLNKLDD  KELAKRKSIM  120
121   DELFEKNQKK  KDDPNFVYDI  EVEFPQDEQL  QSCGWDTESA  EEF  163
Nucleotide CDS Sequence (FASTA)
1     ATGATGTGCA  CTGCCAAAAA  ATGTGGAATT  AGGTTCCAGC  CTCCGGCTAT  TATCTTAATC  60
61    TACGAGAATG  AAATTAAGGG  GAAAAGTCGC  CAGCGCATCA  TGCCAGTCCG  AAACTTTTCC  120
121   AAGTATTCAG  ATTGCAGTAG  AGCTGCTGAA  CAATTAAAGA  ATAATCCACG  ACACAAGGGT  180
181   TACCTGGAAC  AGGTATCCCT  GAAGCAGCTA  GAGAAGTTAT  TCAGCTTTTT  ACGAGGTAAC  240
241   TTGTGGGGGC  AGAGTCTGGC  AGAAACAATG  GAACAGATTC  AACGGGAAAC  AACCATTGAT  300
301   CCTGAGGAAG  ACCTGAACAA  ACTAGATGAC  AAGGAACTTG  CCAAAAGGAA  GAGCATCATG  360
361   GATGAACTTT  TTGAGAAAAA  TCAGAAGAAG  AAGGATGATC  CAAATTTTGT  CTATGATATT  420
421   GAAGTGGAGT  TCCCACAGGA  TGAACAGCTA  CAGTCCTGTG  GCTGGGACAC  AGAGTCAGCT  480
481   GAAGAGTTCT  GA  492

▼ KEYWORD

ID
Family
Cell projection
Cilium
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centriole
Cellular Component
Centrosome
Cellular Component
Ciliary basal body
Cellular Component
Spindle pole
Biological Process
Cilium assembly
Biological Process
Microtubule anchoring at centrosome
Biological Process
Vesicle targeting, trans-Golgi to periciliary membrane compartment

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tut-0764Tursiops truncatus98.315e-79 237
LLPS-Ova-4041Ovis aries97.551e-115 331
LLPS-Urm-1936Ursus maritimus95.714e-113 325
LLPS-Sus-3293Sus scrofa95.713e-113 325
LLPS-Fec-4573Felis catus94.487e-113 325
LLPS-Ere-0457Erinaceus europaeus94.487e-112 322
LLPS-Cas-3487Carlito syrichta93.878e-110 317
LLPS-Ict-2496Ictidomys tridecemlineatus93.875e-112 322
LLPS-Caf-4278Canis familiaris93.874e-110 318
LLPS-Otg-3215Otolemur garnettii93.874e-111 320
LLPS-Hos-2805Homo sapiens93.876e-110 317
LLPS-Pat-3244Pan troglodytes93.874e-110 318
LLPS-Pap-4604Pan paniscus93.874e-110 318
LLPS-Aim-1916Ailuropoda melanoleuca93.872e-111 321
LLPS-Gog-1403Gorilla gorilla93.879e-110 317
LLPS-Caj-4690Callithrix jacchus93.877e-110 317
LLPS-Aon-3247Aotus nancymaae93.875e-110 317
LLPS-Eqc-2396Equus caballus93.331e-77 233
LLPS-Nol-1138Nomascus leucogenys93.252e-109 316
LLPS-Mup-1171Mustela putorius furo93.256e-109 315
LLPS-Myl-2868Myotis lucifugus93.255e-109 315
LLPS-Poa-4315Pongo abelii92.641e-108 314
LLPS-Paa-3064Papio anubis92.642e-109 316
LLPS-Dio-1059Dipodomys ordii92.643e-108 313
LLPS-Orc-1607Oryctolagus cuniculus92.024e-108 313
LLPS-Mal-4597Mandrillus leucophaeus92.024e-108 313
LLPS-Chs-1491Chlorocebus sabaeus91.413e-108 313
LLPS-Cea-4280Cercocebus atys91.412e-107 311
LLPS-Mam-1885Macaca mulatta90.81e-107 311
LLPS-Man-4586Macaca nemestrina90.81e-107 311
LLPS-Maf-1359Macaca fascicularis90.81e-107 311
LLPS-Cap-3275Cavia porcellus89.511e-101 296
LLPS-Ran-4744Rattus norvegicus87.123e-102 298
LLPS-Loa-2945Loxodonta africana86.143e-102 298
LLPS-Fud-3491Fukomys damarensis85.86e-99 289
LLPS-Mum-4438Mus musculus85.282e-100 293
LLPS-Mod-3435Monodelphis domestica83.444e-98 287
LLPS-Rhb-3484Rhinopithecus bieti82.822e-93 275
LLPS-Sah-3180Sarcophilus harrisii82.213e-94 277
LLPS-Tag-3503Taeniopygia guttata80.07e-65 201
LLPS-Anp-0713Anas platyrhynchos79.148e-94 276
LLPS-Ora-2286Ornithorhynchus anatinus78.881e-91 270
LLPS-Meg-1275Meleagris gallopavo77.33e-89 264
LLPS-Gaga-1067Gallus gallus75.467e-88 261
LLPS-Fia-1362Ficedula albicollis75.467e-87 260
LLPS-Xet-1898Xenopus tropicalis73.623e-85 254
LLPS-Anc-3866Anolis carolinensis72.397e-84 251
LLPS-Lac-3137Latimeria chalumnae68.97e-80 241
LLPS-Pof-2612Poecilia formosa58.283e-63 198
LLPS-Leo-3443Lepisosteus oculatus57.141e-67 209
LLPS-Orn-3423Oreochromis niloticus56.443e-58 186
LLPS-Scf-0594Scleropages formosus55.776e-58 185
LLPS-Icp-3808Ictalurus punctatus55.215e-58 185
LLPS-Scm-1459Scophthalmus maximus53.992e-56 181
LLPS-Xim-2838Xiphophorus maculatus53.996e-58 184
LLPS-Orl-0551Oryzias latipes53.373e-53 172
LLPS-Dar-0422Danio rerio52.471e-53 173
LLPS-Ten-3796Tetraodon nigroviridis52.152e-50 165
LLPS-Gaa-2934Gasterosteus aculeatus52.153e-53 173
LLPS-Asm-3829Astyanax mexicanus50.922e-53 173
LLPS-Tar-2325Takifugu rubripes50.311e-50 166
LLPS-Cii-0771Ciona intestinalis45.063e-43 147
LLPS-Cis-1086Ciona savignyi42.413e-43 147