• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-3285
CYB5R1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: NADH-cytochrome b5 reductase 1
Gene Name: CYB5R1
Ensembl Gene: ENSBTAG00000019927.5
Ensembl Protein: ENSBTAP00000026548.5
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGLQPSPVLL  ASLGVGLLTL  LGVALGAYLV  RRSRRPPVTL  LDPNEKYQLR  LLDKTTVNHN  60
61    TKRFRFALPT  AHHVLGLPVG  KHVYLSARID  GSLVIRPYTP  VTSDEDQGYV  DLVIKVYLKG  120
121   VHPKFPEGGK  MSQYLDSLKI  GDVVEFRGPS  GLLTYAGKGK  FNIQPNKKAP  PEARVARNLG  180
181   MIAGGTGITP  MLQLIRAILK  DPEDPTQCFL  LFANQTEKDI  ILREDLEELQ  ARHPGRFKLW  240
241   FTLDHPPEGW  AYSKGFVSVD  MIREHLPAPG  EDVLLLLCGP  PPMVQLACHP  SLDKLGYSPK  300
301   MRFTY  305
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCTGC  AGCCAAGCCC  GGTCCTGCTG  GCCTCCCTGG  GCGTGGGGCT  GCTGACGCTG  60
61    CTCGGCGTGG  CTCTGGGCGC  CTACCTGGTG  CGGAGGTCCC  GCCGGCCGCC  GGTCACGCTC  120
121   CTGGACCCCA  ATGAGAAGTA  CCAGCTGCGA  CTGCTAGACA  AGACGACCGT  GAACCACAAC  180
181   ACCAAGAGGT  TCCGCTTTGC  CCTGCCGACG  GCTCACCACG  TTCTGGGGCT  GCCTGTGGGC  240
241   AAACATGTCT  ACCTCTCTGC  CCGGATCGAT  GGCAGCCTGG  TCATCAGGCC  GTACACTCCC  300
301   GTCACCAGCG  ATGAGGACCA  GGGCTACGTG  GATCTTGTCA  TCAAGGTCTA  TCTGAAGGGT  360
361   GTGCACCCCA  AATTCCCTGA  GGGAGGGAAG  ATGTCTCAGT  ACCTGGATAG  CCTGAAGATT  420
421   GGGGACGTGG  TGGAGTTTCG  GGGGCCAAGC  GGGCTGCTTA  CTTATGCCGG  AAAAGGGAAG  480
481   TTTAACATCC  AGCCCAACAA  AAAGGCTCCA  CCAGAAGCGC  GCGTGGCCAG  GAACCTGGGA  540
541   ATGATTGCCG  GAGGCACAGG  AATCACTCCA  ATGCTGCAGC  TGATCCGGGC  CATCCTGAAA  600
601   GACCCAGAAG  ATCCCACCCA  GTGCTTTCTG  CTGTTTGCCA  ACCAGACTGA  AAAGGACATC  660
661   ATCTTACGAG  AGGACTTGGA  GGAGCTGCAG  GCCCGACACC  CCGGCCGCTT  TAAGCTCTGG  720
721   TTCACCCTGG  ATCACCCCCC  AGAAGGTTGG  GCCTACAGCA  AGGGCTTCGT  CTCTGTGGAC  780
781   ATGATCCGGG  AGCACCTGCC  CGCTCCCGGG  GAAGACGTGC  TGCTGCTGCT  CTGCGGGCCA  840
841   CCCCCGATGG  TGCAGCTGGC  CTGCCACCCC  AGCCTGGACA  AACTGGGCTA  CTCGCCAAAG  900
901   ATGCGCTTCA  CCTACTGA  918

▼ KEYWORD

ID
Family
Complete proteome
FAD
Flavoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
NAD
Oxidoreductase
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Molecular Function
Cytochrome-b5 reductase activity, acting on NAD(P)H
Molecular Function
FAD binding
Biological Process
Sterol biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-3856Ovis aries96.00.0 543
LLPS-Dio-3871Dipodomys ordii92.986e-111 326
LLPS-Orc-4072Oryctolagus cuniculus92.360.0 525
LLPS-Mam-3730Macaca mulatta91.640.0 521
LLPS-Ict-4564Ictidomys tridecemlineatus91.270.0 522
LLPS-Cap-2696Cavia porcellus91.150.0 528
LLPS-Aim-1076Ailuropoda melanoleuca90.910.0 519
LLPS-Chs-1034Chlorocebus sabaeus90.820.0 527
LLPS-Maf-3860Macaca fascicularis90.820.0 527
LLPS-Cea-3369Cercocebus atys90.820.0 527
LLPS-Mal-3083Mandrillus leucophaeus90.820.0 527
LLPS-Paa-1652Papio anubis90.820.0 527
LLPS-Man-3061Macaca nemestrina90.820.0 527
LLPS-Mup-4284Mustela putorius furo90.550.0 520
LLPS-Aon-3499Aotus nancymaae90.490.0 526
LLPS-Sus-0907Sus scrofa90.490.0 524
LLPS-Caj-3578Callithrix jacchus90.490.0 524
LLPS-Fec-3584Felis catus90.490.0 520
LLPS-Rhb-3119Rhinopithecus bieti90.490.0 525
LLPS-Gog-3642Gorilla gorilla90.160.0 524
LLPS-Pap-3595Pan paniscus90.160.0 524
LLPS-Pat-3073Pan troglodytes90.160.0 524
LLPS-Hos-1748Homo sapiens90.160.0 524
LLPS-Poa-2698Pongo abelii90.160.0 525
LLPS-Nol-3019Nomascus leucogenys90.160.0 525
LLPS-Mum-4608Mus musculus89.840.0 520
LLPS-Fud-4068Fukomys damarensis89.840.0 524
LLPS-Mea-4450Mesocricetus auratus89.510.0 523
LLPS-Ran-1335Rattus norvegicus89.510.0 518
LLPS-Urm-2176Ursus maritimus89.180.0 519
LLPS-Otg-2221Otolemur garnettii89.180.0 522
LLPS-Eqc-2432Equus caballus89.180.0 516
LLPS-Cas-2571Carlito syrichta89.180.0 520
LLPS-Caf-3946Canis familiaris88.520.0 517
LLPS-Loa-2879Loxodonta africana88.20.0 516
LLPS-Sah-0689Sarcophilus harrisii86.890.0 513
LLPS-Mod-3941Monodelphis domestica84.095e-175 494
LLPS-Tar-3371Takifugu rubripes70.192e-144 418
LLPS-Ten-3185Tetraodon nigroviridis69.121e-145 419
LLPS-Meg-3224Meleagris gallopavo68.862e-140 406
LLPS-Gaga-0964Gallus gallus68.771e-128 379
LLPS-Lac-1778Latimeria chalumnae68.616e-147 422
LLPS-Pes-2169Pelodiscus sinensis68.611e-142 412
LLPS-Fia-3309Ficedula albicollis68.614e-144 415
LLPS-Anc-3189Anolis carolinensis68.271e-141 409
LLPS-Anp-2196Anas platyrhynchos68.152e-140 406
LLPS-Gaa-1582Gasterosteus aculeatus67.652e-144 416
LLPS-Asm-0548Astyanax mexicanus67.282e-142 411
LLPS-Scf-3582Scleropages formosus67.283e-142 410
LLPS-Tag-0175Taeniopygia guttata67.152e-141 408
LLPS-Pof-3413Poecilia formosa66.911e-143 414
LLPS-Orn-1189Oreochromis niloticus66.915e-142 410
LLPS-Icp-3539Ictalurus punctatus66.543e-141 408
LLPS-Xim-3671Xiphophorus maculatus66.182e-141 409
LLPS-Dar-2719Danio rerio65.691e-141 409
LLPS-Scm-3090Scophthalmus maximus65.661e-134 393
LLPS-Xet-0208Xenopus tropicalis65.192e-137 398
LLPS-Tut-0345Tursiops truncatus64.819e-132 384
LLPS-Cii-1482Ciona intestinalis59.466e-114 338
LLPS-Drm-0791Drosophila melanogaster54.611e-108 326
LLPS-Cae-1938Caenorhabditis elegans54.444e-107 321
LLPS-Pot-2279Populus trichocarpa50.968e-84 276
LLPS-Via-2439Vigna angularis50.392e-82 272
LLPS-Phv-2509Phaseolus vulgaris50.02e-82 272
LLPS-Php-0099Physcomitrella patens49.812e-80 267
LLPS-Glm-2370Glycine max49.624e-86 283
LLPS-Bro-2732Brassica oleracea49.241e-84 279
LLPS-Cus-1925Cucumis sativus49.221e-80 267
LLPS-Gor-0699Gossypium raimondii49.064e-82 272
LLPS-Mae-1525Manihot esculenta49.031e-84 268
LLPS-Arl-0918Arabidopsis lyrata48.881e-83 276
LLPS-Brn-2911Brassica napus48.856e-87 277
LLPS-Art-2553Arabidopsis thaliana48.512e-83 275
LLPS-Brr-0913Brassica rapa48.481e-83 276
LLPS-Vir-1091Vigna radiata48.444e-79 264
LLPS-Orm-0649Oryza meridionalis48.342e-80 268
LLPS-Chc-0303Chondrus crispus48.34e-84 277
LLPS-Orbr-0613Oryza brachyantha48.115e-79 263
LLPS-Orb-1173Oryza barthii47.733e-79 264
LLPS-Met-0346Medicago truncatula47.732e-81 270
LLPS-Orgl-1127Oryza glumaepatula47.62e-81 270
LLPS-Sob-2553Sorghum bicolor47.431e-81 271
LLPS-Org-0550Oryza glaberrima47.432e-81 270
LLPS-Ori-2234Oryza indica47.352e-78 262
LLPS-Orp-1578Oryza punctata47.354e-78 261
LLPS-Ors-2008Oryza sativa47.231e-80 268
LLPS-Amt-1870Amborella trichopoda47.172e-75 254
LLPS-Mua-0978Musa acuminata47.019e-75 253
LLPS-Brd-2324Brachypodium distachyon46.978e-76 254
LLPS-Sei-1112Setaria italica46.973e-77 258
LLPS-Dac-1893Daucus carota46.771e-83 276
LLPS-Hea-1011Helianthus annuus46.748e-80 266
LLPS-Osl-1112Ostreococcus lucimarinus46.336e-67 216
LLPS-Tra-1407Triticum aestivum45.764e-80 266
LLPS-Abg-1521Absidia glauca44.577e-70 224
LLPS-Fuv-1252Fusarium verticillioides44.194e-64 214
LLPS-Asni-1212Aspergillus niger44.191e-66 219
LLPS-Asn-1511Aspergillus nidulans43.876e-68 221
LLPS-Lep-0825Leersia perrieri43.844e-72 230
LLPS-Aso-1526Aspergillus oryzae43.468e-62 209
LLPS-Phn-1295Phaeosphaeria nodorum43.352e-66 216
LLPS-Sem-0424Selaginella moellendorffii43.335e-77 258
LLPS-Trv-0142Trichoderma virens43.195e-61 207
LLPS-Asf-0163Aspergillus flavus43.124e-67 218
LLPS-Asfu-0441Aspergillus fumigatus43.127e-66 215
LLPS-Thc-0575Theobroma cacao42.914e-69 223
LLPS-Sot-1934Solanum tuberosum42.911e-71 229
LLPS-Coc-1384Corchorus capsularis42.864e-70 225
LLPS-Nef-1204Neosartorya fischeri42.753e-66 218
LLPS-Gas-0713Galdieria sulphuraria42.76e-61 203
LLPS-Tru-1238Triticum urartu42.553e-68 221
LLPS-Sol-2005Solanum lycopersicum42.187e-70 225
LLPS-Viv-0819Vitis vinifera42.183e-66 216
LLPS-Miv-1500Microbotryum violaceum42.142e-60 212
LLPS-Prp-1912Prunus persica41.976e-68 220
LLPS-Nia-2439Nicotiana attenuata41.616e-70 225
LLPS-Zem-1100Zea mays41.289e-65 213
LLPS-Tum-1479Tuber melanosporum41.252e-62 207
LLPS-Fus-0624Fusarium solani41.131e-57 194
LLPS-Chr-0042Chlamydomonas reinhardtii41.014e-64 210
LLPS-Ast-1427Aspergillus terreus40.982e-56 196
LLPS-Beb-0790Beauveria bassiana40.752e-56 191
LLPS-Cogr-1387Colletotrichum graminicola40.714e-55 187
LLPS-Trr-0856Trichoderma reesei40.231e-56 192
LLPS-Hov-1896Hordeum vulgare39.865e-54 185
LLPS-Mao-1088Magnaporthe oryzae39.681e-45 166
LLPS-Sac-0876Saccharomyces cerevisiae39.541e-52 181
LLPS-Coo-1569Colletotrichum orbiculare38.256e-54 185
LLPS-Dos-0942Dothistroma septosporum38.212e-48 171
LLPS-Kop-1158Komagataella pastoris36.554e-47 166
LLPS-Zyt-0703Zymoseptoria tritici35.194e-49 173
LLPS-Asg-1269Ashbya gossypii34.943e-43 156