LLPS-Bot-2878
PSMD13
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5 |
| Gene Name: | PSMD13 |
| Ensembl Gene: | ENSBTAG00000002045.6 |
| Ensembl Protein: | ENSBTAP00000002650.6 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000002650.6 | ENSBTAP00000002650.6 |
| UniProt | Q5E964, PSD13_BOVIN, Q3T0Z1 | |
| GeneBank | BT021056, BC102200 | AAX09073.1, AAI02201.1 |
| RefSeq | NM_001024532.2 | NP_001019703.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKDVPGFLQQ SQSSGPGQAA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY 60 61 ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALSFLEKT REKVKSSDEA VILCKTAIGA 120 121 LKLNIGDLQV TKETIEDVEE MLSNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL 180 181 GCVDIKDLPV SEQQERAFTL GLAGLLGDGV FNFGELLMHP VLESLRDTDR QWLIDTLYAF 240 241 NSGNVERFQT LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIARSA 300 301 KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV 360 361 KSMEMLVEHQ AHDILT 376 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGGACG TACCCGGCTT CTTACAACAG AGTCAGAGCT CCGGGCCCGG CCAGGCCGCC 60 61 GTGTGGCACC GTTTGGAGGA GCTTTACACC AAGAAGTTGT GGCATCAGCT GACACTTCAA 120 121 GTGCTTGATT TTGTGCAGGA CCCCTGCTTT GCCCAAGGAG ATGGTCTCAT TAAGCTTTAT 180 181 GAAAACTTCA TCAGTGAATT TGAACACAGG GTGAATCCTT TGTCCCTGGT AGAGATCATT 240 241 CTACATGTAG TTAGACAGAT GACTGATCCT AACGTGGCTC TTAGTTTTCT GGAAAAGACT 300 301 CGTGAGAAGG TGAAAAGTAG TGACGAGGCG GTGATCCTGT GCAAAACCGC GATTGGAGCT 360 361 CTGAAGCTGA ACATCGGTGA CCTGCAGGTT ACAAAGGAAA CTATCGAAGA TGTTGAGGAA 420 421 ATGCTCAGCA ACCTCCCTGG GGTGACATCC GTTCACAGTC GTTTCTACGA CCTCTCCAGT 480 481 AAATACTATC AAACGATTGG AAACCACGCG TCCTACTACA AAGACGCTCT GCGGTTTCTG 540 541 GGCTGTGTGG ACATCAAGGA TCTGCCAGTG TCTGAGCAGC AGGAGAGAGC TTTCACGCTG 600 601 GGACTGGCGG GACTTCTTGG CGACGGAGTT TTCAACTTTG GCGAGCTGCT CATGCACCCC 660 661 GTGCTGGAGT CGCTGAGGGA CACGGACCGG CAGTGGCTGA TCGACACCCT CTATGCCTTC 720 721 AACAGCGGCA ACGTGGAGCG ATTCCAGACC CTGAAGACCG CCTGGGGCCA GCAGCCTGAT 780 781 CTAGCAGCCA ACGAAGCCCA GCTTCTCAGG AAGATTCAGT TACTGTGCCT CATGGAGATG 840 841 ACTTTTACAC GACCTGCCAA TCATAGGCAA CTCACTTTTG AAGAAATTGC CAGAAGTGCT 900 901 AAAATCACCG TGAACGAGGT GGAGTTGCTG GTAATGAAGG CCCTCTCGGT GGGGCTGGTG 960 961 AAAGGCAGTA TTGACGAGGT GGATAAGCGG GTTCACATGA CCTGGGTGCA GCCCCGCGTG 1020 1021 CTGGATTTGC AGCAGATCAA GGGGATGAAG GACCGCCTGG AGTTCTGGTG CACCGACGTG 1080 1081 AAAAGCATGG AGATGCTGGT GGAGCACCAG GCCCACGACA TCCTCACCTA G 1131 |
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | Proteasome accessory complex | |
Cellular Component | Proteasome regulatory particle, lid subcomplex | |
Molecular Function | Structural molecule activity | |
Biological Process | Meiosis I | |
Biological Process | Proteasome assembly | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sus-0498 | Sus scrofa | 98.67 | 0.0 | 736 |
| LLPS-Gog-3601 | Gorilla gorilla | 98.4 | 0.0 | 734 |
| LLPS-Pap-0207 | Pan paniscus | 98.4 | 0.0 | 734 |
| LLPS-Pat-1651 | Pan troglodytes | 98.4 | 0.0 | 734 |
| LLPS-Caf-1644 | Canis familiaris | 98.4 | 0.0 | 734 |
| LLPS-Tut-1068 | Tursiops truncatus | 98.14 | 0.0 | 733 |
| LLPS-Poa-2203 | Pongo abelii | 98.14 | 0.0 | 729 |
| LLPS-Maf-4073 | Macaca fascicularis | 97.87 | 0.0 | 731 |
| LLPS-Otg-3456 | Otolemur garnettii | 97.87 | 0.0 | 730 |
| LLPS-Cas-1910 | Carlito syrichta | 97.87 | 0.0 | 726 |
| LLPS-Mam-0897 | Macaca mulatta | 97.87 | 0.0 | 731 |
| LLPS-Ova-2159 | Ovis aries | 97.61 | 0.0 | 728 |
| LLPS-Mup-2151 | Mustela putorius furo | 97.61 | 0.0 | 730 |
| LLPS-Ict-2005 | Ictidomys tridecemlineatus | 97.61 | 0.0 | 729 |
| LLPS-Fud-2414 | Fukomys damarensis | 96.81 | 0.0 | 723 |
| LLPS-Aim-3407 | Ailuropoda melanoleuca | 96.54 | 0.0 | 722 |
| LLPS-Urm-1435 | Ursus maritimus | 96.52 | 0.0 | 671 |
| LLPS-Mum-3208 | Mus musculus | 96.28 | 0.0 | 719 |
| LLPS-Ran-3291 | Rattus norvegicus | 96.01 | 0.0 | 719 |
| LLPS-Mea-3021 | Mesocricetus auratus | 95.62 | 0.0 | 610 |
| LLPS-Eqc-3067 | Equus caballus | 95.51 | 0.0 | 666 |
| LLPS-Cap-0498 | Cavia porcellus | 95.37 | 0.0 | 528 |
| LLPS-Myl-2151 | Myotis lucifugus | 95.21 | 0.0 | 713 |
| LLPS-Pes-3334 | Pelodiscus sinensis | 95.07 | 0.0 | 667 |
| LLPS-Loa-4525 | Loxodonta africana | 94.97 | 0.0 | 713 |
| LLPS-Gaga-3208 | Gallus gallus | 94.95 | 0.0 | 716 |
| LLPS-Anc-2067 | Anolis carolinensis | 94.68 | 0.0 | 716 |
| LLPS-Sah-3004 | Sarcophilus harrisii | 94.25 | 0.0 | 667 |
| LLPS-Fia-2416 | Ficedula albicollis | 93.88 | 0.0 | 711 |
| LLPS-Dio-1091 | Dipodomys ordii | 92.6 | 0.0 | 667 |
| LLPS-Orc-4207 | Oryctolagus cuniculus | 91.73 | 0.0 | 678 |
| LLPS-Tag-2971 | Taeniopygia guttata | 91.28 | 0.0 | 635 |
| LLPS-Cea-3717 | Cercocebus atys | 91.03 | 0.0 | 659 |
| LLPS-Chs-1419 | Chlorocebus sabaeus | 90.72 | 0.0 | 662 |
| LLPS-Nol-3690 | Nomascus leucogenys | 89.42 | 0.0 | 681 |
| LLPS-Aon-0115 | Aotus nancymaae | 88.36 | 0.0 | 642 |
| LLPS-Paa-1950 | Papio anubis | 88.1 | 0.0 | 641 |
| LLPS-Caj-1482 | Callithrix jacchus | 87.83 | 0.0 | 639 |
| LLPS-Fec-3028 | Felis catus | 87.53 | 0.0 | 641 |
| LLPS-Hos-0047 | Homo sapiens | 86.86 | 0.0 | 642 |
| LLPS-Xet-1000 | Xenopus tropicalis | 86.24 | 0.0 | 643 |
| LLPS-Lac-4010 | Latimeria chalumnae | 84.66 | 0.0 | 641 |
| LLPS-Mal-2868 | Mandrillus leucophaeus | 81.22 | 0.0 | 596 |
| LLPS-Leo-3238 | Lepisosteus oculatus | 80.95 | 0.0 | 619 |
| LLPS-Scf-4188 | Scleropages formosus | 79.63 | 0.0 | 609 |
| LLPS-Scm-3243 | Scophthalmus maximus | 78.57 | 0.0 | 603 |
| LLPS-Dar-0012 | Danio rerio | 78.31 | 0.0 | 600 |
| LLPS-Pof-3554 | Poecilia formosa | 78.31 | 0.0 | 596 |
| LLPS-Man-4359 | Macaca nemestrina | 78.31 | 0.0 | 569 |
| LLPS-Gaa-3650 | Gasterosteus aculeatus | 78.04 | 0.0 | 598 |
| LLPS-Xim-0604 | Xiphophorus maculatus | 77.51 | 0.0 | 596 |
| LLPS-Orl-0253 | Oryzias latipes | 77.25 | 0.0 | 587 |
| LLPS-Tar-3333 | Takifugu rubripes | 77.25 | 0.0 | 598 |
| LLPS-Asm-1108 | Astyanax mexicanus | 76.82 | 0.0 | 591 |
| LLPS-Rhb-0995 | Rhinopithecus bieti | 75.8 | 1e-176 | 501 |
| LLPS-Orn-0718 | Oreochromis niloticus | 75.4 | 0.0 | 565 |
| LLPS-Ten-1361 | Tetraodon nigroviridis | 75.37 | 9e-67 | 215 |
| LLPS-Meg-1292 | Meleagris gallopavo | 74.71 | 1e-175 | 499 |
| LLPS-Icp-1554 | Ictalurus punctatus | 73.54 | 0.0 | 563 |
| LLPS-Ora-2902 | Ornithorhynchus anatinus | 61.83 | 9e-102 | 309 |
| LLPS-Cis-1614 | Ciona savignyi | 60.19 | 1e-34 | 129 |
| LLPS-Mod-2818 | Monodelphis domestica | 58.09 | 4e-131 | 387 |
| LLPS-Cii-1281 | Ciona intestinalis | 55.46 | 8e-142 | 415 |
| LLPS-Drm-0719 | Drosophila melanogaster | 46.8 | 1e-113 | 343 |
| LLPS-Cae-1815 | Caenorhabditis elegans | 41.48 | 4e-90 | 283 |
| LLPS-Brd-1167 | Brachypodium distachyon | 41.24 | 8e-90 | 282 |
| LLPS-Orni-2051 | Oryza nivara | 40.97 | 3e-91 | 286 |
| LLPS-Orb-2252 | Oryza barthii | 40.97 | 3e-91 | 286 |
| LLPS-Lep-2192 | Leersia perrieri | 40.92 | 9e-88 | 278 |
| LLPS-Pot-0954 | Populus trichocarpa | 40.82 | 6e-89 | 280 |
| LLPS-Sol-1106 | Solanum lycopersicum | 40.71 | 1e-87 | 277 |
| LLPS-Sot-0951 | Solanum tuberosum | 40.71 | 8e-88 | 277 |
| LLPS-Ori-1847 | Oryza indica | 40.7 | 1e-91 | 287 |
| LLPS-Cus-1793 | Cucumis sativus | 40.7 | 2e-89 | 281 |
| LLPS-Orgl-1943 | Oryza glumaepatula | 40.7 | 2e-91 | 286 |
| LLPS-Ors-1419 | Oryza sativa | 40.7 | 1e-91 | 287 |
| LLPS-Org-0998 | Oryza glaberrima | 40.7 | 2e-91 | 286 |
| LLPS-Orm-2060 | Oryza meridionalis | 40.7 | 3e-91 | 286 |
| LLPS-Orr-0963 | Oryza rufipogon | 40.7 | 1e-91 | 287 |
| LLPS-Orp-1227 | Oryza punctata | 40.43 | 4e-91 | 286 |
| LLPS-Dac-2055 | Daucus carota | 40.33 | 3e-89 | 281 |
| LLPS-Thc-1400 | Theobroma cacao | 40.16 | 8e-89 | 280 |
| LLPS-Hov-1202 | Hordeum vulgare | 40.16 | 7e-89 | 281 |
| LLPS-Sob-2159 | Sorghum bicolor | 40.16 | 2e-87 | 276 |
| LLPS-Tru-0854 | Triticum urartu | 40.16 | 2e-90 | 284 |
| LLPS-Tra-1771 | Triticum aestivum | 39.89 | 1e-89 | 281 |
| LLPS-Sei-0521 | Setaria italica | 39.89 | 9e-86 | 272 |
| LLPS-Gor-2720 | Gossypium raimondii | 39.89 | 4e-90 | 283 |
| LLPS-Coc-1825 | Corchorus capsularis | 39.89 | 1e-87 | 277 |
| LLPS-Via-2126 | Vigna angularis | 39.84 | 2e-89 | 281 |
| LLPS-Spr-0725 | Sporisorium reilianum | 39.83 | 3e-85 | 271 |
| LLPS-Mel-0355 | Melampsora laricipopulina | 39.63 | 5e-77 | 250 |
| LLPS-Phv-0652 | Phaseolus vulgaris | 39.58 | 1e-89 | 281 |
| LLPS-Viv-1908 | Vitis vinifera | 39.47 | 1e-89 | 281 |
| LLPS-Zem-1997 | Zea mays | 39.35 | 7e-88 | 277 |
| LLPS-Nec-1462 | Neurospora crassa | 39.27 | 3e-85 | 270 |
| LLPS-Mua-0951 | Musa acuminata | 39.21 | 6e-88 | 277 |
| LLPS-Glm-1517 | Glycine max | 39.05 | 7e-87 | 275 |
| LLPS-Hea-0814 | Helianthus annuus | 38.95 | 1e-86 | 274 |
| LLPS-Php-0313 | Physcomitrella patens | 38.68 | 3e-87 | 276 |
| LLPS-Prp-2452 | Prunus persica | 38.68 | 1e-85 | 271 |
| LLPS-Orbr-1734 | Oryza brachyantha | 38.64 | 2e-86 | 274 |
| LLPS-Miv-0912 | Microbotryum violaceum | 38.55 | 1e-80 | 259 |
| LLPS-Abg-0889 | Absidia glauca | 38.54 | 2e-89 | 282 |
| LLPS-Usm-0263 | Ustilago maydis | 38.44 | 3e-81 | 260 |
| LLPS-Brn-2258 | Brassica napus | 38.42 | 7e-87 | 275 |
| LLPS-Mae-1913 | Manihot esculenta | 38.42 | 3e-86 | 273 |
| LLPS-Bro-0633 | Brassica oleracea | 38.42 | 7e-87 | 275 |
| LLPS-Ved-0298 | Verticillium dahliae | 38.31 | 3e-80 | 257 |
| LLPS-Nia-1955 | Nicotiana attenuata | 38.27 | 5e-83 | 265 |
| LLPS-Amt-0770 | Amborella trichopoda | 38.16 | 4e-85 | 270 |
| LLPS-Brr-2978 | Brassica rapa | 38.16 | 7e-85 | 270 |
| LLPS-Met-1610 | Medicago truncatula | 37.99 | 3e-85 | 270 |
| LLPS-Tum-0238 | Tuber melanosporum | 37.87 | 7e-82 | 261 |
| LLPS-Pug-1262 | Puccinia graminis | 37.81 | 6e-72 | 239 |
| LLPS-Mao-1136 | Magnaporthe oryzae | 37.75 | 3e-82 | 263 |
| LLPS-Sem-1750 | Selaginella moellendorffii | 37.74 | 5e-79 | 254 |
| LLPS-Blg-1534 | Blumeria graminis | 37.4 | 1e-74 | 243 |
| LLPS-Arl-0184 | Arabidopsis lyrata | 37.37 | 7e-84 | 267 |
| LLPS-Art-2112 | Arabidopsis thaliana | 37.11 | 3e-83 | 265 |
| LLPS-Scp-1454 | Schizosaccharomyces pombe | 36.96 | 7e-65 | 218 |
| LLPS-Vir-1772 | Vigna radiata | 36.95 | 4e-74 | 253 |
| LLPS-Yal-1530 | Yarrowia lipolytica | 36.86 | 3e-73 | 239 |
| LLPS-Coo-1163 | Colletotrichum orbiculare | 36.83 | 1e-80 | 258 |
| LLPS-Osl-0151 | Ostreococcus lucimarinus | 36.83 | 6e-66 | 221 |
| LLPS-Lem-0350 | Leptosphaeria maculans | 36.8 | 1e-74 | 243 |
| LLPS-Trr-0577 | Trichoderma reesei | 36.72 | 1e-77 | 251 |
| LLPS-Cogr-1344 | Colletotrichum graminicola | 36.6 | 3e-83 | 265 |
| LLPS-Map-0408 | Magnaporthe poae | 36.57 | 7e-76 | 246 |
| LLPS-Asn-0964 | Aspergillus nidulans | 36.27 | 1e-77 | 251 |
| LLPS-Pyt-1652 | Pyrenophora teres | 36.27 | 2e-78 | 253 |
| LLPS-Pytr-1269 | Pyrenophora triticirepentis | 36.27 | 5e-78 | 252 |
| LLPS-Trv-1646 | Trichoderma virens | 36.17 | 1e-79 | 256 |
| LLPS-Cog-0255 | Colletotrichum gloeosporioides | 36.07 | 8e-81 | 259 |
| LLPS-Gag-1448 | Gaeumannomyces graminis | 36.01 | 4e-79 | 254 |
| LLPS-Zyt-1529 | Zymoseptoria tritici | 35.98 | 2e-75 | 245 |
| LLPS-Nef-1064 | Neosartorya fischeri | 35.73 | 1e-76 | 248 |
| LLPS-Asfu-1485 | Aspergillus fumigatus | 35.73 | 8e-76 | 247 |
| LLPS-Phn-1461 | Phaeosphaeria nodorum | 35.73 | 1e-77 | 251 |
| LLPS-Ast-1227 | Aspergillus terreus | 35.69 | 1e-75 | 246 |
| LLPS-Dos-1581 | Dothistroma septosporum | 35.69 | 4e-71 | 234 |
| LLPS-Asf-1131 | Aspergillus flavus | 35.47 | 4e-75 | 244 |
| LLPS-Asc-0523 | Aspergillus clavatus | 35.36 | 2e-75 | 245 |
| LLPS-Scs-1002 | Sclerotinia sclerotiorum | 34.98 | 2e-54 | 188 |
| LLPS-Asni-0737 | Aspergillus niger | 34.93 | 6e-74 | 241 |
| LLPS-Crn-1149 | Cryptococcus neoformans | 34.85 | 7e-74 | 242 |
| LLPS-Fuv-1488 | Fusarium verticillioides | 34.84 | 6e-73 | 238 |
| LLPS-Fuo-0548 | Fusarium oxysporum | 34.84 | 6e-73 | 238 |
| LLPS-Aso-0981 | Aspergillus oryzae | 34.73 | 2e-72 | 238 |
| LLPS-Beb-1540 | Beauveria bassiana | 34.57 | 5e-76 | 246 |
| LLPS-Scc-0697 | Schizosaccharomyces cryophilus | 34.42 | 2e-66 | 221 |
| LLPS-Gas-0519 | Galdieria sulphuraria | 34.28 | 1e-63 | 214 |
| LLPS-Chr-0652 | Chlamydomonas reinhardtii | 34.08 | 2e-65 | 219 |
| LLPS-Chc-1202 | Chondrus crispus | 34.08 | 7e-66 | 220 |
| LLPS-Put-1225 | Puccinia triticina | 33.7 | 1e-38 | 147 |
| LLPS-Fus-1533 | Fusarium solani | 33.6 | 9e-75 | 243 |
| LLPS-Asg-1196 | Ashbya gossypii | 33.16 | 1e-58 | 201 |
| LLPS-Cym-1023 | Cyanidioschyzon merolae | 32.45 | 2e-50 | 180 |
| LLPS-Sac-1660 | Saccharomyces cerevisiae | 31.3 | 1e-57 | 199 |
| LLPS-Scj-1377 | Schizosaccharomyces japonicus | 31.22 | 2e-59 | 203 |
| LLPS-Kop-0958 | Komagataella pastoris | 30.5 | 2e-51 | 183 |