LLPS-Bot-2820
CRYAB
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Alpha-crystallin B chain; Alpha(B)-crystallin |
| Gene Name: | CRYAB, CRYA2 |
| Ensembl Gene: | ENSBTAG00000000434.6 |
| Ensembl Protein: | ENSBTAP00000000556.6 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle, Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000000556.6 | ENSBTAP00000000556.6 |
| Ensembl | ENSBTAT00000087415.1 | ENSBTAP00000068917.1 |
| Ensembl | ENSBTAT00000076985.1 | ENSBTAP00000059200.1 |
| UniProt | P02510, CRYAB_BOVIN, O46508, Q3SZQ9 | |
| GeneBank | BC102745, AF029793 | AAI02746.1, AAB95323.2 |
| RefSeq | NM_174290.2 | NP_776715.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQTTFYPLFG GGLSEYWKLH KTAYIRGWLQ LRLKELTSQL TPHTHLTTMD IAIHHPWIRR 60 61 PFFPFHSPSR LFDQFFGEHL LESDLFPAST SLSPFYLRPP SFLRAPSWID TGLSEMRLEK 120 121 DRFSVNLDVK HFSPEELKVK VLGDVIEVHG KHEERQDEHG FISREFHRKY RIPADVDPLA 180 181 ITSSLSSDGV LTVNGPRKQA SGPERTIPIT REEKPAVTAA PKK 223 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAAACAA CATTCTACCC TTTATTTGGG GGTGGGAAGC TTCACAAGAC TGCGTATATA 60 61 AGGGGCTGGC TGCAGCTGCG GCTGAAGGAG CTGACCAGCC AGCTGACGCC CCACACTCAC 120 121 CTAACCACCA TGGATATCGC CATCCACCAC CCCTGGATCC GCCGCCCCTT CTTCCCTTTC 180 181 CACTCTCCCA GCCGCCTCTT TGACCAGTTT TTTGGCGAGC ACCTGTTGGA GTCTGATCTC 240 241 TTCCCAGCTT CTACTTCCCT GAGCCCCTTC TACCTTCGGC CGCCCTCATT TCTGCGGGCA 300 301 CCCAGCTGGA TTGACACTGG CCTCTCAGAG ATGCGTCTGG AGAAGGACAG ATTCTCTGTC 360 361 AACCTGGATG TGAAGCACTT CTCCCCAGAG GAACTCAAGG TCAAGGTGCT GGGAGATGTG 420 421 ATTGAGGTGC ATGGCAAACA TGAAGAGCGC CAGGATGAAC ATGGTTTTAT CTCCCGGGAG 480 481 TTCCACAGGA AATACCGGAT CCCAGCTGAC GTGGACCCTC TCGCCATTAC TTCATCCCTG 540 541 TCCTCTGATG GGGTCCTCAC TGTGAATGGA CCAAGGAAAC AGGCCTCCGG CCCTGAGCGC 600 601 ACCATTCCCA TCACCCGTGA AGAGAAGCCG GCTGTCACTG CAGCCCCCAA GAAGTAG 657 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Structural constituent of eye lens | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Negative regulation of intracellular transport |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-2021 | Ovis aries | 99.43 | 6e-123 | 353 |
| LLPS-Aim-2899 | Ailuropoda melanoleuca | 99.43 | 6e-123 | 353 |
| LLPS-Mup-3319 | Mustela putorius furo | 99.43 | 6e-123 | 353 |
| LLPS-Caf-0036 | Canis familiaris | 99.43 | 6e-123 | 353 |
| LLPS-Eqc-2350 | Equus caballus | 98.86 | 3e-120 | 346 |
| LLPS-Orc-0978 | Oryctolagus cuniculus | 98.3 | 5e-122 | 351 |
| LLPS-Caj-0518 | Callithrix jacchus | 97.71 | 4e-121 | 348 |
| LLPS-Hos-1059 | Homo sapiens | 97.71 | 1e-120 | 347 |
| LLPS-Ict-2626 | Ictidomys tridecemlineatus | 97.71 | 5e-121 | 348 |
| LLPS-Fec-0597 | Felis catus | 97.63 | 5e-147 | 416 |
| LLPS-Chs-4052 | Chlorocebus sabaeus | 97.14 | 2e-120 | 347 |
| LLPS-Maf-0542 | Macaca fascicularis | 97.14 | 2e-120 | 347 |
| LLPS-Aon-0985 | Aotus nancymaae | 97.14 | 2e-120 | 347 |
| LLPS-Cea-1250 | Cercocebus atys | 97.14 | 2e-120 | 347 |
| LLPS-Gog-3518 | Gorilla gorilla | 97.14 | 2e-120 | 347 |
| LLPS-Ere-0285 | Erinaceus europaeus | 97.14 | 2e-120 | 347 |
| LLPS-Ran-1678 | Rattus norvegicus | 97.14 | 1e-120 | 347 |
| LLPS-Pap-3743 | Pan paniscus | 97.14 | 2e-120 | 347 |
| LLPS-Pat-0591 | Pan troglodytes | 97.14 | 2e-120 | 347 |
| LLPS-Man-2032 | Macaca nemestrina | 97.14 | 2e-120 | 347 |
| LLPS-Rhb-3871 | Rhinopithecus bieti | 97.14 | 2e-120 | 347 |
| LLPS-Mam-0145 | Macaca mulatta | 97.14 | 2e-120 | 347 |
| LLPS-Mum-1165 | Mus musculus | 96.57 | 2e-119 | 344 |
| LLPS-Mea-0129 | Mesocricetus auratus | 96.57 | 2e-120 | 347 |
| LLPS-Dio-2542 | Dipodomys ordii | 96.3 | 2e-69 | 214 |
| LLPS-Otg-3033 | Otolemur garnettii | 96.0 | 3e-119 | 343 |
| LLPS-Paa-1397 | Papio anubis | 95.43 | 1e-113 | 330 |
| LLPS-Sus-0462 | Sus scrofa | 94.31 | 4e-143 | 407 |
| LLPS-Cap-1077 | Cavia porcellus | 94.29 | 1e-114 | 332 |
| LLPS-Sah-1775 | Sarcophilus harrisii | 93.71 | 2e-116 | 336 |
| LLPS-Mod-0934 | Monodelphis domestica | 90.86 | 9e-113 | 327 |
| LLPS-Meg-1013 | Meleagris gallopavo | 76.0 | 1e-91 | 273 |
| LLPS-Gaga-1178 | Gallus gallus | 76.0 | 1e-91 | 273 |
| LLPS-Fia-2131 | Ficedula albicollis | 74.29 | 1e-88 | 266 |
| LLPS-Tag-0258 | Taeniopygia guttata | 74.29 | 1e-88 | 266 |
| LLPS-Lac-0067 | Latimeria chalumnae | 72.16 | 6e-86 | 259 |
| LLPS-Xet-0718 | Xenopus tropicalis | 68.57 | 2e-82 | 250 |
| LLPS-Anc-0157 | Anolis carolinensis | 65.36 | 7e-68 | 213 |
| LLPS-Scf-0050 | Scleropages formosus | 65.14 | 2e-71 | 222 |
| LLPS-Pes-2610 | Pelodiscus sinensis | 64.8 | 6e-82 | 249 |
| LLPS-Asm-0265 | Astyanax mexicanus | 64.57 | 9e-75 | 230 |
| LLPS-Icp-3889 | Ictalurus punctatus | 63.43 | 2e-74 | 230 |
| LLPS-Dar-3992 | Danio rerio | 62.87 | 8e-65 | 205 |
| LLPS-Leo-0276 | Lepisosteus oculatus | 61.58 | 2e-67 | 211 |
| LLPS-Drm-1699 | Drosophila melanogaster | 51.58 | 2e-20 | 90.9 |
| LLPS-Tar-3692 | Takifugu rubripes | 47.89 | 2e-15 | 76.3 |
| LLPS-Xim-2619 | Xiphophorus maculatus | 47.89 | 3e-15 | 75.9 |
| LLPS-Pof-2016 | Poecilia formosa | 47.89 | 2e-15 | 76.3 |
| LLPS-Orn-2209 | Oreochromis niloticus | 47.89 | 3e-15 | 75.5 |
| LLPS-Ten-3405 | Tetraodon nigroviridis | 47.89 | 4e-15 | 75.1 |
| LLPS-Orl-2954 | Oryzias latipes | 46.48 | 3e-14 | 72.8 |
| LLPS-Scm-4000 | Scophthalmus maximus | 46.48 | 1e-14 | 73.9 |
| LLPS-Cis-0901 | Ciona savignyi | 45.31 | 1e-27 | 109 |
| LLPS-Myl-2606 | Myotis lucifugus | 43.93 | 3e-31 | 119 |
| LLPS-Cii-0238 | Ciona intestinalis | 43.54 | 3e-31 | 119 |
| LLPS-Anp-1799 | Anas platyrhynchos | 43.24 | 2e-13 | 67.8 |
| LLPS-Cae-1848 | Caenorhabditis elegans | 40.45 | 3e-18 | 82.4 |
| LLPS-Gaa-2210 | Gasterosteus aculeatus | 40.34 | 2e-29 | 115 |
| LLPS-Poa-3670 | Pongo abelii | 38.41 | 7e-29 | 112 |
| LLPS-Mal-0833 | Mandrillus leucophaeus | 37.8 | 1e-28 | 112 |
| LLPS-Nol-2677 | Nomascus leucogenys | 37.8 | 2e-28 | 111 |
| LLPS-Fud-1943 | Fukomys damarensis | 37.65 | 4e-29 | 113 |
| LLPS-Tut-1351 | Tursiops truncatus | 37.65 | 2e-29 | 114 |
| LLPS-Urm-1755 | Ursus maritimus | 37.65 | 1e-28 | 112 |
| LLPS-Loa-3272 | Loxodonta africana | 37.65 | 6e-29 | 112 |
| LLPS-Cas-1573 | Carlito syrichta | 33.99 | 1e-15 | 76.6 |