• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Bot-2374
DROSHA

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Drosha ribonuclease III
Gene Name: DROSHA
Ensembl Gene: ENSBTAG00000017551.6
Ensembl Protein: ENSBTAP00000057912.1
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Others


▼ PROPERTY



▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Stress granulePredicted from orthologs(View)

▼ SEQUENCE


Protein Sequence (FASTA)
1     MQGSACHRMS  FHPGGPRCPR  GRGGHGARPS  SAPAFRPQNL  RLLHPQQPPV  QYQYEPPSAP  60
61    STTFSNSPAP  NFLPPRPDFV  PFPPPMPPSA  QGPLPPCPIR  PPFPNHQMRP  PFPVPPCFPP  120
121   MPPPLPCPNN  PPVPGAPPGQ  GAFPFMMPPP  SLPHPPPPPV  VPQQVNYQYP  PGYSHHSFPP  180
181   PNFNSFQNSP  SSFPPSASNS  SSPHFRHLPP  YPLPKAPSER  RSPERLKHYD  DHRHRDHSHG  240
241   RGERHRSLER  RERGRSPDRR  RQDSRYRSDH  ERGRTPSRHR  SYERSRERER  ERHRHRDSRR  300
301   SPSLERSYKK  EYKRSGSRSP  SREKKRGRWE  EEKDRWSDIP  GSGKEKNYTS  IKEKEPEEGL  360
361   PDKNEEEEEE  LLKPVWIRCT  HSENYYSSDP  MDQVGDSTVV  GTSRLRDLYD  KFEEELGSRQ  420
421   EKAKAARPPW  EPPKTKLDED  LESSSESECE  SDEDSTCSSS  SDSEVFDVIA  EIKRKKAHPD  480
481   RLHDELWYND  PGQMNDGPLC  KCSAKARRTG  IRHSIYPGEE  AIKPCRPMTN  NAGRLFHYRI  540
541   TVSPPTNFLT  DRPTVIEYDD  HEYIFEGFSM  FAHAPLTNIP  LCKVIRFNID  YTIHFIEEMM  600
601   PENFCVKGLE  LFSLFLFRDI  LELYDWNLKG  PLFEDSPPCC  PRFHFMPRFV  RFLPDGGKEV  660
661   LSMHQILLYL  LRCSKALVPE  EEIANMLQWE  ELEWQKYAEE  CKGMIVTNPG  AKPSSVRIDQ  720
721   LDREQFNPDV  ITFPIIVHFG  IRPAQLSYAG  DPQYQKLWKS  YVKLRHLLAN  SPKVKQTDKQ  780
781   KLAQREEALQ  KIRQKNTMRR  EVTVELSSQG  FWKTGIRSDV  CQHAMMLPVL  THHIRYHQCL  840
841   MHLDKLIGYT  FQDRCLLQLA  MTHPSHHLNF  GMNPDHARNS  LSNCGIRQPK  YGDRKVHHMH  900
901   MRKKGINTLI  NIMSRLGQDD  PTPSRINHNE  RLEFLGDAVV  EFLTSVHLYY  LFPSLEEGGL  960
961   ATYRTAIVQN  QHLAMLAKKL  ELDRFMLYAH  GPDLCRESDL  RHAMANCFEA  LIGAVYLEGS  1020
1021  LEEAKQLFGR  LLFNDPDLRE  VWLNYPLHPL  QLQEPNTDRQ  LIETSPVLQK  LTEFEDAIGV  1080
1081  IFTHVRLLAR  AFTLRTVGFN  HLTLGHNQRM  EFLGDSIMQL  VATEYLFIHF  PDHHEGHLTL  1140
1141  LRSSLVNNRT  QAKVAEELGM  QEYAITNDKT  KRPVALRTKT  LADLLESFIA  ALYIDKDLEY  1200
1201  VHTFMNVCFF  PRLKEFILNQ  DWNDPKSQLQ  QCCLTLRTEG  KEPDIPLYKT  LQTVGPSHAR  1260
1261  TYTVAVYFKG  ERIGCGKGPS  IQQAEMGAAM  DALEKYNFPQ  MAHQKRFIER  KYRQELKEMR  1320
1321  WEREHQEKEP  DETEDIKK  1338
Nucleotide CDS Sequence (FASTA)
1     ATGTCGTTCC  ACCCAGGAGG  ACCCAGGTGT  CCCCGAGGGC  GAGGGGGACA  TGGAGCCAGA  60
61    CCCTCCTCCG  CACCAGCCTT  CAGGCCCCAA  AATCTGAGAC  TGCTTCACCC  TCAGCAGCCT  120
121   CCTGTGCAAT  ACCAATACGA  ACCTCCCAGC  GCCCCTTCCA  CCACGTTCTC  CAACTCTCCG  180
181   GCCCCCAATT  TTCTGCCTCC  AAGACCAGAC  TTTGTACCCT  TCCCTCCGCC  CATGCCTCCT  240
241   TCAGCGCAAG  GCCCCCTACC  CCCCTGCCCG  ATCCGGCCCC  CGTTCCCCAA  CCACCAGATG  300
301   AGGCCCCCCT  TCCCCGTGCC  CCCCTGTTTC  CCTCCCATGC  CGCCTCCGCT  ACCCTGTCCC  360
361   AATAACCCCC  CAGTCCCCGG  AGCGCCTCCT  GGCCAAGGCG  CCTTCCCCTT  CATGATGCCG  420
421   CCGCCATCCC  TGCCGCATCC  GCCGCCGCCT  CCCGTCGTTC  CGCAGCAGGT  CAATTACCAG  480
481   TACCCACCCG  GGTACTCGCA  CCACAGTTTC  CCACCCCCCA  ACTTCAATAG  CTTCCAGAAT  540
541   AGCCCCAGTT  CCTTCCCGCC  CAGTGCTAGT  AACAGCAGTA  GTCCTCACTT  CAGGCACCTC  600
601   CCTCCGTACC  CGCTCCCCAA  GGCTCCCAGT  GAGAGGCGGT  CCCCAGAAAG  GCTAAAGCAT  660
661   TACGACGACC  ACAGGCACCG  GGACCACAGT  CACGGGAGGG  GCGAACGGCA  TCGGTCCCTG  720
721   GAGCGCCGGG  AGCGAGGCCG  GAGCCCCGAC  CGGAGAAGGC  AGGACAGCCG  CTACAGGTCC  780
781   GATCACGAGC  GGGGGCGCAC  GCCCTCCCGC  CACCGGAGCT  ACGAGCGGAG  CAGAGAGCGG  840
841   GAACGGGAGA  GACACAGGCA  CCGGGACAGC  CGAAGATCAC  CATCTCTGGA  AAGGTCCTAC  900
901   AAAAAAGAGT  ATAAGAGATC  TGGAAGTCGC  TCCCCAAGCA  GGGAGAAGAA  GAGAGGTCGC  960
961   TGGGAGGAAG  AAAAAGACAG  ATGGAGTGAC  ATCCCGGGCT  CTGGCAAAGA  GAAGAATTAT  1020
1021  ACCTCAATCA  AGGAAAAGGA  GCCAGAGGAG  GGGCTGCCTG  ACAAAAATGA  GGAGGAGGAA  1080
1081  GAAGAACTCC  TTAAGCCTGT  GTGGATTCGC  TGCACCCACT  CAGAAAACTA  CTACTCCAGT  1140
1141  GACCCCATGG  ATCAGGTGGG  AGATTCTACT  GTAGTTGGAA  CAAGTAGGCT  CCGTGACTTA  1200
1201  TATGACAAAT  TTGAGGAAGA  GTTGGGGAGC  AGGCAAGAGA  AGGCCAAAGC  TGCTAGACCC  1260
1261  CCATGGGAGC  CTCCCAAGAC  GAAGCTAGAT  GAAGATTTAG  AGAGTTCCAG  TGAATCCGAA  1320
1321  TGCGAGTCCG  ATGAGGACAG  CACCTGCTCT  AGCAGCTCAG  ACTCTGAAGT  TTTCGACGTC  1380
1381  ATTGCAGAAA  TCAAACGTAA  AAAGGCCCAT  CCTGACCGAC  TTCATGATGA  ACTTTGGTAC  1440
1441  AACGACCCAG  GCCAGATGAA  TGATGGCCCA  CTCTGCAAAT  GCAGCGCAAA  AGCGAGACGC  1500
1501  ACGGGCATCA  GGCACAGCAT  TTATCCCGGA  GAAGAGGCCA  TCAAGCCCTG  TCGTCCTATG  1560
1561  ACCAACAATG  CTGGCAGGCT  TTTCCACTAT  CGAATTACAG  TCTCACCTCC  CACAAACTTT  1620
1621  TTAACTGACA  GGCCAACTGT  TATTGAATAT  GATGATCACG  AGTATATCTT  TGAAGGATTT  1680
1681  TCTATGTTTG  CACACGCCCC  CCTGACCAAT  ATTCCACTGT  GTAAAGTAAT  TAGATTCAAC  1740
1741  ATAGACTACA  CGATTCATTT  CATAGAAGAG  ATGATGCCTG  AGAATTTTTG  TGTGAAAGGA  1800
1801  CTTGAACTCT  TTTCATTATT  CCTATTCAGA  GATATTTTGG  AATTGTATGA  CTGGAATCTC  1860
1861  AAAGGTCCTT  TGTTTGAAGA  CAGTCCTCCC  TGCTGTCCAA  GATTTCATTT  TATGCCACGT  1920
1921  TTTGTAAGAT  TTCTTCCAGA  TGGAGGGAAA  GAAGTACTGT  CTATGCACCA  GATCCTCCTC  1980
1981  TACTTACTAC  GGTGTAGCAA  AGCCCTTGTT  CCCGAAGAGG  AGATTGCCAA  TATGCTTCAG  2040
2041  TGGGAGGAAC  TTGAGTGGCA  GAAATACGCG  GAAGAGTGCA  AAGGCATGAT  TGTCACCAAC  2100
2101  CCTGGAGCGA  AACCAAGCTC  TGTCCGCATC  GATCAACTGG  ATCGTGAACA  GTTCAACCCT  2160
2161  GATGTGATTA  CTTTTCCGAT  TATCGTTCAC  TTTGGGATAC  GCCCTGCACA  GTTGAGTTAT  2220
2221  GCTGGAGACC  CACAGTACCA  GAAACTGTGG  AAGAGTTATG  TTAAGCTTCG  CCACCTCCTA  2280
2281  GCAAATAGTC  CAAAAGTCAA  ACAGACTGAC  AAGCAGAAGC  TGGCACAGAG  GGAGGAAGCG  2340
2341  CTCCAAAAAA  TACGACAGAA  GAATACCATG  AGGCGAGAAG  TAACGGTGGA  GCTGAGTAGC  2400
2401  CAAGGCTTCT  GGAAAACTGG  CATCCGTTCT  GATGTCTGTC  AGCATGCCAT  GATGCTGCCA  2460
2461  GTTCTGACCC  ATCATATTCG  CTACCACCAG  TGCCTAATGC  ATCTGGACAA  GTTGATAGGA  2520
2521  TATACTTTCC  AAGATCGTTG  TCTGTTACAG  CTGGCCATGA  CCCACCCAAG  TCATCACTTA  2580
2581  AATTTTGGAA  TGAATCCTGA  TCATGCCAGG  AATTCTTTGT  CTAACTGTGG  AATTCGGCAG  2640
2641  CCCAAATATG  GAGATAGAAA  AGTTCATCAC  ATGCACATGC  GGAAAAAAGG  AATTAACACC  2700
2701  TTAATAAATA  TTATGTCACG  CCTTGGCCAA  GATGACCCAA  CTCCCTCAAG  GATTAATCAC  2760
2761  AACGAACGGT  TGGAGTTCCT  GGGTGATGCT  GTCGTTGAAT  TTCTGACCAG  TGTCCATTTG  2820
2821  TACTATCTGT  TTCCCAGTCT  GGAAGAGGGG  GGATTAGCAA  CCTATCGGAC  TGCCATCGTT  2880
2881  CAGAACCAGC  ACCTTGCCAT  GCTAGCAAAG  AAACTTGAAC  TGGATCGGTT  TATGCTTTAT  2940
2941  GCTCATGGAC  CTGACCTTTG  TAGAGAATCA  GACCTTCGGC  ATGCAATGGC  TAATTGTTTT  3000
3001  GAAGCATTAA  TAGGAGCTGT  TTACTTGGAG  GGAAGCCTGG  AGGAAGCCAA  GCAGTTATTT  3060
3061  GGACGCTTAC  TCTTTAATGA  TCCGCTTCAA  GAGCCAAATA  CTGATCGACA  ACTTATTGAG  3120
3121  ACTTCTCCAG  TTCTACAGAA  ACTTACTGAA  TTTGAAGATG  CAATTGGAGT  AATTTTTACA  3180
3181  CATGTTCGAC  TTTTGGCAAG  AGCATTCACA  TTGAGAACTG  TGGGATTTAA  CCATCTGACC  3240
3241  CTAGGCCACA  ATCAGAGGAT  GGAATTCCTT  GGTGACTCCA  TAATGCAGCT  GGTAGCAACG  3300
3301  GAGTACTTAT  TCATTCATTT  TCCAGATCAT  CACGAAGGAC  ACTTAACTCT  GTTGCGAAGC  3360
3361  TCTTTGGTGA  ATAACAGAAC  TCAGGCCAAG  GTGGCGGAGG  AATTGGGCAT  GCAGGAATAC  3420
3421  GCCATCACCA  ATGACAAGAC  CAAAAGACCT  GTCGCCCTGA  GAACCAAGAC  CTTGGCTGAC  3480
3481  CTTTTGGAAT  CATTTATTGC  AGCACTGTAC  ATTGATAAAG  ACTTGGAATA  CGTTCATACT  3540
3541  TTCATGAATG  TTTGTTTCTT  TCCACGATTA  AAAGAATTCA  TTTTGAATCA  GGATTGGAAC  3600
3601  GACCCCAAGT  CCCAGCTTCA  GCAGTGCTGC  CTGACTCTTA  GGACAGAAGG  AAAAGAACCA  3660
3661  GACATTCCGC  TATACAAGAC  TCTGCAGACA  GTGGGGCCAT  CCCACGCGAG  GACCTACACT  3720
3721  GTGGCTGTCT  ACTTCAAGGG  AGAAAGAATT  GGCTGTGGGA  AAGGACCAAG  TATTCAGCAA  3780
3781  GCAGAAATGG  GAGCAGCAAT  GGATGCACTT  GAAAAATATA  ACTTTCCCCA  GATGGCCCAT  3840
3841  CAGAAACGGT  TCATTGAACG  GAAATACAGA  CAAGAGTTAA  AAGAAATGAG  GTGGGAAAGA  3900
3901  GAGCATCAAG  AGAAGGAGCC  AGATGAGACC  GAAGACATAA  AGAAATAA  3948

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-2308Ursus maritimus100.08e-0654.7
LLPS-Caf-4574Canis familiaris99.840.01306
LLPS-Sus-2070Sus scrofa99.030.02042
LLPS-Paa-2419Papio anubis98.680.02038
LLPS-Chs-1538Chlorocebus sabaeus98.680.02039
LLPS-Maf-2929Macaca fascicularis98.590.02039
LLPS-Cas-2560Carlito syrichta98.515e-87 284
LLPS-Orc-2083Oryctolagus cuniculus98.50.02035
LLPS-Man-1897Macaca nemestrina98.410.02034
LLPS-Ova-3005Ovis aries97.530.02050
LLPS-Ict-2531Ictidomys tridecemlineatus97.010.01884
LLPS-Fec-2750Felis catus95.810.02021
LLPS-Eqc-1330Equus caballus95.640.02020
LLPS-Hos-0695Homo sapiens95.560.02018
LLPS-Mup-2687Mustela putorius furo95.560.02016
LLPS-Poa-0414Pongo abelii95.470.02011
LLPS-Caj-0398Callithrix jacchus95.470.02016
LLPS-Nol-1418Nomascus leucogenys95.380.02015
LLPS-Aim-1342Ailuropoda melanoleuca95.220.02019
LLPS-Loa-3982Loxodonta africana95.050.02002
LLPS-Tut-1368Tursiops truncatus94.960.02010
LLPS-Mea-2623Mesocricetus auratus94.440.02006
LLPS-Dio-2983Dipodomys ordii94.240.01969
LLPS-Mam-1514Macaca mulatta94.190.01984
LLPS-Mum-0043Mus musculus94.110.01998
LLPS-Ran-3712Rattus norvegicus94.020.01992
LLPS-Rhb-1821Rhinopithecus bieti93.940.01963
LLPS-Myl-2365Myotis lucifugus93.870.01984
LLPS-Otg-0377Otolemur garnettii93.60.01965
LLPS-Cea-2940Cercocebus atys93.530.01980
LLPS-Fud-0816Fukomys damarensis93.270.02014
LLPS-Gog-2731Gorilla gorilla93.110.01984
LLPS-Pap-0031Pan paniscus93.030.01981
LLPS-Pat-1906Pan troglodytes93.030.01981
LLPS-Cap-3922Cavia porcellus92.910.01998
LLPS-Aon-3432Aotus nancymaae92.650.01929
LLPS-Leo-1348Lepisosteus oculatus92.180.01785
LLPS-Dar-1190Danio rerio91.510.01769
LLPS-Pof-3230Poecilia formosa91.510.01790
LLPS-Lac-2504Latimeria chalumnae91.210.01883
LLPS-Pes-0145Pelodiscus sinensis91.20.01924
LLPS-Orn-1285Oreochromis niloticus91.190.01782
LLPS-Xim-1701Xiphophorus maculatus91.190.01778
LLPS-Asm-2971Astyanax mexicanus90.570.01742
LLPS-Orl-2103Oryzias latipes90.170.01774
LLPS-Gaga-1342Gallus gallus90.150.01922
LLPS-Xet-0425Xenopus tropicalis89.630.01729
LLPS-Mod-0125Monodelphis domestica89.50.01937
LLPS-Mal-0224Mandrillus leucophaeus89.50.01828
LLPS-Sah-3475Sarcophilus harrisii89.50.01939
LLPS-Tar-0000Takifugu rubripes89.170.01607
LLPS-Gaa-0078Gasterosteus aculeatus88.855e-163 495
LLPS-Fia-1700Ficedula albicollis88.690.01891
LLPS-Ten-1028Tetraodon nigroviridis88.210.01780
LLPS-Icp-2275Ictalurus punctatus88.080.01672
LLPS-Anp-0566Anas platyrhynchos87.360.01907
LLPS-Meg-0379Meleagris gallopavo87.150.01899
LLPS-Scf-2090Scleropages formosus86.650.01720
LLPS-Tag-1260Taeniopygia guttata86.550.01871
LLPS-Anc-2673Anolis carolinensis84.880.01855
LLPS-Ora-0762Ornithorhynchus anatinus80.740.01251
LLPS-Cii-2070Ciona intestinalis61.90.0 578
LLPS-Cis-1135Ciona savignyi58.970.01038
LLPS-Drm-0899Drosophila melanogaster54.80.01045
LLPS-Art-2979Arabidopsis thaliana45.07e-0655.1
LLPS-Cae-0120Caenorhabditis elegans38.142e-0760.1
LLPS-Asfu-1152Aspergillus fumigatus34.112e-0863.9
LLPS-Scj-1080Schizosaccharomyces japonicus33.591e-0862.4
LLPS-Asn-0446Aspergillus nidulans32.523e-0863.2
LLPS-Blg-0562Blumeria graminis32.262e-0966.6
LLPS-Asc-1452Aspergillus clavatus32.064e-0759.3
LLPS-Scs-0010Sclerotinia sclerotiorum31.713e-0862.8
LLPS-Nec-1499Neurospora crassa30.841e-0657.8
LLPS-Gag-1261Gaeumannomyces graminis30.143e-0759.7
LLPS-Scc-0110Schizosaccharomyces cryophilus30.094e-0655.8
LLPS-Hea-0056Helianthus annuus30.082e-0657.0
LLPS-Trr-0461Trichoderma reesei30.072e-0760.1
LLPS-Gas-0808Galdieria sulphuraria29.816e-1894.0
LLPS-Phn-0271Phaeosphaeria nodorum29.13e-1482.4
LLPS-Asni-0793Aspergillus niger28.471e-0760.8
LLPS-Ast-0011Aspergillus terreus28.248e-1067.8
LLPS-Phv-1759Phaseolus vulgaris27.951e-1380.9
LLPS-Cogr-1123Colletotrichum graminicola27.751e-0657.4
LLPS-Aso-1172Aspergillus oryzae27.611e-1587.4
LLPS-Gor-2286Gossypium raimondii27.544e-1689.0
LLPS-Brd-2052Brachypodium distachyon27.484e-0862.4
LLPS-Arl-0675Arabidopsis lyrata27.432e-1793.2
LLPS-Kop-1306Komagataella pastoris27.41e-0863.5
LLPS-Tru-1692Triticum urartu27.353e-1895.9
LLPS-Cog-1133Colletotrichum gloeosporioides27.351e-1070.9
LLPS-Thc-1909Theobroma cacao27.228e-1584.3
LLPS-Coc-0817Corchorus capsularis27.043e-1275.9
LLPS-Scm-2593Scophthalmus maximus27.041e-1173.9
LLPS-Map-0131Magnaporthe poae26.923e-1069.7
LLPS-Amt-1665Amborella trichopoda26.895e-1585.1
LLPS-Php-2444Physcomitrella patens26.897e-1791.3
LLPS-Bro-2301Brassica oleracea26.712e-1896.7
LLPS-Brr-0580Brassica rapa26.715e-1791.7
LLPS-Brn-2418Brassica napus26.717e-1997.8
LLPS-Pyt-0688Pyrenophora teres26.676e-1068.6
LLPS-Pot-0582Populus trichocarpa26.518e-1894.4
LLPS-Glm-0322Glycine max26.322e-1483.6
LLPS-Hov-1842Hordeum vulgare26.278e-1790.9
LLPS-Lem-0805Leptosphaeria maculans26.242e-0966.6
LLPS-Mao-0204Magnaporthe oryzae26.221e-1277.4
LLPS-Orr-1140Oryza rufipogon26.196e-1894.7
LLPS-Orb-2344Oryza barthii26.198e-1894.4
LLPS-Orbr-0238Oryza brachyantha26.15e-1172.0
LLPS-Sob-1359Sorghum bicolor26.076e-1378.2
LLPS-Asf-0158Aspergillus flavus26.072e-1379.0
LLPS-Fus-0064Fusarium solani26.041e-1483.6
LLPS-Mua-1275Musa acuminata25.92e-1586.7
LLPS-Tra-2552Triticum aestivum25.886e-1894.7
LLPS-Cus-1250Cucumis sativus25.824e-1585.5
LLPS-Met-0661Medicago truncatula25.673e-1792.4
LLPS-Fuo-0810Fusarium oxysporum25.572e-0967.0
LLPS-Orp-1304Oryza punctata25.457e-1791.3
LLPS-Nef-0084Neosartorya fischeri25.432e-1276.6
LLPS-Scp-0101Schizosaccharomyces pombe25.295e-1172.0
LLPS-Tum-0169Tuber melanosporum25.05e-22 108
LLPS-Trv-1621Trichoderma virens24.913e-0862.8
LLPS-Dac-1582Daucus carota24.862e-1587.0
LLPS-Vir-1119Vigna radiata24.783e-1275.9
LLPS-Orni-2038Oryza nivara24.765e-1068.6
LLPS-Ori-1839Oryza indica24.766e-1068.6
LLPS-Mel-0234Melampsora laricipopulina24.72e-0656.6
LLPS-Nia-0174Nicotiana attenuata24.682e-0966.6
LLPS-Abg-0025Absidia glauca24.617e-1584.7
LLPS-Dos-1240Dothistroma septosporum24.231e-1484.0
LLPS-Viv-1479Vitis vinifera24.082e-0656.6
LLPS-Ved-0953Verticillium dahliae24.022e-1173.6
LLPS-Sot-1046Solanum tuberosum23.945e-1171.6
LLPS-Zyt-1005Zymoseptoria tritici23.377e-0861.6
LLPS-Coo-1131Colletotrichum orbiculare23.322e-1173.6
LLPS-Put-0919Puccinia triticina23.094e-1069.3
LLPS-Pytr-0219Pyrenophora triticirepentis21.847e-1068.2