• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-2062
MTHFD2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Gene Name: MTHFD2
Ensembl Gene: ENSBTAG00000004881.6
Ensembl Protein: ENSBTAP00000006419.6
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGAGRRRGLP  RCSGITVRPA  RASFPELTMA  AASFITSLVT  RLLRSAQSGR  LHQRPFHLSA  60
61    VRNEAVVISG  RKLAEQIKQE  VRQEVEEWVA  SGNKRPHLSV  VLVGENPASQ  SYVLNKTRAA  120
121   ASVGINSETI  LKPASISEEE  LLNLINKLNN  DDNVDGLLVQ  LPLPEHIDER  KVCNAVSPDK  180
181   DVDGFHVINV  GRMCLDQCSM  LPATPWGVWE  IIKRTGIPTL  GKNVVVAGRS  KNVGMPIAML  240
241   LHTDGAHERP  GGDATVTISH  RYTPKEELKK  HTALADIVIS  AAGIPNLITA  DMIKEGAAVI  300
301   DVGINRIQDP  ITAKPKLVGD  VDFEGVKKKA  GYITPVPGGV  GPMTVAMLMK  NTIIAAKKVL  360
361   RLEEQEVLKS  KELGVASN  378
Nucleotide CDS Sequence (FASTA)
1     ATGGGTGCCG  GCAGGAGGCG  AGGCCTGCCA  CGCTGCAGCG  GTATAACCGT  GCGGCCAGCG  60
61    CGCGCATCTT  TCCCCGAGCT  GACGATGGCC  GCAGCCTCCT  TTATAACCTC  TTTGGTCACC  120
121   CGACTGCTCC  GGTCCGCGCA  GAGTGGCCGC  CTCCATCAAC  GCCCTTTCCA  CCTCTCGGCA  180
181   GTGCGAAATG  AAGCTGTTGT  CATTTCTGGA  AGGAAACTTG  CTGAGCAGAT  CAAGCAGGAA  240
241   GTGCGGCAGG  AGGTGGAAGA  GTGGGTGGCG  TCAGGCAACA  AGCGGCCACA  CCTGAGCGTG  300
301   GTTCTGGTTG  GAGAGAATCC  TGCGAGTCAG  TCCTACGTCC  TCAACAAAAC  CAGAGCAGCT  360
361   GCCAGCGTGG  GAATCAACAG  TGAGACCATT  CTGAAACCAG  CTTCAATTTC  AGAGGAAGAA  420
421   CTGTTGAATT  TGATCAATAA  ACTAAATAAT  GATGATAATG  TAGACGGCCT  CCTTGTTCAG  480
481   CTGCCTCTTC  CAGAGCACAT  CGATGAGAGA  AAGGTCTGCA  ATGCTGTTTC  TCCAGACAAA  540
541   GATGTCGATG  GCTTTCATGT  AATTAATGTA  GGGCGAATGT  GTTTGGACCA  GTGTTCCATG  600
601   TTACCAGCTA  CTCCATGGGG  TGTGTGGGAA  ATAATTAAGC  GAACTGGCAT  TCCAACCCTA  660
661   GGGAAGAATG  TGGTTGTGGC  CGGAAGGTCA  AAAAATGTTG  GAATGCCCAT  TGCAATGTTG  720
721   CTGCACACAG  ATGGGGCACA  TGAACGGCCC  GGAGGCGATG  CCACTGTCAC  AATATCTCAT  780
781   CGATACACTC  CTAAGGAGGA  GCTAAAGAAA  CATACAGCTC  TTGCAGATAT  TGTGATCTCC  840
841   GCTGCAGGTA  TTCCAAATCT  GATCACAGCA  GATATGATCA  AGGAAGGAGC  AGCTGTCATT  900
901   GATGTGGGAA  TAAATAGAAT  TCAAGATCCC  ATAACTGCTA  AACCCAAGTT  GGTTGGAGAT  960
961   GTGGATTTTG  AAGGAGTCAA  GAAGAAAGCA  GGTTACATCA  CTCCAGTCCC  TGGGGGTGTT  1020
1021  GGTCCCATGA  CTGTGGCAAT  GCTGATGAAG  AATACCATTA  TTGCTGCAAA  AAAAGTGCTG  1080
1081  AGGCTCGAAG  AGCAGGAAGT  ACTGAAGTCT  AAGGAACTTG  GAGTAGCAAG  TAATTGA  1137

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Hydrolase
Isopeptide bond
Magnesium
Mitochondrion
Multifunctional enzyme
NAD
NADP
One-carbon metabolism
Oxidoreductase
Reference proteome
Transit peptide
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Magnesium ion binding
Molecular Function
Methenyltetrahydrofolate cyclohydrolase activity
Molecular Function
Methylenetetrahydrofolate dehydrogenase (NAD+) activity
Molecular Function
Methylenetetrahydrofolate dehydrogenase (NADP+) activity
Molecular Function
Phosphate ion binding
Biological Process
Tetrahydrofolate interconversion
Biological Process
Tetrahydrofolate metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-1782Ovis aries97.710.0 655
LLPS-Mal-2781Mandrillus leucophaeus94.30.0 568
LLPS-Ict-3250Ictidomys tridecemlineatus92.290.0 616
LLPS-Orc-1024Oryctolagus cuniculus92.00.0 608
LLPS-Aim-2746Ailuropoda melanoleuca92.00.0 616
LLPS-Caf-2766Canis familiaris91.710.0 611
LLPS-Fec-1515Felis catus91.710.0 611
LLPS-Cas-1599Carlito syrichta91.430.0 617
LLPS-Urm-1853Ursus maritimus91.430.0 611
LLPS-Dio-1385Dipodomys ordii91.290.0 580
LLPS-Mup-0726Mustela putorius furo91.140.0 611
LLPS-Myl-1615Myotis lucifugus91.140.0 605
LLPS-Pat-0252Pan troglodytes90.860.0 610
LLPS-Pap-3402Pan paniscus90.860.0 610
LLPS-Hos-2199Homo sapiens90.860.0 608
LLPS-Chs-3087Chlorocebus sabaeus90.860.0 610
LLPS-Gog-1959Gorilla gorilla90.860.0 610
LLPS-Paa-2214Papio anubis90.570.0 608
LLPS-Aon-1601Aotus nancymaae90.570.0 603
LLPS-Poa-0776Pongo abelii90.290.0 604
LLPS-Nol-3934Nomascus leucogenys90.290.0 605
LLPS-Otg-1166Otolemur garnettii90.290.0 603
LLPS-Fud-3588Fukomys damarensis90.290.0 606
LLPS-Caj-3934Callithrix jacchus90.290.0 602
LLPS-Cap-3831Cavia porcellus90.00.0 604
LLPS-Rhb-1065Rhinopithecus bieti89.710.0 605
LLPS-Mea-0861Mesocricetus auratus89.050.0 578
LLPS-Sus-3749Sus scrofa88.890.0 616
LLPS-Mum-4131Mus musculus88.290.0 595
LLPS-Loa-2289Loxodonta africana88.00.0 593
LLPS-Ran-4728Rattus norvegicus87.210.0 582
LLPS-Eqc-3329Equus caballus86.910.0 620
LLPS-Mod-3472Monodelphis domestica86.573e-156 449
LLPS-Meg-1684Meleagris gallopavo85.990.0 523
LLPS-Gaga-3822Gallus gallus85.670.0 527
LLPS-Pes-3483Pelodiscus sinensis84.210.0 529
LLPS-Mam-3249Macaca mulatta84.050.0 579
LLPS-Xet-1288Xenopus tropicalis84.010.0 522
LLPS-Sah-2274Sarcophilus harrisii83.860.0 545
LLPS-Leo-0142Lepisosteus oculatus83.180.0 513
LLPS-Man-4537Macaca nemestrina82.570.0 535
LLPS-Lac-3290Latimeria chalumnae82.520.0 528
LLPS-Fia-0544Ficedula albicollis82.435e-177 504
LLPS-Scf-3046Scleropages formosus82.32e-176 501
LLPS-Cea-2797Cercocebus atys82.00.0 526
LLPS-Tar-2912Takifugu rubripes81.971e-164 472
LLPS-Anp-1353Anas platyrhynchos81.230.0 528
LLPS-Icp-4137Ictalurus punctatus80.750.0 514
LLPS-Pof-3781Poecilia formosa80.451e-174 497
LLPS-Anc-2176Anolis carolinensis80.30.0 525
LLPS-Asm-3406Astyanax mexicanus79.949e-178 505
LLPS-Xim-3314Xiphophorus maculatus79.445e-174 496
LLPS-Dar-2198Danio rerio78.964e-176 501
LLPS-Scm-1071Scophthalmus maximus78.724e-171 488
LLPS-Orn-3292Oreochromis niloticus78.054e-174 496
LLPS-Ten-3797Tetraodon nigroviridis76.398e-157 452
LLPS-Gaa-2255Gasterosteus aculeatus76.384e-174 496
LLPS-Orl-0405Oryzias latipes75.917e-172 490
LLPS-Tag-3182Taeniopygia guttata66.467e-63 206
LLPS-Drm-1432Drosophila melanogaster57.095e-105 319
LLPS-Sem-0487Selaginella moellendorffii50.346e-76 243
LLPS-Tru-1040Triticum urartu48.873e-63 211
LLPS-Tra-2005Triticum aestivum48.874e-63 211
LLPS-Orm-1592Oryza meridionalis47.813e-70 229
LLPS-Orgl-1184Oryza glumaepatula47.815e-70 228
LLPS-Orr-1650Oryza rufipogon47.475e-69 225
LLPS-Org-0357Oryza glaberrima47.475e-69 225
LLPS-Ors-1431Oryza sativa47.475e-69 225
LLPS-Orp-2128Oryza punctata47.476e-69 225
LLPS-Sob-1014Sorghum bicolor47.475e-69 225
LLPS-Orb-1306Oryza barthii47.475e-69 225
LLPS-Ori-1753Oryza indica47.475e-69 225
LLPS-Mua-1716Musa acuminata47.471e-67 222
LLPS-Orni-2262Oryza nivara47.475e-69 225
LLPS-Hea-2000Helianthus annuus47.195e-67 221
LLPS-Sei-1863Setaria italica47.145e-69 226
LLPS-Amt-1888Amborella trichopoda46.892e-69 227
LLPS-Met-0382Medicago truncatula46.824e-68 223
LLPS-Orbr-1681Oryza brachyantha46.87e-68 223
LLPS-Pot-1201Populus trichocarpa46.731e-68 224
LLPS-Coc-0359Corchorus capsularis46.671e-68 226
LLPS-Via-0722Vigna angularis46.674e-69 226
LLPS-Brn-2091Brassica napus46.514e-67 221
LLPS-Hov-2124Hordeum vulgare46.461e-68 224
LLPS-Thc-2396Theobroma cacao46.365e-68 223
LLPS-Brr-3057Brassica rapa46.189e-67 220
LLPS-Mae-2142Manihot esculenta46.188e-69 225
LLPS-Viv-1717Vitis vinifera46.051e-68 225
LLPS-Nia-0574Nicotiana attenuata46.035e-68 223
LLPS-Sol-1066Solanum lycopersicum46.032e-67 221
LLPS-Phv-1647Phaseolus vulgaris46.03e-68 223
LLPS-Brd-0316Brachypodium distachyon45.793e-67 222
LLPS-Ved-1029Verticillium dahliae45.742e-50 186
LLPS-Glm-2663Glycine max45.678e-67 220
LLPS-Prp-1020Prunus persica45.547e-68 223
LLPS-Gas-1188Galdieria sulphuraria45.512e-63 211
LLPS-Bro-2634Brassica oleracea45.137e-68 223
LLPS-Chr-1469Chlamydomonas reinhardtii45.122e-65 218
LLPS-Cus-1837Cucumis sativus45.072e-66 221
LLPS-Osl-0189Ostreococcus lucimarinus45.06e-65 215
LLPS-Arl-0173Arabidopsis lyrata44.924e-68 223
LLPS-Art-1436Arabidopsis thaliana44.31e-67 222
LLPS-Kop-1040Komagataella pastoris43.991e-57 206
LLPS-Vir-1497Vigna radiata43.961e-56 192
LLPS-Yal-0784Yarrowia lipolytica43.816e-54 196
LLPS-Spr-0078Sporisorium reilianum43.421e-55 201
LLPS-Abg-1275Absidia glauca43.283e-57 205
LLPS-Gag-1502Gaeumannomyces graminis43.262e-54 198
LLPS-Usm-1140Ustilago maydis43.091e-54 198
LLPS-Cis-1752Ciona savignyi43.02e-48 180
LLPS-Cym-0282Cyanidioschyzon merolae43.08e-59 202
LLPS-Scj-0687Schizosaccharomyces japonicus42.726e-50 185
LLPS-Chc-1079Chondrus crispus42.718e-59 199
LLPS-Dac-1359Daucus carota42.522e-57 194
LLPS-Scc-1034Schizosaccharomyces cryophilus42.382e-51 189
LLPS-Beb-0726Beauveria bassiana42.226e-54 197
LLPS-Map-0253Magnaporthe poae42.026e-53 193
LLPS-Asfu-1298Aspergillus fumigatus42.07e-51 187
LLPS-Nef-1502Neosartorya fischeri42.03e-51 188
LLPS-Asg-1091Ashbya gossypii41.892e-48 181
LLPS-Zem-1635Zea mays41.825e-63 211
LLPS-Gor-0889Gossypium raimondii41.829e-64 213
LLPS-Dos-0919Dothistroma septosporum41.643e-50 186
LLPS-Coo-1353Colletotrichum orbiculare41.642e-53 195
LLPS-Mel-0585Melampsora laricipopulina41.534e-50 185
LLPS-Cii-1940Ciona intestinalis41.53e-49 183
LLPS-Trv-1187Trichoderma virens41.457e-48 179
LLPS-Trr-0560Trichoderma reesei41.458e-49 182
LLPS-Cogr-1031Colletotrichum graminicola41.391e-54 198
LLPS-Fus-0110Fusarium solani41.299e-49 181
LLPS-Ast-1552Aspergillus terreus41.02e-49 184
LLPS-Miv-0389Microbotryum violaceum40.992e-53 196
LLPS-Fuv-1126Fusarium verticillioides40.979e-50 184
LLPS-Nec-0638Neurospora crassa40.926e-52 191
LLPS-Asc-1399Aspergillus clavatus40.862e-49 184
LLPS-Aso-0383Aspergillus oryzae40.672e-45 172
LLPS-Asf-1589Aspergillus flavus40.662e-48 181
LLPS-Fuo-0768Fusarium oxysporum40.656e-50 185
LLPS-Zyt-1230Zymoseptoria tritici40.541e-49 184
LLPS-Scp-0866Schizosaccharomyces pombe40.267e-51 187
LLPS-Tum-0936Tuber melanosporum40.25e-47 176
LLPS-Blg-1007Blumeria graminis40.067e-55 199
LLPS-Lem-0713Leptosphaeria maculans39.871e-50 188
LLPS-Phn-1206Phaeosphaeria nodorum39.568e-49 183
LLPS-Scs-0713Sclerotinia sclerotiorum39.489e-50 184
LLPS-Mao-0031Magnaporthe oryzae39.238e-54 197
LLPS-Asn-1266Aspergillus nidulans38.723e-49 183
LLPS-Crn-1190Cryptococcus neoformans37.573e-45 172