LLPS-Bot-1924
AHCYL2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Adenosylhomocysteinase 3 |
| Gene Name: | AHCYL2 |
| Ensembl Gene: | ENSBTAG00000001754.5 |
| Ensembl Protein: | ENSBTAP00000064178.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle, Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000076650.1 | ENSBTAP00000064178.1 |
| Ensembl | ENSBTAT00000002300.4 | ENSBTAP00000002300.3 |
| Ensembl | ENSBTAT00000067617.1 | ENSBTAP00000062806.1 |
| Ensembl | ENSBTAT00000068290.1 | ENSBTAP00000068288.1 |
| Ensembl | ENSBTAT00000073305.1 | ENSBTAP00000064295.1 |
| UniProt | A6QLP2, SAHH3_BOVIN | |
| GeneBank | DAAA02011505, DAAA02011501, DAAA02011503, DAAA02011504, DAAA02011502, BC148036 | , AAI48037.1 |
| RefSeq | NM_001101143.1 | NP_001094613.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVQVVSAAA AAKVPEVELK DLSPSEAEPQ LGLSTAAVSA MAPPAGGGDP EAPAPAAERP 60 61 PAPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK 120 121 KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS 180 181 KGNSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA 240 241 VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE 300 301 GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN 360 361 DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV 420 421 TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH 480 481 SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIILLAE GRLLNLSCST VPTFVLSITA 540 541 TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK 600 601 NGPFKPNYYR Y 611 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGTGC AGGTCGTGTC AGCAGCTGCT GCCGCGAAGG TGCCTGAGGT GGAGCTGAAG 60 61 GACCTGAGCC CCTCCGAGGC GGAGCCGCAG CTGGGACTGA GCACAGCGGC CGTGAGCGCC 120 121 ATGGCCCCCC CAGCGGGTGG TGGGGACCCT GAAGCTCCAG CTCCGGCCGC GGAGCGGCCC 180 181 CCAGCCCCCG GTCCGGGATC GGGCCCCGCA GCGGCTCTCA GCCCGGCCGC TGGGAAAGTG 240 241 CCTCAGGCGT CGGCCATGAA GCGGAGCGAC CCTCACCACC AGCATCAGAG GCACCGGGAC 300 301 GGCGGCGAAG CCCTGGTCAG CCCCGACGGC ACCGTCACCG AGGCGCCGCG CACAGTCAAG 360 361 AAGCAGATCC AATTTGCTGA TCAGAAGCAA GAATTCAATA AACGTCCCAC CAAAATTGGA 420 421 CGTCGCTCTC TGTCTCGTTC GATTTCCCAG TCATCGACTG ACAGCTACAG CTCAGCGGCT 480 481 TCATATACAG ATAGCTCTGA TGATGAGACC TCTCCTAGAG ACAAACAGCA AAAGAACTCT 540 541 AAGGGGAACA GTGACTTCTG TGTCAAGAAC ATCAAACAGG CAGAGTTTGG ACGAAGAGAA 600 601 ATTGAAATTG CTGAGCAAGA AATGCCAGCA CTGATGGCTT TGCGGAAGAG AGCTCAAGGA 660 661 GAGAAACCTT TGGCCGGCGC CAAGATTGTG GGTTGCACAC ACATCACTGC CCAGACTGCT 720 721 GTGCTTATGG AAACTCTGGG AGCTCTGGGA GCACAGTGCC GATGGGCTGC CTGCAACATC 780 781 TATTCCACCC TCAACGAAGT GGCTGCTGCT CTAGCAGAAA GTGGATTTCC TGTGTTTGCC 840 841 TGGAAAGGAG AGTCAGAAGA TGACTTCTGG TGGTGCATTG ACAGATGTGT GAATGTGGAG 900 901 GGCTGGCAGC CAAACATGAT CTTGGATGAT GGAGGGGATC TTACTCACTG GATTTATAAG 960 961 AAGTATCCCA ACATGTTTAA GAAAATCAAG GGCATAGTGG AGGAGAGTGT TACCGGAGTT 1020 1021 CATAGGCTCT ACCAGCTATC CAAAGCTGGG AAGCTGTGTG TTCCAGCCAT GAATGTCAAT 1080 1081 GACTCAGTCA CGAAACAGAA ATTTGACAAC CTCTACTGTT GCCGTGAATC AATTCTTGAT 1140 1141 GGACTTAAAA GAACAACAGA CATGATGTTT GGTGGGAAGC AGGTGGTAGT CTGTGGCTAT 1200 1201 GGAGAGGTCG GGAAGGGGTG CTGTGCTGCC TTGAAAGCTA TGGGCTCCAT TGTGTATGTG 1260 1261 ACTGAGATCG ACCCCATCTG CGCTCTTCAA GCCTGTATGG ATGGATTTCG ACTGGTGAAA 1320 1321 TTAAATGAGG TCATCCGACA AGTGGATATT GTTATTACCT GTACAGGTAA TAAGAATGTG 1380 1381 GTAACCAGAG AGCATTTAGA TCGTATGAAG AATAGCTGCA TTGTTTGTAA CATGGGACAT 1440 1441 TCCAACACGG AGATTGATGT GGCAAGTCTG CGGACACCAG AACTGACGTG GGAGCGAGTG 1500 1501 AGATCCCAAG TTGATCATGT AATATGGCCT GACGGCAAGA GGATAATATT GTTGGCAGAG 1560 1561 GGCCGTCTGC TGAACCTAAG CTGCTCCACA GTGCCTACAT TTGTGCTCTC AATCACTGCT 1620 1621 ACAACTCAGG CTCTAGCCTT GATAGAGCTC TACAATGCTC CCGAGGGTCG CTATAAGCAA 1680 1681 GATGTCTACC TGTTGCCCAA GAAAATGGAT GAGTATGTGG CCAGCCTACA CCTGCCCACC 1740 1741 TTTGATGCCC ACCTGACTGA GCTGACAGAT GAACAAGCCA AGTATCTAGG GCTCAACAAG 1800 1801 AATGGGCCCT TCAAGCCCAA TTACTACAGG TATTAA 1836 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Neuron projection | |
Molecular Function | Hydrolase activity | |
Biological Process | One-carbon metabolic process | |
Biological Process | S-adenosylmethionine cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-1739 | Ovis aries | 99.81 | 0.0 | 1047 |
| LLPS-Fud-1966 | Fukomys damarensis | 99.61 | 0.0 | 989 |
| LLPS-Mal-0899 | Mandrillus leucophaeus | 99.61 | 0.0 | 992 |
| LLPS-Pap-3156 | Pan paniscus | 99.61 | 0.0 | 1000 |
| LLPS-Chs-0704 | Chlorocebus sabaeus | 99.59 | 0.0 | 951 |
| LLPS-Mup-2928 | Mustela putorius furo | 99.59 | 0.0 | 952 |
| LLPS-Ict-2499 | Ictidomys tridecemlineatus | 99.59 | 0.0 | 946 |
| LLPS-Cas-3220 | Carlito syrichta | 99.59 | 0.0 | 947 |
| LLPS-Caf-2091 | Canis familiaris | 99.49 | 0.0 | 1069 |
| LLPS-Aim-2986 | Ailuropoda melanoleuca | 99.44 | 0.0 | 1041 |
| LLPS-Otg-0154 | Otolemur garnettii | 99.43 | 0.0 | 1038 |
| LLPS-Sah-2689 | Sarcophilus harrisii | 99.39 | 0.0 | 949 |
| LLPS-Meg-2755 | Meleagris gallopavo | 99.39 | 0.0 | 952 |
| LLPS-Sus-0835 | Sus scrofa | 99.33 | 0.0 | 1067 |
| LLPS-Cea-1098 | Cercocebus atys | 99.33 | 0.0 | 1071 |
| LLPS-Maf-4602 | Macaca fascicularis | 99.33 | 0.0 | 1071 |
| LLPS-Paa-0656 | Papio anubis | 99.33 | 0.0 | 1071 |
| LLPS-Loa-4568 | Loxodonta africana | 99.33 | 0.0 | 1069 |
| LLPS-Pat-0282 | Pan troglodytes | 99.33 | 0.0 | 1069 |
| LLPS-Fec-1951 | Felis catus | 99.33 | 0.0 | 1069 |
| LLPS-Mam-1620 | Macaca mulatta | 99.33 | 0.0 | 1071 |
| LLPS-Ora-0345 | Ornithorhynchus anatinus | 99.19 | 0.0 | 954 |
| LLPS-Pes-2351 | Pelodiscus sinensis | 99.19 | 0.0 | 954 |
| LLPS-Myl-3924 | Myotis lucifugus | 99.18 | 0.0 | 952 |
| LLPS-Man-1941 | Macaca nemestrina | 99.16 | 0.0 | 1070 |
| LLPS-Hos-4103 | Homo sapiens | 99.16 | 0.0 | 1071 |
| LLPS-Gog-0630 | Gorilla gorilla | 98.99 | 0.0 | 1065 |
| LLPS-Nol-2539 | Nomascus leucogenys | 98.65 | 0.0 | 1066 |
| LLPS-Caj-3498 | Callithrix jacchus | 98.32 | 0.0 | 1056 |
| LLPS-Poa-1310 | Pongo abelii | 98.15 | 0.0 | 1054 |
| LLPS-Anp-3136 | Anas platyrhynchos | 97.6 | 0.0 | 949 |
| LLPS-Lac-2611 | Latimeria chalumnae | 97.35 | 0.0 | 937 |
| LLPS-Mum-2732 | Mus musculus | 97.32 | 0.0 | 1066 |
| LLPS-Urm-1110 | Ursus maritimus | 97.14 | 0.0 | 922 |
| LLPS-Ran-2925 | Rattus norvegicus | 96.98 | 0.0 | 1059 |
| LLPS-Gaga-1142 | Gallus gallus | 96.7 | 0.0 | 958 |
| LLPS-Mod-3570 | Monodelphis domestica | 96.13 | 0.0 | 1053 |
| LLPS-Rhb-1790 | Rhinopithecus bieti | 94.96 | 0.0 | 1065 |
| LLPS-Leo-2213 | Lepisosteus oculatus | 94.93 | 0.0 | 982 |
| LLPS-Orc-2475 | Oryctolagus cuniculus | 94.33 | 0.0 | 1059 |
| LLPS-Aon-4750 | Aotus nancymaae | 94.31 | 0.0 | 887 |
| LLPS-Icp-2029 | Ictalurus punctatus | 94.18 | 0.0 | 980 |
| LLPS-Orl-0764 | Oryzias latipes | 93.62 | 0.0 | 977 |
| LLPS-Asm-2260 | Astyanax mexicanus | 93.62 | 0.0 | 975 |
| LLPS-Scm-3981 | Scophthalmus maximus | 93.62 | 0.0 | 974 |
| LLPS-Pof-0477 | Poecilia formosa | 93.43 | 0.0 | 979 |
| LLPS-Tar-0928 | Takifugu rubripes | 93.25 | 0.0 | 969 |
| LLPS-Orn-1957 | Oreochromis niloticus | 93.25 | 0.0 | 970 |
| LLPS-Scf-3441 | Scleropages formosus | 93.22 | 0.0 | 943 |
| LLPS-Dar-3367 | Danio rerio | 93.06 | 0.0 | 966 |
| LLPS-Gaa-0990 | Gasterosteus aculeatus | 92.92 | 0.0 | 966 |
| LLPS-Xet-1809 | Xenopus tropicalis | 92.82 | 0.0 | 951 |
| LLPS-Xim-2421 | Xiphophorus maculatus | 91.11 | 0.0 | 891 |
| LLPS-Ten-1345 | Tetraodon nigroviridis | 90.0 | 0.0 | 900 |
| LLPS-Drm-1459 | Drosophila melanogaster | 81.18 | 0.0 | 771 |
| LLPS-Cii-0203 | Ciona intestinalis | 80.45 | 0.0 | 775 |
| LLPS-Cis-0160 | Ciona savignyi | 80.14 | 0.0 | 770 |
| LLPS-Abg-1603 | Absidia glauca | 54.1 | 2e-98 | 308 |
| LLPS-Eqc-3984 | Equus caballus | 50.26 | 8e-127 | 388 |
| LLPS-Mua-0526 | Musa acuminata | 47.99 | 5e-130 | 395 |
| LLPS-Thc-2167 | Theobroma cacao | 47.99 | 2e-131 | 401 |
| LLPS-Brn-0968 | Brassica napus | 47.4 | 2e-144 | 434 |
| LLPS-Cus-2035 | Cucumis sativus | 47.19 | 2e-139 | 422 |
| LLPS-Sei-0299 | Setaria italica | 47.19 | 1e-143 | 433 |
| LLPS-Prp-1720 | Prunus persica | 47.19 | 3e-142 | 429 |
| LLPS-Bro-0364 | Brassica oleracea | 47.19 | 1e-143 | 433 |
| LLPS-Brr-0667 | Brassica rapa | 46.99 | 6e-143 | 431 |
| LLPS-Mae-2263 | Manihot esculenta | 46.99 | 1e-141 | 427 |
| LLPS-Tra-1641 | Triticum aestivum | 46.78 | 2e-142 | 430 |
| LLPS-Pot-1894 | Populus trichocarpa | 46.78 | 3e-141 | 427 |
| LLPS-Gor-0804 | Gossypium raimondii | 46.69 | 7e-140 | 423 |
| LLPS-Sol-1563 | Solanum lycopersicum | 46.57 | 5e-141 | 426 |
| LLPS-Arl-1594 | Arabidopsis lyrata | 46.57 | 2e-141 | 427 |
| LLPS-Hov-1899 | Hordeum vulgare | 46.57 | 2e-141 | 428 |
| LLPS-Hea-1080 | Helianthus annuus | 46.36 | 8e-140 | 423 |
| LLPS-Vir-1198 | Vigna radiata | 46.36 | 2e-139 | 422 |
| LLPS-Viv-2413 | Vitis vinifera | 46.36 | 3e-138 | 419 |
| LLPS-Art-1835 | Arabidopsis thaliana | 46.36 | 2e-139 | 422 |
| LLPS-Nia-1880 | Nicotiana attenuata | 46.36 | 3e-139 | 421 |
| LLPS-Osl-1293 | Ostreococcus lucimarinus | 46.23 | 2e-129 | 396 |
| LLPS-Via-1016 | Vigna angularis | 46.07 | 1e-138 | 420 |
| LLPS-Phv-2362 | Phaseolus vulgaris | 45.66 | 6e-137 | 416 |
| LLPS-Glm-2506 | Glycine max | 45.53 | 5e-137 | 416 |
| LLPS-Dac-0930 | Daucus carota | 45.53 | 4e-138 | 418 |
| LLPS-Tru-1902 | Triticum urartu | 45.33 | 1e-118 | 366 |
| LLPS-Met-1622 | Medicago truncatula | 45.21 | 5e-137 | 416 |
| LLPS-Coc-2210 | Corchorus capsularis | 37.02 | 2e-67 | 235 |