LLPS-Bot-1708
SPHK2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Sphingosine kinase 2 |
| Gene Name: | SPHK2 |
| Ensembl Gene: | ENSBTAG00000009872.6 |
| Ensembl Protein: | ENSBTAP00000072849.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000069876.1 | ENSBTAP00000072849.1 |
| Ensembl | ENSBTAT00000013019.6 | ENSBTAP00000013019.6 |
| Ensembl | ENSBTAT00000074462.1 | ENSBTAP00000067621.1 |
| Ensembl | ENSBTAT00000070534.1 | ENSBTAP00000070291.1 |
| UniProt | E1BJM1, E1BJM1_BOVIN |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPDAGPLVHL ASAPCPQESS HTLSGPVSLW CFRLACWHPS PHYLLLSTGP ARAPLCPPQG 60 61 SWTLTPALLP LPQRPEQELT WSWGYRPRSA LDRVKAMAPP PPLAPSTPLL HGEFGSYPDR 120 121 GPRFALTLTP QALHIQRLRP KPEARPRGGL VLLTEVSGCC TLRSRSPLDS AAYFCVYTYP 180 181 RGRRGARRRA ARTFRADGAA TYEENRAEAQ RWATALTCLL RGLPLPGDGE ITPDLLPRPP 240 241 RLLLLVNPFG GRGLAWQWCK NHVLPMISEA GLSFNLIQTE RQNHARELVQ GLNLSEWDGI 300 301 VTVSGDGLLY EVLNGLLQRP DWEEAVKTPV GILPCGSGNA LAGAVNRHGG FEPALGIDLL 360 361 LNCSLLLCRG GSHPLDLLSV TLASGSRCFS FLSVAWGFVS DVDIQSERFR ALGSARFTLG 420 421 TVLGLATLHT YRGRFSYLPA TVEPASPAPA HGLPRAKSEL TLAPAPAPPV AHSPLHRSVS 480 481 DLPLPLPQPA LTSPGSPEPL PILSLNGGGP ELAGDWGGAG DAPLSPDPLL PSPPGTPKAA 540 541 QLSPISEGAS EMAASSGLPP PTPGAPVSIS AGGPPDHLLP PLGTPIPPGW VTMEGDFVLI 600 601 LAILPSHLGA DLVAAPHARF DDGLVHLCWV RSGISRAALL RMFLAMERGT HFSLGCPYLG 660 661 YAAAHAFRLE PLTPRGVLTV DGEQVEYGPL QAQVHPGLGT LLTGPPGCPG REA 713 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAATGGAA ACCTTGAAGC AGAGGAGCGG CAGGACCAGA GGCCAGAGCA GGAGCTGACC 60 61 TGGAGCTGGG GCTACCGGCC TAGAAGCGCC CTGGACAGGG TCAAGGCCAT GGCCCCCCCA 120 121 CCGCCACTGG CCCCCAGCAC CCCACTCCTG CATGGCGAGT TTGGCTCCTA CCCAGACCGC 180 181 GGCCCACGCT TCGCCCTCAC TCTCACACCA CAAGCCCTGC ACATACAGCG GTTGCGCCCA 240 241 AAGCCCGAGG CCCGGCCCCG GGGTGGCCTG GTCCTGCTGA CCGAGGTCTC AGGCTGCTGC 300 301 ACCCTGCGGA GCCGAAGCCC CCTGGACTCA GCAGCCTACT TCTGCGTCTA CACCTACCCC 360 361 AGGGGCCGGC GCGGGGCCCG GCGCAGAGCT GCACGCACCT TCCGGGCCGA CGGGGCAGCC 420 421 ACCTACGAGG AGAACCGCGC TGAGGCCCAG CGCTGGGCCA CTGCCCTCAC GTGTCTGCTC 480 481 CGTGGACTGC CACTGCCTGG GGACGGGGAA ATCACCCCGG ACCTCCTGCC TAGGCCGCCC 540 541 CGATTGCTCC TATTGGTCAA TCCCTTTGGG GGGCGGGGCC TGGCCTGGCA GTGGTGTAAG 600 601 AACCATGTGC TGCCCATGAT CTCCGAAGCG GGGCTGTCCT TCAACCTGAT CCAGACAGAA 660 661 CGACAGAACC ATGCCCGTGA GCTGGTCCAG GGGCTGAACC TGAGCGAATG GGACGGCATC 720 721 GTCACAGTCT CGGGAGATGG GCTGCTGTAT GAGGTGCTGA ATGGACTCCT ACAACGCCCC 780 781 GACTGGGAAG AGGCTGTGAA GACCCCCGTG GGCATTCTCC CCTGTGGCTC GGGCAATGCG 840 841 TTAGCAGGAG CCGTGAACCG GCATGGGGGA TTTGAGCCTG CCCTGGGCAT TGACCTGCTA 900 901 CTCAACTGCT CCTTACTGCT CTGCCGGGGT GGCAGCCACC CGCTGGACCT GCTCTCCGTG 960 961 ACTCTGGCCT CCGGCTCCCG CTGTTTCTCT TTCCTGTCTG TGGCCTGGGG CTTCGTGTCA 1020 1021 GATGTGGACA TCCAGAGCGA GCGCTTCAGG GCCCTGGGCA GTGCTCGCTT CACGCTGGGC 1080 1081 ACAGTCCTGG GCCTTGCCAC GCTGCACACC TACCGCGGCC GCTTCTCCTA CCTCCCTGCC 1140 1141 ACTGTGGAAC CCGCCTCGCC TGCCCCTGCC CATGGCCTGC CAAGGGCCAA GTCAGAGTTG 1200 1201 ACCCTGGCCC CGGCCCCAGC CCCACCCGTG GCCCACTCAC CCCTGCATCG CTCAGTGTCA 1260 1261 GACCTGCCCC TGCCCCTGCC TCAGCCTGCC CTGACCTCCC CTGGCTCACC TGAACCCCTG 1320 1321 CCCATCCTGT CTCTCAACGG TGGGGGCCCA GAGCTGGCTG GGGACTGGGG TGGGGCTGGG 1380 1381 GATGCCCCAC TCTCCCCGGA CCCACTGCTG CCCTCGCCCC CGGGGACCCC CAAGGCAGCT 1440 1441 CAGCTCTCAC CCATCAGCGA GGGGGCCTCA GAAATGGCAG CATCCTCTGG GCTCCCACCT 1500 1501 CCCACCCCTG GTGCCCCAGT ATCCATCTCT GCTGGGGGAC CACCTGATCA CCTGCTCCCT 1560 1561 CCTCTAGGCA CTCCGATACC CCCAGGCTGG GTGACGATGG AGGGAGACTT TGTGCTTATT 1620 1621 TTGGCCATCT TACCCAGCCA CCTGGGGGCT GACCTCGTGG CGGCCCCCCA CGCGCGCTTT 1680 1681 GACGACGGCC TGGTGCACCT GTGCTGGGTT CGCAGCGGCA TCTCGCGGGC GGCGCTACTG 1740 1741 CGCATGTTTC TGGCCATGGA GCGTGGTACC CACTTCAGCC TGGGCTGTCC GTACCTGGGC 1800 1801 TACGCCGCAG CTCATGCCTT CCGCCTAGAG CCGCTCACGC CCCGCGGCGT GCTCACGGTG 1860 1861 GACGGGGAGC AGGTGGAGTA CGGGCCATTG CAGGCGCAGG TGCATCCTGG CCTCGGTACA 1920 1921 TTGCTCACGG GTCCTCCAGG CTGCCCTGGG CGGGAAGCCT AA 1962 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-0304 | Ovis aries | 95.81 | 0.0 | 889 |
| LLPS-Pat-0791 | Pan troglodytes | 94.58 | 7e-131 | 394 |
| LLPS-Sus-3368 | Sus scrofa | 93.16 | 0.0 | 838 |
| LLPS-Hos-2265 | Homo sapiens | 91.79 | 0.0 | 834 |
| LLPS-Pap-3325 | Pan paniscus | 91.62 | 0.0 | 833 |
| LLPS-Gog-0346 | Gorilla gorilla | 91.62 | 0.0 | 835 |
| LLPS-Eqc-2277 | Equus caballus | 90.11 | 0.0 | 831 |
| LLPS-Rhb-3383 | Rhinopithecus bieti | 89.91 | 0.0 | 827 |
| LLPS-Mal-4349 | Mandrillus leucophaeus | 89.74 | 0.0 | 827 |
| LLPS-Aon-1408 | Aotus nancymaae | 89.57 | 0.0 | 828 |
| LLPS-Caf-4679 | Canis familiaris | 88.66 | 0.0 | 832 |
| LLPS-Man-1070 | Macaca nemestrina | 88.33 | 0.0 | 843 |
| LLPS-Chs-4257 | Chlorocebus sabaeus | 88.33 | 0.0 | 840 |
| LLPS-Paa-3242 | Papio anubis | 88.33 | 0.0 | 843 |
| LLPS-Mam-4445 | Macaca mulatta | 88.17 | 0.0 | 841 |
| LLPS-Cea-4092 | Cercocebus atys | 88.17 | 0.0 | 842 |
| LLPS-Loa-1380 | Loxodonta africana | 88.03 | 0.0 | 817 |
| LLPS-Maf-3824 | Macaca fascicularis | 88.01 | 0.0 | 840 |
| LLPS-Fec-3811 | Felis catus | 87.96 | 0.0 | 818 |
| LLPS-Caj-4086 | Callithrix jacchus | 87.68 | 0.0 | 826 |
| LLPS-Cas-0670 | Carlito syrichta | 87.52 | 0.0 | 828 |
| LLPS-Ora-0368 | Ornithorhynchus anatinus | 87.5 | 4e-59 | 201 |
| LLPS-Aim-0993 | Ailuropoda melanoleuca | 87.4 | 0.0 | 823 |
| LLPS-Poa-0509 | Pongo abelii | 87.2 | 0.0 | 793 |
| LLPS-Sah-1232 | Sarcophilus harrisii | 87.03 | 2e-77 | 255 |
| LLPS-Mup-3807 | Mustela putorius furo | 86.95 | 0.0 | 811 |
| LLPS-Nol-3601 | Nomascus leucogenys | 85.74 | 0.0 | 771 |
| LLPS-Mea-0181 | Mesocricetus auratus | 84.79 | 0.0 | 777 |
| LLPS-Ran-1927 | Rattus norvegicus | 84.62 | 0.0 | 753 |
| LLPS-Mum-3141 | Mus musculus | 84.1 | 0.0 | 760 |
| LLPS-Ict-1350 | Ictidomys tridecemlineatus | 83.71 | 0.0 | 812 |
| LLPS-Urm-0693 | Ursus maritimus | 83.56 | 0.0 | 538 |
| LLPS-Fud-1105 | Fukomys damarensis | 83.08 | 0.0 | 749 |
| LLPS-Otg-3861 | Otolemur garnettii | 81.14 | 0.0 | 833 |
| LLPS-Dio-2148 | Dipodomys ordii | 81.13 | 2e-47 | 182 |
| LLPS-Myl-2476 | Myotis lucifugus | 78.45 | 0.0 | 736 |
| LLPS-Cap-4563 | Cavia porcellus | 78.18 | 0.0 | 741 |
| LLPS-Dar-3040 | Danio rerio | 74.53 | 1e-42 | 169 |
| LLPS-Icp-3219 | Ictalurus punctatus | 74.53 | 3e-43 | 172 |
| LLPS-Scf-0845 | Scleropages formosus | 74.53 | 1e-42 | 170 |
| LLPS-Asm-3080 | Astyanax mexicanus | 73.33 | 8e-41 | 164 |
| LLPS-Lac-0594 | Latimeria chalumnae | 70.75 | 2e-42 | 164 |
| LLPS-Ten-3743 | Tetraodon nigroviridis | 70.75 | 8e-39 | 156 |
| LLPS-Gaa-1971 | Gasterosteus aculeatus | 70.75 | 2e-39 | 157 |
| LLPS-Tar-0574 | Takifugu rubripes | 69.81 | 2e-39 | 160 |
| LLPS-Xet-3363 | Xenopus tropicalis | 65.09 | 3e-39 | 157 |
| LLPS-Anc-3780 | Anolis carolinensis | 65.09 | 3e-39 | 157 |
| LLPS-Orl-0719 | Oryzias latipes | 60.0 | 7e-32 | 134 |
| LLPS-Scm-2190 | Scophthalmus maximus | 59.81 | 2e-33 | 137 |
| LLPS-Orn-0923 | Oreochromis niloticus | 58.88 | 1e-32 | 137 |
| LLPS-Xim-3451 | Xiphophorus maculatus | 57.01 | 1e-29 | 128 |
| LLPS-Pof-2536 | Poecilia formosa | 56.07 | 5e-29 | 126 |
| LLPS-Tag-0624 | Taeniopygia guttata | 53.33 | 2e-27 | 119 |
| LLPS-Drm-2202 | Drosophila melanogaster | 45.28 | 8e-23 | 107 |
| LLPS-Brr-1347 | Brassica rapa | 43.27 | 1e-20 | 98.2 |
| LLPS-Php-2103 | Physcomitrella patens | 40.82 | 8e-36 | 145 |
| LLPS-Sei-2439 | Setaria italica | 40.0 | 1e-37 | 151 |
| LLPS-Phv-2216 | Phaseolus vulgaris | 39.49 | 4e-37 | 149 |
| LLPS-Hea-2699 | Helianthus annuus | 39.49 | 5e-37 | 149 |
| LLPS-Glm-1482 | Glycine max | 39.49 | 3e-36 | 147 |
| LLPS-Abg-0950 | Absidia glauca | 39.16 | 6e-23 | 104 |
| LLPS-Gor-0388 | Gossypium raimondii | 38.97 | 4e-38 | 152 |
| LLPS-Brd-1779 | Brachypodium distachyon | 38.5 | 9e-37 | 148 |
| LLPS-Bro-2322 | Brassica oleracea | 38.46 | 6e-39 | 154 |
| LLPS-Brn-2350 | Brassica napus | 38.46 | 4e-39 | 155 |
| LLPS-Sob-2455 | Sorghum bicolor | 38.4 | 2e-38 | 153 |
| LLPS-Tra-0705 | Triticum aestivum | 37.95 | 7e-39 | 152 |
| LLPS-Zem-0456 | Zea mays | 37.93 | 4e-29 | 125 |
| LLPS-Art-3023 | Arabidopsis thaliana | 37.76 | 2e-36 | 147 |
| LLPS-Crn-0450 | Cryptococcus neoformans | 37.7 | 3e-25 | 115 |
| LLPS-Orr-1259 | Oryza rufipogon | 37.44 | 2e-33 | 139 |
| LLPS-Orm-1865 | Oryza meridionalis | 37.44 | 3e-33 | 138 |
| LLPS-Orgl-2244 | Oryza glumaepatula | 37.44 | 1e-33 | 139 |
| LLPS-Orp-2091 | Oryza punctata | 36.92 | 6e-33 | 137 |
| LLPS-Nia-2608 | Nicotiana attenuata | 35.9 | 2e-32 | 137 |
| LLPS-Tru-0669 | Triticum urartu | 35.58 | 4e-24 | 108 |
| LLPS-Orb-2176 | Oryza barthii | 35.18 | 3e-32 | 135 |
| LLPS-Sol-1054 | Solanum lycopersicum | 34.87 | 2e-31 | 132 |
| LLPS-Sot-0507 | Solanum tuberosum | 34.87 | 2e-31 | 132 |
| LLPS-Orc-4307 | Oryctolagus cuniculus | 33.04 | 2e-06 | 55.5 |
| LLPS-Sac-1494 | Saccharomyces cerevisiae | 32.63 | 1e-18 | 94.7 |
| LLPS-Miv-0981 | Microbotryum violaceum | 32.39 | 2e-19 | 96.7 |
| LLPS-Lep-0502 | Leersia perrieri | 32.31 | 4e-28 | 122 |
| LLPS-Cii-2026 | Ciona intestinalis | 30.02 | 9e-59 | 215 |
| LLPS-Leo-3309 | Lepisosteus oculatus | 28.71 | 4e-09 | 63.9 |
| LLPS-Mod-3668 | Monodelphis domestica | 27.57 | 8e-09 | 62.8 |
| LLPS-Orni-1837 | Oryza nivara | 26.48 | 1e-20 | 100 |