• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Bot-1595
SIGMAR1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; Sigma1-receptor; Sigma1R
Gene Name: SIGMAR1, OPRS1
Ensembl Gene: ENSBTAG00000015804.3
Ensembl Protein: ENSBTAP00000020990.2
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).

▼ SEQUENCE


Protein Sequence (FASTA)
1     MCWAVGRRWA  WAALLLAVAA  VLAQVVWLWL  GTQSFVFQHE  EIAQLARQYA  GEPGVNGWRT  60
61    TGWGGPGRAG  GSRGTVSQFR  TGAGPDCVVP  LPPPGLDHEL  AFSRLIVELR  RLHPGHVLPD  120
121   EDLQWVFVNA  GGWMGAMCLL  HASLSEYVLL  FGTALGSSGH  SGRYWAEISD  TIISGTFHQW  180
181   REGTTKSEVF  YPGETVVHGP  GEATAVEWGP  NTWMVEYGRG  VIPSTLGFAL  ADTVFSTQDF  240
241   LTLFYTLRAY  ARGLRLELTT  YLFGQDA  267
Nucleotide CDS Sequence (FASTA)
1     ATGTGTTGGG  CCGTGGGCCG  GCGGTGGGCG  TGGGCCGCGC  TGCTCCTGGC  GGTCGCGGCA  60
61    GTGCTGGCCC  AGGTGGTCTG  GCTCTGGCTG  GGAACTCAGA  GCTTCGTCTT  CCAGCACGAA  120
121   GAGATCGCGC  AGCTGGCTCG  GCAGTACGCG  GGGCTGGACC  ACGAGCTGGC  CTTCTCTCGG  180
181   CTGATCGTGG  AGCTGCGGCG  GCTGCACCCG  GGCCACGTGC  TGCCCGACGA  GGACCTGCAG  240
241   TGGGTGTTCG  TGAACGCGGG  AGGCTGGATG  GGCGCCATGT  GCCTTCTGCA  CGCCTCCCTG  300
301   TCCGAGTACG  TGCTGCTCTT  CGGCACCGCT  CTGGGCTCTA  GCGGCCACTC  GGGGCGCTAC  360
361   TGGGCTGAGA  TCTCGGATAC  CATCATCTCT  GGCACCTTCC  ACCAGTGGAG  AGAGGGTACT  420
421   ACTAAAAGTG  AGGTCTTCTA  CCCAGGGGAG  ACAGTGGTGC  ACGGACCTGG  TGAGGCAACG  480
481   GCTGTGGAGT  GGGGGCCAAA  CACATGGATG  GTGGAGTATG  GCCGGGGTGT  CATCCCCTCT  540
541   ACCCTGGGCT  TCGCACTGGC  TGACACTGTC  TTCAGCACCC  AGGACTTCCT  CACCCTCTTC  600
601   TACACTCTTC  GAGCCTATGC  CCGGGGCCTC  CGGCTGGAAC  TCACCACCTA  CCTCTTCGGC  660
661   CAGGATGCCT  GA  672

▼ KEYWORD


ID
Family
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Lipid droplet
Lipid transport
Membrane
Nucleus
Postsynaptic cell membrane
Receptor
Reference proteome
Synapse
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Cytoplasmic vesicle
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Growth cone
Cellular Component
Integral component of membrane
Cellular Component
Lipid droplet
Cellular Component
Nuclear inner membrane
Cellular Component
Nuclear outer membrane
Cellular Component
Postsynaptic density
Cellular Component
Postsynaptic membrane
Biological Process
Cell death in response to hydrogen peroxide
Biological Process
Lipid transport
Biological Process
Regulation of neuron apoptotic process

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cas-2308Carlito syrichta97.743e-88 265
LLPS-Mal-4610Mandrillus leucophaeus97.743e-88 265
LLPS-Pap-4215Pan paniscus97.734e-87 262
LLPS-Dio-2389Dipodomys ordii95.495e-86 259
LLPS-Tut-0132Tursiops truncatus95.481e-119 347
LLPS-Ova-4045Ovis aries81.362e-128 370
LLPS-Myl-2488Myotis lucifugus80.05e-126 365
LLPS-Urm-3339Ursus maritimus79.577e-125 362
LLPS-Fec-3938Felis catus79.578e-125 362
LLPS-Loa-2390Loxodonta africana79.575e-125 362
LLPS-Aim-4059Ailuropoda melanoleuca79.576e-125 362
LLPS-Hos-4803Homo sapiens79.151e-123 358
LLPS-Pat-1939Pan troglodytes79.151e-123 358
LLPS-Man-3932Macaca nemestrina79.151e-123 358
LLPS-Rhb-1509Rhinopithecus bieti79.151e-123 358
LLPS-Poa-1849Pongo abelii79.151e-123 358
LLPS-Mam-1558Macaca mulatta79.151e-123 358
LLPS-Nol-3795Nomascus leucogenys79.151e-123 358
LLPS-Maf-2403Macaca fascicularis79.152e-123 358
LLPS-Mea-0863Mesocricetus auratus79.153e-124 360
LLPS-Chs-3276Chlorocebus sabaeus79.151e-123 358
LLPS-Cea-0484Cercocebus atys79.151e-123 358
LLPS-Aon-3473Aotus nancymaae79.157e-124 359
LLPS-Gog-4634Gorilla gorilla79.151e-123 358
LLPS-Caj-0069Callithrix jacchus79.152e-123 358
LLPS-Paa-0501Papio anubis79.151e-123 358
LLPS-Mup-1240Mustela putorius furo79.153e-124 360
LLPS-Caf-2559Canis familiaris78.723e-123 358
LLPS-Eqc-4418Equus caballus78.723e-123 358
LLPS-Otg-4210Otolemur garnettii78.31e-121 353
LLPS-Ict-1084Ictidomys tridecemlineatus78.31e-122 356
LLPS-Sus-3851Sus scrofa78.31e-122 356
LLPS-Ran-1831Rattus norvegicus78.36e-123 357
LLPS-Orc-0275Oryctolagus cuniculus77.974e-122 355
LLPS-Cap-1648Cavia porcellus77.873e-122 355
LLPS-Fud-0213Fukomys damarensis77.784e-120 350
LLPS-Lac-2901Latimeria chalumnae77.512e-96 290
LLPS-Anc-1072Anolis carolinensis77.381e-92 280
LLPS-Tag-3582Taeniopygia guttata77.387e-95 285
LLPS-Fia-3013Ficedula albicollis76.921e-95 285
LLPS-Gaga-2535Gallus gallus76.793e-93 282
LLPS-Mum-4020Mus musculus76.274e-120 350
LLPS-Xet-1529Xenopus tropicalis76.193e-94 282
LLPS-Anp-2675Anas platyrhynchos72.194e-84 256
LLPS-Pes-3687Pelodiscus sinensis71.323e-63 201
LLPS-Mod-1827Monodelphis domestica70.093e-108 320
LLPS-Sah-1666Sarcophilus harrisii70.092e-108 320
LLPS-Leo-3015Lepisosteus oculatus61.042e-97 292
LLPS-Dar-2793Danio rerio60.618e-97 290
LLPS-Ten-1407Tetraodon nigroviridis60.613e-95 286
LLPS-Scf-1570Scleropages formosus59.741e-94 285
LLPS-Icp-3794Ictalurus punctatus59.311e-94 285
LLPS-Asm-1550Astyanax mexicanus59.133e-94 284
LLPS-Pof-1100Poecilia formosa58.444e-93 281
LLPS-Scm-0479Scophthalmus maximus58.442e-93 281
LLPS-Gaa-3622Gasterosteus aculeatus58.441e-93 282
LLPS-Orn-3124Oreochromis niloticus58.015e-93 281
LLPS-Xim-1122Xiphophorus maculatus57.141e-90 274
LLPS-Tar-0891Takifugu rubripes56.613e-90 274
LLPS-Orl-2836Oryzias latipes51.552e-50 171
LLPS-Gas-0923Galdieria sulphuraria48.243e-51 174
LLPS-Gag-0995Gaeumannomyces graminis44.359e-2192.4
LLPS-Trv-1043Trichoderma virens44.065e-24 101
LLPS-Asni-0659Aspergillus niger44.031e-23 100
LLPS-Tum-0717Tuber melanosporum43.485e-2295.9
LLPS-Asn-1565Aspergillus nidulans43.382e-24 102
LLPS-Nec-0878Neurospora crassa42.522e-2297.8
LLPS-Sac-0317Saccharomyces cerevisiae41.983e-2194.0
LLPS-Map-0559Magnaporthe poae41.962e-2297.4
LLPS-Trr-1526Trichoderma reesei41.721e-23 100
LLPS-Dos-1311Dothistroma septosporum41.611e-23 100
LLPS-Lem-0270Leptosphaeria maculans41.565e-24 102
LLPS-Coo-1308Colletotrichum orbiculare41.512e-24 102
LLPS-Ast-0071Aspergillus terreus41.362e-25 105
LLPS-Crn-1466Cryptococcus neoformans40.994e-27 110
LLPS-Cog-0249Colletotrichum gloeosporioides40.882e-24 102
LLPS-Abg-0457Absidia glauca40.743e-27 110
LLPS-Cogr-0567Colletotrichum graminicola40.614e-26 107
LLPS-Aso-0018Aspergillus oryzae40.611e-25 106
LLPS-Asf-1195Aspergillus flavus40.611e-25 106
LLPS-Asg-0891Ashbya gossypii40.462e-1988.6
LLPS-Asc-0132Aspergillus clavatus40.372e-26 108
LLPS-Ved-1432Verticillium dahliae40.263e-2296.7
LLPS-Mao-1550Magnaporthe oryzae40.155e-1987.4
LLPS-Pyt-1565Pyrenophora teres40.131e-23 100
LLPS-Fus-1387Fusarium solani40.07e-26 106
LLPS-Pug-1047Puccinia graminis39.861e-23 101
LLPS-Fuo-1576Fusarium oxysporum39.752e-24 102
LLPS-Fuv-1491Fusarium verticillioides39.753e-24 102
LLPS-Put-1075Puccinia triticina39.712e-23 100
LLPS-Chc-0851Chondrus crispus39.633e-29 117
LLPS-Beb-1171Beauveria bassiana39.472e-24 102
LLPS-Nef-1398Neosartorya fischeri39.022e-26 108
LLPS-Asfu-1457Aspergillus fumigatus39.023e-26 108
LLPS-Mel-1223Melampsora laricipopulina38.32e-2297.8
LLPS-Spr-0813Sporisorium reilianum38.172e-1783.2
LLPS-Scj-0308Schizosaccharomyces japonicus37.743e-2091.3
LLPS-Miv-1260Microbotryum violaceum37.56e-1885.1
LLPS-Scc-1048Schizosaccharomyces cryophilus37.421e-1989.4
LLPS-Scp-0289Schizosaccharomyces pombe37.414e-1884.7
LLPS-Yal-1507Yarrowia lipolytica37.42e-1989.0
LLPS-Kop-1336Komagataella pastoris36.171e-1885.9
LLPS-Usm-0138Ustilago maydis35.41e-1783.6
LLPS-Blg-1039Blumeria graminis34.733e-2194.0
LLPS-Cii-1102Ciona intestinalis27.73e-1576.6