LLPS-Bot-1595
SIGMAR1
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; Sigma1-receptor; Sigma1R |
Gene Name: | SIGMAR1, OPRS1 |
Ensembl Gene: | ENSBTAG00000015804.3 |
Ensembl Protein: | ENSBTAP00000020990.2 |
Organism: | Bos taurus |
Taxa ID: | 9913 |
LLPS Type: | Regulator |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity). |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSBTAT00000020990.3 | ENSBTAP00000020990.2 |
Ensembl | ENSBTAT00000078449.1 | ENSBTAP00000066304.1 |
UniProt | Q58DH7, SGMR1_BOVIN | |
GeneBank | BT021620 | AAX46467.1 |
RefSeq | NM_001034655.1 | NP_001029827.1 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MCWAVGRRWA WAALLLAVAA VLAQVVWLWL GTQSFVFQHE EIAQLARQYA GEPGVNGWRT 60 61 TGWGGPGRAG GSRGTVSQFR TGAGPDCVVP LPPPGLDHEL AFSRLIVELR RLHPGHVLPD 120 121 EDLQWVFVNA GGWMGAMCLL HASLSEYVLL FGTALGSSGH SGRYWAEISD TIISGTFHQW 180 181 REGTTKSEVF YPGETVVHGP GEATAVEWGP NTWMVEYGRG VIPSTLGFAL ADTVFSTQDF 240 241 LTLFYTLRAY ARGLRLELTT YLFGQDA 267 |
Nucleotide CDS Sequence (FASTA) |
1 ATGTGTTGGG CCGTGGGCCG GCGGTGGGCG TGGGCCGCGC TGCTCCTGGC GGTCGCGGCA 60 61 GTGCTGGCCC AGGTGGTCTG GCTCTGGCTG GGAACTCAGA GCTTCGTCTT CCAGCACGAA 120 121 GAGATCGCGC AGCTGGCTCG GCAGTACGCG GGGCTGGACC ACGAGCTGGC CTTCTCTCGG 180 181 CTGATCGTGG AGCTGCGGCG GCTGCACCCG GGCCACGTGC TGCCCGACGA GGACCTGCAG 240 241 TGGGTGTTCG TGAACGCGGG AGGCTGGATG GGCGCCATGT GCCTTCTGCA CGCCTCCCTG 300 301 TCCGAGTACG TGCTGCTCTT CGGCACCGCT CTGGGCTCTA GCGGCCACTC GGGGCGCTAC 360 361 TGGGCTGAGA TCTCGGATAC CATCATCTCT GGCACCTTCC ACCAGTGGAG AGAGGGTACT 420 421 ACTAAAAGTG AGGTCTTCTA CCCAGGGGAG ACAGTGGTGC ACGGACCTGG TGAGGCAACG 480 481 GCTGTGGAGT GGGGGCCAAA CACATGGATG GTGGAGTATG GCCGGGGTGT CATCCCCTCT 540 541 ACCCTGGGCT TCGCACTGGC TGACACTGTC TTCAGCACCC AGGACTTCCT CACCCTCTTC 600 601 TACACTCTTC GAGCCTATGC CCGGGGCCTC CGGCTGGAAC TCACCACCTA CCTCTTCGGC 660 661 CAGGATGCCT GA 672 |
▼ KEYWORD
ID | Family |
Cell junction | |
Cell membrane | |
Cell projection | |
Complete proteome | |
Cytoplasmic vesicle | |
Endoplasmic reticulum | |
Lipid droplet | |
Lipid transport | |
Membrane | |
Nucleus | |
Postsynaptic cell membrane | |
Receptor | |
Reference proteome | |
Synapse | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Growth cone | |
Cellular Component | Integral component of membrane | |
Cellular Component | Lipid droplet | |
Cellular Component | Nuclear inner membrane | |
Cellular Component | Nuclear outer membrane | |
Cellular Component | Postsynaptic density | |
Cellular Component | Postsynaptic membrane | |
Biological Process | Cell death in response to hydrogen peroxide | |
Biological Process | Lipid transport | |
Biological Process | Regulation of neuron apoptotic process |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Cas-2308 | Carlito syrichta | 97.74 | 3e-88 | 265 |
LLPS-Mal-4610 | Mandrillus leucophaeus | 97.74 | 3e-88 | 265 |
LLPS-Pap-4215 | Pan paniscus | 97.73 | 4e-87 | 262 |
LLPS-Dio-2389 | Dipodomys ordii | 95.49 | 5e-86 | 259 |
LLPS-Tut-0132 | Tursiops truncatus | 95.48 | 1e-119 | 347 |
LLPS-Ova-4045 | Ovis aries | 81.36 | 2e-128 | 370 |
LLPS-Myl-2488 | Myotis lucifugus | 80.0 | 5e-126 | 365 |
LLPS-Urm-3339 | Ursus maritimus | 79.57 | 7e-125 | 362 |
LLPS-Fec-3938 | Felis catus | 79.57 | 8e-125 | 362 |
LLPS-Loa-2390 | Loxodonta africana | 79.57 | 5e-125 | 362 |
LLPS-Aim-4059 | Ailuropoda melanoleuca | 79.57 | 6e-125 | 362 |
LLPS-Hos-4803 | Homo sapiens | 79.15 | 1e-123 | 358 |
LLPS-Pat-1939 | Pan troglodytes | 79.15 | 1e-123 | 358 |
LLPS-Man-3932 | Macaca nemestrina | 79.15 | 1e-123 | 358 |
LLPS-Rhb-1509 | Rhinopithecus bieti | 79.15 | 1e-123 | 358 |
LLPS-Poa-1849 | Pongo abelii | 79.15 | 1e-123 | 358 |
LLPS-Mam-1558 | Macaca mulatta | 79.15 | 1e-123 | 358 |
LLPS-Nol-3795 | Nomascus leucogenys | 79.15 | 1e-123 | 358 |
LLPS-Maf-2403 | Macaca fascicularis | 79.15 | 2e-123 | 358 |
LLPS-Mea-0863 | Mesocricetus auratus | 79.15 | 3e-124 | 360 |
LLPS-Chs-3276 | Chlorocebus sabaeus | 79.15 | 1e-123 | 358 |
LLPS-Cea-0484 | Cercocebus atys | 79.15 | 1e-123 | 358 |
LLPS-Aon-3473 | Aotus nancymaae | 79.15 | 7e-124 | 359 |
LLPS-Gog-4634 | Gorilla gorilla | 79.15 | 1e-123 | 358 |
LLPS-Caj-0069 | Callithrix jacchus | 79.15 | 2e-123 | 358 |
LLPS-Paa-0501 | Papio anubis | 79.15 | 1e-123 | 358 |
LLPS-Mup-1240 | Mustela putorius furo | 79.15 | 3e-124 | 360 |
LLPS-Caf-2559 | Canis familiaris | 78.72 | 3e-123 | 358 |
LLPS-Eqc-4418 | Equus caballus | 78.72 | 3e-123 | 358 |
LLPS-Otg-4210 | Otolemur garnettii | 78.3 | 1e-121 | 353 |
LLPS-Ict-1084 | Ictidomys tridecemlineatus | 78.3 | 1e-122 | 356 |
LLPS-Sus-3851 | Sus scrofa | 78.3 | 1e-122 | 356 |
LLPS-Ran-1831 | Rattus norvegicus | 78.3 | 6e-123 | 357 |
LLPS-Orc-0275 | Oryctolagus cuniculus | 77.97 | 4e-122 | 355 |
LLPS-Cap-1648 | Cavia porcellus | 77.87 | 3e-122 | 355 |
LLPS-Fud-0213 | Fukomys damarensis | 77.78 | 4e-120 | 350 |
LLPS-Lac-2901 | Latimeria chalumnae | 77.51 | 2e-96 | 290 |
LLPS-Anc-1072 | Anolis carolinensis | 77.38 | 1e-92 | 280 |
LLPS-Tag-3582 | Taeniopygia guttata | 77.38 | 7e-95 | 285 |
LLPS-Fia-3013 | Ficedula albicollis | 76.92 | 1e-95 | 285 |
LLPS-Gaga-2535 | Gallus gallus | 76.79 | 3e-93 | 282 |
LLPS-Mum-4020 | Mus musculus | 76.27 | 4e-120 | 350 |
LLPS-Xet-1529 | Xenopus tropicalis | 76.19 | 3e-94 | 282 |
LLPS-Anp-2675 | Anas platyrhynchos | 72.19 | 4e-84 | 256 |
LLPS-Pes-3687 | Pelodiscus sinensis | 71.32 | 3e-63 | 201 |
LLPS-Mod-1827 | Monodelphis domestica | 70.09 | 3e-108 | 320 |
LLPS-Sah-1666 | Sarcophilus harrisii | 70.09 | 2e-108 | 320 |
LLPS-Leo-3015 | Lepisosteus oculatus | 61.04 | 2e-97 | 292 |
LLPS-Dar-2793 | Danio rerio | 60.61 | 8e-97 | 290 |
LLPS-Ten-1407 | Tetraodon nigroviridis | 60.61 | 3e-95 | 286 |
LLPS-Scf-1570 | Scleropages formosus | 59.74 | 1e-94 | 285 |
LLPS-Icp-3794 | Ictalurus punctatus | 59.31 | 1e-94 | 285 |
LLPS-Asm-1550 | Astyanax mexicanus | 59.13 | 3e-94 | 284 |
LLPS-Pof-1100 | Poecilia formosa | 58.44 | 4e-93 | 281 |
LLPS-Scm-0479 | Scophthalmus maximus | 58.44 | 2e-93 | 281 |
LLPS-Gaa-3622 | Gasterosteus aculeatus | 58.44 | 1e-93 | 282 |
LLPS-Orn-3124 | Oreochromis niloticus | 58.01 | 5e-93 | 281 |
LLPS-Xim-1122 | Xiphophorus maculatus | 57.14 | 1e-90 | 274 |
LLPS-Tar-0891 | Takifugu rubripes | 56.61 | 3e-90 | 274 |
LLPS-Orl-2836 | Oryzias latipes | 51.55 | 2e-50 | 171 |
LLPS-Gas-0923 | Galdieria sulphuraria | 48.24 | 3e-51 | 174 |
LLPS-Gag-0995 | Gaeumannomyces graminis | 44.35 | 9e-21 | 92.4 |
LLPS-Trv-1043 | Trichoderma virens | 44.06 | 5e-24 | 101 |
LLPS-Asni-0659 | Aspergillus niger | 44.03 | 1e-23 | 100 |
LLPS-Tum-0717 | Tuber melanosporum | 43.48 | 5e-22 | 95.9 |
LLPS-Asn-1565 | Aspergillus nidulans | 43.38 | 2e-24 | 102 |
LLPS-Nec-0878 | Neurospora crassa | 42.52 | 2e-22 | 97.8 |
LLPS-Sac-0317 | Saccharomyces cerevisiae | 41.98 | 3e-21 | 94.0 |
LLPS-Map-0559 | Magnaporthe poae | 41.96 | 2e-22 | 97.4 |
LLPS-Trr-1526 | Trichoderma reesei | 41.72 | 1e-23 | 100 |
LLPS-Dos-1311 | Dothistroma septosporum | 41.61 | 1e-23 | 100 |
LLPS-Lem-0270 | Leptosphaeria maculans | 41.56 | 5e-24 | 102 |
LLPS-Coo-1308 | Colletotrichum orbiculare | 41.51 | 2e-24 | 102 |
LLPS-Ast-0071 | Aspergillus terreus | 41.36 | 2e-25 | 105 |
LLPS-Crn-1466 | Cryptococcus neoformans | 40.99 | 4e-27 | 110 |
LLPS-Cog-0249 | Colletotrichum gloeosporioides | 40.88 | 2e-24 | 102 |
LLPS-Abg-0457 | Absidia glauca | 40.74 | 3e-27 | 110 |
LLPS-Cogr-0567 | Colletotrichum graminicola | 40.61 | 4e-26 | 107 |
LLPS-Aso-0018 | Aspergillus oryzae | 40.61 | 1e-25 | 106 |
LLPS-Asf-1195 | Aspergillus flavus | 40.61 | 1e-25 | 106 |
LLPS-Asg-0891 | Ashbya gossypii | 40.46 | 2e-19 | 88.6 |
LLPS-Asc-0132 | Aspergillus clavatus | 40.37 | 2e-26 | 108 |
LLPS-Ved-1432 | Verticillium dahliae | 40.26 | 3e-22 | 96.7 |
LLPS-Mao-1550 | Magnaporthe oryzae | 40.15 | 5e-19 | 87.4 |
LLPS-Pyt-1565 | Pyrenophora teres | 40.13 | 1e-23 | 100 |
LLPS-Fus-1387 | Fusarium solani | 40.0 | 7e-26 | 106 |
LLPS-Pug-1047 | Puccinia graminis | 39.86 | 1e-23 | 101 |
LLPS-Fuo-1576 | Fusarium oxysporum | 39.75 | 2e-24 | 102 |
LLPS-Fuv-1491 | Fusarium verticillioides | 39.75 | 3e-24 | 102 |
LLPS-Put-1075 | Puccinia triticina | 39.71 | 2e-23 | 100 |
LLPS-Chc-0851 | Chondrus crispus | 39.63 | 3e-29 | 117 |
LLPS-Beb-1171 | Beauveria bassiana | 39.47 | 2e-24 | 102 |
LLPS-Nef-1398 | Neosartorya fischeri | 39.02 | 2e-26 | 108 |
LLPS-Asfu-1457 | Aspergillus fumigatus | 39.02 | 3e-26 | 108 |
LLPS-Mel-1223 | Melampsora laricipopulina | 38.3 | 2e-22 | 97.8 |
LLPS-Spr-0813 | Sporisorium reilianum | 38.17 | 2e-17 | 83.2 |
LLPS-Scj-0308 | Schizosaccharomyces japonicus | 37.74 | 3e-20 | 91.3 |
LLPS-Miv-1260 | Microbotryum violaceum | 37.5 | 6e-18 | 85.1 |
LLPS-Scc-1048 | Schizosaccharomyces cryophilus | 37.42 | 1e-19 | 89.4 |
LLPS-Scp-0289 | Schizosaccharomyces pombe | 37.41 | 4e-18 | 84.7 |
LLPS-Yal-1507 | Yarrowia lipolytica | 37.4 | 2e-19 | 89.0 |
LLPS-Kop-1336 | Komagataella pastoris | 36.17 | 1e-18 | 85.9 |
LLPS-Usm-0138 | Ustilago maydis | 35.4 | 1e-17 | 83.6 |
LLPS-Blg-1039 | Blumeria graminis | 34.73 | 3e-21 | 94.0 |
LLPS-Cii-1102 | Ciona intestinalis | 27.7 | 3e-15 | 76.6 |