DrLLPS - Data resource of LLPS

LLPS-Bot-1522
PRKN

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Parkin RBR E3 ubiquitin protein ligase
Gene Name:	PRKN
Ensembl Gene:	ENSBTAG00000018996.6
Ensembl Protein:	ENSBTAP00000055427.2
Organism:	Bos taurus
Taxa ID:	9913
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, Centrosome/Spindle pole body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-2430	Q9WVS6	Client	Nucleolus	73.81	0.0	681
Homo sapiens	LLPS-Hos-1877	O60260	Client	Centrosome/Spindle pole body	78.35	0.0	698

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSBTAT00000064741.2	ENSBTAP00000055427.2
Ensembl	ENSBTAT00000079512.1	ENSBTAP00000058742.1
Ensembl	ENSBTAT00000065043.2	ENSBTAP00000054449.1
Ensembl	ENSBTAT00000062978.2	ENSBTAP00000055410.1
Ensembl	ENSBTAT00000025286.6	ENSBTAP00000025286.6
Ensembl	ENSBTAT00000063967.2	ENSBTAP00000056268.2
Ensembl	ENSBTAT00000064521.2	ENSBTAP00000054593.2
UniProt		G3MY23, G3MY23_BOVIN

▼ SEQUENCE

Protein Sequence (FASTA)
1 MKVFVRFNSN HGFPVEVDSD TSIFQLKEVV ARRQGVPADQ LCVIFAGKEL RNDWTVQSCD 60 61 LDQQSIVHIV LRPRRKGPEG HSPRPAWGRS DREPESLTRV DLSSSMLPAD SVGLAVILQD 120 121 GEESGASSAR RPAGRPTYNS FYVYCKGPCQ GVQPGKLRVR CSTCQQATLT LAQGPSCWED 180 181 VLIPNRMSGE CQSPNCPGTR AEFFFKCGAH PTSDKETSVA LNLITTNSRD ISCITCTDIR 240 241 SPVLVFQCTH RHVICLDCFH LYCVTRLNDR QFVHDPQLGY SLPCVAGCPN SLIKELHHFR 300 301 ILGEEQYNRY QQYGAEECVL QLGGVLCPGP GCGAGLLPEP GQRKVSCEPG HGLGCGDSPG 360 361 SPVVKTPCST AGGTGSIPGW GTKILLRCMF VFCRDCKEPY HEGDCGAVIE ASGTVTQAYR 420 421 VNEKAAEQAR WEEASKETIK KTTKPCPRCH VPVEKNGESG LTEERGCGGL SSEGGREVGI 480 481 YKGFLAGELS AGALGPSGQG LNLSTHVKLL NLLNRKSSSV K 521
Nucleotide CDS Sequence (FASTA)
1 ATGAAAGGGA AATCCCATAG GATAACTCCA TTTTTCTCCA AATTGTTTGT CAGGTTCAAC 60 61 TCTAACCACG GGTTCCCAGT GGAGGTCGAT TCTGACACCA GCATCTTCCA GCTCAAGGAG 120 121 GTGGTTGCTA GGCGACAGGG GGTTCCAGCT GACCAGCTGT GTGTGATTTT CGCAGGGAAG 180 181 GAGCTCAGGA ATGACTGGAC AGTGCAGAGC TGTGACCTGG ATCAGCAGAG CATCGTTCAC 240 241 ATTGTGCTGA GACCGCGGAG AAAAGGCCCA GAAGGGCACA GCCCGCGGCC CGCTTGGGGG 300 301 CGCTCTGACA GGGAGCCCGA GAGCCTGACT CGAGTGGACC TCAGCAGCTC GATGCTCCCC 360 361 GCGGACTCGG TGGGCCTGGC TGTTATACTG CAGGACGGCG AGGAGAGCGG CGCCTCGTCA 420 421 GCCCGCAGGC CAGCAGGTAG ACCGACCTAC AACAGCTTTT ATGTCTACTG CAAAGGCCCG 480 481 TGTCAAGGAG TGCAGCCGGG AAAGCTCAGG GTGCGGTGCA GCACCTGCCA ACAAGCAACG 540 541 CTCACCTTGG CCCAGGGTCC TTCTTGCTGG GAAGATGTCT TAATCCCAAA CCGAATGAGT 600 601 GGTGAATGTC AGTCTCCAAA CTGCCCTGGG ACCAGAGCGG TAAGTACGGG TCCGATCTGG 660 661 AAGCACAAGA ATATTGGAGT GGGTAACCTA TCCCTTCTCC GCTGA 705

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ova-2288	Ovis aries	91.11	0.0	644
LLPS-Sah-1725	Sarcophilus harrisii	90.74	3e-26	106
LLPS-Dio-0663	Dipodomys ordii	90.2	1e-22	97.1
LLPS-Mod-2849	Monodelphis domestica	89.19	6e-14	72.4
LLPS-Ora-0844	Ornithorhynchus anatinus	85.19	4e-24	100
LLPS-Aim-0913	Ailuropoda melanoleuca	84.03	6e-169	486
LLPS-Mal-1825	Mandrillus leucophaeus	83.29	0.0	558
LLPS-Meg-1213	Meleagris gallopavo	83.1	3e-19	87.8
LLPS-Caf-1121	Canis familiaris	82.99	2e-167	484
LLPS-Mup-1573	Mustela putorius furo	80.56	2e-160	466
LLPS-Sus-2632	Sus scrofa	79.0	0.0	679
LLPS-Fec-2043	Felis catus	78.7	0.0	672
LLPS-Ran-1905	Rattus norvegicus	78.47	5e-159	461
LLPS-Hos-1877	Homo sapiens	78.35	0.0	676
LLPS-Otg-1659	Otolemur garnettii	78.26	0.0	671
LLPS-Pat-2589	Pan troglodytes	78.14	0.0	674
LLPS-Gog-1789	Gorilla gorilla	78.14	0.0	676
LLPS-Pap-2627	Pan paniscus	78.09	0.0	677
LLPS-Eqc-2901	Equus caballus	77.87	5e-52	181
LLPS-Rhb-2553	Rhinopithecus bieti	77.71	0.0	676
LLPS-Mam-1849	Macaca mulatta	77.71	0.0	677
LLPS-Maf-2270	Macaca fascicularis	77.71	0.0	677
LLPS-Aon-2166	Aotus nancymaae	77.71	0.0	676
LLPS-Paa-2829	Papio anubis	77.71	0.0	673
LLPS-Man-3863	Macaca nemestrina	77.49	0.0	676
LLPS-Caj-2331	Callithrix jacchus	77.27	0.0	668
LLPS-Myl-0889	Myotis lucifugus	77.26	0.0	542
LLPS-Mea-2032	Mesocricetus auratus	77.03	2e-30	119
LLPS-Cea-2941	Cercocebus atys	76.84	0.0	662
LLPS-Fud-2424	Fukomys damarensis	75.0	5e-124	370
LLPS-Cas-1886	Carlito syrichta	74.19	4e-89	280
LLPS-Mum-2430	Mus musculus	73.81	0.0	634
LLPS-Anc-0319	Anolis carolinensis	71.83	7e-26	107
LLPS-Cap-3591	Cavia porcellus	71.21	0.0	591
LLPS-Urm-1035	Ursus maritimus	71.1	2e-56	193
LLPS-Nol-2451	Nomascus leucogenys	70.56	0.0	588
LLPS-Anp-3018	Anas platyrhynchos	70.55	2e-145	428
LLPS-Poa-0380	Pongo abelii	68.4	1e-140	416
LLPS-Pes-2416	Pelodiscus sinensis	67.93	1e-111	338
LLPS-Fia-3091	Ficedula albicollis	66.67	0.0	572
LLPS-Tag-0158	Taeniopygia guttata	65.95	0.0	572
LLPS-Gaga-3102	Gallus gallus	63.76	1e-168	494
LLPS-Asm-0983	Astyanax mexicanus	61.44	2e-124	378
LLPS-Leo-0825	Lepisosteus oculatus	61.03	1e-174	508
LLPS-Orc-3301	Oryctolagus cuniculus	60.0	1e-18	86.3
LLPS-Loa-2129	Loxodonta africana	58.89	1e-19	89.0
LLPS-Dar-0113	Danio rerio	57.33	6e-157	462
LLPS-Icp-3560	Ictalurus punctatus	56.91	3e-104	322
LLPS-Scf-1995	Scleropages formosus	56.21	3e-156	461
LLPS-Xim-2402	Xiphophorus maculatus	49.33	2e-57	198
LLPS-Orl-1042	Oryzias latipes	48.39	9e-138	414
LLPS-Orn-1468	Oreochromis niloticus	47.69	3e-124	379
LLPS-Pof-1498	Poecilia formosa	46.51	5e-124	377
LLPS-Ten-1388	Tetraodon nigroviridis	46.36	4e-122	374
LLPS-Gaa-0752	Gasterosteus aculeatus	44.82	6e-119	365
LLPS-Tar-0257	Takifugu rubripes	41.6	4e-17	84.0
LLPS-Drm-0782	Drosophila melanogaster	36.67	4e-82	270
LLPS-Php-0629	Physcomitrella patens	35.14	4e-08	57.0
LLPS-Thc-0554	Theobroma cacao	35.14	3e-07	57.0
LLPS-Abg-0310	Absidia glauca	35.14	3e-07	57.0
LLPS-Orbr-0671	Oryza brachyantha	33.78	5e-07	53.5
LLPS-Trr-0288	Trichoderma reesei	33.78	1e-07	55.8
LLPS-Sob-1218	Sorghum bicolor	33.78	5e-07	53.9
LLPS-Cog-0210	Colletotrichum gloeosporioides	33.78	3e-07	55.5
LLPS-Fus-0037	Fusarium solani	33.78	4e-07	53.9
LLPS-Nia-2595	Nicotiana attenuata	33.78	3e-07	54.7
LLPS-Nef-0940	Neosartorya fischeri	33.78	6e-07	55.5
LLPS-Mae-1560	Manihot esculenta	33.78	3e-07	54.7
LLPS-Phv-1050	Phaseolus vulgaris	33.78	3e-07	54.7
LLPS-Art-0169	Arabidopsis thaliana	33.78	5e-07	53.5
LLPS-Gor-0256	Gossypium raimondii	33.78	3e-07	54.7
LLPS-Ors-1129	Oryza sativa	33.78	4e-07	53.9
LLPS-Brr-1587	Brassica rapa	33.78	3e-07	54.7
LLPS-Pug-0825	Puccinia graminis	33.78	5e-08	57.4
LLPS-Viv-1123	Vitis vinifera	33.78	1e-07	55.8
LLPS-Beb-0348	Beauveria bassiana	33.78	6e-07	55.5
LLPS-Pot-1864	Populus trichocarpa	33.78	6e-07	53.5
LLPS-Ast-0805	Aspergillus terreus	33.78	6e-07	55.5
LLPS-Bro-1621	Brassica oleracea	33.78	6e-07	53.1
LLPS-Asfu-0561	Aspergillus fumigatus	33.78	8e-08	56.2
LLPS-Dos-0093	Dothistroma septosporum	33.78	3e-07	55.5
LLPS-Ved-0270	Verticillium dahliae	33.78	3e-07	55.5
LLPS-Phn-1557	Phaeosphaeria nodorum	33.78	3e-07	55.5
LLPS-Zem-0048	Zea mays	33.78	5e-07	53.5
LLPS-Org-1705	Oryza glaberrima	33.78	3e-07	54.7
LLPS-Usm-1547	Ustilago maydis	33.78	1e-07	56.2
LLPS-Orr-0680	Oryza rufipogon	33.78	3e-07	54.7
LLPS-Orm-0643	Oryza meridionalis	33.78	5e-07	53.5
LLPS-Coc-0913	Corchorus capsularis	33.78	3e-07	54.7
LLPS-Fuo-1309	Fusarium oxysporum	33.78	3e-07	55.5
LLPS-Prp-0886	Prunus persica	33.78	6e-07	53.5
LLPS-Put-1089	Puccinia triticina	33.78	3e-07	54.7
LLPS-Trv-0048	Trichoderma virens	33.78	1e-07	55.8
LLPS-Pytr-1592	Pyrenophora triticirepentis	33.78	3e-07	55.5
LLPS-Coo-1209	Colletotrichum orbiculare	33.78	3e-07	55.5
LLPS-Asn-0550	Aspergillus nidulans	33.78	6e-07	55.5
LLPS-Hea-0635	Helianthus annuus	33.78	5e-07	53.5
LLPS-Orni-1025	Oryza nivara	33.78	2e-07	55.1
LLPS-Mua-0405	Musa acuminata	33.78	3e-07	54.7
LLPS-Asc-0676	Aspergillus clavatus	33.78	6e-07	55.5
LLPS-Scc-0374	Schizosaccharomyces cryophilus	33.78	2e-07	55.1
LLPS-Sol-2129	Solanum lycopersicum	33.78	6e-07	53.1
LLPS-Fuv-0391	Fusarium verticillioides	33.78	3e-07	54.3
LLPS-Glm-2928	Glycine max	33.78	5e-07	53.5
LLPS-Gag-1210	Gaeumannomyces graminis	33.78	6e-07	53.5
LLPS-Cis-2017	Ciona savignyi	33.78	3e-07	54.3
LLPS-Ori-1969	Oryza indica	33.78	3e-07	54.7
LLPS-Brn-2961	Brassica napus	33.78	3e-07	54.7
LLPS-Orb-1679	Oryza barthii	33.78	5e-07	53.5
LLPS-Brd-0283	Brachypodium distachyon	33.78	3e-07	54.7
LLPS-Tra-1216	Triticum aestivum	33.78	3e-07	54.7
LLPS-Sei-0111	Setaria italica	33.78	5e-07	53.5
LLPS-Cus-1956	Cucumis sativus	33.78	1e-07	56.2
LLPS-Hov-0711	Hordeum vulgare	33.78	4e-07	56.6
LLPS-Chr-0965	Chlamydomonas reinhardtii	33.78	2e-07	54.7
LLPS-Met-0393	Medicago truncatula	33.78	6e-07	53.1
LLPS-Tum-1221	Tuber melanosporum	33.78	6e-07	55.5
LLPS-Zyt-1131	Zymoseptoria tritici	33.78	3e-07	55.5
LLPS-Chc-0247	Chondrus crispus	33.78	3e-07	54.3
LLPS-Nec-1078	Neurospora crassa	33.78	4e-07	55.8
LLPS-Arl-1417	Arabidopsis lyrata	33.78	3e-07	54.7
LLPS-Scj-0929	Schizosaccharomyces japonicus	33.78	3e-07	54.3
LLPS-Lem-0567	Leptosphaeria maculans	33.78	9e-08	56.2
LLPS-Kop-0878	Komagataella pastoris	33.78	2e-07	54.7
LLPS-Pyt-0818	Pyrenophora teres	33.78	5e-07	53.9
LLPS-Via-0511	Vigna angularis	33.78	6e-07	53.1
LLPS-Sot-1346	Solanum tuberosum	33.78	3e-07	54.7
LLPS-Blg-0185	Blumeria graminis	33.78	5e-07	53.5
LLPS-Osl-0423	Ostreococcus lucimarinus	33.77	4e-07	53.9
LLPS-Orgl-2228	Oryza glumaepatula	33.33	1e-07	55.5
LLPS-Gas-0937	Galdieria sulphuraria	32.94	1e-07	55.8
LLPS-Lac-2350	Latimeria chalumnae	32.43	4e-07	54.3
LLPS-Tru-1008	Triticum urartu	32.43	4e-07	53.9
LLPS-Ict-1031	Ictidomys tridecemlineatus	32.43	4e-07	53.9
LLPS-Chs-1777	Chlorocebus sabaeus	32.43	4e-07	53.9
LLPS-Tut-1064	Tursiops truncatus	32.43	4e-07	53.9
LLPS-Cae-0507	Caenorhabditis elegans	24.02	7e-27	115

LLPS-Bot-1522PRKN

Protein Sequence

Nucleotide Sequence

LLPS-Bot-1522
PRKN