DrLLPS - Data resource of LLPS

LLPS-Bot-1355
FKBP1A

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Peptidyl-prolyl cis-trans isomerase FKBP1A
Gene Name:	FKBP1A, FKBP1
Ensembl Gene:	ENSBTAG00000054596.1
Ensembl Protein:	ENSBTAP00000060070.1
Organism:	Bos taurus
Taxa ID:	9913
LLPS Type:	Others

PDB: 1TCO (A, B, C) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0472	P20081	Client	Stress granule	55.66	3e-38	130

▼ FUNCTION

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSBTAT00000063784.2	ENSBTAP00000060070.1
UniProt		P18203, FKB1A_BOVIN, Q5E945
GeneBank	BT021075	AAX09092.1
RefSeq	NM_001035456.1	NP_001030533.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MGVQVKTISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFV LGKQEVIRGW 60 61 EEWVAQMSVG QRAKLTISPD YAYGATGHPG IIPPNATLIF DVEFLKLE 108
Nucleotide CDS Sequence (FASTA)
1 ATGGGAGTGC AGGTGAAGAC CATCTCTCCC GGAGACGGGC GCACCTTCCC AAAGCGTGGC 60 61 CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT CGATTCCTCC 120 121 CGGGACAGAA ACAAGCCCTT TAAGTTTGTG CTGGGCAAGC AGGAGGTGAT CCGAGGCTGG 180 181 GAAGAATGGG TTGCCCAGAT GAGCGTGGGT CAGAGAGCCA AGCTGACTAT CTCCCCAGAC 240 241 TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CAAATGCCAC TCTCATCTTT 300 301 GACGTGGAAT TTCTAAAACT GGAATGA 327

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0413	Isomerase
KW-0472	Membrane
KW-1185	Reference proteome
KW-0697	Rotamase
KW-0703	Sarcoplasmic reticulum

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0098562	Cellular Component	Cytoplasmic side of membrane
GO:0005829	Cellular Component	Cytosol
GO:0070062	Cellular Component	Extracellular exosome
GO:0031312	Cellular Component	Extrinsic component of organelle membrane
GO:0016020	Cellular Component	Membrane
GO:1990425	Cellular Component	Ryanodine receptor complex
GO:0016529	Cellular Component	Sarcoplasmic reticulum
GO:0033017	Cellular Component	Sarcoplasmic reticulum membrane
GO:0030018	Cellular Component	Z disc
GO:0048185	Molecular Function	Activin binding
GO:0019855	Molecular Function	Calcium channel inhibitor activity
GO:0008144	Molecular Function	Drug binding
GO:0005528	Molecular Function	FK506 binding
GO:0044325	Molecular Function	Ion channel binding
GO:0003755	Molecular Function	Peptidyl-prolyl cis-trans isomerase activity
GO:0042803	Molecular Function	Protein homodimerization activity
GO:0046332	Molecular Function	SMAD binding
GO:1990000	Biological Process	Amyloid fibril formation
GO:0061077	Biological Process	Chaperone-mediated protein folding
GO:0019221	Biological Process	Cytokine-mediated signaling pathway
GO:0003007	Biological Process	Heart morphogenesis
GO:0060347	Biological Process	Heart trabecula formation
GO:0006936	Biological Process	Muscle contraction
GO:0032515	Biological Process	Negative regulation of phosphoprotein phosphatase activity
GO:0001933	Biological Process	Negative regulation of protein phosphorylation
GO:0051280	Biological Process	Negative regulation of release of sequestered calcium ion into cytosol
GO:0060315	Biological Process	Negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0043123	Biological Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032092	Biological Process	Positive regulation of protein binding
GO:0031398	Biological Process	Positive regulation of protein ubiquitination
GO:0000413	Biological Process	Protein peptidyl-prolyl isomerization
GO:0032925	Biological Process	Regulation of activin receptor signaling pathway
GO:1902991	Biological Process	Regulation of amyloid precursor protein catabolic process
GO:0050776	Biological Process	Regulation of immune response
GO:0032880	Biological Process	Regulation of protein localization
GO:0060314	Biological Process	Regulation of ryanodine-sensitive calcium-release channel activity
GO:0051209	Biological Process	Release of sequestered calcium ion into cytosol
GO:0031000	Biological Process	Response to caffeine
GO:0007183	Biological Process	SMAD protein complex assembly
GO:0097435	Biological Process	Supramolecular fiber organization
GO:0042110	Biological Process	T cell activation
GO:0042098	Biological Process	T cell proliferation
GO:0055010	Biological Process	Ventricular cardiac muscle tissue morphogenesis

▼ KEGG

bta:614795

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Sus-2983	Sus scrofa	96.3	1e-72	218
LLPS-Myl-1001	Myotis lucifugus	95.37	3e-72	218
LLPS-Gog-2470	Gorilla gorilla	94.44	4e-71	215
LLPS-Caj-0181	Callithrix jacchus	94.44	2e-70	216
LLPS-Fud-3873	Fukomys damarensis	94.44	2e-71	215
LLPS-Paa-2159	Papio anubis	94.44	9e-72	217
LLPS-Urm-1120	Ursus maritimus	93.83	9e-50	159
LLPS-Sah-0868	Sarcophilus harrisii	93.52	3e-71	216
LLPS-Orc-1428	Oryctolagus cuniculus	92.68	2e-50	160
LLPS-Ict-3960	Ictidomys tridecemlineatus	92.59	7e-70	211
LLPS-Man-4638	Macaca nemestrina	91.67	3e-69	209
LLPS-Hos-3296	Homo sapiens	89.81	3e-67	204
LLPS-Pes-2985	Pelodiscus sinensis	88.89	2e-48	155
LLPS-Ova-0675	Ovis aries	87.96	3e-67	204
LLPS-Leo-1048	Lepisosteus oculatus	85.19	6e-66	201
LLPS-Pof-1781	Poecilia formosa	83.33	5e-64	196
LLPS-Dar-3177	Danio rerio	83.33	2e-64	197
LLPS-Asm-1796	Astyanax mexicanus	83.33	2e-63	197
LLPS-Aim-3063	Ailuropoda melanoleuca	83.33	4e-56	176
LLPS-Ere-0826	Erinaceus europaeus	83.16	2e-55	174
LLPS-Mal-2908	Mandrillus leucophaeus	83.16	2e-55	174
LLPS-Fec-3645	Felis catus	82.41	7e-64	196
LLPS-Scm-1179	Scophthalmus maximus	82.41	1e-63	195
LLPS-Pap-3780	Pan paniscus	82.41	7e-64	196
LLPS-Pat-2999	Pan troglodytes	82.41	7e-64	196
LLPS-Loa-3504	Loxodonta africana	82.41	7e-64	196
LLPS-Rhb-3884	Rhinopithecus bieti	82.41	7e-64	196
LLPS-Eqc-2914	Equus caballus	82.41	1e-61	194
LLPS-Cap-3446	Cavia porcellus	82.41	7e-64	196
LLPS-Caf-2813	Canis familiaris	82.41	4e-64	197
LLPS-Poa-1163	Pongo abelii	82.41	7e-64	196
LLPS-Mam-3197	Macaca mulatta	82.41	7e-64	196
LLPS-Nol-3772	Nomascus leucogenys	82.41	7e-64	196
LLPS-Chs-3669	Chlorocebus sabaeus	82.41	7e-64	196
LLPS-Maf-2346	Macaca fascicularis	82.41	7e-64	196
LLPS-Aon-1476	Aotus nancymaae	82.41	7e-64	196
LLPS-Cea-0519	Cercocebus atys	82.41	7e-64	196
LLPS-Icp-2547	Ictalurus punctatus	82.41	4e-63	195
LLPS-Tut-1021	Tursiops truncatus	82.41	7e-64	196
LLPS-Scf-0341	Scleropages formosus	82.41	3e-64	196
LLPS-Mup-3076	Mustela putorius furo	82.41	1e-62	196
LLPS-Xim-0840	Xiphophorus maculatus	81.82	5e-62	191
LLPS-Mod-0733	Monodelphis domestica	81.48	4e-63	194
LLPS-Otg-3962	Otolemur garnettii	81.48	3e-63	194
LLPS-Orn-0947	Oreochromis niloticus	81.48	1e-62	193
LLPS-Mea-3206	Mesocricetus auratus	81.48	5e-63	194
LLPS-Mum-1739	Mus musculus	81.48	6e-63	193
LLPS-Orl-1165	Oryzias latipes	81.48	8e-63	193
LLPS-Gaa-3419	Gasterosteus aculeatus	81.48	5e-63	194
LLPS-Dio-2361	Dipodomys ordii	81.48	4e-63	194
LLPS-Ran-1003	Rattus norvegicus	81.48	5e-63	194
LLPS-Xet-3214	Xenopus tropicalis	81.25	2e-54	172
LLPS-Ten-0985	Tetraodon nigroviridis	79.63	2e-61	189
LLPS-Meg-1536	Meleagris gallopavo	79.17	1e-54	172
LLPS-Anp-1264	Anas platyrhynchos	79.17	1e-54	172
LLPS-Fia-1935	Ficedula albicollis	79.17	1e-54	172
LLPS-Gaga-1863	Gallus gallus	78.7	2e-62	192
LLPS-Tag-0495	Taeniopygia guttata	78.7	2e-62	192
LLPS-Cas-0079	Carlito syrichta	77.78	4e-60	186
LLPS-Anc-1630	Anolis carolinensis	77.78	4e-61	189
LLPS-Tar-3285	Takifugu rubripes	77.08	4e-52	167
LLPS-Drm-2000	Drosophila melanogaster	75.0	9e-56	175
LLPS-Lac-3962	Latimeria chalumnae	72.22	2e-54	173
LLPS-Chr-0385	Chlamydomonas reinhardtii	70.48	9e-47	152
LLPS-Cis-1790	Ciona savignyi	69.44	6e-51	163
LLPS-Asn-0384	Aspergillus nidulans	61.11	1e-41	139
LLPS-Abg-0707	Absidia glauca	61.0	2e-38	131
LLPS-Tum-0541	Tuber melanosporum	60.19	4e-41	137
LLPS-Yal-0962	Yarrowia lipolytica	59.26	1e-43	144
LLPS-Cae-0604	Caenorhabditis elegans	59.05	2e-36	125
LLPS-Sob-2482	Sorghum bicolor	58.43	1e-27	110
LLPS-Prp-2255	Prunus persica	58.43	2e-27	109
LLPS-Zem-0640	Zea mays	58.43	1e-27	110
LLPS-Crn-0137	Cryptococcus neoformans	58.33	6e-41	138
LLPS-Coc-2039	Corchorus capsularis	57.3	1e-26	107
LLPS-Sei-1925	Setaria italica	57.3	1e-26	107
LLPS-Miv-1006	Microbotryum violaceum	56.48	8e-40	134
LLPS-Nef-1256	Neosartorya fischeri	56.48	2e-37	129
LLPS-Asfu-1392	Aspergillus fumigatus	56.48	1e-37	129
LLPS-Scc-0445	Schizosaccharomyces cryophilus	56.48	2e-39	134
LLPS-Scp-1558	Schizosaccharomyces pombe	56.48	2e-39	134
LLPS-Scj-0836	Schizosaccharomyces japonicus	56.48	4e-40	135
LLPS-Orp-1923	Oryza punctata	56.18	5e-25	103
LLPS-Mae-1678	Manihot esculenta	56.18	8e-26	105
LLPS-Met-2280	Medicago truncatula	56.18	1e-25	104
LLPS-Sac-0472	Saccharomyces cerevisiae	55.66	3e-38	130
LLPS-Tru-0770	Triticum urartu	54.81	6e-30	116
LLPS-Brd-2458	Brachypodium distachyon	54.81	5e-30	117
LLPS-Tra-1931	Triticum aestivum	54.81	2e-30	118
LLPS-Via-1366	Vigna angularis	54.74	1e-26	107
LLPS-Asg-1353	Ashbya gossypii	54.72	3e-37	128
LLPS-Gor-2167	Gossypium raimondii	53.85	3e-29	114
LLPS-Mua-1570	Musa acuminata	53.85	3e-30	117
LLPS-Hov-2058	Hordeum vulgare	53.85	1e-29	115
LLPS-Kop-0916	Komagataella pastoris	53.77	1e-37	130
LLPS-Pug-1305	Puccinia graminis	53.27	1e-33	119
LLPS-Asni-0919	Aspergillus niger	53.27	1e-31	113
LLPS-Ved-0665	Verticillium dahliae	53.04	3e-28	106
LLPS-Ors-1886	Oryza sativa	52.88	2e-29	115
LLPS-Orbr-0527	Oryza brachyantha	52.88	3e-27	109
LLPS-Nia-1741	Nicotiana attenuata	52.88	8e-30	116
LLPS-Orm-0322	Oryza meridionalis	52.88	2e-29	115
LLPS-Orr-0586	Oryza rufipogon	52.88	2e-29	115
LLPS-Glm-2781	Glycine max	52.88	2e-29	115
LLPS-Ori-2478	Oryza indica	52.88	2e-29	115
LLPS-Orb-1800	Oryza barthii	52.88	3e-29	115
LLPS-Php-1705	Physcomitrella patens	52.88	4e-28	111
LLPS-Hea-2149	Helianthus annuus	52.88	1e-28	112
LLPS-Dac-1249	Daucus carota	52.88	8e-28	110
LLPS-Orni-1340	Oryza nivara	52.88	3e-29	115
LLPS-Orgl-0772	Oryza glumaepatula	52.88	7e-28	111
LLPS-Sot-0424	Solanum tuberosum	52.88	3e-29	114
LLPS-Cus-1375	Cucumis sativus	52.88	5e-29	114
LLPS-Zyt-0889	Zymoseptoria tritici	52.78	2e-31	113
LLPS-Beb-1269	Beauveria bassiana	52.25	1e-26	100
LLPS-Pot-1230	Populus trichocarpa	51.92	3e-28	112
LLPS-Amt-1552	Amborella trichopoda	51.92	5e-29	114
LLPS-Org-0530	Oryza glaberrima	51.92	2e-27	109
LLPS-Sem-1436	Selaginella moellendorffii	51.92	3e-27	109
LLPS-Sol-1470	Solanum lycopersicum	51.92	2e-29	115
LLPS-Thc-1440	Theobroma cacao	51.92	2e-29	115
LLPS-Lep-0836	Leersia perrieri	51.92	8e-27	108
LLPS-Arl-0348	Arabidopsis lyrata	51.92	8e-28	110
LLPS-Asc-0874	Aspergillus clavatus	51.85	7e-35	122
LLPS-Art-0171	Arabidopsis thaliana	51.43	1e-27	110
LLPS-Osl-1191	Ostreococcus lucimarinus	51.43	3e-27	108
LLPS-Viv-2183	Vitis vinifera	50.96	1e-28	112
LLPS-Phv-0176	Phaseolus vulgaris	50.96	1e-27	110
LLPS-Bro-1090	Brassica oleracea	50.96	4e-27	108
LLPS-Brn-2646	Brassica napus	50.96	2e-27	107
LLPS-Vir-0078	Vigna radiata	50.96	5e-28	110
LLPS-Usm-0775	Ustilago maydis	50.93	8e-31	111
LLPS-Spr-0191	Sporisorium reilianum	50.93	9e-31	111
LLPS-Put-1315	Puccinia triticina	50.47	7e-32	114
LLPS-Fus-0030	Fusarium solani	50.43	5e-27	103
LLPS-Brr-2258	Brassica rapa	50.0	1e-25	104
LLPS-Mel-0831	Melampsora laricipopulina	49.53	5e-30	109
LLPS-Trv-0076	Trichoderma virens	48.7	4e-25	104
LLPS-Cogr-1016	Colletotrichum graminicola	48.7	5e-24	94.4
LLPS-Fuv-1603	Fusarium verticillioides	48.7	3e-26	100
LLPS-Coo-1528	Colletotrichum orbiculare	48.7	2e-24	95.1
LLPS-Fuo-0274	Fusarium oxysporum	47.83	5e-26	100
LLPS-Asf-0421	Aspergillus flavus	47.83	5e-33	117
LLPS-Cii-1889	Ciona intestinalis	47.66	9e-25	100
LLPS-Gag-0895	Gaeumannomyces graminis	46.09	3e-24	94.7
LLPS-Blg-0350	Blumeria graminis	46.09	1e-23	93.2
LLPS-Dos-0126	Dothistroma septosporum	45.22	1e-24	96.3
LLPS-Scs-0340	Sclerotinia sclerotiorum	44.92	1e-23	94.4
LLPS-Lem-0676	Leptosphaeria maculans	44.74	1e-24	95.5
LLPS-Phn-0272	Phaeosphaeria nodorum	44.35	4e-24	95.1
LLPS-Nec-1373	Neurospora crassa	43.93	2e-26	102
LLPS-Aso-0992	Aspergillus oryzae	43.48	5e-26	99.8

LLPS-Bot-1355FKBP1A

Protein Sequence

Nucleotide Sequence

LLPS-Bot-1355
FKBP1A