LLPS-Bot-1306
PLAUR
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Urokinase plasminogen activator surface receptor |
| Gene Name: | PLAUR |
| Ensembl Gene: | ENSBTAG00000013125.5 |
| Ensembl Protein: | ENSBTAP00000063135.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000070244.1 | ENSBTAP00000063135.1 |
| Ensembl | ENSBTAT00000017446.5 | ENSBTAP00000017446.4 |
| UniProt | Q05588, UPAR_BOVIN, A5PJ83 | |
| GeneBank | S70635, L03545, BC134754, BC142002 | AAB30120.1, AAI42003.1, AAA30802.1, AAI34755.1 |
| RefSeq | NM_174423.3 | NP_776848.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGQPLLLLLL VYTYIPGSWG LRCLQCENTT SCSVEECTPG QDLCRTTVLS VWEGGNEMNV 60 61 VRKGCTHPDK TNRSMSYRAA DQIITLSETV CRSDLCNKPN PGRDATVSRN RYLECASCSS 120 121 TDLSCERGWD QTMQCLKSRD QCVDVITHRS LKENPGDERH IRGCGILPGC PGPTGFHNNH 180 181 TFHFLRCCNT TKCNAGSVLE LQNLPPNGLQ CYSCEGNGAH RCSSEETFLI DCRGPMNQCL 240 241 EATGTKGLRN PSYTIRGCAA PSWCQSLHVA EAFDLTHVNV SCCTGSGCNH PARDDQPGKG 300 301 GAPKTSPAHL SFFVSLLLTA RLWGATLLCT 330 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGCCAAC CGCTGCTGCT ACTGCTGTTG GTTTACACCT ACATTCCAGG CTCTTGGGGC 60 61 CTGCGGTGCT TACAGTGTGA GAACACGACG AGCTGCAGTG TTGAAGAGTG TACTCCTGGT 120 121 CAGGACCTCT GCAGGACCAC GGTCCTGAGT GTGTGGGAAG GTGGCAATGA GATGAACGTG 180 181 GTGAGAAAAG GCTGTACCCA TCCGGACAAG ACCAACAGGT CCATGAGCTA TCGGGCTGCC 240 241 GATCAGATCA TCACCCTTTC AGAGACCGTG TGCAGGTCAG ACTTGTGCAA CAAGCCCAAC 300 301 CCTGGCCGAG ATGCTACTGT TTCCAGAAAC CGCTACCTCG AATGTGCTTC CTGTTCCTCG 360 361 ACAGACCTCA GCTGTGAGAG GGGCTGGGAC CAGACCATGC AATGCCTCAA ATCTAGAGAT 420 421 CAGTGCGTGG ATGTGATAAC CCACCGGAGC CTGAAAGAGA ATCCAGGCGA TGAGCGCCAC 480 481 ATCAGAGGCT GTGGCATCCT TCCTGGCTGC CCAGGCCCCA CCGGATTCCA CAACAACCAC 540 541 ACCTTCCACT TCCTGCGGTG CTGCAACACC ACCAAATGCA ATGCAGGCTC AGTCCTGGAG 600 601 CTTCAAAACC TGCCACCAAA CGGCTTGCAG TGTTACAGCT GTGAGGGGAA CGGCGCCCAC 660 661 AGGTGTTCTT CTGAAGAAAC TTTCCTCATT GACTGCCGCG GCCCTATGAA TCAATGTCTG 720 721 GAAGCGACAG GCACTAAAGG ACTGAGGAAC CCAAGCTACA CCATCAGAGG CTGCGCAGCC 780 781 CCCTCGTGGT GCCAAAGCCT CCACGTGGCT GAAGCCTTCG ACCTCACCCA CGTCAACGTC 840 841 TCCTGCTGTA CTGGAAGTGG CTGTAACCAT CCAGCCAGGG ATGACCAGCC CGGCAAGGGG 900 901 GGTGCCCCCA AGACCAGCCC TGCCCACCTC AGCTTCTTTG TCAGCCTGCT CTTGACTGCC 960 961 AGACTTTGGG GAGCCACTCT CCTCTGCACT TGA 993 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Anchored component of membrane | |
Cellular Component | Apical part of cell | |
Cellular Component | Cell surface | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Plasma membrane | |
Molecular Function | Protein domain specific binding | |
Molecular Function | Signaling receptor binding | |
Molecular Function | Urokinase plasminogen activator receptor activity | |
Molecular Function | Zymogen binding | |
Biological Process | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | |
Biological Process | Negative regulation of intrinsic apoptotic signaling pathway | |
Biological Process | Positive regulation of DNA binding | |
Biological Process | Positive regulation of epidermal growth factor receptor signaling pathway | |
Biological Process | Positive regulation of protein phosphorylation | |
Biological Process | Positive regulation of release of cytochrome c from mitochondria |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-3467 | Ovis aries | 90.24 | 0.0 | 607 |
| LLPS-Caf-3466 | Canis familiaris | 72.34 | 5e-110 | 327 |
| LLPS-Tut-1956 | Tursiops truncatus | 71.3 | 1e-164 | 470 |
| LLPS-Sus-1662 | Sus scrofa | 70.61 | 4e-162 | 463 |
| LLPS-Urm-3545 | Ursus maritimus | 70.19 | 4e-157 | 451 |
| LLPS-Eqc-0760 | Equus caballus | 69.06 | 1e-153 | 442 |
| LLPS-Myl-3214 | Myotis lucifugus | 69.01 | 1e-159 | 456 |
| LLPS-Fec-2164 | Felis catus | 68.75 | 9e-162 | 462 |
| LLPS-Aim-3577 | Ailuropoda melanoleuca | 68.0 | 1e-151 | 437 |
| LLPS-Cas-1134 | Carlito syrichta | 66.67 | 1e-104 | 313 |
| LLPS-Loa-1981 | Loxodonta africana | 66.25 | 1e-148 | 429 |
| LLPS-Otg-1709 | Otolemur garnettii | 66.15 | 6e-149 | 430 |
| LLPS-Orc-3231 | Oryctolagus cuniculus | 65.31 | 2e-148 | 428 |
| LLPS-Rhb-0305 | Rhinopithecus bieti | 62.61 | 2e-98 | 299 |
| LLPS-Nol-1740 | Nomascus leucogenys | 61.8 | 2e-138 | 403 |
| LLPS-Mam-0191 | Macaca mulatta | 61.49 | 1e-138 | 404 |
| LLPS-Man-0379 | Macaca nemestrina | 61.49 | 8e-139 | 404 |
| LLPS-Cea-4337 | Cercocebus atys | 61.18 | 5e-143 | 415 |
| LLPS-Maf-4155 | Macaca fascicularis | 61.18 | 8e-138 | 401 |
| LLPS-Paa-4133 | Papio anubis | 60.87 | 3e-137 | 400 |
| LLPS-Hos-1677 | Homo sapiens | 60.87 | 3e-135 | 395 |
| LLPS-Pap-0088 | Pan paniscus | 60.87 | 2e-137 | 400 |
| LLPS-Pat-2602 | Pan troglodytes | 60.87 | 2e-137 | 400 |
| LLPS-Fud-4422 | Fukomys damarensis | 60.06 | 5e-137 | 399 |
| LLPS-Cap-3188 | Cavia porcellus | 58.92 | 5e-121 | 358 |
| LLPS-Mum-4334 | Mus musculus | 58.49 | 4e-124 | 366 |
| LLPS-Mup-0307 | Mustela putorius furo | 57.54 | 4e-114 | 340 |
| LLPS-Ran-4129 | Rattus norvegicus | 57.37 | 5e-115 | 343 |
| LLPS-Gog-4079 | Gorilla gorilla | 56.7 | 2e-69 | 224 |
| LLPS-Aon-3998 | Aotus nancymaae | 56.21 | 2e-123 | 365 |
| LLPS-Caj-3288 | Callithrix jacchus | 55.9 | 7e-124 | 366 |
| LLPS-Poa-3659 | Pongo abelii | 54.66 | 2e-115 | 343 |
| LLPS-Dio-0157 | Dipodomys ordii | 52.53 | 2e-90 | 280 |
| LLPS-Chs-3871 | Chlorocebus sabaeus | 52.17 | 6e-111 | 333 |
| LLPS-Sah-1423 | Sarcophilus harrisii | 51.95 | 2e-72 | 231 |
| LLPS-Mal-4718 | Mandrillus leucophaeus | 50.0 | 2e-99 | 302 |
| LLPS-Anc-1626 | Anolis carolinensis | 37.15 | 2e-58 | 198 |
| LLPS-Xet-3093 | Xenopus tropicalis | 27.98 | 1e-14 | 76.3 |
| LLPS-Icp-3914 | Ictalurus punctatus | 25.95 | 2e-10 | 63.2 |