• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Bot-1112
POLR2G

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA-directed RNA polymerase II subunit RPB7
Gene Name: POLR2G
Ensembl Gene: ENSBTAG00000009483.3
Ensembl Protein: ENSBTAP00000012481.2
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Others
PDB: 5OIK (A, B, C, D, E, F, G, H, I, J, K, L, N, P, T, Y, Z) More


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION


DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MFYHISLEHE  ILLHPRYFGP  NLLNTVKQKL  FTEVEGTCTG  KYGFVIAVTT  IDNIGAGVIQ  60
61    PGRGFVLYPV  KYKAIVFRPF  KGEVVDAVVT  QVNKVGLFTE  IGPMSCFISR  HSIPSEMEFD  120
121   PNSNPPCYKT  MDEDIVIQQD  DEIRLKIVGT  RVDKNDIFAI  GSLMDDYLGL  VS  172
Nucleotide CDS Sequence (FASTA)
1     ATGTTTTACC  ACATCTCCCT  GGAGCACGAG  ATTCTTCTGC  ACCCGCGATA  CTTCGGCCCT  60
61    AACCTGCTCA  ACACGGTGAA  ACAAAAGCTC  TTCACCGAGG  TGGAGGGGAC  CTGCACCGGC  120
121   AAGTATGGCT  TTGTAATTGC  CGTCACTACC  ATCGACAATA  TCGGTGCTGG  TGTGATCCAG  180
181   CCAGGCCGAG  GCTTTGTCCT  TTATCCGGTT  AAGTACAAGG  CCATTGTTTT  CCGGCCCTTT  240
241   AAAGGGGAGG  TCGTGGATGC  GGTGGTCACT  CAGGTCAACA  AGGTTGGACT  CTTCACAGAA  300
301   ATCGGGCCCA  TGTCCTGCTT  CATCTCTCGA  CATTCCATCC  CATCAGAGAT  GGAATTTGAT  360
361   CCTAACTCCA  ACCCACCGTG  TTACAAAACG  ATGGATGAGG  ACATTGTGAT  TCAGCAGGAT  420
421   GATGAGATCC  GCTTGAAGAT  TGTGGGGACC  CGTGTGGACA  AGAATGACAT  TTTTGCTATC  480
481   GGCTCCCTGA  TGGATGATTA  CCTGGGGCTT  GTGAGCTGA  519

▼ KEYWORD


ID
Family
3D-structure
Complete proteome
DNA-directed RNA polymerase
Nucleus
Reference proteome
RNA-binding
Transcription

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Nucleus
Cellular Component
P-body
Cellular Component
RNA polymerase II, core complex
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Molecular Function
Single-stranded DNA binding
Molecular Function
Single-stranded RNA binding
Molecular Function
Translation initiation factor binding
Biological Process
Nuclear-transcribed mRNA catabolic process, exonucleolytic
Biological Process
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Biological Process
Positive regulation of translational initiation
Biological Process
Transcription by RNA polymerase II
Biological Process
Transcription initiation from RNA polymerase II promoter

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Chs-0225Chlorocebus sabaeus100.07e-113 325
LLPS-Mum-0381Mus musculus100.07e-113 325
LLPS-Mea-0847Mesocricetus auratus100.01e-61 192
LLPS-Sus-0807Sus scrofa100.07e-113 325
LLPS-Aon-1940Aotus nancymaae100.07e-113 325
LLPS-Gog-1494Gorilla gorilla100.07e-113 325
LLPS-Fud-0445Fukomys damarensis100.07e-113 325
LLPS-Tut-0258Tursiops truncatus100.07e-113 325
LLPS-Ran-0833Rattus norvegicus100.07e-113 325
LLPS-Mup-0143Mustela putorius furo100.07e-113 325
LLPS-Aim-2484Ailuropoda melanoleuca100.07e-113 325
LLPS-Mal-3204Mandrillus leucophaeus100.07e-113 325
LLPS-Fec-0090Felis catus100.02e-111 325
LLPS-Hos-1063Homo sapiens100.07e-113 325
LLPS-Pat-2754Pan troglodytes100.01e-2189.0
LLPS-Urm-0998Ursus maritimus100.02e-75 230
LLPS-Pap-2653Pan paniscus100.07e-113 325
LLPS-Rhb-3914Rhinopithecus bieti100.07e-113 325
LLPS-Orc-2150Oryctolagus cuniculus100.07e-113 325
LLPS-Cap-3251Cavia porcellus100.07e-113 325
LLPS-Eqc-1176Equus caballus100.01e-110 320
LLPS-Caf-2769Canis familiaris100.07e-62 194
LLPS-Ora-0556Ornithorhynchus anatinus99.424e-112 323
LLPS-Sah-1951Sarcophilus harrisii99.424e-112 323
LLPS-Asm-2652Astyanax mexicanus99.424e-112 323
LLPS-Scf-1176Scleropages formosus99.424e-112 323
LLPS-Gaa-2605Gasterosteus aculeatus99.424e-112 323
LLPS-Myl-2245Myotis lucifugus99.424e-112 323
LLPS-Loa-0588Loxodonta africana99.424e-112 323
LLPS-Pes-1005Pelodiscus sinensis99.428e-112 324
LLPS-Orn-0463Oreochromis niloticus99.424e-112 323
LLPS-Cas-0478Carlito syrichta99.421e-112 325
LLPS-Maf-0715Macaca fascicularis99.48e-107 312
LLPS-Man-1197Macaca nemestrina99.48e-107 312
LLPS-Mam-2349Macaca mulatta99.43e-107 312
LLPS-Nol-2966Nomascus leucogenys99.222e-77 236
LLPS-Pof-0277Poecilia formosa98.953e-61 192
LLPS-Icp-1965Ictalurus punctatus98.844e-112 323
LLPS-Lac-1624Latimeria chalumnae98.843e-111 321
LLPS-Dar-1535Danio rerio98.844e-112 323
LLPS-Xet-0854Xenopus tropicalis98.844e-112 323
LLPS-Ict-0516Ictidomys tridecemlineatus98.847e-113 325
LLPS-Xim-0921Xiphophorus maculatus98.823e-109 316
LLPS-Ova-0428Ovis aries98.822e-107 313
LLPS-Anc-0800Anolis carolinensis98.83e-108 313
LLPS-Ten-0521Tetraodon nigroviridis98.362e-2599.0
LLPS-Scm-0408Scophthalmus maximus98.221e-108 316
LLPS-Tag-1247Taeniopygia guttata97.715e-91 268
LLPS-Orl-2289Oryzias latipes97.675e-109 315
LLPS-Mod-0373Monodelphis domestica97.673e-110 318
LLPS-Tar-0488Takifugu rubripes97.632e-107 312
LLPS-Anp-3112Anas platyrhynchos97.563e-1981.6
LLPS-Gaga-1617Gallus gallus97.563e-2188.2
LLPS-Dio-0417Dipodomys ordii95.939e-108 312
LLPS-Paa-1946Papio anubis92.92e-98 291
LLPS-Cea-1723Cercocebus atys91.912e-97 289
LLPS-Cii-0266Ciona intestinalis91.863e-104 303
LLPS-Caj-2106Callithrix jacchus91.122e-94 278
LLPS-Poa-0024Pongo abelii88.572e-96 284
LLPS-Cis-0767Ciona savignyi88.371e-99 291
LLPS-Drm-1121Drosophila melanogaster81.41e-94 279
LLPS-Otg-1443Otolemur garnettii81.252e-84 253
LLPS-Cae-1000Caenorhabditis elegans76.746e-90 268
LLPS-Glm-2079Glycine max55.815e-61 193
LLPS-Via-0178Vigna angularis55.819e-61 193
LLPS-Met-0024Medicago truncatula55.814e-61 194
LLPS-Phv-0454Phaseolus vulgaris55.815e-61 193
LLPS-Mae-0947Manihot esculenta55.232e-60 192
LLPS-Thc-1797Theobroma cacao54.659e-60 190
LLPS-Cus-0923Cucumis sativus54.656e-60 191
LLPS-Pot-0835Populus trichocarpa54.654e-60 191
LLPS-Prp-2132Prunus persica54.651e-59 190
LLPS-Php-1055Physcomitrella patens54.392e-59 189
LLPS-Mua-1467Musa acuminata54.076e-61 193
LLPS-Mel-0797Melampsora laricipopulina53.852e-61 194
LLPS-Sem-1091Selaginella moellendorffii53.85e-60 191
LLPS-Hea-0970Helianthus annuus53.755e-54 175
LLPS-Tra-0885Triticum aestivum53.495e-60 191
LLPS-Brd-1374Brachypodium distachyon53.494e-60 191
LLPS-Hov-0852Hordeum vulgare53.495e-60 191
LLPS-Gor-0404Gossypium raimondii53.494e-59 189
LLPS-Art-2077Arabidopsis thaliana53.497e-59 188
LLPS-Viv-1372Vitis vinifera53.491e-58 187
LLPS-Orbr-0061Oryza brachyantha53.498e-59 189
LLPS-Pug-1108Puccinia graminis53.251e-59 190
LLPS-Coc-0150Corchorus capsularis53.124e-52 170
LLPS-Ori-0213Oryza indica52.912e-59 189
LLPS-Orb-0651Oryza barthii52.912e-59 189
LLPS-Orni-0036Oryza nivara52.915e-59 189
LLPS-Orgl-1902Oryza glumaepatula52.912e-59 189
LLPS-Sei-0344Setaria italica52.911e-58 191
LLPS-Arl-0407Arabidopsis lyrata52.917e-59 188
LLPS-Ors-0550Oryza sativa52.912e-59 189
LLPS-Orp-0291Oryza punctata52.912e-59 189
LLPS-Sob-0584Sorghum bicolor52.911e-59 190
LLPS-Orr-0090Oryza rufipogon52.912e-59 189
LLPS-Orm-0028Oryza meridionalis52.912e-59 189
LLPS-Org-1332Oryza glaberrima52.912e-59 189
LLPS-Zem-0660Zea mays52.911e-59 190
LLPS-Sot-0004Solanum tuberosum52.51e-53 174
LLPS-Nia-1638Nicotiana attenuata52.59e-54 174
LLPS-Dac-0186Daucus carota52.411e-45 154
LLPS-Sol-1458Solanum lycopersicum52.332e-58 187
LLPS-Miv-0926Microbotryum violaceum52.332e-54 176
LLPS-Scj-0281Schizosaccharomyces japonicus52.026e-53 172
LLPS-Brn-1428Brassica napus51.746e-58 186
LLPS-Brr-0716Brassica rapa51.746e-58 186
LLPS-Bro-0202Brassica oleracea51.746e-58 186
LLPS-Crn-1082Cryptococcus neoformans50.881e-53 174
LLPS-Scp-0765Schizosaccharomyces pombe50.873e-52 171
LLPS-Scc-0524Schizosaccharomyces cryophilus50.584e-53 173
LLPS-Abg-0570Absidia glauca49.669e-50 164
LLPS-Yal-0901Yarrowia lipolytica49.43e-48 161
LLPS-Osl-0084Ostreococcus lucimarinus48.552e-50 166
LLPS-Blg-0022Blumeria graminis47.938e-47 157
LLPS-Tum-0599Tuber melanosporum47.931e-46 157
LLPS-Usm-0537Ustilago maydis47.932e-52 171
LLPS-Spr-0917Sporisorium reilianum47.932e-52 171
LLPS-Asfu-0490Aspergillus fumigatus47.271e-26 104
LLPS-Lep-0883Leersia perrieri46.824e-51 167
LLPS-Asc-0837Aspergillus clavatus46.154e-41 142
LLPS-Asn-0525Aspergillus nidulans46.157e-41 142
LLPS-Asni-0609Aspergillus niger46.154e-41 142
LLPS-Nef-0305Neosartorya fischeri46.153e-41 142
LLPS-Coo-0433Colletotrichum orbiculare45.611e-44 154
LLPS-Aso-1171Aspergillus oryzae45.562e-40 140
LLPS-Trr-0730Trichoderma reesei45.566e-45 152
LLPS-Chr-0149Chlamydomonas reinhardtii45.351e-48 161
LLPS-Asf-0466Aspergillus flavus45.351e-40 141
LLPS-Kop-1153Komagataella pastoris45.096e-48 160
LLPS-Ved-0603Verticillium dahliae44.975e-44 150
LLPS-Nec-0560Neurospora crassa44.774e-43 147
LLPS-Ast-0876Aspergillus terreus44.774e-40 140
LLPS-Cog-0658Colletotrichum gloeosporioides44.772e-45 153
LLPS-Trv-0390Trichoderma virens44.774e-45 152
LLPS-Cogr-1067Colletotrichum graminicola44.772e-45 153
LLPS-Fuv-0715Fusarium verticillioides44.198e-44 149
LLPS-Beb-0242Beauveria bassiana44.195e-44 150
LLPS-Fuo-0437Fusarium oxysporum44.198e-44 149
LLPS-Amt-1810Amborella trichopoda43.952e-34 124
LLPS-Asg-0021Ashbya gossypii43.933e-44 150
LLPS-Gas-0537Galdieria sulphuraria43.029e-45 152
LLPS-Sac-0298Saccharomyces cerevisiae42.774e-40 139
LLPS-Put-0743Puccinia triticina42.622e-26 103
LLPS-Gag-0328Gaeumannomyces graminis42.444e-42 145
LLPS-Map-0526Magnaporthe poae42.444e-42 145
LLPS-Lem-1337Leptosphaeria maculans42.426e-28 115
LLPS-Pyt-0286Pyrenophora teres42.011e-37 133
LLPS-Pytr-0550Pyrenophora triticirepentis42.011e-37 133
LLPS-Phn-0392Phaeosphaeria nodorum39.251e-33 123
LLPS-Fus-0691Fusarium solani38.952e-31 116
LLPS-Cym-0903Cyanidioschyzon merolae37.572e-36 130
LLPS-Dos-0478Dothistroma septosporum36.693e-32 119
LLPS-Mao-0736Magnaporthe oryzae36.096e-35 126
LLPS-Zyt-0922Zymoseptoria tritici35.51e-31 118
LLPS-Vir-0646Vigna radiata32.022e-1472.0
LLPS-Tru-0083Triticum urartu28.413e-1059.7