LLPS-Bot-1112
POLR2G
Integrated Annotations
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSBTAT00000012481.3 | ENSBTAP00000012481.2 |
UniProt | Q5E9B8, RPB7_BOVIN | |
GeneBank | BT021002 | AAX09019.1 |
RefSeq | NM_001015633.1 | NP_001015633.1 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ 60 61 PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD 120 121 PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS 172 |
Nucleotide CDS Sequence (FASTA) |
1 ATGTTTTACC ACATCTCCCT GGAGCACGAG ATTCTTCTGC ACCCGCGATA CTTCGGCCCT 60 61 AACCTGCTCA ACACGGTGAA ACAAAAGCTC TTCACCGAGG TGGAGGGGAC CTGCACCGGC 120 121 AAGTATGGCT TTGTAATTGC CGTCACTACC ATCGACAATA TCGGTGCTGG TGTGATCCAG 180 181 CCAGGCCGAG GCTTTGTCCT TTATCCGGTT AAGTACAAGG CCATTGTTTT CCGGCCCTTT 240 241 AAAGGGGAGG TCGTGGATGC GGTGGTCACT CAGGTCAACA AGGTTGGACT CTTCACAGAA 300 301 ATCGGGCCCA TGTCCTGCTT CATCTCTCGA CATTCCATCC CATCAGAGAT GGAATTTGAT 360 361 CCTAACTCCA ACCCACCGTG TTACAAAACG ATGGATGAGG ACATTGTGAT TCAGCAGGAT 420 421 GATGAGATCC GCTTGAAGAT TGTGGGGACC CGTGTGGACA AGAATGACAT TTTTGCTATC 480 481 GGCTCCCTGA TGGATGATTA CCTGGGGCTT GTGAGCTGA 519 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Cellular Component | P-body | |
Cellular Component | RNA polymerase II, core complex | |
Molecular Function | DNA-directed 5'-3' RNA polymerase activity | |
Molecular Function | Single-stranded DNA binding | |
Molecular Function | Single-stranded RNA binding | |
Molecular Function | Translation initiation factor binding | |
Biological Process | Nuclear-transcribed mRNA catabolic process, exonucleolytic | |
Biological Process | Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | |
Biological Process | Positive regulation of translational initiation | |
Biological Process | Transcription by RNA polymerase II | |
Biological Process | Transcription initiation from RNA polymerase II promoter |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Chs-0225 | Chlorocebus sabaeus | 100.0 | 7e-113 | 325 |
LLPS-Mum-0381 | Mus musculus | 100.0 | 7e-113 | 325 |
LLPS-Mea-0847 | Mesocricetus auratus | 100.0 | 1e-61 | 192 |
LLPS-Sus-0807 | Sus scrofa | 100.0 | 7e-113 | 325 |
LLPS-Aon-1940 | Aotus nancymaae | 100.0 | 7e-113 | 325 |
LLPS-Gog-1494 | Gorilla gorilla | 100.0 | 7e-113 | 325 |
LLPS-Fud-0445 | Fukomys damarensis | 100.0 | 7e-113 | 325 |
LLPS-Tut-0258 | Tursiops truncatus | 100.0 | 7e-113 | 325 |
LLPS-Ran-0833 | Rattus norvegicus | 100.0 | 7e-113 | 325 |
LLPS-Mup-0143 | Mustela putorius furo | 100.0 | 7e-113 | 325 |
LLPS-Aim-2484 | Ailuropoda melanoleuca | 100.0 | 7e-113 | 325 |
LLPS-Mal-3204 | Mandrillus leucophaeus | 100.0 | 7e-113 | 325 |
LLPS-Fec-0090 | Felis catus | 100.0 | 2e-111 | 325 |
LLPS-Hos-1063 | Homo sapiens | 100.0 | 7e-113 | 325 |
LLPS-Pat-2754 | Pan troglodytes | 100.0 | 1e-21 | 89.0 |
LLPS-Urm-0998 | Ursus maritimus | 100.0 | 2e-75 | 230 |
LLPS-Pap-2653 | Pan paniscus | 100.0 | 7e-113 | 325 |
LLPS-Rhb-3914 | Rhinopithecus bieti | 100.0 | 7e-113 | 325 |
LLPS-Orc-2150 | Oryctolagus cuniculus | 100.0 | 7e-113 | 325 |
LLPS-Cap-3251 | Cavia porcellus | 100.0 | 7e-113 | 325 |
LLPS-Eqc-1176 | Equus caballus | 100.0 | 1e-110 | 320 |
LLPS-Caf-2769 | Canis familiaris | 100.0 | 7e-62 | 194 |
LLPS-Ora-0556 | Ornithorhynchus anatinus | 99.42 | 4e-112 | 323 |
LLPS-Sah-1951 | Sarcophilus harrisii | 99.42 | 4e-112 | 323 |
LLPS-Asm-2652 | Astyanax mexicanus | 99.42 | 4e-112 | 323 |
LLPS-Scf-1176 | Scleropages formosus | 99.42 | 4e-112 | 323 |
LLPS-Gaa-2605 | Gasterosteus aculeatus | 99.42 | 4e-112 | 323 |
LLPS-Myl-2245 | Myotis lucifugus | 99.42 | 4e-112 | 323 |
LLPS-Loa-0588 | Loxodonta africana | 99.42 | 4e-112 | 323 |
LLPS-Pes-1005 | Pelodiscus sinensis | 99.42 | 8e-112 | 324 |
LLPS-Orn-0463 | Oreochromis niloticus | 99.42 | 4e-112 | 323 |
LLPS-Cas-0478 | Carlito syrichta | 99.42 | 1e-112 | 325 |
LLPS-Maf-0715 | Macaca fascicularis | 99.4 | 8e-107 | 312 |
LLPS-Man-1197 | Macaca nemestrina | 99.4 | 8e-107 | 312 |
LLPS-Mam-2349 | Macaca mulatta | 99.4 | 3e-107 | 312 |
LLPS-Nol-2966 | Nomascus leucogenys | 99.22 | 2e-77 | 236 |
LLPS-Pof-0277 | Poecilia formosa | 98.95 | 3e-61 | 192 |
LLPS-Icp-1965 | Ictalurus punctatus | 98.84 | 4e-112 | 323 |
LLPS-Lac-1624 | Latimeria chalumnae | 98.84 | 3e-111 | 321 |
LLPS-Dar-1535 | Danio rerio | 98.84 | 4e-112 | 323 |
LLPS-Xet-0854 | Xenopus tropicalis | 98.84 | 4e-112 | 323 |
LLPS-Ict-0516 | Ictidomys tridecemlineatus | 98.84 | 7e-113 | 325 |
LLPS-Xim-0921 | Xiphophorus maculatus | 98.82 | 3e-109 | 316 |
LLPS-Ova-0428 | Ovis aries | 98.82 | 2e-107 | 313 |
LLPS-Anc-0800 | Anolis carolinensis | 98.8 | 3e-108 | 313 |
LLPS-Ten-0521 | Tetraodon nigroviridis | 98.36 | 2e-25 | 99.0 |
LLPS-Scm-0408 | Scophthalmus maximus | 98.22 | 1e-108 | 316 |
LLPS-Tag-1247 | Taeniopygia guttata | 97.71 | 5e-91 | 268 |
LLPS-Orl-2289 | Oryzias latipes | 97.67 | 5e-109 | 315 |
LLPS-Mod-0373 | Monodelphis domestica | 97.67 | 3e-110 | 318 |
LLPS-Tar-0488 | Takifugu rubripes | 97.63 | 2e-107 | 312 |
LLPS-Anp-3112 | Anas platyrhynchos | 97.56 | 3e-19 | 81.6 |
LLPS-Gaga-1617 | Gallus gallus | 97.56 | 3e-21 | 88.2 |
LLPS-Dio-0417 | Dipodomys ordii | 95.93 | 9e-108 | 312 |
LLPS-Paa-1946 | Papio anubis | 92.9 | 2e-98 | 291 |
LLPS-Cea-1723 | Cercocebus atys | 91.91 | 2e-97 | 289 |
LLPS-Cii-0266 | Ciona intestinalis | 91.86 | 3e-104 | 303 |
LLPS-Caj-2106 | Callithrix jacchus | 91.12 | 2e-94 | 278 |
LLPS-Poa-0024 | Pongo abelii | 88.57 | 2e-96 | 284 |
LLPS-Cis-0767 | Ciona savignyi | 88.37 | 1e-99 | 291 |
LLPS-Drm-1121 | Drosophila melanogaster | 81.4 | 1e-94 | 279 |
LLPS-Otg-1443 | Otolemur garnettii | 81.25 | 2e-84 | 253 |
LLPS-Cae-1000 | Caenorhabditis elegans | 76.74 | 6e-90 | 268 |
LLPS-Glm-2079 | Glycine max | 55.81 | 5e-61 | 193 |
LLPS-Via-0178 | Vigna angularis | 55.81 | 9e-61 | 193 |
LLPS-Met-0024 | Medicago truncatula | 55.81 | 4e-61 | 194 |
LLPS-Phv-0454 | Phaseolus vulgaris | 55.81 | 5e-61 | 193 |
LLPS-Mae-0947 | Manihot esculenta | 55.23 | 2e-60 | 192 |
LLPS-Thc-1797 | Theobroma cacao | 54.65 | 9e-60 | 190 |
LLPS-Cus-0923 | Cucumis sativus | 54.65 | 6e-60 | 191 |
LLPS-Pot-0835 | Populus trichocarpa | 54.65 | 4e-60 | 191 |
LLPS-Prp-2132 | Prunus persica | 54.65 | 1e-59 | 190 |
LLPS-Php-1055 | Physcomitrella patens | 54.39 | 2e-59 | 189 |
LLPS-Mua-1467 | Musa acuminata | 54.07 | 6e-61 | 193 |
LLPS-Mel-0797 | Melampsora laricipopulina | 53.85 | 2e-61 | 194 |
LLPS-Sem-1091 | Selaginella moellendorffii | 53.8 | 5e-60 | 191 |
LLPS-Hea-0970 | Helianthus annuus | 53.75 | 5e-54 | 175 |
LLPS-Tra-0885 | Triticum aestivum | 53.49 | 5e-60 | 191 |
LLPS-Brd-1374 | Brachypodium distachyon | 53.49 | 4e-60 | 191 |
LLPS-Hov-0852 | Hordeum vulgare | 53.49 | 5e-60 | 191 |
LLPS-Gor-0404 | Gossypium raimondii | 53.49 | 4e-59 | 189 |
LLPS-Art-2077 | Arabidopsis thaliana | 53.49 | 7e-59 | 188 |
LLPS-Viv-1372 | Vitis vinifera | 53.49 | 1e-58 | 187 |
LLPS-Orbr-0061 | Oryza brachyantha | 53.49 | 8e-59 | 189 |
LLPS-Pug-1108 | Puccinia graminis | 53.25 | 1e-59 | 190 |
LLPS-Coc-0150 | Corchorus capsularis | 53.12 | 4e-52 | 170 |
LLPS-Ori-0213 | Oryza indica | 52.91 | 2e-59 | 189 |
LLPS-Orb-0651 | Oryza barthii | 52.91 | 2e-59 | 189 |
LLPS-Orni-0036 | Oryza nivara | 52.91 | 5e-59 | 189 |
LLPS-Orgl-1902 | Oryza glumaepatula | 52.91 | 2e-59 | 189 |
LLPS-Sei-0344 | Setaria italica | 52.91 | 1e-58 | 191 |
LLPS-Arl-0407 | Arabidopsis lyrata | 52.91 | 7e-59 | 188 |
LLPS-Ors-0550 | Oryza sativa | 52.91 | 2e-59 | 189 |
LLPS-Orp-0291 | Oryza punctata | 52.91 | 2e-59 | 189 |
LLPS-Sob-0584 | Sorghum bicolor | 52.91 | 1e-59 | 190 |
LLPS-Orr-0090 | Oryza rufipogon | 52.91 | 2e-59 | 189 |
LLPS-Orm-0028 | Oryza meridionalis | 52.91 | 2e-59 | 189 |
LLPS-Org-1332 | Oryza glaberrima | 52.91 | 2e-59 | 189 |
LLPS-Zem-0660 | Zea mays | 52.91 | 1e-59 | 190 |
LLPS-Sot-0004 | Solanum tuberosum | 52.5 | 1e-53 | 174 |
LLPS-Nia-1638 | Nicotiana attenuata | 52.5 | 9e-54 | 174 |
LLPS-Dac-0186 | Daucus carota | 52.41 | 1e-45 | 154 |
LLPS-Sol-1458 | Solanum lycopersicum | 52.33 | 2e-58 | 187 |
LLPS-Miv-0926 | Microbotryum violaceum | 52.33 | 2e-54 | 176 |
LLPS-Scj-0281 | Schizosaccharomyces japonicus | 52.02 | 6e-53 | 172 |
LLPS-Brn-1428 | Brassica napus | 51.74 | 6e-58 | 186 |
LLPS-Brr-0716 | Brassica rapa | 51.74 | 6e-58 | 186 |
LLPS-Bro-0202 | Brassica oleracea | 51.74 | 6e-58 | 186 |
LLPS-Crn-1082 | Cryptococcus neoformans | 50.88 | 1e-53 | 174 |
LLPS-Scp-0765 | Schizosaccharomyces pombe | 50.87 | 3e-52 | 171 |
LLPS-Scc-0524 | Schizosaccharomyces cryophilus | 50.58 | 4e-53 | 173 |
LLPS-Abg-0570 | Absidia glauca | 49.66 | 9e-50 | 164 |
LLPS-Yal-0901 | Yarrowia lipolytica | 49.4 | 3e-48 | 161 |
LLPS-Osl-0084 | Ostreococcus lucimarinus | 48.55 | 2e-50 | 166 |
LLPS-Blg-0022 | Blumeria graminis | 47.93 | 8e-47 | 157 |
LLPS-Tum-0599 | Tuber melanosporum | 47.93 | 1e-46 | 157 |
LLPS-Usm-0537 | Ustilago maydis | 47.93 | 2e-52 | 171 |
LLPS-Spr-0917 | Sporisorium reilianum | 47.93 | 2e-52 | 171 |
LLPS-Asfu-0490 | Aspergillus fumigatus | 47.27 | 1e-26 | 104 |
LLPS-Lep-0883 | Leersia perrieri | 46.82 | 4e-51 | 167 |
LLPS-Asc-0837 | Aspergillus clavatus | 46.15 | 4e-41 | 142 |
LLPS-Asn-0525 | Aspergillus nidulans | 46.15 | 7e-41 | 142 |
LLPS-Asni-0609 | Aspergillus niger | 46.15 | 4e-41 | 142 |
LLPS-Nef-0305 | Neosartorya fischeri | 46.15 | 3e-41 | 142 |
LLPS-Coo-0433 | Colletotrichum orbiculare | 45.61 | 1e-44 | 154 |
LLPS-Aso-1171 | Aspergillus oryzae | 45.56 | 2e-40 | 140 |
LLPS-Trr-0730 | Trichoderma reesei | 45.56 | 6e-45 | 152 |
LLPS-Chr-0149 | Chlamydomonas reinhardtii | 45.35 | 1e-48 | 161 |
LLPS-Asf-0466 | Aspergillus flavus | 45.35 | 1e-40 | 141 |
LLPS-Kop-1153 | Komagataella pastoris | 45.09 | 6e-48 | 160 |
LLPS-Ved-0603 | Verticillium dahliae | 44.97 | 5e-44 | 150 |
LLPS-Nec-0560 | Neurospora crassa | 44.77 | 4e-43 | 147 |
LLPS-Ast-0876 | Aspergillus terreus | 44.77 | 4e-40 | 140 |
LLPS-Cog-0658 | Colletotrichum gloeosporioides | 44.77 | 2e-45 | 153 |
LLPS-Trv-0390 | Trichoderma virens | 44.77 | 4e-45 | 152 |
LLPS-Cogr-1067 | Colletotrichum graminicola | 44.77 | 2e-45 | 153 |
LLPS-Fuv-0715 | Fusarium verticillioides | 44.19 | 8e-44 | 149 |
LLPS-Beb-0242 | Beauveria bassiana | 44.19 | 5e-44 | 150 |
LLPS-Fuo-0437 | Fusarium oxysporum | 44.19 | 8e-44 | 149 |
LLPS-Amt-1810 | Amborella trichopoda | 43.95 | 2e-34 | 124 |
LLPS-Asg-0021 | Ashbya gossypii | 43.93 | 3e-44 | 150 |
LLPS-Gas-0537 | Galdieria sulphuraria | 43.02 | 9e-45 | 152 |
LLPS-Sac-0298 | Saccharomyces cerevisiae | 42.77 | 4e-40 | 139 |
LLPS-Put-0743 | Puccinia triticina | 42.62 | 2e-26 | 103 |
LLPS-Gag-0328 | Gaeumannomyces graminis | 42.44 | 4e-42 | 145 |
LLPS-Map-0526 | Magnaporthe poae | 42.44 | 4e-42 | 145 |
LLPS-Lem-1337 | Leptosphaeria maculans | 42.42 | 6e-28 | 115 |
LLPS-Pyt-0286 | Pyrenophora teres | 42.01 | 1e-37 | 133 |
LLPS-Pytr-0550 | Pyrenophora triticirepentis | 42.01 | 1e-37 | 133 |
LLPS-Phn-0392 | Phaeosphaeria nodorum | 39.25 | 1e-33 | 123 |
LLPS-Fus-0691 | Fusarium solani | 38.95 | 2e-31 | 116 |
LLPS-Cym-0903 | Cyanidioschyzon merolae | 37.57 | 2e-36 | 130 |
LLPS-Dos-0478 | Dothistroma septosporum | 36.69 | 3e-32 | 119 |
LLPS-Mao-0736 | Magnaporthe oryzae | 36.09 | 6e-35 | 126 |
LLPS-Zyt-0922 | Zymoseptoria tritici | 35.5 | 1e-31 | 118 |
LLPS-Vir-0646 | Vigna radiata | 32.02 | 2e-14 | 72.0 |
LLPS-Tru-0083 | Triticum urartu | 28.41 | 3e-10 | 59.7 |