LLPS-Bot-1049
PSMF1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Proteasome inhibitor PI31 subunit |
| Gene Name: | PSMF1 |
| Ensembl Gene: | ENSBTAG00000018417.5 |
| Ensembl Protein: | ENSBTAP00000024505.4 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000024505.5 | ENSBTAP00000024505.4 |
| UniProt | Q3SX30, PSMF1_BOVIN, Q1JPI8 | |
| GeneBank | BT025365, BC104535 | ABF57321.1, AAI04536.1 |
| RefSeq | NM_001076478.1 | NP_001069946.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGLEVLFAS AAPAITCAQD ALVCFLHWEV VTHGYYGLGA GDQPGPNDKK SELLPVEWNS 60 61 NKDLYVLRYE SKDGSRKLLV KAVTVENSMI INVLEHGSQQ VSDLTLNLND YIDSEHLVDF 120 121 HRVYKNSEEL RSRIVSGIIT PIHEQWEKAN LSPHREFPPA TAREVDPLRI HPQHPHTSRQ 180 181 PTWCDPLGPF AVGGEDLDPF GCRRGGMIVD PLRSGFPRAL IDPSSGLPNR LPPGAVPPGA 240 241 RFDPFGPIGT SPSGPNPDHL PPPGYDDMYL 270 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTGGCT TGGAGGTACT GTTCGCGTCG GCGGCGCCGG CCATCACCTG CGCGCAGGAC 60 61 GCGCTTGTCT GCTTCCTGCA CTGGGAGGTG GTCACGCACG GCTACTACGG CTTGGGTGCC 120 121 GGCGACCAGC CGGGTCCCAA TGATAAGAAA TCAGAACTGC TGCCAGTGGA ATGGAACAGT 180 181 AATAAAGACC TGTATGTCCT CCGGTATGAG TCCAAGGATG GGTCCAGAAA GCTCCTCGTG 240 241 AAGGCTGTCA CCGTGGAGAA CAGCATGATC ATCAATGTGC TGGAACATGG CTCACAGCAA 300 301 GTGTCAGATT TGACCCTGAA CTTGAATGAT TATATCGATT CAGAACATCT GGTTGACTTC 360 361 CACAGGGTCT ACAAGAACAG CGAGGAACTT CGGTCCCGTA TTGTGTCTGG GATTATTACA 420 421 CCTATTCATG AGCAGTGGGA AAAAGCCAAT CTAAGTCCCC ACCGGGAGTT TCCCCCTGCC 480 481 ACTGCCAGAG AGGTGGACCC ACTCCGGATT CACCCACAAC ACCCACATAC CAGCCGACAG 540 541 CCTACCTGGT GTGATCCCCT GGGCCCGTTT GCTGTCGGGG GAGAGGACCT AGACCCCTTT 600 601 GGGTGTCGGA GAGGTGGCAT GATTGTGGAT CCCCTGAGAT CCGGCTTCCC AAGAGCACTT 660 661 ATTGACCCGT CATCAGGACT CCCAAACCGG CTTCCTCCAG GCGCTGTGCC CCCAGGAGCA 720 721 CGCTTTGACC CCTTTGGACC CATTGGGACC AGCCCATCTG GACCTAACCC AGACCATCTG 780 781 CCCCCGCCGG GCTACGATGA CATGTACCTG TGA 813 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Proteasome complex | |
Molecular Function | Proteasome binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Negative regulation of proteasomal protein catabolic process | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-2730 | Ovis aries | 99.63 | 0.0 | 553 |
| LLPS-Eqc-4463 | Equus caballus | 95.2 | 0.0 | 529 |
| LLPS-Sus-4290 | Sus scrofa | 95.08 | 0.0 | 513 |
| LLPS-Fec-0285 | Felis catus | 94.46 | 0.0 | 523 |
| LLPS-Urm-0283 | Ursus maritimus | 93.45 | 8e-154 | 437 |
| LLPS-Aim-3133 | Ailuropoda melanoleuca | 93.36 | 0.0 | 521 |
| LLPS-Caf-3012 | Canis familiaris | 93.36 | 0.0 | 516 |
| LLPS-Mup-4188 | Mustela putorius furo | 92.25 | 0.0 | 515 |
| LLPS-Pat-0246 | Pan troglodytes | 91.88 | 0.0 | 508 |
| LLPS-Pap-0315 | Pan paniscus | 91.88 | 0.0 | 508 |
| LLPS-Poa-0236 | Pongo abelii | 91.51 | 0.0 | 506 |
| LLPS-Chs-2685 | Chlorocebus sabaeus | 91.14 | 2e-180 | 504 |
| LLPS-Maf-4623 | Macaca fascicularis | 91.14 | 2e-180 | 504 |
| LLPS-Cea-3463 | Cercocebus atys | 91.14 | 2e-180 | 504 |
| LLPS-Mal-0230 | Mandrillus leucophaeus | 91.14 | 2e-180 | 504 |
| LLPS-Hos-3774 | Homo sapiens | 91.14 | 6e-180 | 503 |
| LLPS-Man-4141 | Macaca nemestrina | 91.14 | 2e-180 | 504 |
| LLPS-Gog-3813 | Gorilla gorilla | 90.98 | 1e-167 | 474 |
| LLPS-Nol-2713 | Nomascus leucogenys | 90.77 | 4e-179 | 501 |
| LLPS-Mam-4696 | Macaca mulatta | 90.77 | 1e-179 | 503 |
| LLPS-Rhb-4552 | Rhinopithecus bieti | 90.41 | 8e-179 | 501 |
| LLPS-Loa-2083 | Loxodonta africana | 90.37 | 1e-176 | 495 |
| LLPS-Paa-1304 | Papio anubis | 90.12 | 3e-165 | 469 |
| LLPS-Caj-0633 | Callithrix jacchus | 89.67 | 3e-178 | 499 |
| LLPS-Orc-2405 | Oryctolagus cuniculus | 89.67 | 3e-178 | 499 |
| LLPS-Cas-3425 | Carlito syrichta | 89.34 | 1e-176 | 495 |
| LLPS-Otg-4429 | Otolemur garnettii | 89.3 | 1e-174 | 490 |
| LLPS-Cap-1089 | Cavia porcellus | 89.3 | 3e-176 | 494 |
| LLPS-Ran-2651 | Rattus norvegicus | 88.56 | 1e-175 | 492 |
| LLPS-Fud-3891 | Fukomys damarensis | 87.82 | 3e-172 | 484 |
| LLPS-Ict-4590 | Ictidomys tridecemlineatus | 87.82 | 4e-176 | 494 |
| LLPS-Dio-2662 | Dipodomys ordii | 87.13 | 4e-171 | 481 |
| LLPS-Mea-1277 | Mesocricetus auratus | 87.08 | 2e-172 | 484 |
| LLPS-Aon-0752 | Aotus nancymaae | 87.08 | 1e-161 | 457 |
| LLPS-Myl-0230 | Myotis lucifugus | 86.72 | 6e-172 | 483 |
| LLPS-Mum-4504 | Mus musculus | 84.87 | 1e-168 | 475 |
| LLPS-Mod-4107 | Monodelphis domestica | 76.01 | 6e-148 | 422 |
| LLPS-Sah-2444 | Sarcophilus harrisii | 75.55 | 1e-119 | 349 |
| LLPS-Gaga-1232 | Gallus gallus | 61.99 | 4e-119 | 349 |
| LLPS-Meg-3184 | Meleagris gallopavo | 61.25 | 8e-117 | 343 |
| LLPS-Tag-2288 | Taeniopygia guttata | 60.37 | 4e-111 | 328 |
| LLPS-Fia-3817 | Ficedula albicollis | 60.0 | 2e-112 | 332 |
| LLPS-Anc-0996 | Anolis carolinensis | 59.46 | 2e-106 | 317 |
| LLPS-Leo-2288 | Lepisosteus oculatus | 57.85 | 4e-104 | 312 |
| LLPS-Lac-3988 | Latimeria chalumnae | 57.78 | 2e-107 | 319 |
| LLPS-Scf-2716 | Scleropages formosus | 55.68 | 9e-110 | 325 |
| LLPS-Asm-3348 | Astyanax mexicanus | 52.55 | 6e-102 | 305 |
| LLPS-Gaa-2373 | Gasterosteus aculeatus | 52.21 | 2e-96 | 290 |
| LLPS-Icp-1853 | Ictalurus punctatus | 51.84 | 1e-92 | 281 |
| LLPS-Dar-2308 | Danio rerio | 50.74 | 3e-97 | 293 |
| LLPS-Orn-3110 | Oreochromis niloticus | 50.18 | 9e-91 | 277 |
| LLPS-Scm-3883 | Scophthalmus maximus | 48.81 | 6e-92 | 280 |
| LLPS-Pof-3503 | Poecilia formosa | 48.72 | 9e-90 | 274 |
| LLPS-Hea-1474 | Helianthus annuus | 28.24 | 1e-07 | 55.8 |
| LLPS-Thc-0476 | Theobroma cacao | 26.71 | 4e-11 | 66.6 |
| LLPS-Phv-1579 | Phaseolus vulgaris | 26.52 | 4e-12 | 68.6 |
| LLPS-Gor-0073 | Gossypium raimondii | 26.16 | 2e-11 | 66.6 |
| LLPS-Viv-2504 | Vitis vinifera | 25.0 | 6e-09 | 59.7 |
| LLPS-Prp-2145 | Prunus persica | 24.73 | 4e-11 | 65.9 |
| LLPS-Glm-0412 | Glycine max | 24.48 | 1e-08 | 58.5 |
| LLPS-Dac-2051 | Daucus carota | 23.78 | 6e-07 | 53.9 |
| LLPS-Vir-1841 | Vigna radiata | 23.0 | 4e-06 | 51.2 |
| LLPS-Art-0382 | Arabidopsis thaliana | 22.96 | 7e-07 | 53.5 |
| LLPS-Met-0317 | Medicago truncatula | 22.92 | 1e-07 | 55.8 |
| LLPS-Coc-1385 | Corchorus capsularis | 22.22 | 5e-07 | 53.9 |
| LLPS-Nia-0293 | Nicotiana attenuata | 21.99 | 6e-06 | 50.8 |