LLPS-Bot-1019
NLE1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Notchless protein homolog 1 |
| Gene Name: | NLE1 |
| Ensembl Gene: | ENSBTAG00000019094.5 |
| Ensembl Protein: | ENSBTAP00000062201.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000072193.1 | ENSBTAP00000062201.1 |
| Ensembl | ENSBTAT00000080209.1 | ENSBTAP00000063737.1 |
| Ensembl | ENSBTAT00000025423.5 | ENSBTAP00000025423.4 |
| Ensembl | ENSBTAT00000067467.1 | ENSBTAP00000063224.1 |
| UniProt | Q58D20, NLE1_BOVIN | |
| GeneBank | BT021777 | AAX46624.1 |
| RefSeq | NM_001014887.1 | NP_001014887.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 RPPRLSAQDE AATRDVQRLL VQFQDEGGQL LGSPFDVPVD ITPDKLQLVC NALLAQEDPL 60 61 PLAFYVHDAE IVSSLGRTLE SQAVETEKVL DIIYQPQAIF RVRAVTRCTS SLEGHSEAVI 120 121 SVAFSPTGKY LASGSGDTTV RFWDLSTETP HFTCQGHRHW VLSISWSPDG KKLASGCKNG 180 181 QILLWDPSTG KQVGRALTGH SKWITALSWE PLHANPECRY VASSSKDGSV RVWDTTAGRC 240 241 ERTLTGHAQS VTCLRWGGDG LLYSASQDRT IKVWRAHDGV LCRTLQGHGH WVNTMALSTD 300 301 YALRTGAFEP AEASVNAQDL RGSLQELKER ALSRYNLVRG QGPERLVSGS DDFTLFLWSP 360 361 AEDKKPLARM TGHQALINQV VFSPDSRVIA SASFDKSIKL WDGRTGKYLA SLRGHVAAVY 420 421 QIAWSADSRL LVSGSSDSTL KVWDVKAQKL STDLPGHADE VYAVDWSPDG QRVASGGKDK 480 481 CLRIWRR 487 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCGG CGGCGGCGGC GGACGAGGCG GCGACGCGCG ATGTGCAGCG GCTGCTCGTG 60 61 CAGTTCCAGG ATGAGGGCGG GCAGCTGCTG GGCTCGCCGT TCGACGTGCC CGTGGACATC 120 121 ACCCCGGACA AGCTGCAGCT CGTGTGCAAC GCTCTACTGG CCCAGGAGGA TCCCCTGCCA 180 181 CTGGCTTTCT ATGTGCACGA TGCGGAGATC GTCTCCTCGC TGGGGAGGAC GCTGGAGTCC 240 241 CAGGCGGTGG AGACAGAGAA GGTCTTGGAC ATCATTTACC AGCCACAAGC TATCTTCAGG 300 301 GTTCGCGCTG TGACCCGCTG CACCAGCTCC TTGGAGGGTC ACAGTGAGGC GGTCATTTCC 360 361 GTGGCCTTCA GCCCCACGGG AAAGTACCTG GCCAGTGGCT CCGGAGACAC GACAGTTCGC 420 421 TTCTGGGATC TCAGCACTGA GACGCCACAC TTCACATGCC AGGGACACAG ACACTGGGTC 480 481 CTGAGCATAT CCTGGTCCCC AGATGGCAAG AAGCTGGCTT CAGGCTGTAA GAATGGCCAG 540 541 ATTCTCCTGT GGGACCCAAG CACAGGGAAG CAAGTGGGCA GGGCGCTCAC TGGCCACAGC 600 601 AAGTGGATCA CAGCCCTGAG CTGGGAGCCC CTCCATGCCA ACCCCGAGTG TCGCTACGTG 660 661 GCCAGCAGCT CCAAGGACGG CAGTGTGCGG GTCTGGGACA CGACTGCGGG CCGCTGCGAG 720 721 CGCACCCTCA CCGGGCACGC GCAGTCAGTC ACCTGTCTCC GGTGGGGAGG GGACGGACTT 780 781 CTCTACTCGG CCTCCCAGGA CCGCACCATC AAAGTCTGGA GGGCTCATGA TGGCGTGCTG 840 841 TGCCGGACTC TGCAAGGCCA CGGCCACTGG GTGAACACCA TGGCCCTCAG CACCGACTAC 900 901 GCCCTGCGCA CAGGGGCCTT TGAGCCCGCC GAGGCCTCAG TGAACGCCCA AGACCTCCGA 960 961 GGGTCCTTGC AGGAGTTGAA GGAGAGGGCC CTTAGCCGCT ACAACCTCGT GCGGGGCCAG 1020 1021 GGCCCAGAGA GGCTAGTGTC TGGCTCAGAT GACTTCACCC TGTTCCTGTG GTCCCCGGCA 1080 1081 GAGGACAAGA AGCCCCTGGC ACGGATGACG GGGCACCAGG CCCTCATCAA CCAGGTGGTC 1140 1141 TTCTCCCCAG ACTCCCGTGT CATCGCCAGC GCCTCCTTCG ACAAGTCCAT CAAGCTGTGG 1200 1201 GACGGCAGGA CCGGCAAGTA CCTGGCCTCC CTGCGCGGCC ACGTGGCTGC CGTGTACCAG 1260 1261 ATCGCGTGGT CGGCCGACAG CCGGCTCCTG GTCAGCGGCA GCAGCGACAG CACGCTCAAA 1320 1321 GTGTGGGACG TGAAGGCCCA GAAGCTGTCC ACGGACCTGC CGGGCCACGC GGACGAGGTA 1380 1381 TACGCTGTCG ACTGGAGTCC CGATGGCCAG AGAGTGGCCA GTGGTGGGAA GGACAAGTGC 1440 1441 CTCCGGATAT GGAGGAGATG A 1461 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleolus | |
Biological Process | Notch signaling pathway | |
Biological Process | Ribosomal large subunit assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-3138 | Ovis aries | 98.8 | 0.0 | 845 |
| LLPS-Eqc-2456 | Equus caballus | 97.1 | 0.0 | 892 |
| LLPS-Aim-1651 | Ailuropoda melanoleuca | 96.62 | 0.0 | 946 |
| LLPS-Myl-2716 | Myotis lucifugus | 96.41 | 0.0 | 946 |
| LLPS-Fec-2916 | Felis catus | 96.41 | 0.0 | 942 |
| LLPS-Sus-0688 | Sus scrofa | 96.3 | 0.0 | 958 |
| LLPS-Loa-0068 | Loxodonta africana | 96.08 | 0.0 | 961 |
| LLPS-Pat-2426 | Pan troglodytes | 95.99 | 0.0 | 942 |
| LLPS-Orc-0206 | Oryctolagus cuniculus | 95.98 | 0.0 | 937 |
| LLPS-Urm-2627 | Ursus maritimus | 95.87 | 0.0 | 865 |
| LLPS-Ict-3116 | Ictidomys tridecemlineatus | 95.82 | 0.0 | 950 |
| LLPS-Nol-0269 | Nomascus leucogenys | 95.78 | 0.0 | 938 |
| LLPS-Pap-1217 | Pan paniscus | 95.78 | 0.0 | 940 |
| LLPS-Mup-1517 | Mustela putorius furo | 95.77 | 0.0 | 934 |
| LLPS-Fud-0262 | Fukomys damarensis | 95.77 | 0.0 | 937 |
| LLPS-Otg-1349 | Otolemur garnettii | 95.77 | 0.0 | 938 |
| LLPS-Hos-0323 | Homo sapiens | 95.62 | 0.0 | 949 |
| LLPS-Gog-3180 | Gorilla gorilla | 95.57 | 0.0 | 934 |
| LLPS-Cas-1859 | Carlito syrichta | 95.45 | 0.0 | 950 |
| LLPS-Mal-0591 | Mandrillus leucophaeus | 95.36 | 0.0 | 853 |
| LLPS-Mum-1452 | Mus musculus | 95.35 | 0.0 | 937 |
| LLPS-Caf-0294 | Canis familiaris | 95.15 | 0.0 | 854 |
| LLPS-Mea-0643 | Mesocricetus auratus | 95.13 | 0.0 | 931 |
| LLPS-Caj-2128 | Callithrix jacchus | 94.87 | 0.0 | 881 |
| LLPS-Chs-3295 | Chlorocebus sabaeus | 94.86 | 0.0 | 956 |
| LLPS-Paa-0557 | Papio anubis | 94.78 | 0.0 | 944 |
| LLPS-Maf-2911 | Macaca fascicularis | 94.78 | 0.0 | 942 |
| LLPS-Cap-1202 | Cavia porcellus | 94.71 | 0.0 | 934 |
| LLPS-Rhb-2827 | Rhinopithecus bieti | 94.7 | 0.0 | 889 |
| LLPS-Mam-3329 | Macaca mulatta | 94.65 | 0.0 | 954 |
| LLPS-Aon-1986 | Aotus nancymaae | 94.52 | 0.0 | 894 |
| LLPS-Man-1729 | Macaca nemestrina | 94.48 | 0.0 | 885 |
| LLPS-Cea-3065 | Cercocebus atys | 94.44 | 0.0 | 952 |
| LLPS-Ran-2219 | Rattus norvegicus | 94.0 | 0.0 | 945 |
| LLPS-Dio-0656 | Dipodomys ordii | 93.98 | 0.0 | 936 |
| LLPS-Poa-0342 | Pongo abelii | 91.98 | 0.0 | 892 |
| LLPS-Sah-0048 | Sarcophilus harrisii | 89.0 | 0.0 | 900 |
| LLPS-Mod-1274 | Monodelphis domestica | 87.94 | 0.0 | 888 |
| LLPS-Fia-0181 | Ficedula albicollis | 86.4 | 1e-158 | 457 |
| LLPS-Tag-0592 | Taeniopygia guttata | 84.14 | 0.0 | 850 |
| LLPS-Pes-0404 | Pelodiscus sinensis | 83.33 | 5e-64 | 210 |
| LLPS-Meg-1432 | Meleagris gallopavo | 83.29 | 0.0 | 655 |
| LLPS-Gaga-2238 | Gallus gallus | 83.16 | 0.0 | 847 |
| LLPS-Anp-1466 | Anas platyrhynchos | 83.04 | 0.0 | 804 |
| LLPS-Asm-1112 | Astyanax mexicanus | 80.76 | 0.0 | 823 |
| LLPS-Icp-0004 | Ictalurus punctatus | 80.42 | 0.0 | 828 |
| LLPS-Leo-1008 | Lepisosteus oculatus | 80.29 | 0.0 | 825 |
| LLPS-Orn-1306 | Oreochromis niloticus | 79.45 | 0.0 | 816 |
| LLPS-Xim-0280 | Xiphophorus maculatus | 79.41 | 0.0 | 811 |
| LLPS-Scm-1107 | Scophthalmus maximus | 78.78 | 0.0 | 809 |
| LLPS-Scf-1415 | Scleropages formosus | 78.65 | 0.0 | 805 |
| LLPS-Gaa-0509 | Gasterosteus aculeatus | 78.2 | 0.0 | 796 |
| LLPS-Orl-0244 | Oryzias latipes | 77.94 | 0.0 | 801 |
| LLPS-Dar-1278 | Danio rerio | 77.59 | 0.0 | 799 |
| LLPS-Ten-0797 | Tetraodon nigroviridis | 77.11 | 0.0 | 802 |
| LLPS-Anc-0482 | Anolis carolinensis | 75.97 | 1e-60 | 201 |
| LLPS-Tar-0508 | Takifugu rubripes | 75.69 | 0.0 | 761 |
| LLPS-Xet-1471 | Xenopus tropicalis | 75.62 | 0.0 | 786 |
| LLPS-Pof-1769 | Poecilia formosa | 71.01 | 0.0 | 698 |
| LLPS-Cis-0644 | Ciona savignyi | 67.38 | 0.0 | 685 |
| LLPS-Cii-2065 | Ciona intestinalis | 66.31 | 0.0 | 685 |
| LLPS-Cus-1464 | Cucumis sativus | 61.37 | 0.0 | 552 |
| LLPS-Sot-0411 | Solanum tuberosum | 59.96 | 0.0 | 605 |
| LLPS-Sol-2058 | Solanum lycopersicum | 59.96 | 0.0 | 606 |
| LLPS-Nia-1375 | Nicotiana attenuata | 59.57 | 0.0 | 605 |
| LLPS-Sei-1001 | Setaria italica | 59.31 | 0.0 | 600 |
| LLPS-Ors-0294 | Oryza sativa | 59.31 | 0.0 | 602 |
| LLPS-Php-2115 | Physcomitrella patens | 59.28 | 0.0 | 597 |
| LLPS-Mae-0087 | Manihot esculenta | 59.15 | 0.0 | 605 |
| LLPS-Orgl-0951 | Oryza glumaepatula | 59.1 | 0.0 | 600 |
| LLPS-Orb-1199 | Oryza barthii | 59.1 | 0.0 | 600 |
| LLPS-Orni-1374 | Oryza nivara | 59.1 | 0.0 | 601 |
| LLPS-Mua-2062 | Musa acuminata | 59.1 | 0.0 | 599 |
| LLPS-Orr-1044 | Oryza rufipogon | 59.1 | 0.0 | 602 |
| LLPS-Orm-0469 | Oryza meridionalis | 59.1 | 0.0 | 600 |
| LLPS-Org-0137 | Oryza glaberrima | 59.1 | 0.0 | 600 |
| LLPS-Orp-0479 | Oryza punctata | 59.1 | 0.0 | 600 |
| LLPS-Brd-0273 | Brachypodium distachyon | 58.67 | 0.0 | 597 |
| LLPS-Orbr-1646 | Oryza brachyantha | 58.67 | 0.0 | 597 |
| LLPS-Tra-0767 | Triticum aestivum | 58.46 | 0.0 | 593 |
| LLPS-Amt-0229 | Amborella trichopoda | 58.42 | 0.0 | 582 |
| LLPS-Sob-1896 | Sorghum bicolor | 58.24 | 0.0 | 590 |
| LLPS-Hea-0006 | Helianthus annuus | 58.19 | 0.0 | 595 |
| LLPS-Hov-0688 | Hordeum vulgare | 58.03 | 0.0 | 590 |
| LLPS-Cae-1260 | Caenorhabditis elegans | 58.03 | 0.0 | 580 |
| LLPS-Gor-2045 | Gossypium raimondii | 58.0 | 0.0 | 592 |
| LLPS-Viv-0668 | Vitis vinifera | 58.0 | 0.0 | 590 |
| LLPS-Pot-1479 | Populus trichocarpa | 57.95 | 0.0 | 593 |
| LLPS-Thc-0708 | Theobroma cacao | 57.87 | 0.0 | 584 |
| LLPS-Met-0800 | Medicago truncatula | 57.77 | 0.0 | 596 |
| LLPS-Drm-0675 | Drosophila melanogaster | 57.74 | 0.0 | 586 |
| LLPS-Prp-1666 | Prunus persica | 57.59 | 0.0 | 587 |
| LLPS-Coc-1109 | Corchorus capsularis | 57.36 | 0.0 | 585 |
| LLPS-Vir-1452 | Vigna radiata | 57.14 | 0.0 | 580 |
| LLPS-Glm-0861 | Glycine max | 57.02 | 0.0 | 588 |
| LLPS-Phv-0494 | Phaseolus vulgaris | 57.02 | 0.0 | 585 |
| LLPS-Ori-0927 | Oryza indica | 56.96 | 0.0 | 570 |
| LLPS-Sem-1007 | Selaginella moellendorffii | 56.47 | 0.0 | 570 |
| LLPS-Zem-1464 | Zea mays | 55.78 | 0.0 | 579 |
| LLPS-Brn-0053 | Brassica napus | 55.56 | 0.0 | 560 |
| LLPS-Bro-1682 | Brassica oleracea | 55.56 | 0.0 | 560 |
| LLPS-Brr-1216 | Brassica rapa | 55.34 | 0.0 | 557 |
| LLPS-Art-0132 | Arabidopsis thaliana | 54.43 | 0.0 | 559 |
| LLPS-Dac-0871 | Daucus carota | 54.33 | 0.0 | 575 |
| LLPS-Arl-2106 | Arabidopsis lyrata | 54.22 | 0.0 | 559 |
| LLPS-Pug-1173 | Puccinia graminis | 54.14 | 2e-157 | 466 |
| LLPS-Map-0105 | Magnaporthe poae | 53.7 | 1e-69 | 236 |
| LLPS-Chr-1530 | Chlamydomonas reinhardtii | 53.69 | 0.0 | 541 |
| LLPS-Lep-1119 | Leersia perrieri | 53.65 | 0.0 | 532 |
| LLPS-Gas-0312 | Galdieria sulphuraria | 53.3 | 3e-180 | 521 |
| LLPS-Osl-0673 | Ostreococcus lucimarinus | 52.93 | 3e-177 | 514 |
| LLPS-Cog-0631 | Colletotrichum gloeosporioides | 52.79 | 3e-130 | 393 |
| LLPS-Tru-0455 | Triticum urartu | 52.19 | 0.0 | 565 |
| LLPS-Tum-0768 | Tuber melanosporum | 52.0 | 2e-167 | 490 |
| LLPS-Asf-1140 | Aspergillus flavus | 51.94 | 5e-129 | 386 |
| LLPS-Abg-0641 | Absidia glauca | 51.48 | 2e-160 | 469 |
| LLPS-Miv-0640 | Microbotryum violaceum | 50.0 | 8e-164 | 481 |
| LLPS-Yal-0859 | Yarrowia lipolytica | 49.9 | 1e-166 | 488 |
| LLPS-Pyt-0486 | Pyrenophora teres | 49.55 | 1e-143 | 429 |
| LLPS-Crn-0900 | Cryptococcus neoformans | 49.51 | 4e-168 | 492 |
| LLPS-Pytr-1247 | Pyrenophora triticirepentis | 49.32 | 2e-143 | 429 |
| LLPS-Lem-1023 | Leptosphaeria maculans | 49.18 | 2e-135 | 413 |
| LLPS-Chc-0404 | Chondrus crispus | 48.47 | 2e-172 | 502 |
| LLPS-Trv-1101 | Trichoderma virens | 48.33 | 1e-152 | 452 |
| LLPS-Scc-1135 | Schizosaccharomyces cryophilus | 48.31 | 2e-148 | 441 |
| LLPS-Beb-0397 | Beauveria bassiana | 48.31 | 7e-145 | 432 |
| LLPS-Blg-0947 | Blumeria graminis | 48.24 | 2e-154 | 457 |
| LLPS-Asg-0961 | Ashbya gossypii | 48.05 | 2e-154 | 457 |
| LLPS-Dos-1413 | Dothistroma septosporum | 48.03 | 7e-155 | 458 |
| LLPS-Coo-1002 | Colletotrichum orbiculare | 48.02 | 3e-148 | 441 |
| LLPS-Trr-0795 | Trichoderma reesei | 47.96 | 2e-153 | 454 |
| LLPS-Cogr-0076 | Colletotrichum graminicola | 47.81 | 2e-147 | 439 |
| LLPS-Fus-0344 | Fusarium solani | 47.6 | 2e-152 | 452 |
| LLPS-Zyt-0876 | Zymoseptoria tritici | 47.58 | 3e-145 | 433 |
| LLPS-Sac-1202 | Saccharomyces cerevisiae | 47.46 | 7e-159 | 468 |
| LLPS-Gag-0189 | Gaeumannomyces graminis | 47.3 | 2e-144 | 432 |
| LLPS-Asc-0951 | Aspergillus clavatus | 47.28 | 2e-152 | 452 |
| LLPS-Scp-0911 | Schizosaccharomyces pombe | 47.27 | 5e-149 | 442 |
| LLPS-Fuo-1383 | Fusarium oxysporum | 47.18 | 3e-151 | 449 |
| LLPS-Nef-0511 | Neosartorya fischeri | 46.98 | 3e-152 | 451 |
| LLPS-Fuv-0634 | Fusarium verticillioides | 46.76 | 4e-150 | 446 |
| LLPS-Scj-0841 | Schizosaccharomyces japonicus | 46.75 | 2e-147 | 439 |
| LLPS-Cym-0045 | Cyanidioschyzon merolae | 46.68 | 5e-137 | 415 |
| LLPS-Phn-0587 | Phaeosphaeria nodorum | 46.5 | 2e-144 | 431 |
| LLPS-Mao-0086 | Magnaporthe oryzae | 46.39 | 2e-143 | 429 |
| LLPS-Asfu-0681 | Aspergillus fumigatus | 46.31 | 3e-152 | 451 |
| LLPS-Aso-1436 | Aspergillus oryzae | 46.2 | 1e-151 | 450 |
| LLPS-Asni-0776 | Aspergillus niger | 45.92 | 5e-150 | 446 |
| LLPS-Asn-0684 | Aspergillus nidulans | 45.91 | 2e-150 | 447 |
| LLPS-Ast-0961 | Aspergillus terreus | 45.79 | 2e-150 | 447 |
| LLPS-Mel-0183 | Melampsora laricipopulina | 45.73 | 3e-149 | 444 |
| LLPS-Ved-0067 | Verticillium dahliae | 45.4 | 1e-139 | 419 |
| LLPS-Scs-0860 | Sclerotinia sclerotiorum | 45.32 | 3e-143 | 428 |
| LLPS-Nec-0856 | Neurospora crassa | 44.38 | 6e-139 | 417 |
| LLPS-Put-0788 | Puccinia triticina | 44.34 | 3e-114 | 355 |
| LLPS-Kop-0533 | Komagataella pastoris | 43.94 | 4e-152 | 451 |
| LLPS-Usm-0163 | Ustilago maydis | 41.99 | 2e-146 | 440 |
| LLPS-Spr-0764 | Sporisorium reilianum | 41.62 | 8e-147 | 441 |
| LLPS-Via-0473 | Vigna angularis | 40.62 | 6e-94 | 303 |