LLPS-Bot-0979
POC1A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | POC1 centriolar protein homolog A; WD repeat-containing protein 51A |
| Gene Name: | POC1A, WDR51A |
| Ensembl Gene: | ENSBTAG00000001471.4 |
| Ensembl Protein: | ENSBTAP00000070356.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Microtubule | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000080034.1 | ENSBTAP00000070356.1 |
| Ensembl | ENSBTAT00000067514.1 | ENSBTAP00000072657.1 |
| Ensembl | ENSBTAT00000077428.1 | ENSBTAP00000062575.1 |
| Ensembl | ENSBTAT00000069856.1 | ENSBTAP00000071208.1 |
| Ensembl | ENSBTAT00000076786.1 | ENSBTAP00000068448.1 |
| Ensembl | ENSBTAT00000070458.1 | ENSBTAP00000070775.1 |
| Ensembl | ENSBTAT00000001927.4 | ENSBTAP00000001927.4 |
| UniProt | Q2TBP4, POC1A_BOVIN | |
| GeneBank | BC109862 | AAI09863.1 |
| RefSeq | NM_001038560.2 | NP_001033649.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEEKAITPTG TGGEGNPSHK EGFQKKASGS MDSCLMVWHM KPQTRAYRFA GHKDAVTCVN 60 61 FSPSGHLLAS GSRDKTVRIW VPNVKGESTV FRAHTATVRS VHFCSDGQSF VTASDDKTVK 120 121 VWSTHRQKFL FSLSQHINWV RCAKFSPDGR LIVSASDDKT VKLWDKTSRE CVHSYCEHGG 180 181 FVTYVDFHPS GTCIAAAGMD NTVKVWDVRT HRLLQHYQLH SAAVNALSFH PSGNYLVTAS 240 241 SDSTLKILDL MEGRLLYTLH GHQGPATTVA FSRTGEYFAS GGSDEQVMVW KSNFDIVDYG 300 301 EVLRVQRPPA TRASSSGTLP EVDPLVPPGR GRSQESMQSH SQEPVSVPQS LTSTLEHIVG 360 361 QLDVLTQTVS ILEQRLTLTE DKLKQCLENQ QLIMQRTTP 399 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCACAC ATACTTTTAT TCCGCTCCAG CCTGCTCGAG CTGAGGGTCA CGTGTCCGCT 60 61 CTCTCCTCAG CCAGTGGCTC CATGGACTCG TGCCTTATGG TGTGGCACAT GAAGCCCCAG 120 121 ACCCGTGCCT ACCGATTTGC CGGCCACAAG GACGCCGTAA CTTGTGTGAA CTTTTCCCCT 180 181 TCGGGACACC TGCTTGCTTC TGGCTCCCGC GACAAGACTG TCCGCATATG GGTACCCAAC 240 241 GTCAAAGGCG AGTCAACTGT GTTTCGTGCA CACACGGCCA CAGTGAGGAG CGTCCATTTC 300 301 TGCAGTGATG GCCAGTCCTT CGTGACAGCC TCTGACGACA AGACAGTCAA GGTGTGGTCC 360 361 ACTCATCGCC AGAAATTCCT GTTCTCCCTG AGCCAGCATA TCAACTGGGT CCGCTGTGCC 420 421 AAGTTCTCCC CGGATGGGCG GCTCATCGTA TCCGCCAGTG ATGACAAAAC TGTCAAACTG 480 481 TGGGACAAGA CCAGCCGGGA GTGTGTCCAC TCATACTGTG AGCATGGCGG CTTTGTCACC 540 541 TACGTGGACT TCCACCCCAG TGGCACGTGC ATCGCTGCTG CCGGCATGGA CAACACGGTG 600 601 AAGGTGTGGG ACGTGCGGAC TCACCGGCTC TTACAGCACT ATCAGTTGCA CAGCGCGGCA 660 661 GTGAACGCCC TCTCCTTCCA CCCGTCGGGG AACTACCTGG TCACAGCCTC CAGCGACTCA 720 721 ACCCTGAAGA TCCTGGACCT CATGGAGGGC CGGCTGCTCT ACACACTCCA TGGCCATCAG 780 781 GGTCCAGCCA CCACGGTTGC CTTTTCAAGA ACGGGGGAGT ATTTTGCCTC TGGCGGTTCA 840 841 GATGAACAAG TGATGGTTTG GAAGAGTAAC TTTGACATCG TCGATTATGG CGAAGTGCTA 900 901 AGAGTGCAGA GGCCCCCAGC CACGCGGGCC AGCTCCTCTG GGACTCTGCC AGAAGTGGAT 960 961 CCCCTCGTCC CGCCAGGCAG GGGCAGAAGT CAGGAGTCGA TGCAGAGCCA CTCCCAGGAG 1020 1021 CCCGTGAGCG TGCCCCAGTC GCTGACCAGC ACGCTGGAGC ACATCGTGGG CCAGTTGGAC 1080 1081 GTCCTCACCC AGACAGTCTC CATCTTGGAG CAGCGGCTGA CACTGACAGA AGACAAGCTG 1140 1141 AAGCAGTGTC TGGAGAACCA GCAGCTAATC ATGCAGAGAA CAACACCGTG A 1191 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centriole | |
Cellular Component | Ciliary basal body | |
Cellular Component | Spindle pole | |
Biological Process | Cell projection organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sus-0684 | Sus scrofa | 94.44 | 0.0 | 751 |
| LLPS-Pat-4271 | Pan troglodytes | 94.31 | 0.0 | 726 |
| LLPS-Pap-0762 | Pan paniscus | 94.04 | 0.0 | 723 |
| LLPS-Fec-1788 | Felis catus | 93.62 | 0.0 | 739 |
| LLPS-Hos-1865 | Homo sapiens | 93.62 | 0.0 | 734 |
| LLPS-Urm-1234 | Ursus maritimus | 93.5 | 0.0 | 726 |
| LLPS-Gog-4010 | Gorilla gorilla | 93.35 | 0.0 | 732 |
| LLPS-Eqc-0968 | Equus caballus | 93.26 | 0.0 | 669 |
| LLPS-Chs-3466 | Chlorocebus sabaeus | 93.22 | 0.0 | 725 |
| LLPS-Nol-0840 | Nomascus leucogenys | 93.22 | 0.0 | 723 |
| LLPS-Rhb-4008 | Rhinopithecus bieti | 92.95 | 0.0 | 721 |
| LLPS-Mup-1160 | Mustela putorius furo | 92.82 | 0.0 | 733 |
| LLPS-Poa-1506 | Pongo abelii | 92.82 | 0.0 | 732 |
| LLPS-Mal-0791 | Mandrillus leucophaeus | 92.68 | 0.0 | 720 |
| LLPS-Maf-4218 | Macaca fascicularis | 92.68 | 0.0 | 720 |
| LLPS-Man-4572 | Macaca nemestrina | 92.41 | 0.0 | 718 |
| LLPS-Aon-0980 | Aotus nancymaae | 92.29 | 0.0 | 726 |
| LLPS-Cea-3908 | Cercocebus atys | 92.02 | 0.0 | 727 |
| LLPS-Orc-4225 | Oryctolagus cuniculus | 91.33 | 0.0 | 708 |
| LLPS-Fud-4374 | Fukomys damarensis | 90.69 | 0.0 | 720 |
| LLPS-Paa-0530 | Papio anubis | 90.03 | 0.0 | 715 |
| LLPS-Ict-2797 | Ictidomys tridecemlineatus | 89.95 | 0.0 | 723 |
| LLPS-Mea-2894 | Mesocricetus auratus | 89.84 | 0.0 | 703 |
| LLPS-Cap-3584 | Cavia porcellus | 88.83 | 0.0 | 709 |
| LLPS-Caj-4400 | Callithrix jacchus | 86.07 | 0.0 | 710 |
| LLPS-Otg-0197 | Otolemur garnettii | 84.96 | 0.0 | 669 |
| LLPS-Loa-3731 | Loxodonta africana | 82.67 | 0.0 | 614 |
| LLPS-Mod-3359 | Monodelphis domestica | 77.91 | 0.0 | 574 |
| LLPS-Gaga-3996 | Gallus gallus | 74.8 | 0.0 | 577 |
| LLPS-Tag-1264 | Taeniopygia guttata | 74.19 | 0.0 | 577 |
| LLPS-Scm-0190 | Scophthalmus maximus | 71.11 | 5e-11 | 68.2 |
| LLPS-Icp-1807 | Ictalurus punctatus | 67.44 | 0.0 | 551 |
| LLPS-Scf-2280 | Scleropages formosus | 67.41 | 0.0 | 559 |
| LLPS-Lac-3453 | Latimeria chalumnae | 66.51 | 0.0 | 573 |
| LLPS-Asm-3877 | Astyanax mexicanus | 65.86 | 7e-179 | 509 |
| LLPS-Dio-2544 | Dipodomys ordii | 64.29 | 3e-135 | 405 |
| LLPS-Ora-2425 | Ornithorhynchus anatinus | 63.2 | 3e-133 | 397 |
| LLPS-Cas-3026 | Carlito syrichta | 62.72 | 7e-134 | 397 |
| LLPS-Dar-3864 | Danio rerio | 62.5 | 1e-140 | 417 |
| LLPS-Aim-2560 | Ailuropoda melanoleuca | 60.79 | 4e-132 | 394 |
| LLPS-Caf-3682 | Canis familiaris | 60.14 | 3e-132 | 395 |
| LLPS-Tar-3636 | Takifugu rubripes | 59.72 | 1e-128 | 387 |
| LLPS-Orl-3079 | Oryzias latipes | 58.84 | 6e-179 | 514 |
| LLPS-Ran-1512 | Rattus norvegicus | 57.55 | 2e-130 | 390 |
| LLPS-Xim-1890 | Xiphophorus maculatus | 56.66 | 2e-123 | 374 |
| LLPS-Leo-2953 | Lepisosteus oculatus | 54.77 | 2e-162 | 473 |
| LLPS-Anp-3342 | Anas platyrhynchos | 52.8 | 2e-155 | 453 |
| LLPS-Mum-4957 | Mus musculus | 49.08 | 1e-142 | 422 |
| LLPS-Fia-2614 | Ficedula albicollis | 48.14 | 4e-138 | 411 |
| LLPS-Myl-1815 | Myotis lucifugus | 47.13 | 3e-136 | 404 |
| LLPS-Meg-0952 | Meleagris gallopavo | 46.72 | 7e-141 | 417 |
| LLPS-Sem-1780 | Selaginella moellendorffii | 46.32 | 2e-86 | 272 |
| LLPS-Php-2319 | Physcomitrella patens | 43.1 | 3e-06 | 52.8 |
| LLPS-Tra-2832 | Triticum aestivum | 40.94 | 8e-16 | 81.6 |
| LLPS-Hov-1642 | Hordeum vulgare | 39.69 | 5e-15 | 79.7 |
| LLPS-Lep-1671 | Leersia perrieri | 37.42 | 5e-26 | 110 |
| LLPS-Sei-1717 | Setaria italica | 36.59 | 2e-24 | 106 |
| LLPS-Crn-0295 | Cryptococcus neoformans | 35.83 | 9e-14 | 76.6 |
| LLPS-Gaa-1027 | Gasterosteus aculeatus | 35.74 | 1e-41 | 155 |
| LLPS-Pof-0621 | Poecilia formosa | 35.74 | 3e-42 | 157 |
| LLPS-Orn-0386 | Oreochromis niloticus | 35.74 | 7e-42 | 155 |
| LLPS-Drm-0507 | Drosophila melanogaster | 35.41 | 3e-41 | 154 |
| LLPS-Xet-0522 | Xenopus tropicalis | 35.41 | 6e-42 | 156 |
| LLPS-Sah-1670 | Sarcophilus harrisii | 35.34 | 2e-41 | 154 |
| LLPS-Mam-2300 | Macaca mulatta | 35.34 | 2e-41 | 155 |
| LLPS-Anc-0825 | Anolis carolinensis | 35.34 | 3e-41 | 154 |
| LLPS-Pes-0019 | Pelodiscus sinensis | 35.34 | 2e-41 | 154 |
| LLPS-Org-2252 | Oryza glaberrima | 35.09 | 1e-23 | 103 |
| LLPS-Ors-1106 | Oryza sativa | 35.09 | 1e-23 | 103 |
| LLPS-Orp-2192 | Oryza punctata | 34.91 | 1e-23 | 103 |
| LLPS-Sob-1767 | Sorghum bicolor | 34.82 | 4e-38 | 145 |
| LLPS-Ova-2373 | Ovis aries | 34.68 | 7e-42 | 155 |
| LLPS-Zem-1499 | Zea mays | 34.41 | 3e-37 | 142 |
| LLPS-Thc-0178 | Theobroma cacao | 34.35 | 2e-42 | 157 |
| LLPS-Sot-1154 | Solanum tuberosum | 33.72 | 7e-41 | 152 |
| LLPS-Sol-0428 | Solanum lycopersicum | 33.72 | 6e-41 | 152 |
| LLPS-Cus-2080 | Cucumis sativus | 33.46 | 2e-39 | 149 |
| LLPS-Gor-2545 | Gossypium raimondii | 33.46 | 1e-38 | 147 |
| LLPS-Cii-1105 | Ciona intestinalis | 33.33 | 3e-14 | 78.2 |
| LLPS-Cis-1325 | Ciona savignyi | 33.33 | 2e-38 | 147 |
| LLPS-Hea-1495 | Helianthus annuus | 33.33 | 6e-40 | 150 |
| LLPS-Mua-0915 | Musa acuminata | 33.12 | 2e-39 | 149 |
| LLPS-Mae-0054 | Manihot esculenta | 33.08 | 1e-38 | 147 |
| LLPS-Arl-2861 | Arabidopsis lyrata | 32.95 | 2e-39 | 149 |
| LLPS-Prp-2085 | Prunus persica | 32.71 | 4e-39 | 148 |
| LLPS-Abg-1768 | Absidia glauca | 32.57 | 5e-40 | 152 |
| LLPS-Art-2692 | Arabidopsis thaliana | 32.57 | 4e-38 | 145 |
| LLPS-Tut-2058 | Tursiops truncatus | 32.46 | 9e-13 | 73.6 |
| LLPS-Vir-0994 | Vigna radiata | 32.45 | 3e-37 | 143 |
| LLPS-Phv-1454 | Phaseolus vulgaris | 32.45 | 1e-37 | 144 |
| LLPS-Brn-2608 | Brassica napus | 32.18 | 1e-39 | 149 |
| LLPS-Ten-0356 | Tetraodon nigroviridis | 32.18 | 7e-29 | 120 |
| LLPS-Bro-2983 | Brassica oleracea | 32.18 | 5e-39 | 147 |
| LLPS-Brr-1568 | Brassica rapa | 32.18 | 2e-39 | 149 |
| LLPS-Tum-1611 | Tuber melanosporum | 32.13 | 3e-38 | 146 |
| LLPS-Met-0856 | Medicago truncatula | 32.08 | 3e-37 | 143 |
| LLPS-Pot-0047 | Populus trichocarpa | 32.06 | 6e-37 | 142 |