DrLLPS - Data resource of LLPS

LLPS-Bot-0442
ADRM1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Proteasomal ubiquitin receptor ADRM1; Rpn13 homolog
Gene Name:	ADRM1
Ensembl Gene:	ENSBTAG00000003058.5
Ensembl Protein:	ENSBTAP00000003974.4
Organism:	Bos taurus
Taxa ID:	9913
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Others	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1576	Q16186	Client	Others	98.84	5e-99	308

▼ FUNCTION

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSBTAT00000003974.5	ENSBTAP00000003974.4
Ensembl	ENSBTAT00000053803.2	ENSBTAP00000049144.2
UniProt		A1L5A6, ADRM1_BOVIN
GeneBank	BT029893	ABM21559.1
RefSeq	NM_001080282.1	NP_001073751.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MTTSGALFPS LVPGSRGSSN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC 60 61 WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH 120 121 CRKVNEYLNN PPMPGALGAS GSGGHELSAL GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL 180 181 GGLGALTGPG LASLLGSGGP PASSSSSSSR SQSAAVTPSS TTSSTRATPA PSAPAAASAT 240 241 SPSPAPSSGD GASTAASPAQ PIQLSDLQSI LATMSVPAGP GGGQQVDLAS VLTPEIMAPI 300 301 LANADVQERL LPYLPSGESL PQTAEEIQNT LTSPQFQQAL GMFSAALASG QLGPLMCQFG 360 361 LPAEAVEAAN KGDVEAFAKA MQNSASPEQQ EGDGKDKKDE EEDMSLD 407
Nucleotide CDS Sequence (FASTA)
1 ATGACGACTT CAGGAGCTCT GTTTCCAAGC CTGGTGCCAG GCTCCCGTGG GTCCTCCAAC 60 61 AAGTATTTGG TGGAGTTTCG GGCCGGAAAA ATGTCATTAA AAGGAACTAC CGTCACCCCA 120 121 GATAAACGGA AAGGGCTTGT GTACATTCAG CAGACGGATG ACTCCCTCAT TCACTTTTGC 180 181 TGGAAAGACA GGACATCGGG GAACGTGGAA GATGATCTGA TCATCTTCCC CGATGACTGT 240 241 GAGTTCAAGC GCGTGCCACA GTGCCCCAGC GGGAGGGTCT ACGTGCTCAA GTTTAAGGCA 300 301 GGGTCCAAAC GACTCTTCTT CTGGATGCAG GAGCCCAAGA CGGACCAGGA TGAGGAGCAC 360 361 TGCCGGAAAG TCAACGAGTA TCTGAACAAC CCGCCGATGC CCGGAGCCCT GGGGGCGAGT 420 421 GGGAGCGGAG GCCACGAGCT GTCTGCGCTG GGCGGGGAGG GTGGCCTGCA GAGCCTGCTG 480 481 GGGAACATGA GCCACAGCCA ACTCATGCAG CTCATCGGGC CCGCCGGCCT CGGAGGACTG 540 541 GGTGGCCTGG GGGCCCTGAC CGGGCCGGGC CTGGCCAGCT TACTGGGGAG CGGAGGGCCT 600 601 CCAGCAAGCA GCTCTTCATC CAGCTCCCGG AGCCAGTCAG CAGCAGTCAC CCCATCCTCC 660 661 ACCACCTCTT CCACTCGCGC CACCCCAGCC CCTTCCGCTC CAGCAGCTGC CTCAGCGACC 720 721 AGCCCGAGCC CCGCGCCCAG CTCAGGTGAC GGAGCCAGCA CAGCAGCCAG CCCCGCCCAG 780 781 CCCATCCAGC TCAGCGACCT GCAGAGCATC CTGGCTACCA TGAGTGTGCC GGCTGGGCCG 840 841 GGAGGCGGCC AACAAGTTGA CCTGGCCAGC GTGCTGACAC CTGAGATCAT GGCCCCCATC 900 901 CTTGCCAACG CGGATGTCCA GGAGCGCCTG CTGCCCTACC TGCCATCAGG GGAGTCCCTG 960 961 CCACAGACCG CAGAGGAGAT CCAGAACACG CTGACCTCAC CCCAGTTCCA GCAGGCCCTC 1020 1021 GGCATGTTCA GTGCGGCCTT GGCCTCAGGG CAGCTGGGCC CCCTCATGTG CCAGTTTGGG 1080 1081 CTGCCCGCGG AGGCTGTGGA GGCCGCCAAC AAGGGTGACG TGGAAGCATT TGCCAAAGCC 1140 1141 ATGCAGAATA GCGCCAGCCC CGAGCAGCAG GAGGGCGATG GGAAGGACAA GAAGGATGAA 1200 1201 GAAGAGGACA TGAGCCTGGA TTAG 1224

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-1017	Isopeptide bond
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0647	Proteasome
KW-1185	Reference proteome
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0005654	Cellular Component	Nucleoplasm
GO:0005886	Cellular Component	Plasma membrane
GO:0000502	Cellular Component	Proteasome complex
GO:0008541	Cellular Component	Proteasome regulatory particle, lid subcomplex
GO:0061133	Molecular Function	Endopeptidase activator activity
GO:0002020	Molecular Function	Protease binding
GO:0070628	Molecular Function	Proteasome binding
GO:0043130	Molecular Function	Ubiquitin binding
GO:0043248	Biological Process	Proteasome assembly
GO:0006368	Biological Process	Transcription elongation from RNA polymerase II promoter
GO:0006511	Biological Process	Ubiquitin-dependent protein catabolic process

▼ KEGG

bta:519729

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Sus-3179	Sus scrofa	100.0	2e-95	291
LLPS-Aim-2765	Ailuropoda melanoleuca	100.0	4e-99	308
LLPS-Ova-1671	Ovis aries	100.0	4e-78	254
LLPS-Fec-2739	Felis catus	100.0	2e-99	309
LLPS-Cas-3685	Carlito syrichta	100.0	1e-43	160
LLPS-Fud-2174	Fukomys damarensis	99.42	1e-98	307
LLPS-Ere-0833	Erinaceus europaeus	99.42	2e-98	306
LLPS-Myl-0759	Myotis lucifugus	99.42	1e-98	307
LLPS-Otg-3596	Otolemur garnettii	99.42	2e-100	311
LLPS-Ict-3705	Ictidomys tridecemlineatus	99.42	1e-98	307
LLPS-Caf-2952	Canis familiaris	99.21	1e-75	247
LLPS-Chs-1720	Chlorocebus sabaeus	98.84	2e-99	309
LLPS-Maf-1662	Macaca fascicularis	98.84	2e-99	309
LLPS-Cea-2495	Cercocebus atys	98.84	2e-99	309
LLPS-Gog-4722	Gorilla gorilla	98.84	2e-99	309
LLPS-Paa-2860	Papio anubis	98.84	2e-99	309
LLPS-Mal-3724	Mandrillus leucophaeus	98.84	4e-99	308
LLPS-Pat-2549	Pan troglodytes	98.84	2e-99	309
LLPS-Pap-2532	Pan paniscus	98.84	2e-99	309
LLPS-Hos-1576	Homo sapiens	98.84	2e-99	309
LLPS-Loa-0167	Loxodonta africana	98.84	5e-99	308
LLPS-Man-4842	Macaca nemestrina	98.84	2e-99	309
LLPS-Rhb-1388	Rhinopithecus bieti	98.84	1e-99	309
LLPS-Cap-0108	Cavia porcellus	98.84	8e-99	307
LLPS-Mam-2148	Macaca mulatta	98.84	2e-99	309
LLPS-Mup-0552	Mustela putorius furo	98.44	1e-76	248
LLPS-Mea-4249	Mesocricetus auratus	98.26	3e-96	301
LLPS-Aon-1593	Aotus nancymaae	98.26	2e-97	304
LLPS-Caj-0645	Callithrix jacchus	97.67	3e-96	301
LLPS-Dio-3854	Dipodomys ordii	97.67	2e-97	303
LLPS-Poa-4554	Pongo abelii	97.67	3e-94	295
LLPS-Mum-4170	Mus musculus	97.09	7e-96	300
LLPS-Ran-1727	Rattus norvegicus	97.09	9e-97	302
LLPS-Tut-1314	Tursiops truncatus	96.62	7e-77	250
LLPS-Sah-1995	Sarcophilus harrisii	96.47	3e-94	295
LLPS-Mod-3296	Monodelphis domestica	95.88	3e-94	295
LLPS-Tag-1302	Taeniopygia guttata	95.45	4e-91	279
LLPS-Ora-1902	Ornithorhynchus anatinus	95.29	5e-94	295
LLPS-Nol-2972	Nomascus leucogenys	94.59	3e-74	244
LLPS-Pes-1375	Pelodiscus sinensis	94.12	1e-91	290
LLPS-Fia-1520	Ficedula albicollis	94.12	4e-94	295
LLPS-Gaga-1572	Gallus gallus	94.12	4e-94	295
LLPS-Anc-1896	Anolis carolinensis	94.12	1e-92	290
LLPS-Xet-0730	Xenopus tropicalis	93.53	9e-91	286
LLPS-Anp-3040	Anas platyrhynchos	93.07	3e-41	154
LLPS-Scf-3954	Scleropages formosus	91.76	3e-89	283
LLPS-Leo-3500	Lepisosteus oculatus	90.59	2e-88	281
LLPS-Lac-1802	Latimeria chalumnae	90.0	7e-88	280
LLPS-Dar-4032	Danio rerio	90.0	1e-80	261
LLPS-Gaa-2166	Gasterosteus aculeatus	89.35	1e-87	279
LLPS-Scm-2176	Scophthalmus maximus	89.35	4e-86	275
LLPS-Xim-2748	Xiphophorus maculatus	88.76	2e-85	273
LLPS-Orn-1175	Oreochromis niloticus	88.69	5e-85	275
LLPS-Pof-3687	Poecilia formosa	87.57	2e-77	252
LLPS-Icp-0442	Ictalurus punctatus	86.47	6e-87	277
LLPS-Tar-1062	Takifugu rubripes	85.8	1e-76	251
LLPS-Ten-3713	Tetraodon nigroviridis	85.47	6e-85	271
LLPS-Orl-0338	Oryzias latipes	84.12	1e-84	271
LLPS-Asm-1037	Astyanax mexicanus	81.08	2e-61	210
LLPS-Cis-0362	Ciona savignyi	73.83	8e-54	190
LLPS-Drm-0552	Drosophila melanogaster	71.56	5e-54	191
LLPS-Cii-2072	Ciona intestinalis	70.68	4e-62	211
LLPS-Lep-2066	Leersia perrieri	56.88	1e-35	140
LLPS-Art-3104	Arabidopsis thaliana	56.76	4e-37	142
LLPS-Met-2178	Medicago truncatula	55.96	5e-34	134
LLPS-Orbr-1981	Oryza brachyantha	55.96	6e-36	139
LLPS-Arl-1057	Arabidopsis lyrata	55.86	3e-36	140
LLPS-Sol-0868	Solanum lycopersicum	55.05	2e-32	129
LLPS-Ori-1583	Oryza indica	55.05	2e-34	134
LLPS-Tra-1826	Triticum aestivum	55.05	2e-34	134
LLPS-Ors-0045	Oryza sativa	55.05	2e-34	134
LLPS-Sob-1705	Sorghum bicolor	55.05	9e-35	136
LLPS-Org-1204	Oryza glaberrima	55.05	2e-34	134
LLPS-Hov-1102	Hordeum vulgare	54.13	7e-34	133
LLPS-Mae-0715	Manihot esculenta	54.13	1e-33	132
LLPS-Prp-0854	Prunus persica	54.05	8e-34	133
LLPS-Cus-2228	Cucumis sativus	53.7	6e-33	131
LLPS-Php-2244	Physcomitrella patens	53.21	1e-32	130
LLPS-Brn-0354	Brassica napus	53.15	3e-34	134
LLPS-Brr-1050	Brassica rapa	53.15	3e-34	134
LLPS-Amt-1832	Amborella trichopoda	53.15	2e-34	136
LLPS-Bro-1347	Brassica oleracea	53.15	6e-33	133
LLPS-Mua-0349	Musa acuminata	52.48	4e-28	117
LLPS-Brd-1261	Brachypodium distachyon	52.34	2e-31	126
LLPS-Dac-2104	Daucus carota	52.29	8e-32	127
LLPS-Cae-1626	Caenorhabditis elegans	51.61	2e-35	139
LLPS-Viv-1954	Vitis vinifera	51.35	1e-33	133
LLPS-Pot-2566	Populus trichocarpa	51.35	5e-32	128
LLPS-Hea-0694	Helianthus annuus	50.5	3e-28	117
LLPS-Abg-0530	Absidia glauca	50.0	1e-33	134
LLPS-Scj-0415	Schizosaccharomyces japonicus	48.67	4e-28	118
LLPS-Nia-1877	Nicotiana attenuata	48.51	3e-25	108
LLPS-Sem-2048	Selaginella moellendorffii	47.75	1e-26	112
LLPS-Orb-1478	Oryza barthii	47.71	9e-25	107
LLPS-Orni-0820	Oryza nivara	47.71	9e-25	107
LLPS-Orgl-0099	Oryza glumaepatula	47.71	9e-25	107
LLPS-Orr-2377	Oryza rufipogon	47.71	9e-25	107
LLPS-Coc-2054	Corchorus capsularis	47.69	3e-32	129
LLPS-Gor-2261	Gossypium raimondii	46.92	1e-33	133
LLPS-Orp-1427	Oryza punctata	46.79	7e-24	105
LLPS-Glm-0628	Glycine max	46.15	2e-32	129
LLPS-Orm-0284	Oryza meridionalis	45.87	2e-23	102
LLPS-Scp-1539	Schizosaccharomyces pombe	45.69	5e-26	112
LLPS-Tru-1558	Triticum urartu	44.95	7e-23	101
LLPS-Miv-1405	Microbotryum violaceum	42.59	4e-14	76.6
LLPS-Scc-1433	Schizosaccharomyces cryophilus	42.4	3e-26	113
LLPS-Chr-1553	Chlamydomonas reinhardtii	42.17	4e-06	52.4
LLPS-Via-2133	Vigna angularis	41.41	4e-24	105
LLPS-Cym-0428	Cyanidioschyzon merolae	41.23	3e-25	108
LLPS-Dos-0873	Dothistroma septosporum	40.4	4e-15	80.5
LLPS-Zyt-0881	Zymoseptoria tritici	39.39	4e-14	75.1
LLPS-Cog-0844	Colletotrichum gloeosporioides	39.22	6e-12	70.9
LLPS-Thc-0855	Theobroma cacao	38.67	4e-26	112
LLPS-Vir-2199	Vigna radiata	38.56	9e-27	114
LLPS-Pug-1138	Puccinia graminis	38.39	3e-18	88.2
LLPS-Coo-0610	Colletotrichum orbiculare	38.24	1e-11	70.1
LLPS-Pyt-1011	Pyrenophora teres	37.38	2e-11	68.9
LLPS-Blg-0788	Blumeria graminis	37.37	8e-11	65.5
LLPS-Trr-0711	Trichoderma reesei	37.25	4e-10	65.5
LLPS-Asn-1105	Aspergillus nidulans	37.11	7e-11	67.4
LLPS-Lem-1479	Leptosphaeria maculans	37.04	7e-12	68.6
LLPS-Zem-0407	Zea mays	36.99	1e-21	98.6
LLPS-Yal-0914	Yarrowia lipolytica	36.96	2e-11	68.2
LLPS-Osl-1447	Ostreococcus lucimarinus	36.8	1e-08	60.5
LLPS-Asc-1555	Aspergillus clavatus	36.63	7e-11	67.8
LLPS-Crn-1188	Cryptococcus neoformans	36.61	4e-17	85.1
LLPS-Cogr-1510	Colletotrichum graminicola	36.27	2e-10	66.2
LLPS-Mao-0083	Magnaporthe oryzae	36.19	2e-07	57.0
LLPS-Ved-1034	Verticillium dahliae	36.0	4e-11	68.6
LLPS-Tum-0740	Tuber melanosporum	35.83	3e-17	85.5
LLPS-Ast-1404	Aspergillus terreus	35.64	5e-09	61.6
LLPS-Nef-1650	Neosartorya fischeri	35.64	1e-09	63.5
LLPS-Mel-1535	Melampsora laricipopulina	35.29	1e-15	80.5
LLPS-Nec-0988	Neurospora crassa	35.29	6e-10	64.7
LLPS-Fus-1031	Fusarium solani	35.29	9e-10	63.9
LLPS-Map-1334	Magnaporthe poae	35.24	1e-08	60.5
LLPS-Phv-0848	Phaseolus vulgaris	34.88	3e-10	63.9
LLPS-Phn-1079	Phaeosphaeria nodorum	34.86	3e-10	63.5
LLPS-Aso-1373	Aspergillus oryzae	34.55	2e-11	69.3
LLPS-Asf-0565	Aspergillus flavus	34.55	2e-11	69.3
LLPS-Gag-0754	Gaeumannomyces graminis	34.29	5e-08	58.5
LLPS-Asni-0226	Aspergillus niger	34.26	2e-10	66.6
LLPS-Scs-1071	Sclerotinia sclerotiorum	33.98	6e-08	56.6
LLPS-Beb-1471	Beauveria bassiana	32.46	5e-08	58.5
LLPS-Asg-1023	Ashbya gossypii	32.35	9e-07	52.4
LLPS-Gas-0263	Galdieria sulphuraria	31.43	6e-09	60.8
LLPS-Fuv-0956	Fusarium verticillioides	30.71	3e-10	65.5
LLPS-Fuo-0063	Fusarium oxysporum	30.71	2e-10	66.2

LLPS-Bot-0442ADRM1

Protein Sequence

Nucleotide Sequence

LLPS-Bot-0442
ADRM1