• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-0067
NOC4L

Integrated Annotations

▼ OVERVIEW

Status: Reviewed
Protein Name: Nucleolar complex associated 4 homolog
Gene Name: NOC4L
Ensembl Gene: ENSBTAG00000011889.6
Ensembl Protein: ENSBTAP00000015774.6
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...The proteomic analysis of the MDBK cell nucleoli identified a total of 311 proteins."
MDBK cells20970743

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSBTAT00000015774.6ENSBTAP00000015774.6
UniProtF1MFW8, F1MFW8_BOVIN

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEGDAGPGDA  RRALGHLVEA  VLASRGEANA  VFDILAVLQS  EDQEEIQEAV  HACSRLFGAL  60
61    LARGELFVGQ  LPSEEMVLTG  SRGATRKYKI  WMRHRYQSCC  NRLGELLAHP  SFQVKELALS  120
121   TLMKFVQLEG  EHPLEKPKWE  GNYLFPHQLF  MLVVGGLLSP  EEDRSLLLSQ  FREYLEHDDI  180
181   RYHTMQAASN  TVARTTDGRP  EVPLTFWNNA  FMLLSSVSLP  RQESTLSSFY  VKHTELSDKW  240
241   KVVHLKEHRK  AFQQMWLHFL  KHQLPLRVCK  KVLVIMHDSI  LPHLAQPSLM  IDFLTRAYDI  300
301   GGAVSLLALN  GLFILIHKHN  LEYPDFYRKL  YGLLDPSVFH  VKYRARFFHL  ADLFLSSSHL  360
361   PAYLVAAFTK  RLARLALTAP  PEALLMVLPF  ICNLLRRHPA  CRVLMHRPRG  PELDADPYDP  420
421   TEEDPAQSRA  LESSLWELQA  LQQHYHPEVS  KAASAINQAL  SVPEVSIAPL  LEVTAFEIFE  480
481   RDLKKKGPGS  VPLEFIPARG  LLGRREDLCA  QHFTLS  516
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGGGG  ACGCCGGCCC  CGGGGACGCG  CGGCGGGCGC  TGGGCCACCT  AGTGGAGGCG  60
61    GTACTGGCCA  GCCGCGGCGA  GGCCAACGCC  GTGTTCGACA  TCCTGGCCGT  TCTGCAGTCT  120
121   GAGGACCAGG  AGGAGATCCA  GGAAGCCGTG  CACGCATGCA  GCCGACTTTT  CGGGGCCCTG  180
181   CTAGCCCGAG  GAGAACTGTT  TGTGGGACAA  CTGCCCTCTG  AGGAGATGGT  CCTGACAGGG  240
241   TCCCGGGGGG  CCACTCGCAA  ATACAAGATT  TGGATGCGGC  ACCGGTACCA  GAGCTGCTGC  300
301   AACCGCCTGG  GGGAGCTGTT  GGCTCACCCC  TCCTTTCAGG  TCAAGGAGCT  GGCCCTCAGC  360
361   ACACTCATGA  AGTTTGTGCA  GCTGGAGGGT  GAGCACCCAC  TGGAGAAGCC  CAAGTGGGAA  420
421   GGCAACTATC  TGTTCCCCCA  CCAGCTCTTC  ATGTTGGTGG  TGGGAGGCCT  GCTGTCTCCA  480
481   GAGGAGGACC  GCTCCCTGCT  CCTCTCCCAG  TTCCGGGAGT  ATCTGGAACA  CGATGACATC  540
541   CGCTACCATA  CGATGCAGGC  TGCCTCCAAC  ACCGTGGCCC  GGACCACCGA  TGGGCGCCCT  600
601   GAGGTGCCGC  TCACTTTCTG  GAACAATGCC  TTCATGCTGC  TGTCCTCTGT  GAGCCTGCCC  660
661   CGCCAGGAGA  GCACCCTCTC  CAGCTTCTAT  GTGAAGCACA  CAGAGCTGTC  AGACAAGTGG  720
721   AAGGTCGTTC  ATCTGAAGGA  GCACAGGAAG  GCCTTCCAGC  AGATGTGGCT  CCACTTCCTC  780
781   AAGCACCAGC  TGCCTCTCCG  CGTCTGCAAG  AAGGTGCTGG  TAATCATGCA  CGACTCCATC  840
841   CTGCCCCACC  TGGCGCAGCC  CAGCCTCATG  ATCGACTTCC  TCACCCGCGC  CTATGACATC  900
901   GGTGGAGCCG  TCAGCCTGCT  GGCCTTGAAT  GGACTTTTCA  TCTTGATTCA  TAAACACAAC  960
961   CTGGAGTACC  CTGACTTCTA  CCGGAAGCTG  TATGGCCTTC  TCGATCCGTC  CGTCTTCCAC  1020
1021  GTGAAGTACC  GGGCCCGCTT  CTTTCACTTG  GCCGACCTCT  TCCTGTCGTC  CTCGCACCTG  1080
1081  CCTGCCTACC  TGGTGGCTGC  CTTCACCAAG  CGTCTGGCCC  GCCTGGCCCT  GACAGCACCC  1140
1141  CCCGAGGCCC  TGCTCATGGT  CCTGCCCTTT  ATCTGCAACC  TGCTGCGCAG  ACACCCGGCC  1200
1201  TGCCGGGTCC  TCATGCATCG  GCCCCGGGGC  CCTGAGCTGG  ACGCCGACCC  CTATGACCCC  1260
1261  ACAGAGGAGG  ACCCGGCCCA  GAGCCGAGCC  CTGGAGAGCT  CCCTGTGGGA  GCTGCAGGCC  1320
1321  CTCCAGCAGC  ATTACCACCC  CGAGGTGTCC  AAGGCCGCCA  GCGCCATCAA  CCAGGCACTG  1380
1381  TCCGTGCCTG  AGGTCAGCAT  CGCCCCGCTG  CTGGAGGTCA  CCGCCTTTGA  GATCTTTGAG  1440
1441  CGGGACCTGA  AGAAGAAGGG  GCCTGGGTCG  GTGCCGCTGG  AGTTCATCCC  AGCACGGGGC  1500
1501  CTGCTGGGCC  GGCGGGAGGA  CCTCTGTGCC  CAGCATTTCA  CGCTGAGCTG  A  1551

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-2434Ovis aries97.670.01033
LLPS-Sus-2188Sus scrofa87.660.0 956
LLPS-Urm-0990Ursus maritimus86.070.0 780
LLPS-Mal-2007Mandrillus leucophaeus85.950.0 818
LLPS-Eqc-0055Equus caballus85.280.0 883
LLPS-Chs-1098Chlorocebus sabaeus85.270.0 874
LLPS-Rhb-1310Rhinopithecus bieti85.270.0 875
LLPS-Caj-1862Callithrix jacchus85.090.0 811
LLPS-Paa-1607Papio anubis84.880.0 870
LLPS-Cea-1363Cercocebus atys84.880.0 869
LLPS-Maf-1265Macaca fascicularis84.880.0 870
LLPS-Man-0577Macaca nemestrina84.880.0 872
LLPS-Pap-1031Pan paniscus84.720.0 870
LLPS-Gog-0377Gorilla gorilla84.50.0 869
LLPS-Mam-0644Macaca mulatta84.50.0 866
LLPS-Hos-2166Homo sapiens84.50.0 870
LLPS-Pat-0662Pan troglodytes84.50.0 870
LLPS-Fec-2044Felis catus84.140.0 885
LLPS-Mup-2393Mustela putorius furo83.640.0 738
LLPS-Otg-1440Otolemur garnettii83.530.0 885
LLPS-Myl-0877Myotis lucifugus83.140.0 860
LLPS-Caf-2132Canis familiaris82.750.0 865
LLPS-Aon-1814Aotus nancymaae82.470.0 852
LLPS-Aim-0241Ailuropoda melanoleuca82.180.0 838
LLPS-Ict-1796Ictidomys tridecemlineatus81.80.0 853
LLPS-Orc-1904Oryctolagus cuniculus80.776e-29 122
LLPS-Cap-1484Cavia porcellus80.230.0 850
LLPS-Dio-0759Dipodomys ordii80.120.0 825
LLPS-Mea-0587Mesocricetus auratus79.880.0 839
LLPS-Loa-1198Loxodonta africana79.720.0 813
LLPS-Fud-0012Fukomys damarensis79.270.0 800
LLPS-Mum-0896Mus musculus78.680.0 829
LLPS-Ran-0120Rattus norvegicus78.290.0 837
LLPS-Sah-0257Sarcophilus harrisii72.290.0 721
LLPS-Mod-0141Monodelphis domestica71.670.0 712
LLPS-Poa-0470Pongo abelii70.80.0 612
LLPS-Ora-0331Ornithorhynchus anatinus66.970.0 603
LLPS-Pes-0976Pelodiscus sinensis63.620.0 564
LLPS-Meg-1801Meleagris gallopavo61.041e-160 468
LLPS-Fia-0536Ficedula albicollis60.890.0 542
LLPS-Gaga-0308Gallus gallus59.330.0 621
LLPS-Tag-0951Taeniopygia guttata58.90.0 608
LLPS-Anc-2438Anolis carolinensis57.890.0 599
LLPS-Icp-1268Ictalurus punctatus57.590.0 597
LLPS-Xet-2961Xenopus tropicalis56.750.0 607
LLPS-Orn-2619Oreochromis niloticus56.590.0 580
LLPS-Lac-0688Latimeria chalumnae56.40.0 589
LLPS-Leo-0594Lepisosteus oculatus56.070.0 598
LLPS-Asm-0802Astyanax mexicanus56.010.0 598
LLPS-Xim-0564Xiphophorus maculatus55.980.0 562
LLPS-Gaa-0030Gasterosteus aculeatus55.880.0 567
LLPS-Scf-1575Scleropages formosus55.792e-180 525
LLPS-Orl-2800Oryzias latipes55.40.0 560
LLPS-Scm-2450Scophthalmus maximus55.40.0 570
LLPS-Dar-1430Danio rerio55.230.0 582
LLPS-Ten-0315Tetraodon nigroviridis54.60.0 550
LLPS-Pof-0220Poecilia formosa54.580.0 552
LLPS-Usm-0196Ustilago maydis50.273e-50 188
LLPS-Chr-1038Chlamydomonas reinhardtii45.142e-55 202
LLPS-Mua-1269Musa acuminata43.113e-69 234
LLPS-Amt-1158Amborella trichopoda42.769e-63 222
LLPS-Tar-0454Takifugu rubripes42.722e-63 215
LLPS-Coc-1147Corchorus capsularis42.592e-61 218
LLPS-Hea-0223Helianthus annuus42.323e-57 206
LLPS-Osl-0419Ostreococcus lucimarinus41.951e-68 233
LLPS-Brn-2342Brassica napus41.732e-58 209
LLPS-Mel-0828Melampsora laricipopulina41.561e-53 187
LLPS-Mae-0671Manihot esculenta41.112e-0655.1
LLPS-Bro-0369Brassica oleracea40.863e-57 206
LLPS-Brr-0135Brassica rapa40.863e-57 206
LLPS-Asni-0528Aspergillus niger39.883e-70 239
LLPS-Sol-1139Solanum lycopersicum39.725e-60 214
LLPS-Pug-0286Puccinia graminis39.692e-57 208
LLPS-Scs-0003Sclerotinia sclerotiorum39.24e-69 233
LLPS-Prp-0246Prunus persica39.088e-0653.1
LLPS-Glm-0332Glycine max38.543e-0757.4
LLPS-Viv-0469Vitis vinifera38.541e-0758.5
LLPS-Cus-0752Cucumis sativus38.382e-0654.7
LLPS-Crn-0266Cryptococcus neoformans37.991e-53 197
LLPS-Spr-0166Sporisorium reilianum37.975e-54 199
LLPS-Thc-0465Theobroma cacao36.842e-53 197
LLPS-Pot-1398Populus trichocarpa36.841e-0655.5
LLPS-Cii-0105Ciona intestinalis36.598e-85 278
LLPS-Vir-1074Vigna radiata36.465e-0653.5
LLPS-Via-1022Vigna angularis36.466e-0653.5
LLPS-Ast-0044Aspergillus terreus35.741e-71 244
LLPS-Fuv-0648Fusarium verticillioides35.77e-78 258
LLPS-Php-0761Physcomitrella patens35.564e-72 248
LLPS-Cogr-0848Colletotrichum graminicola35.465e-85 280
LLPS-Sob-1969Sorghum bicolor35.366e-72 246
LLPS-Zyt-0707Zymoseptoria tritici35.338e-55 206
LLPS-Coo-0456Colletotrichum orbiculare35.131e-81 270
LLPS-Fuo-0438Fusarium oxysporum35.064e-75 251
LLPS-Cog-0229Colletotrichum gloeosporioides34.945e-79 263
LLPS-Phn-0417Phaeosphaeria nodorum34.885e-79 263
LLPS-Pytr-0150Pyrenophora triticirepentis34.731e-78 263
LLPS-Map-0475Magnaporthe poae34.653e-79 264
LLPS-Scj-0987Schizosaccharomyces japonicus34.562e-63 221
LLPS-Sem-0018Selaginella moellendorffii34.532e-0758.2
LLPS-Asn-1211Aspergillus nidulans34.486e-76 256
LLPS-Yal-0891Yarrowia lipolytica34.337e-82 271
LLPS-Tum-0905Tuber melanosporum34.35e-70 240
LLPS-Nef-0197Neosartorya fischeri34.263e-73 248
LLPS-Trr-0004Trichoderma reesei34.262e-82 273
LLPS-Chc-0514Chondrus crispus34.152e-37 148
LLPS-Sei-0588Setaria italica34.091e-69 239
LLPS-Fus-0321Fusarium solani34.063e-0963.9
LLPS-Pyt-0769Pyrenophora teres34.031e-74 252
LLPS-Drm-0402Drosophila melanogaster33.964e-62 217
LLPS-Asc-0468Aspergillus clavatus33.913e-75 254
LLPS-Ors-0217Oryza sativa33.841e-67 234
LLPS-Tra-0686Triticum aestivum33.799e-0859.3
LLPS-Tru-1122Triticum urartu33.796e-0859.3
LLPS-Hov-1274Hordeum vulgare33.788e-69 238
LLPS-Trv-0017Trichoderma virens33.664e-81 270
LLPS-Beb-0618Beauveria bassiana33.64e-78 261
LLPS-Mao-0090Magnaporthe oryzae33.595e-77 258
LLPS-Cae-1245Caenorhabditis elegans33.573e-41 160
LLPS-Asfu-0122Aspergillus fumigatus33.521e-70 242
LLPS-Ved-0258Verticillium dahliae33.45e-78 261
LLPS-Orni-0857Oryza nivara33.192e-65 229
LLPS-Ori-1513Oryza indica33.193e-67 233
LLPS-Orb-0734Oryza barthii33.192e-65 229
LLPS-Orr-1351Oryza rufipogon33.192e-65 229
LLPS-Sac-1165Saccharomyces cerevisiae33.122e-66 230
LLPS-Brd-1181Brachypodium distachyon33.115e-0756.6
LLPS-Nec-0349Neurospora crassa33.079e-80 266
LLPS-Orbr-0864Oryza brachyantha32.719e-69 238
LLPS-Asf-0797Aspergillus flavus32.677e-80 266
LLPS-Aso-0119Aspergillus oryzae32.677e-80 266
LLPS-Dos-0146Dothistroma septosporum32.542e-66 230
LLPS-Orgl-1545Oryza glumaepatula32.531e-60 215
LLPS-Scp-0423Schizosaccharomyces pombe32.399e-68 232
LLPS-Met-0434Medicago truncatula32.354e-0757.0
LLPS-Lep-0483Leersia perrieri32.353e-1067.0
LLPS-Abg-0139Absidia glauca32.241e-82 275
LLPS-Gor-0988Gossypium raimondii32.185e-1066.2
LLPS-Gag-0471Gaeumannomyces graminis32.123e-75 254
LLPS-Asg-0869Ashbya gossypii32.059e-68 233
LLPS-Scc-0084Schizosaccharomyces cryophilus32.022e-64 223
LLPS-Arl-0729Arabidopsis lyrata31.995e-58 208
LLPS-Dac-0026Daucus carota31.943e-0757.8
LLPS-Art-0180Arabidopsis thaliana31.787e-58 207
LLPS-Phv-0752Phaseolus vulgaris31.711e-60 216
LLPS-Blg-0555Blumeria graminis31.621e-74 252
LLPS-Zem-0905Zea mays31.626e-57 206
LLPS-Orp-0329Oryza punctata31.491e-0862.4
LLPS-Cym-0387Cyanidioschyzon merolae31.289e-1168.6
LLPS-Nia-1378Nicotiana attenuata31.172e-59 213
LLPS-Kop-0646Komagataella pastoris30.695e-62 219
LLPS-Org-0082Oryza glaberrima30.12e-0861.2
LLPS-Miv-0777Microbotryum violaceum29.916e-67 235
LLPS-Gas-0664Galdieria sulphuraria28.751e-23 107
LLPS-Put-0028Puccinia triticina25.072e-1685.1