• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-0003
RPL7

Integrated Annotations

▼ OVERVIEW

Status: Reviewed
Protein Name: 60S ribosomal protein L7
Gene Name: RPL7
Ensembl Gene: ENSBTAG00000020139.5
Ensembl Protein: ENSBTAP00000026826.4
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...The proteomic analysis of the MDBK cell nucleoli identified a total of 311 proteins."
MDBK cells20970743

▼ FUNCTION

Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEGAEEKKKK  VPAVPETLKK  KRKNFAELKI  KRLRKKFAQK  MLRKARRKLI  YEKAKHYHKE  60
61    YRQMYRTEIR  MARMARKAGN  FYVPAEPKLA  FVIRIRGING  VSPKVRKVLQ  LLRLRQIFNG  120
121   TFVKLNKASI  NMLRIVEPYI  AWGYPNLKSV  NELIYKRGYG  KINKKRIALT  DNALIARSLG  180
181   KYGIICMEDL  IHEIYTVGKR  FKEANNFLWP  FKLSSPRGGM  KKKTTHFVEG  GDAGNREDQI  240
241   NRLIRRMN  248
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGGTG  CAGAAGAGAA  GAAAAAGAAG  GTTCCTGCTG  TGCCAGAAAC  CCTTAAGAAA  60
61    AAGCGGAAGA  ATTTCGCAGA  GCTTAAGATC  AAGCGACTGA  GAAAGAAGTT  TGCCCAAAAG  120
121   ATGCTTCGAA  AGGCAAGGAG  GAAGCTTATC  TATGAAAAAG  CTAAGCATTA  CCACAAGGAA  180
181   TACAGGCAGA  TGTACAGAAC  TGAAATTCGA  ATGGCTAGGA  TGGCACGAAA  AGCCGGTAAC  240
241   TTCTATGTAC  CCGCGGAACC  CAAATTGGCG  TTTGTCATCA  GGATCAGAGG  TATCAATGGT  300
301   GTGAGCCCAA  AGGTTCGAAA  GGTGCTGCAG  CTCCTTCGCC  TCCGGCAGAT  CTTCAACGGC  360
361   ACCTTTGTGA  AGCTCAACAA  GGCGTCAATT  AACATGCTGA  GAATTGTGGA  GCCATACATT  420
421   GCATGGGGGT  ACCCAAATCT  GAAGTCTGTA  AATGAATTGA  TTTACAAGCG  TGGTTACGGC  480
481   AAAATCAACA  AAAAGCGAAT  TGCCCTGACA  GACAACGCAT  TGATTGCTCG  ATCTCTTGGG  540
541   AAATATGGAA  TCATCTGCAT  GGAGGATCTG  ATTCATGAGA  TCTATACCGT  TGGAAAACGT  600
601   TTCAAAGAAG  CAAACAACTT  CCTGTGGCCC  TTTAAATTGT  CTTCTCCACG  AGGTGGAATG  660
661   AAGAAAAAGA  CCACCCATTT  TGTAGAAGGT  GGAGATGCTG  GCAACAGGGA  AGACCAGATC  720
721   AACAGGCTTA  TTAGAAGGAT  GAACTAA  747

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Phosphoprotein
Reference proteome
Repeat
Ribonucleoprotein
Ribosomal protein
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosolic large ribosomal subunit
Molecular Function
RNA binding
Molecular Function
Structural constituent of ribosome
Biological Process
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-3556Nomascus leucogenys100.07e-156 441
LLPS-Ict-2589Ictidomys tridecemlineatus100.03e-138 394
LLPS-Ova-2969Ovis aries100.06e-156 441
LLPS-Dio-1593Dipodomys ordii100.03e-138 394
LLPS-Hos-0915Homo sapiens99.572e-155 440
LLPS-Pap-0258Pan paniscus99.572e-155 440
LLPS-Pat-4139Pan troglodytes99.572e-155 440
LLPS-Man-1823Macaca nemestrina99.572e-155 439
LLPS-Poa-1386Pongo abelii99.571e-155 440
LLPS-Gog-1829Gorilla gorilla99.572e-155 440
LLPS-Maf-4618Macaca fascicularis99.573e-155 439
LLPS-Sus-1883Sus scrofa99.572e-155 440
LLPS-Paa-3207Papio anubis99.572e-155 440
LLPS-Rhb-2396Rhinopithecus bieti99.143e-155 439
LLPS-Loa-0089Loxodonta africana99.142e-154 437
LLPS-Caj-1487Callithrix jacchus99.142e-154 437
LLPS-Tut-0823Tursiops truncatus99.141e-154 438
LLPS-Mup-4418Mustela putorius furo99.042e-138 395
LLPS-Otg-0359Otolemur garnettii98.719e-154 435
LLPS-Urm-0623Ursus maritimus98.719e-155 438
LLPS-Fec-0374Felis catus98.714e-154 436
LLPS-Cas-1388Carlito syrichta98.711e-154 438
LLPS-Caf-0299Canis familiaris98.719e-155 438
LLPS-Cap-2605Cavia porcellus98.534e-135 387
LLPS-Orc-2762Oryctolagus cuniculus98.286e-153 433
LLPS-Eqc-0532Equus caballus98.282e-153 435
LLPS-Mam-0537Macaca mulatta98.282e-153 434
LLPS-Aon-0701Aotus nancymaae98.284e-153 434
LLPS-Mal-3633Mandrillus leucophaeus98.284e-153 433
LLPS-Aim-1852Ailuropoda melanoleuca98.283e-153 434
LLPS-Fud-0727Fukomys damarensis97.844e-153 434
LLPS-Cea-1985Cercocebus atys96.982e-147 419
LLPS-Ere-0674Erinaceus europaeus96.982e-151 429
LLPS-Ran-1101Rattus norvegicus96.557e-152 431
LLPS-Mod-2737Monodelphis domestica90.958e-139 398
LLPS-Sah-1283Sarcophilus harrisii90.525e-138 395
LLPS-Chs-3125Chlorocebus sabaeus90.093e-140 401
LLPS-Ora-1196Ornithorhynchus anatinus89.741e-71 221
LLPS-Anp-2000Anas platyrhynchos88.895e-127 367
LLPS-Pes-2293Pelodiscus sinensis87.82e-91 274
LLPS-Anc-0253Anolis carolinensis87.52e-133 384
LLPS-Meg-1062Meleagris gallopavo85.341e-130 376
LLPS-Gaga-0811Gallus gallus85.341e-130 376
LLPS-Tag-1160Taeniopygia guttata84.915e-128 370
LLPS-Fia-1632Ficedula albicollis84.481e-127 369
LLPS-Leo-1764Lepisosteus oculatus83.628e-129 372
LLPS-Xim-1212Xiphophorus maculatus83.622e-126 366
LLPS-Orn-2051Oreochromis niloticus83.194e-128 370
LLPS-Pof-3958Poecilia formosa82.337e-125 362
LLPS-Scf-1146Scleropages formosus82.331e-127 369
LLPS-Icp-1075Ictalurus punctatus81.477e-122 355
LLPS-Orl-1349Oryzias latipes81.474e-125 362
LLPS-Dar-3488Danio rerio80.174e-120 350
LLPS-Xet-2468Xenopus tropicalis80.171e-123 359
LLPS-Ten-2234Tetraodon nigroviridis80.174e-125 362
LLPS-Asm-1028Astyanax mexicanus80.175e-122 355
LLPS-Tar-3216Takifugu rubripes80.174e-119 347
LLPS-Mea-1979Mesocricetus auratus79.746e-116 338
LLPS-Gaa-1934Gasterosteus aculeatus79.743e-124 360
LLPS-Scm-0740Scophthalmus maximus79.315e-122 355
LLPS-Myl-2813Myotis lucifugus75.863e-102 304
LLPS-Lac-3008Latimeria chalumnae72.692e-98 294
LLPS-Mae-0424Manihot esculenta69.82e-91 276
LLPS-Orbr-0582Oryza brachyantha68.328e-87 265
LLPS-Cus-2212Cucumis sativus68.329e-87 265
LLPS-Amt-1815Amborella trichopoda67.824e-86 263
LLPS-Ors-1834Oryza sativa67.826e-86 263
LLPS-Orp-0900Oryza punctata67.821e-85 263
LLPS-Pot-2460Populus trichocarpa67.821e-86 266
LLPS-Org-1546Oryza glaberrima67.826e-86 263
LLPS-Orr-1619Oryza rufipogon67.821e-85 261
LLPS-Orm-0497Oryza meridionalis67.826e-86 263
LLPS-Prp-2547Prunus persica67.827e-89 270
LLPS-Orni-0758Oryza nivara67.821e-85 261
LLPS-Orb-0906Oryza barthii67.821e-85 261
LLPS-Ori-0642Oryza indica67.826e-86 263
LLPS-Orgl-1518Oryza glumaepatula67.821e-85 261
LLPS-Lep-1004Leersia perrieri67.822e-85 261
LLPS-Pytr-1091Pyrenophora triticirepentis67.763e-62 199
LLPS-Sei-2170Setaria italica67.336e-85 260
LLPS-Art-1659Arabidopsis thaliana66.832e-87 266
LLPS-Brd-1868Brachypodium distachyon66.833e-85 261
LLPS-Arl-0520Arabidopsis lyrata66.831e-87 267
LLPS-Tru-0940Triticum urartu66.671e-82 258
LLPS-Tra-2504Triticum aestivum66.671e-84 259
LLPS-Brr-2400Brassica rapa66.341e-85 261
LLPS-Bro-1828Brassica oleracea66.341e-85 261
LLPS-Brn-3167Brassica napus66.342e-86 265
LLPS-Hov-0671Hordeum vulgare66.345e-86 263
LLPS-Cii-1722Ciona intestinalis65.951e-90 275
LLPS-Sem-1628Selaginella moellendorffii65.523e-93 281
LLPS-Scj-1030Schizosaccharomyces japonicus65.353e-82 253
LLPS-Drm-1477Drosophila melanogaster65.312e-78 243
LLPS-Osl-1342Ostreococcus lucimarinus64.856e-82 252
LLPS-Cis-1226Ciona savignyi64.664e-92 279
LLPS-Vir-0807Vigna radiata64.633e-90 273
LLPS-Phv-0817Phaseolus vulgaris64.223e-90 273
LLPS-Via-1890Vigna angularis64.223e-90 273
LLPS-Mua-0855Musa acuminata63.364e-90 275
LLPS-Glm-1864Glycine max63.364e-91 277
LLPS-Pyt-0408Pyrenophora teres63.114e-86 263
LLPS-Ast-1150Aspergillus terreus62.664e-87 266
LLPS-Asfu-0185Aspergillus fumigatus62.662e-91 279
LLPS-Asf-0870Aspergillus flavus62.662e-88 269
LLPS-Aso-1441Aspergillus oryzae62.662e-88 269
LLPS-Viv-1097Vitis vinifera62.59e-89 270
LLPS-Coc-1606Corchorus capsularis62.57e-89 270
LLPS-Met-0577Medicago truncatula62.51e-88 270
LLPS-Tum-0168Tuber melanosporum62.232e-85 261
LLPS-Gor-0863Gossypium raimondii62.074e-90 273
LLPS-Nef-0451Neosartorya fischeri61.86e-90 274
LLPS-Asni-0401Aspergillus niger61.81e-85 263
LLPS-Hea-2045Helianthus annuus61.641e-87 269
LLPS-Sol-0244Solanum lycopersicum61.646e-84 272
LLPS-Sot-0577Solanum tuberosum61.642e-90 274
LLPS-Asn-0070Aspergillus nidulans61.379e-88 268
LLPS-Abg-1794Absidia glauca61.277e-78 243
LLPS-Nia-1811Nicotiana attenuata61.214e-89 272
LLPS-Thc-1275Theobroma cacao61.212e-88 269
LLPS-Asc-0120Aspergillus clavatus60.948e-88 268
LLPS-Zem-1644Zea mays60.788e-86 262
LLPS-Dac-0415Daucus carota60.74e-85 260
LLPS-Php-1349Physcomitrella patens60.344e-85 260
LLPS-Beb-0315Beauveria bassiana60.096e-85 260
LLPS-Cogr-1075Colletotrichum graminicola60.092e-86 265
LLPS-Scs-0527Sclerotinia sclerotiorum60.094e-88 268
LLPS-Nec-1266Neurospora crassa60.092e-85 261
LLPS-Scp-1303Schizosaccharomyces pombe60.06e-79 245
LLPS-Zyt-0277Zymoseptoria tritici59.834e-86 264
LLPS-Mao-1468Magnaporthe oryzae59.661e-88 270
LLPS-Gag-0832Gaeumannomyces graminis59.665e-86 263
LLPS-Yal-0737Yarrowia lipolytica59.43e-84 258
LLPS-Trr-1228Trichoderma reesei58.84e-82 253
LLPS-Fus-1570Fusarium solani58.86e-85 261
LLPS-Phn-1518Phaeosphaeria nodorum58.81e-84 259
LLPS-Trv-0749Trichoderma virens58.82e-81 252
LLPS-Coo-1150Colletotrichum orbiculare58.85e-84 259
LLPS-Lem-0003Leptosphaeria maculans58.742e-77 241
LLPS-Chc-0497Chondrus crispus58.44e-79 246
LLPS-Ved-0957Verticillium dahliae58.371e-85 263
LLPS-Map-1120Magnaporthe poae58.371e-85 262
LLPS-Gas-0723Galdieria sulphuraria58.236e-79 245
LLPS-Fuo-0510Fusarium oxysporum57.946e-82 253
LLPS-Fuv-1302Fusarium verticillioides57.946e-82 253
LLPS-Blg-0251Blumeria graminis57.941e-86 264
LLPS-Chr-0254Chlamydomonas reinhardtii57.581e-79 246
LLPS-Asg-0786Ashbya gossypii57.07e-73 229
LLPS-Cog-0274Colletotrichum gloeosporioides56.656e-82 253
LLPS-Scc-0196Schizosaccharomyces cryophilus56.471e-83 257
LLPS-Cae-1472Caenorhabditis elegans56.282e-83 256
LLPS-Mel-0321Melampsora laricipopulina55.53e-74 233
LLPS-Sob-0034Sorghum bicolor55.453e-69 221
LLPS-Sac-1020Saccharomyces cerevisiae55.073e-71 225
LLPS-Pug-0867Puccinia graminis54.941e-76 239
LLPS-Put-0235Puccinia triticina54.517e-75 234
LLPS-Crn-1476Cryptococcus neoformans54.463e-68 218
LLPS-Kop-0311Komagataella pastoris53.112e-68 218
LLPS-Usm-0250Ustilago maydis52.365e-72 227
LLPS-Miv-0089Microbotryum violaceum48.311e-60 198