• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Asm-0716

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: 26S proteasome non-ATPase regulatory subunit 2
Ensembl Gene: ENSAMXG00000011807.2
Ensembl Protein: ENSAMXP00000012137.2
Organism: Astyanax mexicanus
Taxa ID: 7994
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole body, Stress granule, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION


Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MVERLGEKDT  SLYHPALEEL  RRQIRSSTTS  MTSVPKPLKF  LRPHYGKLKE  IYEGMAPGEN  60
61    KHFCADVVSV  LAMTMSGERE  CLKYRLLGSQ  EELASWGHEY  VRHLAGEVAK  EWQEIEEGDK  120
121   VQQETLLKLV  KEIVPYNMAH  NAEHEACDLL  MEIEHLDMLE  MYIDENAYAK  VCLYLTSCVS  180
181   YVPEPENSAL  LKCALKIFRK  FNRYPEALRL  ALMLNDVELV  ENIFTSCKDI  VVQKEMAFML  240
241   GRHGMFLELN  EDVEDYEDLT  EIMSNVQLNS  NFLALARELD  IMEPKVPDDI  YKTHLENNRF  300
301   GGSGSQVDSA  RMNLASSFVN  GFVNAAFGQD  KLLTEDGNKW  LYKNKDHGML  SAAASLGMIL  360
361   LWDVDGGLTQ  IDKYLYSSED  YIKSGALLAC  GIVNSGVRNE  CDPALALLSD  YVLHNSNVMR  420
421   IGAIFGLGLA  YAGSNREDVL  SLLLPVMGDS  KSSMEVAGVT  ALACGMIAVG  SCNGDVTSTI  480
481   LQTIMEKNEQ  ELKDTYARWL  PLGLGLNHLG  KGEAIETTLA  ALQVVPEPFR  SFSNTLVDIC  540
541   AYAGSGNVLK  VQQLLHTCSE  HYDNTKDKDE  DKDKKDKKDK  DKKESAADMG  SHQGAAVLGI  600
601   ALIAMGEEIG  SEMALRTFGH  LLRYGEPTLR  RAVPLALALI  SVSNPRLNIL  DTLSKFSHDA  660
661   DPEVSHNSIF  AMGMVGSGTN  NARLAAMLRQ  LAQYHAKDPN  NLFMVRLAQG  LTHLGKGTLT  720
721   LCPYHSDRQL  MSQVAVAGLL  TVLVSFLDVK  NIILGKSHYV  LYGLVAAMQP  RMLVTFDEEL  780
781   RPLPVSVRVG  QAVDVVGQAG  KPKAITGFQT  HTTPVLLGSR  RESGAGHRRI  SPSHPHTGGL  840
841   RHPAQESQLR  CLDTQTHTYP  VIECFPVRVI  MYPPFSALHN  CVFSSCQHTL  LPRP  894
Nucleotide CDS Sequence (FASTA)
1     ATGGTCGAGA  GACTTGGTCA  TTTCTGTGCT  GATGTGGTGT  CTGTCCTTGC  CATGACCATG  60
61    AGTGGTGAGA  GAGAGTGTTT  GAAATATCGC  CTGTTGGGCT  CGCAAGAGGA  GTTGGCGTCC  120
121   TGGGGGCACG  AGTATGTCAG  GCACCTTGCA  GGAGAAGTGG  CTAAAGAGTG  GCAGGAGATT  180
181   GAGGAGGGCG  ATAAGGTGCA  ACAGGAGACT  CTGCTAAAGC  TGGTTAAAGA  GATTGTGCCC  240
241   TATAACATGG  CCCACAATGC  TGAGCACGAA  GCCTGCGACC  TGCTCATGGA  GATCGAGCAT  300
301   CTCGACATGT  TGGAGATGTA  CATCGATGAA  AACGCGTATG  CTAAAGTCTG  CCTCTACCTC  360
361   ACAAGCTGTG  TGAGTTACGT  TCCTGAGCCG  GAGAACTCTG  CTTTGCTGAA  GTGTGCGCTG  420
421   AAAATCTTCC  GCAAGTTCAA  TCGTTATCCA  GAAGCCCTCA  GACTGGCGCT  CATGCTCAAC  480
481   GATGTGGAGC  TTGTAGAGAA  CATCTTTACC  TCCTGCAAAG  ACATTGTGGT  TCAGAAGGAG  540
541   ATGGCATTTA  TGCTGGGCAG  ACATGGCATG  TTTCTGGAGC  TGAATGAAGA  CGTGGAGGAT  600
601   TATGAAGACC  TGACCGAGAT  CATGTCCAAC  GTACAGCTCA  ACAGCAACTT  CCTTGCCCTC  660
661   GCTCGTGAGT  TGGATATCAT  GGAGCCCAAA  GTGCCAGATG  ACATTTATAA  AACCCACCTG  720
721   GAGAACAACA  GATTTGGTGG  CAGCGGCTCT  CAAGTGGATT  CTGCTCGAAT  GAACCTGGCA  780
781   TCTTCCTTTG  TAAACGGGTT  TGTTAACGCA  GCATTTGGAC  AGGACAAACT  TCTGACTGAG  840
841   GACGGCAACA  AGTGGCTGTA  TAAGAACAAG  GACCACGGAA  TGTTGAGTGC  TGCTGCCTCT  900
901   CTGGGTATGA  TCCTGTTGTG  GGATGTGGAT  GGCGGCCTCA  CTCAGATTGA  CAAATATCTC  960
961   TACTCTTCTG  AAGACTACAT  CAAGTCTGGG  GCCCTGTTAG  CATGTGGTAT  AGTGAACTCT  1020
1021  GGAGTTCGTA  ACGAATGTGA  CCCAGCTTTG  GCTCTTCTCT  CTGATTACGT  CCTGCACAAC  1080
1081  AGCAACGTCA  TGAGGATAGG  AGCCATCTTT  GGGCTTGGTC  TGGCTTATGC  AGGCTCTAAC  1140
1141  AGAGAGGACG  TCCTCTCGCT  TTTGCTGCCG  GTCATGGGAG  ATTCCAAGTC  CAGCATGGAG  1200
1201  GTTGCCGGTG  TGACTGCACT  GGCCTGCGGG  ATGATCGCTG  TGGGCTCCTG  TAATGGGGAT  1260
1261  GTCACTTCCA  CCATTCTGCA  GACCATTATG  GAAAAGAATG  AGCAGGAGCT  GAAAGACACG  1320
1321  TACGCCCGCT  GGCTCCCCCT  CGGCCTGGGA  CTCAACCACC  TCGGCAAAGG  AGAGGCAATT  1380
1381  GAGACTACTT  TGGCAGCTCT  GCAGGTTGTC  CCAGAACCTT  TCCGTAGCTT  CTCAAACACA  1440
1441  CTTGTGGACA  TCTGTGCCTA  TGCAGGGTCT  GGTAATGTTT  TGAAGGTGCA  GCAGTTGTTG  1500
1501  CACACCTGCA  GTGAGCACTA  CGACAACACA  AAGGACAAAG  ATGAGGACAA  AGACAAGAAA  1560
1561  GACAAAAAGG  ACAAGGACAA  GAAAGAAAGT  GCAGCAGACA  TGGGCTCCCA  CCAGGGTGCG  1620
1621  GCTGTGCTGG  GAATTGCACT  CATCGCTATG  GGAGAGGAGA  TTGGATCGGA  GATGGCACTG  1680
1681  CGCACATTTG  GCCACCTGTT  GCGCTATGGG  GAGCCCACTC  TGCGCAGAGC  GGTACCGTTA  1740
1741  GCGTTGGCTC  TGATCTCAGT  TTCCAACCCC  CGACTCAACA  TTCTGGACAC  ACTTAGTAAG  1800
1801  TTCTCCCACG  ACGCCGACCC  TGAAGTGTCC  CACAACTCCA  TCTTCGCCAT  GGGCATGGTG  1860
1861  GGCAGCGGAA  CCAATAATGC  ACGACTTGCA  GCTATGCTGC  GACAACTGGC  CCAGTACCAC  1920
1921  GCCAAGGACC  CCAACAACCT  GTTCATGGTC  CGACTTGCAC  AGGGTCTGAC  TCATCTGGGG  1980
1981  AAAGGGACGT  TGACCCTGTG  TCCCTACCAC  AGCGACCGGC  AGCTCATGAG  TCAGGTAGCA  2040
2041  GTCGCCGGAC  TCCTCACAGT  CCTTGTGTCC  TTCCTTGATG  TCAAAAACAT  AATCCTGGGA  2100
2101  AAATCACACT  ACGTACTGTA  CGGACTTGTA  GCAGCAATGC  AACCTCGTAT  GCTCGTCACA  2160
2161  TTTGACGAAG  AACTGCGGCC  ACTGCCAGTC  TCTGTCCGGG  TGGGACAGGC  TGTTGACGTG  2220
2221  GTGGGACAGG  CAGGCAAGCC  TAAAGCAATC  ACAGAGAGAG  CGGAGCTGGC  CACAGAAGAA  2280
2281  TATCTCCCAG  TCACCCCCAT  ACTGGAGGGC  TTCGTCATCC  TGCGCAAGAA  TCCCAACTAC  2340
2341  GATGCTTAG  2349

▼ KEYWORD


ID
Family
Complete proteome
Proteasome
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Proteasome regulatory particle, base subcomplex
Molecular Function
Enzyme regulator activity
Biological Process
Regulation of protein catabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Icp-1940Ictalurus punctatus95.630.01469
LLPS-Orn-0126Oreochromis niloticus95.390.01487
LLPS-Xim-1054Xiphophorus maculatus95.360.01465
LLPS-Scm-0875Scophthalmus maximus95.270.01486
LLPS-Pof-2342Poecilia formosa95.030.01476
LLPS-Orl-0618Oryzias latipes94.910.01480
LLPS-Gaa-0366Gasterosteus aculeatus94.670.01475
LLPS-Leo-0428Lepisosteus oculatus94.170.01472
LLPS-Tar-0208Takifugu rubripes93.810.01479
LLPS-Dar-1433Danio rerio93.690.0 907
LLPS-Meg-1343Meleagris gallopavo93.010.01437
LLPS-Mea-0370Mesocricetus auratus93.00.0 703
LLPS-Gaga-1667Gallus gallus92.840.01446
LLPS-Scf-1594Scleropages formosus92.740.01469
LLPS-Fia-0669Ficedula albicollis92.720.01446
LLPS-Tag-0193Taeniopygia guttata92.60.01445
LLPS-Anc-0529Anolis carolinensis92.480.01448
LLPS-Xet-0983Xenopus tropicalis92.350.01458
LLPS-Pat-0361Pan troglodytes92.110.01441
LLPS-Pap-1676Pan paniscus92.110.01441
LLPS-Hos-0389Homo sapiens92.110.01441
LLPS-Orc-1284Oryctolagus cuniculus92.110.01437
LLPS-Rhb-0555Rhinopithecus bieti92.110.01440
LLPS-Mam-2183Macaca mulatta92.110.01441
LLPS-Cap-0789Cavia porcellus92.110.01440
LLPS-Ict-2229Ictidomys tridecemlineatus92.110.01441
LLPS-Nol-0773Nomascus leucogenys92.110.01442
LLPS-Aon-0872Aotus nancymaae92.110.01441
LLPS-Cea-1309Cercocebus atys92.110.01441
LLPS-Chs-0599Chlorocebus sabaeus92.110.01438
LLPS-Gog-0885Gorilla gorilla92.110.01439
LLPS-Paa-0359Papio anubis92.110.01441
LLPS-Otg-1655Otolemur garnettii91.990.01440
LLPS-Caf-0011Canis familiaris91.990.01438
LLPS-Eqc-2342Equus caballus91.990.01438
LLPS-Cas-1766Carlito syrichta91.990.01440
LLPS-Sus-1295Sus scrofa91.990.01439
LLPS-Mum-3389Mus musculus91.990.01439
LLPS-Fud-0496Fukomys damarensis91.990.01440
LLPS-Caj-1186Callithrix jacchus91.990.01441
LLPS-Dio-0934Dipodomys ordii91.990.01441
LLPS-Bot-2672Bos taurus91.990.01438
LLPS-Tut-0493Tursiops truncatus91.990.01437
LLPS-Mup-1779Mustela putorius furo91.990.01440
LLPS-Myl-0437Myotis lucifugus91.990.01440
LLPS-Ova-0544Ovis aries91.990.01438
LLPS-Loa-1322Loxodonta africana91.870.01436
LLPS-Mod-0274Monodelphis domestica91.870.01432
LLPS-Fec-0248Felis catus91.870.01436
LLPS-Aim-0149Ailuropoda melanoleuca91.870.01437
LLPS-Ran-0236Rattus norvegicus91.870.01438
LLPS-Urm-2531Ursus maritimus91.750.01435
LLPS-Pes-1550Pelodiscus sinensis91.680.01433
LLPS-Poa-0181Pongo abelii91.370.01372
LLPS-Man-1356Macaca nemestrina90.940.01415
LLPS-Maf-1394Macaca fascicularis90.940.01418
LLPS-Lac-1028Latimeria chalumnae87.260.01366
LLPS-Ten-0950Tetraodon nigroviridis84.220.01288
LLPS-Ora-1427Ornithorhynchus anatinus82.860.0 754
LLPS-Sah-2626Sarcophilus harrisii82.040.01206
LLPS-Cis-0112Ciona savignyi77.782e-80 286
LLPS-Mal-0196Mandrillus leucophaeus74.267e-42 166
LLPS-Cii-0161Ciona intestinalis71.010.01115
LLPS-Mae-1769Manihot esculenta66.415e-24 112
LLPS-Pug-0148Puccinia graminis65.383e-1275.1
LLPS-Put-0492Puccinia triticina65.383e-1275.1
LLPS-Cae-0149Caenorhabditis elegans64.867e-69 252
LLPS-Drm-0218Drosophila melanogaster62.160.0 954
LLPS-Yal-0823Yarrowia lipolytica61.546e-64 237
LLPS-Mel-0565Melampsora laricipopulina59.626e-1067.4
LLPS-Crn-0518Cryptococcus neoformans58.634e-63 234
LLPS-Asg-0165Ashbya gossypii56.775e-46 182
LLPS-Chc-0245Chondrus crispus56.179e-59 221
LLPS-Sac-0430Saccharomyces cerevisiae54.153e-43 174
LLPS-Php-2387Physcomitrella patens53.520.0 805
LLPS-Abg-0655Absidia glauca53.130.0 802
LLPS-Pytr-0476Pyrenophora triticirepentis52.913e-126 395
LLPS-Nia-0478Nicotiana attenuata52.710.0 798
LLPS-Glm-0619Glycine max52.650.0 795
LLPS-Sem-0183Selaginella moellendorffii52.480.0 795
LLPS-Tum-0428Tuber melanosporum52.460.0 754
LLPS-Sot-0017Solanum tuberosum52.360.0 792
LLPS-Met-0828Medicago truncatula52.240.0 790
LLPS-Chr-0044Chlamydomonas reinhardtii52.210.0 787
LLPS-Phv-0168Phaseolus vulgaris52.060.0 792
LLPS-Cus-0052Cucumis sativus52.060.0 783
LLPS-Amt-0011Amborella trichopoda51.990.0 780
LLPS-Spr-0448Sporisorium reilianum51.940.0 782
LLPS-Usm-0784Ustilago maydis51.830.0 772
LLPS-Orbr-0850Oryza brachyantha51.610.0 793
LLPS-Orp-0302Oryza punctata51.550.0 771
LLPS-Coc-0721Corchorus capsularis51.530.0 777
LLPS-Thc-0842Theobroma cacao51.530.0 777
LLPS-Ors-1065Oryza sativa51.490.0 780
LLPS-Org-0566Oryza glaberrima51.490.0 782
LLPS-Orb-0228Oryza barthii51.490.0 773
LLPS-Ori-0388Oryza indica51.490.0 781
LLPS-Pot-0387Populus trichocarpa51.420.0 774
LLPS-Scj-0644Schizosaccharomyces japonicus51.40.0 750
LLPS-Orgl-0345Oryza glumaepatula51.370.0 759
LLPS-Tra-0322Triticum aestivum51.250.0 789
LLPS-Osl-0280Ostreococcus lucimarinus51.180.0 751
LLPS-Vir-0376Vigna radiata51.170.0 740
LLPS-Hov-1293Hordeum vulgare51.130.0 788
LLPS-Mua-0826Musa acuminata51.080.0 767
LLPS-Brd-0706Brachypodium distachyon51.010.0 779
LLPS-Orni-0084Oryza nivara51.00.0 784
LLPS-Zyt-0259Zymoseptoria tritici50.850.0 747
LLPS-Gor-0737Gossypium raimondii50.830.0 777
LLPS-Prp-0022Prunus persica50.830.0 796
LLPS-Hea-0744Helianthus annuus50.770.0 776
LLPS-Sei-0114Setaria italica50.650.0 784
LLPS-Viv-0685Vitis vinifera50.640.0 773
LLPS-Tru-0427Triticum urartu50.60.0 769
LLPS-Bro-0672Brassica oleracea50.530.0 764
LLPS-Brn-1209Brassica napus50.470.0 766
LLPS-Brr-2634Brassica rapa50.410.0 765
LLPS-Orr-1162Oryza rufipogon50.340.0 655
LLPS-Lem-0160Leptosphaeria maculans50.30.0 767
LLPS-Miv-0266Microbotryum violaceum50.290.0 775
LLPS-Zem-2499Zea mays50.180.0 776
LLPS-Via-1222Vigna angularis50.070.0 655
LLPS-Sob-0103Sorghum bicolor50.060.0 775
LLPS-Orm-0271Oryza meridionalis49.940.0 767
LLPS-Scc-0152Schizosaccharomyces cryophilus49.940.0 741
LLPS-Lep-0094Leersia perrieri49.860.0 655
LLPS-Phn-0588Phaeosphaeria nodorum49.820.0 766
LLPS-Aso-0128Aspergillus oryzae49.820.0 738
LLPS-Asf-0932Aspergillus flavus49.820.0 738
LLPS-Art-0810Arabidopsis thaliana49.760.0 758
LLPS-Asc-0844Aspergillus clavatus49.70.0 728
LLPS-Asni-0191Aspergillus niger49.70.0 738
LLPS-Nec-0580Neurospora crassa49.640.0 744
LLPS-Arl-1507Arabidopsis lyrata49.590.0 757
LLPS-Nef-0350Neosartorya fischeri49.580.0 730
LLPS-Asfu-0233Aspergillus fumigatus49.580.0 729
LLPS-Mao-0266Magnaporthe oryzae49.580.0 721
LLPS-Dos-0693Dothistroma septosporum49.460.0 729
LLPS-Beb-0680Beauveria bassiana49.220.0 704
LLPS-Ast-0400Aspergillus terreus49.10.0 716
LLPS-Asn-0351Aspergillus nidulans49.10.0 729
LLPS-Map-0705Magnaporthe poae48.920.0 713
LLPS-Gag-0351Gaeumannomyces graminis48.80.0 712
LLPS-Pyt-0203Pyrenophora teres48.740.0 721
LLPS-Dac-1632Daucus carota48.650.0 722
LLPS-Sol-1790Solanum lycopersicum48.620.0 743
LLPS-Coo-0203Colletotrichum orbiculare48.560.0 735
LLPS-Scs-0234Sclerotinia sclerotiorum48.440.0 724
LLPS-Cog-0069Colletotrichum gloeosporioides48.380.0 696
LLPS-Cogr-1388Colletotrichum graminicola48.380.0 701
LLPS-Trv-0292Trichoderma virens48.320.0 707
LLPS-Ved-0690Verticillium dahliae48.20.0 715
LLPS-Trr-0633Trichoderma reesei48.080.0 701
LLPS-Fuo-0834Fusarium oxysporum48.00.0 712
LLPS-Fuv-0441Fusarium verticillioides48.00.0 711
LLPS-Blg-0406Blumeria graminis47.960.0 728
LLPS-Scp-0762Schizosaccharomyces pombe47.380.0 702
LLPS-Kop-0392Komagataella pastoris46.250.0 682
LLPS-Fus-0829Fusarium solani45.760.0 665
LLPS-Gas-0542Galdieria sulphuraria44.490.0 656
LLPS-Cym-0273Cyanidioschyzon merolae44.427e-113 374
LLPS-Anp-0405Anas platyrhynchos26.481e-1070.1