• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asg-0830
CWC22

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pre-mRNA-splicing factor CWC22
Gene Name: CWC22, AGL355W
Ensembl Gene: AGOS_AGL355W
Ensembl Protein: AAS54136
Organism: Ashbya gossypii
Taxa ID: 284811
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

May be involved in pre-mRNA splicing.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblAAS54136AAS54136
UniProtQ751P4, CWC22_ASHGO
GeneBankAE016820AAS54136.1
RefSeqNM_211374.1NP_986312.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDEELQLKNW  TELHNHIKSV  LDRLDESRIN  ESFQELLEVN  VIRGRGILAS  EVVREERVVR  60
61    QGAVLGALVE  LFEDYIPELG  IMVSREALLL  FLKSFRGGRT  KYCYGLLALL  CQLCNSDVMH  120
121   EIGLLQLADL  LLEVPRDRAV  GMLCFMLGQA  GAHLMNVCRT  AHDQLLARLT  DMLHDGKLSP  180
181   TSSNRIQELL  RLRRSNYKGQ  ATKFSLPDHG  VCTHRVTLEL  DIPARLEPDS  SLGKFYVDNQ  240
241   FFDTEERFAA  LRRQALERFL  GQQQQQAEPV  KDMTNAEEVQ  YKKQIYLILK  GSLTGDEAAH  300
301   KLLKLRPDAS  QKATIVEIVV  KACAQEQTYT  KFYGILAERL  CGSHRNWPTS  FTNLFRDLYG  360
361   TLHEFEPNQL  RNMGKFWGHM  LAADHIGLNL  FECVHLSEHR  TTPSSRVFLK  FIFQELVADL  420
421   GIAEVRKRLE  DENAQPLVQG  LFPKEGNADT  VFAINYFTAI  GLGVLTESMR  TSLPTQAKSD  480
481   SGNMSPNGQT  LSYPSSRVPR  RTRSRSPPRT  RVRGDSPQRA  RVEQRYSRYD  PGPAHRDRRR  540
541   SRLSVTPPPR  RNIH  554
Nucleotide CDS Sequence (FASTA)
1     ATGGATGAAG  AGCTACAGCT  AAAGAACTGG  ACAGAACTCC  ATAATCACAT  CAAGTCAGTA  60
61    TTGGATCGGT  TAGATGAATC  TAGGATCAAT  GAAAGTTTCC  AGGAACTCCT  TGAGGTGAAT  120
121   GTCATACGGG  GTAGGGGCAT  ATTGGCGTCC  GAAGTTGTGA  GAGAGGAGCG  TGTGGTACGG  180
181   CAGGGCGCCG  TTTTGGGAGC  GTTGGTTGAG  CTATTTGAGG  ATTATATCCC  AGAATTGGGT  240
241   ATTATGGTGT  CACGCGAGGC  GCTGCTGCTA  TTTCTTAAGA  GCTTTCGCGG  TGGCAGAACA  300
301   AAGTACTGTT  ACGGGTTGTT  GGCTCTGCTG  TGCCAGCTGT  GTAACAGCGA  CGTTATGCAT  360
361   GAAATAGGCT  TATTGCAGCT  AGCAGATTTG  CTGTTGGAAG  TGCCCCGTGA  CCGGGCGGTA  420
421   GGGATGCTGT  GCTTCATGCT  TGGGCAGGCT  GGGGCGCATC  TGATGAACGT  GTGCAGGACA  480
481   GCACACGACC  AGTTGCTGGC  TAGGTTGACA  GATATGTTGC  ACGACGGGAA  GCTGAGTCCT  540
541   ACGAGCAGCA  ATCGCATCCA  GGAGCTTCTG  CGCCTGCGCC  GGAGCAATTA  CAAGGGCCAA  600
601   GCGACGAAAT  TCTCCCTCCC  AGATCATGGC  GTATGCACGC  ACCGCGTGAC  ATTGGAGCTT  660
661   GATATTCCTG  CGAGGTTAGA  ACCTGATAGC  TCGCTAGGCA  AGTTCTACGT  TGATAACCAG  720
721   TTTTTCGATA  CTGAGGAGCG  CTTCGCAGCT  TTGCGCCGGC  AAGCGCTGGA  ACGGTTCCTT  780
781   GGGCAACAGC  AACAGCAAGC  AGAGCCGGTA  AAAGATATGA  CCAACGCGGA  AGAGGTGCAG  840
841   TACAAGAAGC  AGATATACCT  CATTTTGAAA  GGATCTCTCA  CCGGCGACGA  GGCAGCGCAC  900
901   AAGCTGCTCA  AGCTTCGCCC  GGACGCAAGT  CAGAAGGCCA  CCATCGTGGA  GATCGTAGTC  960
961   AAGGCATGCG  CGCAGGAGCA  GACATACACA  AAGTTCTACG  GAATTTTGGC  GGAGCGCCTC  1020
1021  TGCGGCAGCC  ATCGAAACTG  GCCCACCAGC  TTTACTAACC  TATTCCGGGA  TTTGTACGGC  1080
1081  ACGCTGCATG  AGTTTGAGCC  CAACCAGCTT  CGCAACATGG  GCAAATTTTG  GGGTCACATG  1140
1141  CTGGCCGCAG  ATCACATAGG  CTTAAACCTT  TTCGAATGTG  TCCATCTCAG  TGAGCACCGC  1200
1201  ACTACGCCTT  CCAGCCGGGT  TTTCCTGAAG  TTTATATTTC  AAGAGTTGGT  GGCTGACCTT  1260
1261  GGCATAGCAG  AGGTCCGGAA  ACGCCTAGAG  GACGAAAATG  CACAGCCCCT  TGTGCAGGGC  1320
1321  CTGTTCCCCA  AAGAAGGAAA  CGCCGATACG  GTATTTGCTA  TTAACTATTT  TACCGCAATT  1380
1381  GGCCTGGGTG  TCCTTACAGA  GAGTATGAGA  ACATCCTTGC  CCACGCAGGC  GAAATCTGAT  1440
1441  TCTGGCAATA  TGTCGCCTAA  TGGGCAGACC  CTGTCTTATC  CGTCGAGCAG  GGTCCCTCGG  1500
1501  AGGACAAGAT  CACGCTCACC  TCCAAGAACT  CGCGTCCGTG  GCGATTCACC  ACAACGTGCG  1560
1561  CGCGTGGAAC  AGCGATATTC  CCGTTACGAT  CCAGGGCCCG  CTCACAGGGA  TCGTAGGCGC  1620
1621  AGTAGATTGT  CTGTGACCCC  ACCTCCCCGG  CGCAACATCC  ACTGA  1665

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
mRNA processing
mRNA splicing
Nucleus
Reference proteome
Spliceosome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Catalytic step 2 spliceosome
Cellular Component
Cytoplasm
Cellular Component
U2-type catalytic step 1 spliceosome
Molecular Function
RNA binding
Biological Process
MRNA splicing, via spliceosome

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-0099Astyanax mexicanus40.581e-47 182
LLPS-Dac-0558Daucus carota38.422e-36 147
LLPS-Sac-1104Saccharomyces cerevisiae33.955e-80 268
LLPS-Kop-0667Komagataella pastoris32.449e-93 302
LLPS-Ran-0230Rattus norvegicus31.461e-68 243
LLPS-Anp-0377Anas platyrhynchos31.151e-63 227
LLPS-Scc-1060Schizosaccharomyces cryophilus30.891e-76 266
LLPS-Crn-0782Cryptococcus neoformans30.821e-79 273
LLPS-Meg-0708Meleagris gallopavo30.86e-71 249
LLPS-Gaga-1448Gallus gallus30.773e-70 248
LLPS-Tag-0801Taeniopygia guttata30.757e-70 246
LLPS-Pes-1187Pelodiscus sinensis30.741e-70 249
LLPS-Fud-0514Fukomys damarensis30.729e-73 255
LLPS-Pap-1132Pan paniscus30.681e-71 251
LLPS-Fia-0109Ficedula albicollis30.689e-71 249
LLPS-Pug-0797Puccinia graminis30.664e-72 254
LLPS-Phn-0036Phaeosphaeria nodorum30.656e-71 247
LLPS-Mea-1614Mesocricetus auratus30.636e-66 234
LLPS-Mel-0696Melampsora laricipopulina30.633e-75 258
LLPS-Sem-1386Selaginella moellendorffii30.64e-70 242
LLPS-Gas-0564Galdieria sulphuraria30.63e-69 243
LLPS-Spr-0360Sporisorium reilianum30.576e-62 224
LLPS-Scf-1103Scleropages formosus30.554e-66 235
LLPS-Cap-2376Cavia porcellus30.545e-72 253
LLPS-Sus-1298Sus scrofa30.486e-73 255
LLPS-Aon-2117Aotus nancymaae30.482e-71 251
LLPS-Cea-0612Cercocebus atys30.485e-72 253
LLPS-Maf-2699Macaca fascicularis30.483e-72 254
LLPS-Chs-0946Chlorocebus sabaeus30.484e-72 253
LLPS-Gog-1871Gorilla gorilla30.481e-71 252
LLPS-Dio-0545Dipodomys ordii30.483e-72 253
LLPS-Bot-0790Bos taurus30.489e-73 255
LLPS-Mal-2375Mandrillus leucophaeus30.485e-72 253
LLPS-Paa-1290Papio anubis30.484e-72 253
LLPS-Aim-0782Ailuropoda melanoleuca30.488e-73 255
LLPS-Mup-0612Mustela putorius furo30.482e-73 257
LLPS-Ova-1701Ovis aries30.481e-71 252
LLPS-Myl-2735Myotis lucifugus30.487e-74 257
LLPS-Man-3117Macaca nemestrina30.484e-72 253
LLPS-Hos-0723Homo sapiens30.481e-71 252
LLPS-Pat-0500Pan troglodytes30.481e-71 252
LLPS-Urm-0088Ursus maritimus30.484e-73 256
LLPS-Fec-0368Felis catus30.484e-73 256
LLPS-Otg-2053Otolemur garnettii30.484e-72 253
LLPS-Mam-0469Macaca mulatta30.483e-72 253
LLPS-Poa-0624Pongo abelii30.481e-71 252
LLPS-Eqc-1511Equus caballus30.485e-73 256
LLPS-Nol-2755Nomascus leucogenys30.487e-72 253
LLPS-Cas-1271Carlito syrichta30.485e-72 253
LLPS-Put-0064Puccinia triticina30.464e-72 253
LLPS-Lem-0075Leptosphaeria maculans30.443e-70 247
LLPS-Ora-2463Ornithorhynchus anatinus30.437e-72 252
LLPS-Scp-0532Schizosaccharomyces pombe30.433e-79 273
LLPS-Mum-0694Mus musculus30.421e-71 252
LLPS-Icp-1293Ictalurus punctatus30.377e-72 253
LLPS-Loa-0156Loxodonta africana30.379e-72 252
LLPS-Caf-0400Canis familiaris30.363e-73 256
LLPS-Mod-2297Monodelphis domestica30.346e-72 253
LLPS-Ict-1217Ictidomys tridecemlineatus30.348e-72 252
LLPS-Gag-0157Gaeumannomyces graminis30.215e-70 248
LLPS-Orl-0724Oryzias latipes30.29e-72 252
LLPS-Usm-0009Ustilago maydis30.171e-67 241
LLPS-Anc-0067Anolis carolinensis30.166e-71 250
LLPS-Scm-1698Scophthalmus maximus30.087e-68 241
LLPS-Xet-0809Xenopus tropicalis30.067e-74 256
LLPS-Pyt-0268Pyrenophora teres30.042e-61 222
LLPS-Nec-0163Neurospora crassa30.023e-72 254
LLPS-Scj-0458Schizosaccharomyces japonicus30.03e-66 236
LLPS-Dar-0804Danio rerio29.987e-71 250
LLPS-Aso-0374Aspergillus oryzae29.942e-71 247
LLPS-Asf-0007Aspergillus flavus29.943e-70 248
LLPS-Gaa-0416Gasterosteus aculeatus29.924e-71 249
LLPS-Sah-1730Sarcophilus harrisii29.881e-68 243
LLPS-Asfu-0567Aspergillus fumigatus29.886e-70 247
LLPS-Tar-0340Takifugu rubripes29.824e-70 248
LLPS-Yal-0811Yarrowia lipolytica29.732e-66 237
LLPS-Tut-0741Tursiops truncatus29.577e-71 249
LLPS-Drm-0502Drosophila melanogaster29.526e-66 238
LLPS-Asc-0106Aspergillus clavatus29.519e-70 246
LLPS-Pof-2004Poecilia formosa29.493e-69 245
LLPS-Asn-1260Aspergillus nidulans29.452e-66 234
LLPS-Orn-0206Oreochromis niloticus29.442e-69 246
LLPS-Cii-0573Ciona intestinalis29.387e-68 239
LLPS-Mao-0310Magnaporthe oryzae29.381e-63 229
LLPS-Cog-0979Colletotrichum gloeosporioides29.363e-72 248
LLPS-Leo-1807Lepisosteus oculatus29.285e-69 245
LLPS-Pytr-1043Pyrenophora triticirepentis29.271e-63 227
LLPS-Cis-1043Ciona savignyi29.262e-70 247
LLPS-Cogr-0298Colletotrichum graminicola29.248e-69 244
LLPS-Beb-0906Beauveria bassiana29.216e-72 251
LLPS-Nef-0194Neosartorya fischeri29.11e-68 243
LLPS-Xim-1698Xiphophorus maculatus29.097e-68 241
LLPS-Osl-0105Ostreococcus lucimarinus29.042e-72 248
LLPS-Fus-0067Fusarium solani29.012e-69 244
LLPS-Mae-1205Manihot esculenta29.05e-61 221
LLPS-Abg-0822Absidia glauca28.976e-69 239
LLPS-Rhb-0979Rhinopithecus bieti28.883e-59 216
LLPS-Ten-0358Tetraodon nigroviridis28.884e-62 224
LLPS-Brn-0076Brassica napus28.872e-66 236
LLPS-Brr-0488Brassica rapa28.876e-66 235
LLPS-Pot-1381Populus trichocarpa28.836e-60 218
LLPS-Trv-0103Trichoderma virens28.757e-71 247
LLPS-Ved-0960Verticillium dahliae28.743e-66 237
LLPS-Fuv-0359Fusarium verticillioides28.698e-69 243
LLPS-Fuo-0502Fusarium oxysporum28.697e-69 243
LLPS-Coc-1024Corchorus capsularis28.572e-64 231
LLPS-Sot-1719Solanum tuberosum28.541e-57 205
LLPS-Chc-0235Chondrus crispus28.548e-58 211
LLPS-Php-0559Physcomitrella patens28.482e-62 224
LLPS-Coo-0321Colletotrichum orbiculare28.468e-69 243
LLPS-Via-0537Vigna angularis28.312e-63 228
LLPS-Sol-0543Solanum lycopersicum28.281e-65 228
LLPS-Sei-2092Setaria italica28.261e-62 225
LLPS-Sob-0802Sorghum bicolor28.261e-62 225
LLPS-Dos-0477Dothistroma septosporum28.232e-67 239
LLPS-Trr-0109Trichoderma reesei28.167e-69 243
LLPS-Glm-1412Glycine max28.149e-63 226
LLPS-Hea-0097Helianthus annuus28.056e-56 207
LLPS-Brd-0929Brachypodium distachyon28.021e-59 216
LLPS-Bro-0657Brassica oleracea28.021e-65 234
LLPS-Chr-0467Chlamydomonas reinhardtii28.015e-64 230
LLPS-Phv-1433Phaseolus vulgaris27.994e-62 224
LLPS-Nia-1689Nicotiana attenuata27.965e-62 224
LLPS-Tum-0058Tuber melanosporum27.812e-67 239
LLPS-Prp-0683Prunus persica27.814e-62 224
LLPS-Gor-1355Gossypium raimondii27.772e-64 231
LLPS-Tra-2724Triticum aestivum27.742e-1067.8
LLPS-Hov-1911Hordeum vulgare27.731e-60 218
LLPS-Asni-0715Aspergillus niger27.714e-69 244
LLPS-Orm-0230Oryza meridionalis27.641e-61 221
LLPS-Lac-1392Latimeria chalumnae27.637e-60 219
LLPS-Art-0795Arabidopsis thaliana27.626e-64 230
LLPS-Zem-0265Zea mays27.624e-62 224
LLPS-Met-0362Medicago truncatula27.612e-62 224
LLPS-Scs-0624Sclerotinia sclerotiorum27.593e-66 231
LLPS-Lep-1056Leersia perrieri27.592e-60 219
LLPS-Blg-0685Blumeria graminis27.576e-65 233
LLPS-Cus-0618Cucumis sativus27.531e-62 225
LLPS-Arl-0523Arabidopsis lyrata27.422e-63 228
LLPS-Orc-0261Oryctolagus cuniculus27.352e-0654.7
LLPS-Orbr-0122Oryza brachyantha27.332e-61 220
LLPS-Orb-0404Oryza barthii27.273e-62 220
LLPS-Ori-0129Oryza indica27.273e-62 220
LLPS-Orni-1208Oryza nivara27.272e-61 221
LLPS-Orgl-1190Oryza glumaepatula27.272e-61 221
LLPS-Orp-0088Oryza punctata27.272e-61 221
LLPS-Ors-1050Oryza sativa27.274e-61 221
LLPS-Orr-0137Oryza rufipogon27.271e-61 221
LLPS-Org-1292Oryza glaberrima27.272e-61 221
LLPS-Thc-0620Theobroma cacao27.252e-61 223
LLPS-Tru-0044Triticum urartu27.145e-63 222
LLPS-Miv-0602Microbotryum violaceum26.753e-60 219
LLPS-Mua-1414Musa acuminata26.733e-60 218
LLPS-Cae-0058Caenorhabditis elegans26.374e-59 216
LLPS-Amt-0200Amborella trichopoda26.281e-0758.9
LLPS-Zyt-0360Zymoseptoria tritici26.121e-63 224
LLPS-Caj-3171Callithrix jacchus25.191e-1170.5
LLPS-Map-0179Magnaporthe poae25.04e-0860.5
LLPS-Vir-1219Vigna radiata24.369e-33 137
LLPS-Ast-0211Aspergillus terreus24.321e-1480.1