• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
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  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asg-0067
JHD1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: JmjC domain-containing histone demethylation protein 1; [Histone-H3]-lysine-36 demethylase 1
Gene Name: JHD1, ADL088W
Ensembl Gene: AGOS_ADL088W
Ensembl Protein: AAS51832
Organism: Ashbya gossypii
Taxa ID: 284811
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblAAS51832AAS51832
UniProtQ75AL5, JHD1_ASHGO
GeneBankAE016817AAS51832.2
RefSeqNM_209361.2NP_984008.2

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLQQVTSTTV  TGADIQLRAK  LLLFSMTDDQ  CVYCKGKMEH  RMWVQCEACP  QWVHVQCIPE  60
61    ECLSGGEYPS  RSSDIAAFEC  SAHGTARARL  ALKGKRRRVE  AKEEPERAGT  RRYRLRKRGP  120
121   LDYIALNEGQ  DVRLRHEHPH  RAAFQGCFTK  WSGLGRTVTS  AELQQSFAEL  REPVLVADPE  180
181   HSGMQTPAMD  EQVLADVLGA  DYSLDVMDVQ  SQQNERWTMG  QWKEYMHTAR  GVRDRIRNVI  240
241   SLEVSHVPEF  GQRIRRPRAV  EDNDLVDLVW  PVQPAPEIGA  KPKVQKYVLM  SAANAYTDFH  300
301   LDFAGTSVYY  SLLRGAKQFL  LFPPTPANLG  AYKAWCADDN  QGLIFLGDRL  QDGVSFSLRP  360
361   GDLFMIPSGF  IHAVYTPEDS  FVVGGNYLCL  RDLSTHIRIV  RIEQETQVPK  KFTFPKFERV  420
421   MGLTAEWLLE  GLPERLQLIT  HEHAVALLDY  LRDTRLKYKP  AHYHTKSTML  ASLEKALEGC  480
481   EPASGP  486
Nucleotide CDS Sequence (FASTA)
1     ATGCTTCAAC  AAGTGACATC  GACAACAGTC  ACCGGGGCAG  ATATACAGCT  ACGGGCAAAG  60
61    TTGCTACTAT  TCAGCATGAC  AGACGATCAA  TGCGTATACT  GCAAGGGCAA  GATGGAGCAT  120
121   AGGATGTGGG  TGCAATGCGA  GGCCTGTCCG  CAGTGGGTGC  ATGTGCAGTG  CATTCCGGAA  180
181   GAGTGCTTGA  GCGGGGGAGA  GTATCCAAGC  CGGTCATCAG  ACATTGCAGC  GTTTGAGTGC  240
241   AGTGCGCACG  GAACAGCACG  GGCGCGTCTA  GCGCTCAAGG  GCAAGCGGCG  GCGGGTCGAG  300
301   GCGAAGGAGG  AGCCGGAGCG  GGCGGGAACG  CGGCGCTACC  GGCTGCGAAA  GCGTGGCCCC  360
361   TTGGACTACA  TAGCACTAAA  CGAGGGCCAG  GACGTGCGGT  TGCGGCACGA  GCACCCGCAC  420
421   CGGGCGGCCT  TTCAGGGCTG  CTTTACCAAG  TGGAGCGGGC  TGGGCCGGAC  TGTGACGAGT  480
481   GCGGAGCTGC  AGCAGAGCTT  CGCGGAGCTG  CGCGAGCCCG  TGCTCGTGGC  GGATCCCGAG  540
541   CACTCAGGGA  TGCAGACGCC  TGCGATGGAC  GAGCAGGTGC  TCGCGGATGT  GCTGGGCGCG  600
601   GACTACTCTC  TCGACGTCAT  GGACGTGCAG  AGCCAGCAGA  ACGAGCGCTG  GACCATGGGC  660
661   CAGTGGAAGG  AGTACATGCA  CACGGCGCGC  GGCGTGCGCG  ACCGGATCCG  CAACGTGATC  720
721   TCACTGGAGG  TCAGCCATGT  GCCAGAGTTC  GGGCAGCGCA  TCAGGCGGCC  GCGCGCGGTC  780
781   GAGGACAACG  ACCTAGTGGA  CCTCGTGTGG  CCTGTGCAGC  CGGCGCCGGA  GATCGGGGCG  840
841   AAGCCCAAGG  TCCAGAAGTA  CGTTCTGATG  TCCGCCGCGA  ACGCGTACAC  GGACTTCCAC  900
901   CTGGACTTCG  CCGGCACCAG  CGTCTACTAC  AGCCTTCTGC  GCGGCGCGAA  GCAGTTTCTT  960
961   CTCTTCCCGC  CGACACCGGC  TAACCTGGGC  GCGTACAAGG  CCTGGTGCGC  GGACGACAAC  1020
1021  CAGGGCCTGA  TATTCCTGGG  CGATCGCCTG  CAGGACGGCG  TCTCGTTCAG  CCTGCGCCCC  1080
1081  GGGGACCTCT  TCATGATTCC  CTCTGGCTTC  ATCCACGCCG  TCTACACCCC  CGAAGACTCG  1140
1141  TTCGTCGTGG  GCGGCAACTA  CCTTTGCCTG  CGGGACCTTT  CCACGCACAT  CCGCATCGTG  1200
1201  CGCATCGAAC  AGGAGACACA  GGTGCCCAAG  AAGTTCACCT  TTCCGAAGTT  TGAGCGGGTT  1260
1261  ATGGGGCTTA  CTGCCGAGTG  GCTTCTGGAG  GGTCTACCCG  AGCGCCTGCA  GCTTATCACG  1320
1321  CATGAGCACG  CCGTTGCGCT  GCTAGACTAC  CTGCGGGACA  CGAGGCTGAA  ATACAAGCCT  1380
1381  GCGCATTACC  ACACGAAGAG  CACCATGCTG  GCAAGTTTGG  AGAAGGCCCT  AGAGGGCTGC  1440
1441  GAGCCCGCTT  CAGGGCCTTA  G  1461

▼ KEYWORD

ID
Family
Chromatin regulator
Complete proteome
Dioxygenase
Iron
Metal-binding
Nucleus
Oxidoreductase
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
Histone demethylase activity (H3-K36 specific)
Molecular Function
Metal ion binding
Molecular Function
Methylated histone binding
Biological Process
Positive regulation of transcription elongation from RNA polymerase II promoter

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pof-0269Poecilia formosa44.027e-58 212
LLPS-Aon-3045Aotus nancymaae43.861e-50 191
LLPS-Pug-0116Puccinia graminis43.581e-54 199
LLPS-Scm-1036Scophthalmus maximus43.082e-56 209
LLPS-Icp-1944Ictalurus punctatus43.081e-55 206
LLPS-Xim-2216Xiphophorus maculatus43.083e-56 208
LLPS-Otg-1100Otolemur garnettii42.984e-47 181
LLPS-Caj-4145Callithrix jacchus42.981e-47 182
LLPS-Orl-1506Oryzias latipes42.692e-54 202
LLPS-Gaa-1206Gasterosteus aculeatus42.693e-56 207
LLPS-Ten-0636Tetraodon nigroviridis42.533e-56 207
LLPS-Sac-1175Saccharomyces cerevisiae42.373e-126 384
LLPS-Anp-3375Anas platyrhynchos42.317e-54 201
LLPS-Gaga-1817Gallus gallus42.315e-54 201
LLPS-Anc-1568Anolis carolinensis42.311e-53 199
LLPS-Asm-1916Astyanax mexicanus42.181e-56 209
LLPS-Scf-0706Scleropages formosus42.153e-53 199
LLPS-Spr-1094Sporisorium reilianum42.054e-61 218
LLPS-Tum-0579Tuber melanosporum41.913e-49 187
LLPS-Dar-1197Danio rerio41.74e-55 204
LLPS-Xet-2671Xenopus tropicalis41.79e-56 202
LLPS-Loa-1347Loxodonta africana41.315e-53 198
LLPS-Cas-0212Carlito syrichta41.315e-53 198
LLPS-Cap-0260Cavia porcellus41.313e-53 199
LLPS-Ora-0758Ornithorhynchus anatinus41.311e-52 189
LLPS-Chs-1987Chlorocebus sabaeus41.315e-53 198
LLPS-Mum-2596Mus musculus41.316e-53 198
LLPS-Ova-1126Ovis aries41.312e-53 199
LLPS-Myl-0459Myotis lucifugus41.315e-53 199
LLPS-Mea-3252Mesocricetus auratus41.251e-49 188
LLPS-Drm-1803Drosophila melanogaster41.227e-54 201
LLPS-Cea-1056Cercocebus atys41.099e-52 194
LLPS-Orc-0439Oryctolagus cuniculus40.866e-49 186
LLPS-Fec-2422Felis catus40.867e-49 186
LLPS-Hos-4636Homo sapiens40.865e-49 187
LLPS-Pap-1908Pan paniscus40.865e-49 187
LLPS-Pat-4697Pan troglodytes40.865e-49 187
LLPS-Man-3712Macaca nemestrina40.866e-49 186
LLPS-Ict-4275Ictidomys tridecemlineatus40.866e-49 186
LLPS-Eqc-2809Equus caballus40.866e-49 186
LLPS-Caf-3605Canis familiaris40.865e-49 187
LLPS-Poa-4360Pongo abelii40.866e-49 186
LLPS-Mam-4108Macaca mulatta40.865e-49 187
LLPS-Maf-2301Macaca fascicularis40.865e-49 187
LLPS-Sus-4104Sus scrofa40.865e-49 187
LLPS-Aim-4370Ailuropoda melanoleuca40.866e-49 186
LLPS-Paa-1784Papio anubis40.865e-49 187
LLPS-Usm-0873Ustilago maydis40.666e-58 209
LLPS-Rhb-4124Rhinopithecus bieti40.546e-49 186
LLPS-Nol-0626Nomascus leucogenys40.546e-49 186
LLPS-Mal-4422Mandrillus leucophaeus40.543e-49 187
LLPS-Bot-0478Bos taurus40.549e-49 186
LLPS-Cii-1502Ciona intestinalis40.02e-48 182
LLPS-Sah-0042Sarcophilus harrisii39.855e-44 171
LLPS-Lac-0159Latimeria chalumnae39.662e-51 194
LLPS-Cis-0892Ciona savignyi39.575e-52 193
LLPS-Leo-1670Lepisosteus oculatus39.383e-51 193
LLPS-Fia-0000Ficedula albicollis38.322e-53 199
LLPS-Meg-2784Meleagris gallopavo38.322e-54 202
LLPS-Tag-0348Taeniopygia guttata38.023e-52 196
LLPS-Mup-1270Mustela putorius furo37.972e-49 187
LLPS-Urm-1108Ursus maritimus37.243e-53 199
LLPS-Fud-1091Fukomys damarensis37.249e-54 200
LLPS-Ran-2933Rattus norvegicus37.243e-53 199
LLPS-Mod-1209Monodelphis domestica36.948e-53 197
LLPS-Cae-0650Caenorhabditis elegans35.382e-39 157
LLPS-Crn-0902Cryptococcus neoformans35.031e-44 172
LLPS-Scc-0717Schizosaccharomyces cryophilus33.962e-39 157
LLPS-Dio-1035Dipodomys ordii33.572e-41 164
LLPS-Php-2294Physcomitrella patens32.932e-44 169
LLPS-Gas-1034Galdieria sulphuraria30.975e-50 184
LLPS-Gog-0331Gorilla gorilla30.043e-31 132
LLPS-Tut-0618Tursiops truncatus25.661e-32 137